The DOI matches its Crossref record; 6 of the 6 references it cites were found in a registry or an index.
Real-time multimodal optical control of neurons and muscles in freely behaving Caenorhabditis elegans
Open accessAbstract
The ability to optically excite or silence specific cells using optogenetics has become a powerful tool to interrogate the nervous system. Optogenetic experiments in small organisms have mostly been performed using whole-field illumination and genetic targeting, but these strategies do not always provide adequate cellular specificity. Targeted illumination can be a valuable alternative but it has only been shown in motionless animals without the ability to observe behavior output. We present a real-time, multimodal illumination technology that allows both tracking and recording the behavior of freely moving C. elegans while stimulating specific cells that express channelrhodopsin-2 or MAC. We used this system to optically manipulate nodes in the C. elegans touch circuit and study the roles of sensory and command neurons and the ultimate behavioral output. This technology enhances our ability to control, alter, observe and investigate how neurons, muscles and circuits ultimately produce behavior in animals using optogenetics.
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Cites
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Cited by
Optogenetics in neural systems
Yizhar, O., Fenno, L. E., Davidson, T. J., Mogri, M., & Deisseroth, K. (2011) · Neuron · doi:10.1016/j.neuron.2011.06.004 · Cited by 1,881
The development and application of optogenetics
Fenno, L., Yizhar, O., & Deisseroth, K. (2011) · Annual Review of Neuroscience · doi:10.1146/annurev-neuro-061010-113817 · Cited by 1,822
Two-photon optogenetic toolbox for fast inhibition, excitation and bistable modulation
Prakash, R., Yizhar, O., Grewe, B., Ramakrishnan, C., Wang, N., Goshen, I., Packer, A. M., Peterka, D. S., Yuste, R., Schnitzer, M. J., et al. (2012) · Nature Methods · doi:10.1038/nmeth.2215 · Cited by 334
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Controlling interneuron activity in Caenorhabditis elegans to evoke chemotactic behaviour
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How Caenorhabditis elegans Senses Mechanical Stress, Temperature, and Other Physical Stimuli
Goodman, M. B., & Sengupta, P. (2019) · Genetics · doi:10.1534/genetics.118.300241 · Cited by 131
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Faumont, S., Rondeau, G., Thiele, T. R., Lawton, K. J., McCormick, K. E., Sottile, M., Griesbeck, O., Heckscher, E. S., Roberts, W. M., Doe, C. Q., et al. (2011) · PLoS ONE · doi:10.1371/journal.pone.0024666 · Cited by 128
Distributed rhythm generators underlie Caenorhabditis elegans forward locomotion
Fouad, A. D., Teng, S., Mark, J. R., Liu, A., Alvarez-Illera, P., Ji, H., Du, A., Bhirgoo, P. D., Cornblath, E., Guan, S. A., et al. (2018) · eLife · doi:10.7554/elife.29913 · Cited by 79
S-MRUT: sectored-multiring ultrasonic transducer for selective powering of brain implants
Hosseini, S., Laursen, K., Rashidi, A., Mondal, T., Corbett, B., & Moradi, F. (2021) · IEEE Transactions on Ultrasonics, Ferroelectrics, and Frequency Control · doi:10.1109/tuffc.2020.3001084 · Cited by 15
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Metadata
- Authors
- Stirman, J. N., Crane, M. M., Husson, S. J., Wabnig, S., Schultheis, C., Gottschalk, A., & Lu, H.
- Venue
- Nature Methods
- Published
- 2011-01-16
- Volume
- 8
- Issue
- 2
- Pages
- 153-158
- ISSN
- 1548-7091 (ISSN-L)
- 1548-7105
- OpenAlex
- W2047228161
- Cited by
- 216
- References
- 6
- FWCI
- 9.41
- Type
- journal article
- Language
- en
- Open access
- green
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