The DOI matches its Crossref record; 2 of the 2 references it cites were found in a registry or an index.
Live-cell imaging of alkyne-tagged small biomolecules by stimulated Raman scattering
Open accessAbstract
Sensitive and specific visualization of small biomolecules in living systems is highly challenging. We report stimulated Raman-scattering imaging of alkyne tags as a general strategy for studying a broad spectrum of small biomolecules in live cells and animals. We demonstrate this technique by tracking alkyne-bearing drugs in mouse tissues and visualizing de novo synthesis of DNA, RNA, proteins, phospholipids and triglycerides through metabolic incorporation of alkyne-tagged small precursors.
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Citations
Cites
Alkyne-Tag Raman Imaging for Visualization of Mobile Small Molecules in Live Cells
Yamakoshi, H., Dodo, K., Palonpon, A., Ando, J., Fujita, K., Kawata, S., & Sodeoka, M. (2012) · Journal of the American Chemical Society · doi:10.1021/ja308529n · Cited by 461
Imaging of EdU, an Alkyne-Tagged Cell Proliferation Probe, by Raman Microscopy
Yamakoshi, H., Dodo, K., Okada, M., Ando, J., Palonpon, A., Fujita, K., Kawata, S., & Sodeoka, M. (2011) · Journal of the American Chemical Society · doi:10.1021/ja108404p · Cited by 356
Cited by
Vibrational spectroscopic imaging of living systems: An emerging platform for biology and medicine
Cheng, J.-X., & Xie, X. S. (2015) · Science · doi:10.1126/science.aaa8870 · Cited by 874
Super-multiplex vibrational imaging
Wei, L., Chen, Z., Shi, L., Long, R., Anzalone, A. V., Zhang, L., Hu, F., Yuste, R., Cornish, V. W., & Min, W. (2017) · Nature · doi:10.1038/nature22051 · Cited by 514
Self-citationRaman spectroscopy: techniques and applications in the life sciences
Shipp, D. W., Sinjab, F., & Notingher, I. (2017) · Advances in Optics and Photonics · doi:10.1364/aop.9.000315 · Cited by 396
Biological imaging of chemical bonds by stimulated Raman scattering microscopy
Hu, F., Shi, L., & Min, W. (2019) · Nature Methods · doi:10.1038/s41592-019-0538-0 · Cited by 392
Self-citationZhang, D., Li, C., Zhang, C., Slipchenko, M. N., Eakins, G., & Cheng, J.-X. (2016) · Science Advances · doi:10.1126/sciadv.1600521 · Cited by 389
Metadata
- Authors
- Wei, L., Hu, F., Shen, Y., Chen, Z., Yu, Y., Lin, C.-C., Wang, M. C., & Min, W.
- Venue
- Nature Methods
- Published
- 2014-03-02
- Volume
- 11
- Issue
- 4
- Pages
- 410-412
- ISSN
- 1548-7091 (ISSN-L)
- 1548-7105
- OpenAlex
- W2037912676
- Cited by
- 504
- References
- 2
- FWCI
- 21.79
- Type
- journal article
- Language
- en
- Open access
- green
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- Wei, L., Hu, F., Shen, Y., Chen, Z., Yu, Y., Lin, C.-C., Wang, M. C., & Min, W. (2014). Live-cell imaging of alkyne-tagged small biomolecules by stimulated Raman scattering. Nature Methods. https://doi.org/10.1038/nmeth.2878
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