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CREST maps somatic structural variation in cancer genomes with base-pair resolution
Open accessAbstract
We developed 'clipping reveals structure' (CREST), an algorithm that uses next-generation sequencing reads with partial alignments to a reference genome to directly map structural variations at the nucleotide level of resolution. Application of CREST to whole-genome sequencing data from five pediatric T-lineage acute lymphoblastic leukemias (T-ALLs) and a human melanoma cell line, COLO-829, identified 160 somatic structural variations. Experimental validation exceeded 80%, demonstrating that CREST had a high predictive accuracy.
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Self-citation
Metadata
- Authors
- Wang, J., Mullighan, C. G., Easton, J., Roberts, S., Heatley, S. L., Ma, J., Rusch, M. C., Chen, K., Harris, C. C., Ding, L., Holmfeldt, L., Payne-Turner, D., Fan, X., Wei, L., Zhao, D., Obenauer, J. C., Naeve, C., Mardis, E. R., Wilson, R. K., Downing, J. R., & Zhang, J.
- Venue
- Nature Methods
- Published
- 2011-06-12
- Volume
- 8
- Issue
- 8
- Pages
- 652-654
- ISSN
- 1548-7091 (ISSN-L)
- 1548-7105
- OpenAlex
- W2169145121
- Cited by
- 496
- References
- 7
- FWCI
- 24.30
- Type
- journal article
- Language
- en
- Open access
- green
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