The DOI matches its Crossref record; 29 of the 29 references it cites were found in a registry or an index.
Tissue tectonics: morphogenetic strain rates, cell shape change and intercalation
Open accessAbstract
The dynamic reshaping of tissues during morphogenesis results from a combination of individual cell behaviors and collective cell rearrangements. However, a comprehensive framework to unambiguously measure and link cell behavior to tissue morphogenesis is lacking. Here we introduce such a kinematic framework, bridging cell and tissue behaviors at an intermediate, mesoscopic, level of cell clusters or domains. By measuring domain deformation in terms of the relative motion of cell positions and the evolution of their shapes, we characterized the basic invariant quantities that measure fundamental classes of cell behavior, namely tensorial rates of cell shape change and cell intercalation. In doing so we introduce an explicit definition of cell intercalation as a continuous process. We mapped strain rates spatiotemporally in three models of tissue morphogenesis, gaining insight into morphogenetic mechanisms. Our quantitative approach has broad relevance for the precise characterization and comparison of morphogenetic phenotypes.
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Apical constriction: A cell shape change that can drive morphogenesis
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Hydrodynamic theory of active matter
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Adherens junctions as molecular regulators of emergent tissue mechanics
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Sculpting Organs: Mechanical Regulation of Tissue Development
Nelson, C. M., & Gleghorn, J. P. (2012) · Annual Review of Biomedical Engineering · doi:10.1146/annurev-bioeng-071811-150043 · Cited by 130
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Metadata
- Authors
- Blanchard, G. B., Kabla, A. J., Schultz, N. L., Butler, L. C., Sanson, B., Gorfinkiel, N., Mahadevan, L., & Adams, R. J.
- Venue
- Nature Methods
- Published
- 2009-05-03
- Volume
- 6
- Issue
- 6
- Pages
- 458-464
- ISSN
- 1548-7091 (ISSN-L)
- 1548-7105
- OpenAlex
- W1992172233
- Cited by
- 302
- References
- 29
- FWCI
- 6.75
- Type
- journal article
- Language
- en
- Open access
- green
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