The DOI matches its Crossref record; 6 of the 6 references it cites were found in a registry or an index.
Real-time multimodal optical control of neurons and muscles in freely behaving Caenorhabditis elegans
Open accessAbstract
The ability to optically excite or silence specific cells using optogenetics has become a powerful tool to interrogate the nervous system. Optogenetic experiments in small organisms have mostly been performed using whole-field illumination and genetic targeting, but these strategies do not always provide adequate cellular specificity. Targeted illumination can be a valuable alternative but it has only been shown in motionless animals without the ability to observe behavior output. We present a real-time, multimodal illumination technology that allows both tracking and recording the behavior of freely moving C. elegans while stimulating specific cells that express channelrhodopsin-2 or MAC. We used this system to optically manipulate nodes in the C. elegans touch circuit and study the roles of sensory and command neurons and the ultimate behavioral output. This technology enhances our ability to control, alter, observe and investigate how neurons, muscles and circuits ultimately produce behavior in animals using optogenetics.
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Cites
The structure of the nervous system of the nematode Caenorhabditis elegans
White, J. G., Southgate, E., Thomson, J. N., & Brenner, S. (1986) · Philosophical Transactions of the Royal Society of London. B, Biological Sciences · doi:10.1098/rstb.1986.0056 · Cited by 5,589
The neural circuit for touch sensitivity in Caenorhabditis elegans
Chalfie, M., Sulston, J., White, J., Southgate, E., Thomson, J., & Brenner, S. (1985) · The Journal of Neuroscience · doi:10.1523/jneurosci.05-04-00956.1985 · Cited by 1,093
Sparse optical microstimulation in barrel cortex drives learned behaviour in freely moving mice
Huber, D., Petreanu, L., Ghitani, N., Ranade, S., Hromádka, T., Mainen, Z., & Svoboda, K. (2008) · Nature · doi:10.1038/nature06445 · Cited by 539
Dimensionality and Dynamics in the Behavior of C. elegans
Stephens, G. J., Johnson-Kerner, B., Bialek, W., & Ryu, W. S. (2008) · PLoS Computational Biology · doi:10.1371/journal.pcbi.1000028 · Cited by 509
Optogenetic dissection of a behavioural module in the vertebrate spinal cord
Wyart, C., Bene, F. D., Warp, E., Scott, E. K., Trauner, D., Baier, H., & Isacoff, E. Y. (2009) · Nature · doi:10.1038/nature08323 · Cited by 409
Integration of mechanosensory stimuli in Caenorhabditis elegans
Wicks, Sr., & Rankin, C. (1995) · The Journal of Neuroscience · doi:10.1523/jneurosci.15-03-02434.1995 · Cited by 240
Cited by
Optogenetics in neural systems
Yizhar, O., Fenno, L. E., Davidson, T. J., Mogri, M., & Deisseroth, K. (2011) · Neuron · doi:10.1016/j.neuron.2011.06.004 · Cited by 1,881
The development and application of optogenetics
Fenno, L., Yizhar, O., & Deisseroth, K. (2011) · Annual Review of Neuroscience · doi:10.1146/annurev-neuro-061010-113817 · Cited by 1,822
Two-photon optogenetic toolbox for fast inhibition, excitation and bistable modulation
Prakash, R., Yizhar, O., Grewe, B., Ramakrishnan, C., Wang, N., Goshen, I., Packer, A. M., Peterka, D. S., Yuste, R., Schnitzer, M. J., et al. (2012) · Nature Methods · doi:10.1038/nmeth.2215 · Cited by 334
Kawano, T., Po, M. D., Gao, S., Leung, G., Ryu, W. S., & Zhen, M. (2011) · Neuron · doi:10.1016/j.neuron.2011.09.005 · Cited by 240
Controlling interneuron activity in Caenorhabditis elegans to evoke chemotactic behaviour
Kocabas, A., Shen, C.-H., Guo, Z. V., & Ramanathan, S. (2012) · Nature · doi:10.1038/nature11431 · Cited by 150
Metadata
- Authors
- Stirman, J. N., Crane, M. M., Husson, S. J., Wabnig, S., Schultheis, C., Gottschalk, A., & Lu, H.
- Venue
- Nature Methods
- Published
- 2011-01-16
- Volume
- 8
- Issue
- 2
- Pages
- 153-158
- ISSN
- 1548-7091 (ISSN-L)
- 1548-7105
- OpenAlex
- W2047228161
- Cited by
- 216
- References
- 6
- FWCI
- 9.41
- Type
- journal article
- Language
- en
- Open access
- green
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- Stirman, J. N., Crane, M. M., Husson, S. J., Wabnig, S., Schultheis, C., Gottschalk, A., & Lu, H. (2011). Real-time multimodal optical control of neurons and muscles in freely behaving Caenorhabditis elegans. Nature Methods. https://doi.org/10.1038/nmeth.1555
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