CRISPR-STOP: gene silencing through base-editing-induced nonsense mutations

Cited by (335)

Items 201–300 of 335

1. An aptamer-mediated base editing platform for simultaneous knockin and multiple gene knockout for allogeneic CAR-T cells generation
   Immacolata Porreca, Robert A. Blassberg, Jennifer A. Harbottle, Bronwyn C. Joubert, Olga Mielczarek, Jesse Stombaugh, Kevin Hemphill, Jonathan Sumner, Deividas Pazeraitis, Julia Liz Touza et al. · 2024 · Molecular Therapy
2. Long-Term Rewritable Report and Recording of Environmental Stimuli in Engineered Bacterial Populations
   Zhen‐Ping Zou, Bang‐Ce Ye · 2020 · ACS Synthetic Biology
3. AsCRISPR: A Web Server for Allele-Specific Single Guide RNA Design in Precision Medicine
   Guihu Zhao, Jinchen Li, Yu Tang · 2020 · The CRISPR Journal
4. Development of Whole Genome‐Scale Base Editing Toolbox to Promote Efficiency of Extracellular Electron Transfer in Shewanella oneidensis MR‐1
   Yaru Chen, Lixia Fang, Xiang Ying, Meijie Cheng, Lin Wang, Panxing Sun, Zhaoyu Zhang, Liang Shi, Yingxiu Cao, Hao Song · 2022 · Advanced Biology
5. Highly efficient multiplex base editing: One-shot deactivation of eight genes in Shewanella oneidensis MR-1
   Yaru Chen, Meijie Cheng, Yan Li, Lin Wang, Lixia Fang, Yingxiu Cao, Hao Song · 2022 · Synthetic and Systems Biotechnology
6. Design and application of the transformer base editor in mammalian cells and mice
   Wenyan Han, Bao‐Qing Gao, Junjie Zhu, Zongxing He, Jianfeng Li, Li Chun Yang, Jia Chen · 2023 · Nature Protocols
7. Current Knowledge of Base Editing and Prime Editing
   Olga A. Averina, S. A. Kuznetsova, Oleg A. Permyakov, Сергиев Петр Владимирович · 2024 · Molecular Biology
8. Large-scale manufacturing of base-edited chimeric antigen receptor T cells
   Rosie Woodruff, Farhaan Parekh, Katarina Lamb, Leila Mekkaoui, Christopher G. Allen, Katerina Smetanova, Jasmine L. Huang, Alex Williams, Gerardo Santiago Toledo, Koki Lilova et al. · 2023 · Molecular Therapy — Methods & Clinical Development
9. Functional Genomics for Cancer Research: Applications In Vivo and In Vitro
   Thomas A. O’Loughlin, Luke A. Gilbert · 2018 · Annual Review of Cancer Biology
10. The next innovations in chimeric antigen receptor T cell immunotherapies for cancer
    Kusala Anupindi, Julia Malachowski, Isabella Hodson, Daniel Zhu, Carl H. June, Bruce L. Levine · 2025 · Cytotherapy
11. Enhancing Understanding of the Visual Cycle by Applying CRISPR/Cas9 Gene Editing in Zebrafish
    Rebecca H. R. Ward, Husvinee Sundaramurthi, Valeria Di Giacomo, Breandán N. Kennedy · 2018 · Frontiers in Cell and Developmental Biology
12. Got mutation? ‘Base editors’ fix genomes one nucleotide at a time.
    Ravindran, Sandeep · 2019 · Nature
13. An engineered baculoviral protein and DNA co-delivery system for CRISPR-based mammalian genome editing
    Julien Capin, Alexandra Harrison, Renata Raele-Rolfe, Sathish K.N. Yadav, Dominique Baiwir, Gabriel Mazzucchelli, Loïc Quinton, Timothy J. Satchwell, Ashley Mark Toye, Christiane Schaffitzel et al. · 2024 · Nucleic Acids Research
14. An Agrobacterium-Mediated CRISPR/Cas9 Platform for Genome Editing in Maize
    Keunsub Lee, Huilan Zhu, Bing Yang, Kan Wang · 2019 · Methods in molecular biology
15. CRISPR/Cas9 gene editing for genodermatoses: progress and perspectives
    Gaetano Naso, Anastasia Petrova · 2019 · Emerging Topics in Life Sciences
16. Whole‐Genome Regulation for Yeast Metabolic Engineering
    Shuangying Jiang, Tong Si, Junbiao Dai · 2019 · Small Methods
17. A method for CRISPR/Cas9 mutation of genes in fathead minnow (Pimephales promelas)
    Jennifer A. Maki, Jenna E. Cavallin, Kevin G. Lott, Travis W. Saari, Gerald T. Ankley, Daniel L. Villeneuve · 2020 · Aquatic Toxicology
18. Simultaneous multiplex genome loci editing of Halomonas bluephagenesis using an engineered CRISPR-guided base editor
    Yulin Zhang, Yang Zheng, Qiwen Hu, Zhen Qi Hu, Jiyuan Sun, Ping Cheng, Xiancai Rao, Xiao‐Ran Jiang · 2024 · Synthetic and Systems Biotechnology
19. Mechanisms and hormonal regulation of shell formation
    Yves Y. Nys, Joël Gautron, Alejandro B. Rodríguez‐Navarro, Maxwell T. Hincke · 2021 · Elsevier eBooks
20. Recent progress of molecular diagnosis via CRISPR Cas-based biosensors and bioassays
    Sophia Nazir · 2023 · Talanta Open
21. Screening an Effective Dual-Adeno-Associated Virus Split-Cytosine Base Editor System for C-to-T Conversion In Vivo
    Qianyi Liu, Yuxi Chen, Sihui Hu, Weiliang Liu, Dongchun Xie, Xin Yang, Wenyan Huang, Simiao Liu, Xiaolin Chen, Haiying Liu et al. · 2023 · Human Gene Therapy
22. Genome, Epigenome, and Transcriptome Editing via Chemical Modification of Nucleobases in Living Cells
    Brodie L. Ranzau, Alexis C. Komor · 2018 · Biochemistry
23. Genome-wide CRISPR screens for the identification of therapeutic targets for cancer treatment
    Vivian Weiwen Xue, Sze Chuen Cesar Wong, William Chi Shing Cho · 2020 · Expert Opinion on Therapeutic Targets
24. CRISPR/Cas-based Human T cell Engineering: Basic Research and Clinical Application
    Bettina E. Bernard, Emmanuelle Landmann, Lukas T. Jeker, Kathrin Schumann · 2022 · Immunology Letters
25. Genome editing in Latin America: research achievements and regulatory evolution
    Alejandro Hernández-Soto, Andrés Gatica-Arias · 2024 · Plant Cell Tissue and Organ Culture (PCTOC)
26. Progression and application of CRISPR-Cas genomic editors
    Li Chun Yang, Jing Tang, Xuelei Ma, Yuan Lin, Guorong Ma, Minghai Shan, Libin Wang, Yanhui Yang · 2021 · Methods
27. Powerful Microbial Base-Editing Toolbox: From Optimization Strategies to Versatile Applications
    Ke Li, Ling-Yun Qin, Zixu Zhang, Chun-Xiao Yan, Yang Mo Gu, Xiao‐Man Sun, He Huang · 2023 · ACS Synthetic Biology
28. CRISPR-Cas9 for selective targeting of somatic mutations in pancreatic cancers
    Selina Shiqing K. Teh, Kirsten Bowland, Eitan Halper‐Stromberg, Akhil Kotwal, Alexis Bennett, Alyza M. Skaist, Jacqueline Tang, Fidel Cai, Antonella Macoretta, Hong Liang et al. · 2024 · NAR Cancer
29. More precise, more universal and more specific – the next generation of RNA‐guided endonucleases for genome editing
    Marek Marzec, Göetz Hensel · 2019 · FEBS Journal
30. Comparison of gene disruption induced by cytosine base editing‐mediated iSTOP with CRISPR/Cas9‐mediated frameshift
    Lu Dang, Guanglei Li, Xinjie Wang, Shisheng Huang, Yu Zhang, Yuanxin Miao, Lisi Zeng, Shuzhong Cui, Xingxu Huang · 2020 · Cell Proliferation
31. Generation of isogenic single and multiplex gene knockout mice by base editing-induced STOP
    Guang Yang, Tianyu Zhu, Zongyang Lu, Guanglei Li, Hao Zhang, Songjie Feng, Yajing Liu, Jianan Li, Yu Zhang, Jia Chen et al. · 2018 · 中国科学通报：英文版
32. Multiplex-edited mice recapitulate woolly mammoth hair phenotypes
    Rui Chen, Melissa L. Coquelin, Kanokwan Srirattana, Rafael Vilar Sampaio, Jacob D. Weston, Rakesh Ganji, Raphael A. Wilson, J. L. Beebe, Alba V. Ledesma, Jacob Sullivan et al. · 2025 · bioRxiv (Cold Spring Harbor Laboratory)
33. Expanding the flexibility of base editing for high-throughput genetic screens in bacteria
    Sandra Gawlitt, Scott P. Collins, Yanying Yu, Samuel A Blackman, Lars Barquist, Chase L. Beisel · 2024 · Nucleic Acids Research
34. CRISPR-Cas systems for genome editing of mammalian cells
    Indra Mani, Takayuki Arazoe, Vijai Singh · 2021 · Progress in molecular biology and translational science
35. Towards a CRISPeR understanding of homologous recombination with high-throughput functional genomics
    Samuel B. Hayward, Alberto Ciccia · 2021 · Current Opinion in Genetics & Development
36. A multi-kingdom genetic barcoding system for precise clone isolation
    Soh Ishiguro, Kana Ishida, Rina C. Sakata, Minori Ichiraku, Ren Takimoto, Rina Yogo, Yusuke Kijima, Hideto Mori, Mamoru Tanaka, S. B. King et al. · 2025 · Nature Biotechnology
37. In Vivo Cancer-Based Functional Genomics
    Chennan Li, Andrea L. Kasinski · 2020 · Trends in cancer
38. Precision genome editing with DNA base editors
    S J Mawson, Kara Dunne-Dombrink, Benjamin R. Pollak, Alexis C. Komor · 2026 · Nature Reviews Methods Primers
39. SOD1-targeting therapies for neurodegenerative diseases: a review of current findings and future potential
    John Franklin, Mimoun Azzouz, Pamela J. Shaw · 2020 · Expert Opinion on Orphan Drugs
40. One-for-all gene inactivation via PAM-independent base editing in bacteria
    Xin Li, Ying Wei, Shuyan Wang, Shuguang Wang, Peng‐Fei Xia · 2024 · Journal of Biological Chemistry
41. Strategies to Eliminate HBV Infection: an Update
    Lydia Tang, Shyam Kottilil, Eleanor M. P. Wilson · 2020 · Future Virology
42. CRISPR/Cas-Based Insect Resistance in Crops
    Muhammad Kashif Zahoor, Aftab Ahmad, Muhammad Asif Zahoor, Humara Naz Majeed, Muhammad Zulhussnain, Kanwal Ranian · 2021 · Springer eBooks
43. In vivo genome editing in single mammalian brain neurons through CRISPR-Cas9 and cytosine base editors
    Beomjong Song, Chan Young Kang, Jun Hee Han, Masanobu Kano, Arthur Konnerth, Sangsu Bae · 2021 · Computational and Structural Biotechnology Journal
44. A simple and efficient strategy to produce transgene-free gene edited plants in one generation using paraquat resistant 1 as a selection marker
    Xiangjiu Kong, Wenbo Pan, Tingyu Zhang, Lijing Liu, Huawei Zhang · 2023 · Frontiers in Plant Science
45. Studying Reversible Protein Post‐translational Modification through Co‐translational Modification
    Dan Wu, Tao Liu · 2023 · ChemBioChem
46. Multiple sgRNAs facilitate base editing-mediated i-stop to induce complete and precise gene disruption
    Kun Jia, Zongyang Lu, Fei Zhou, Zhi‐Qi Xiong, Rui Zhang, Zhiwei Liu, Yue Ma, Lei He, Cong Li, Zhen Zhu et al. · 2019 · Protein & Cell
47. Immunotherapy to get on point with base editing
    Jennifer A. Harbottle · 2021 · Drug Discovery Today
48. CRISPR-Cas technologies: Emerging tools from research to clinical application
    Hana Hyeon, Soonhye Hwang, Yongyang Luo, Eunkyoung Shin, Ji‐Hyun Yeom, Hong‐Man Kim, Minkyung Ryu, Kangseok Lee · 2025 · The Journal of Microbiology
49. The use of base editing technology to characterize single nucleotide variants
    Sophia McDaniel, Alexis C. Komor, Alon Goren · 2022 · Computational and Structural Biotechnology Journal
50. Developing Bottom-Up Induced Pluripotent Stem Cell Derived Solid Tumor Models Using Precision Genome Editing Technologies
    Kelsie L. Becklin, Garrett M. Draper, Rebecca A. Madden, Mitchell G. Kluesner, Tomoyuki Koga, Miller Huang, William A. Weiss, Logan G. Spector, David A. Largaespada, Branden S. Moriarity et al. · 2022 · The CRISPR Journal
51. Overcoming Multidrug Resistance by Base-Editing-Induced Codon Mutation
    He-Hua Zhang, Jian Xiang, Bin‐Cheng Yin, Bang‐Ce Ye · 2023 · ACS Pharmacology & Translational Science
52. CRISPR RNA Array‐Guided Multisite Cleavage for Gene Disruption by Cas9 and Cpf1
    Dan Wang, Dejun Ma, Jingxin Han, Linghao Kong, Lu‐Yuan Li, Zhen Xi · 2018 · ChemBioChem
53. Computational Methods for Analysis of Large-Scale CRISPR Screens
    Xueqiu Lin, Augustine G. Chemparathy, Marie F. La Russa, Timothy Daley, Lei S. Qi · 2020 · Annual Review of Biomedical Data Science
54. Advances in CRISPR Base Editing: From Molecular Evolution to Therapeutic Applications in Genomic Medicine
    Melike Aliciaslan, Ezgi Erbasan, Fulya Erendor, Salih Şanlıoğlu · 2026 · Journal of Cellular and Molecular Medicine
55. Recognizing CRISPR as the new age disease‐modifying drug: Strategies to bioengineer CRISPR/Cas for direct in vivo delivery
    Ramesh Thevendran, Maheswaran Solayappan · 2023 · Biotechnology Journal
56. CRISPR-Cas9-based approaches for genetic analysis and epistatic interaction studies in Coxiella burnetii
    Samuel Steiner, Craig R. Roy · 2024 · mSphere
57. Simultaneous CRISPR/Cas9-induced double-strand breaks are lethal in models of pancreatic cancer
    Selina Shiqing K. Teh, Akhil Kotwal, Alexis Bennett, Eitan Halper‐Stromberg, Laura A. Morsberger, Saum Zamani, Yanan Shi, Alyza Skaist, Qingfeng Zhu, Kirsten Bowland et al. · 2026 · Journal of Clinical Investigation
58. i-Silence, Please! An Alternative for Gene Disruption via Adenine Base Editors
    Hyeon‐Ki Jang, Sangsu Bae · 2020 · Molecular Therapy
59. Efficient silencing of the multicopy DUX4 gene by ABE-mediated start codon mutation in human embryos
    Yubing Liu, Xinmei Lu, Min Ye, Ling Wang, Rongxin Tang, Zhi-Yong Yang, Bongkoch Turathum, Chenchen Liu, Yujing Xue, Menghua Wu et al. · 2022 · Journal of genetics and genomics/Journal of Genetics and Genomics
60. Origin of the genome editing systems: application for crop improvement
    Ambra Viviani, Maria Spada, Tommaso Giordani, Marco Fambrini, Claudio Pugliesi · 2022 · Biologia
61. A single CRISPR base editor to induce simultaneous C-to-T and A-to-G mutations
    Rina C. Sakata, Soh Ishiguro, Hideto Mori, Mamoru Tanaka, M. Seki, Nanami Masuyama, Keiji Nishida, Hiroshi Nishimasu, Akihiko Kondo, Osamu Nureki et al. · 2019 · bioRxiv (Cold Spring Harbor Laboratory)
62. CRISPR-mediated biocontainment
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63. The Development and Application of a Base Editor in Biomedicine
    Fang Wang, Yuqiang Zeng, Yi Wang, Yuyu Niu · 2020 · BioMed Research International
64. Advances in base editing with an emphasis on an AAV-based strategy
    Jiajie Kuang, Qinghua Lyu, Jiao Wang, Yubo Cui, Jun Zhao · 2021 · Methods
65. Dead Cas Systems: Types, Principles, and Applications
    Sergey Brezgin, Anastasiya Kostyusheva, Dmitry S. Kostyushev, Vladimir Chulanov · 2020 · Vide Leaf, Hyderabad eBooks
66. Base editor-mediated large-scale screening of functional mutations in bacteria for industrial phenotypes
    Yaomeng Yuan, Xihao Liao, Shuang Li, Xin‐Hui Xing, Chong Zhang · 2024 · Science China Life Sciences
67. Revolutionizing personalized cancer treatment: the synergy of next-generation sequencing and CRISPR/Cas9
    Muniba Mahmood, Izza Taufiq, Sana Mazhar, Faiqa Hafeez, Kausar A. Malik, Samia Afzal · 2024 · Personalized Medicine
68. Repurposing base editors for targeted knockin and simultaneous multiplex knockouts to generate allo-CAR T cells with minimal translocations
    Viktor Glaser, Becker. Lily Jo, Carla Fuster‐García, Eric J. Aird, Luis Huth, Ana-Maria Nitulescu, Yaolin Pu, Isabell Kassing, Laura Marie Hartmann, Christian Luca Flugel et al. · 2026 · Molecular Therapy
69. CRATES: A one-step assembly method for Class 2 CRISPR arrays
    Chunyu Liao, Rebecca Slotkowski, Chase L. Beisel · 2019 · Methods in enzymology on CD-ROM/Methods in enzymology
70. Efficient and Safe Editing of Porcine Endogenous Retrovirus Genomes by Multiple-Site Base-Editing Editor
    Shuwen Zheng, Haiwen Zhong, Xiaoqing Zhou, Min Chen, Wansheng Li, Zi Yin, Yue Chi, Jinling Wang, Wei Zheng, Qingjian Zou et al. · 2022 · Cells
71. Blood cancer therapy with synthetic receptors and CRISPR technology
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72. Application of CRISPR-Cas9 Screening Technologies to Study Mitochondrial Biology in Healthy and Disease States
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73. CRISPR-dependent Base Editing Screens Identify Separation of Function Mutants of RADX with Altered RAD51 Regulatory Activity
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74. Next generation genetic screens in kinetoplastids
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75. Rationally Designed TadA‐Derived Cytosine Editors Enable Context‐Independent Zebrafish Genome Editing
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76. Techno-economic assessment-guided biofoundry for microbial strain development
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77. In vitro and in vivo base editing of CCR5 in hematopoietic stem cells confers HIV-1 resistance
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78. Cytosine base editor-mediated ZSCAN4 ablation impairs zygotic genome activation via epigenetic dysregulation in porcine parthenogenetic embryos
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79. Genome-Editing Advances for Disease Resistance in Plants
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80. KOnezumi-AID: Automation Software for Efficient Multiplex Gene Knockout Using Target-AID
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81. Leveraging CRISPR/Cas9 in notable bacteria for the production of industrially valuable compounds
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82. CD33 epitope editing unlocks UM171-expanded cord blood grafts for AML immunotherapy
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83. Editing Properties of Base Editors with SpCas9-NG in Discarded Human Tripronuclear Zygotes
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84. PE-STOP: A versatile tool for installing nonsense substitutions amenable for precise reversion
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85. Highly Multiplexed Analysis of CRISPR Genome Editing Outcomes in Mammalian Cells
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86. Target-AID-Mediated Multiplex Base Editing in Porcine Fibroblasts
    Soo‐Young Yum, Goo Jang, Ok Jae Koo · 2021 · Animals
87. Where is the EXIT ? Phenotypic screens for new egress factors in apicomplexan parasites
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88. CRISPR-mediated base editing in mice using cytosine deaminase base editor 4
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89. Massively parallel quantification of CRISPR editing in cells by TRAP-seq enables better design of Cas9, ABE, CBE gRNAs of high efficiency and accuracy
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90. Reprogramming microbial cell factories to overproduce plant natural products through directed genome evolution
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91. Optimizing linker length of base editors for precise crop breeding and gene therapy
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92. CRISPR-Cas orthologs and variants
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93. Genome Editing of Pluripotent Stem Cells for Adoptive and Regenerative Cell Therapies
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94. A review of application of base editing for the treatment of inner ear disorders
    Xingle Zhao, Zhuoer Sun, Wen Kang, Yong Tao, Hao Wu · 2019 · Journal of Bio-X Research
95. Base Editing
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96. Genome Engineering for Enriching Fe and Zn in Rice Grain and Increasing Micronutrient Bioavailability
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97. Decoding disease-relevant variants with base and prime editors at scale
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98. CRISPR-Cas Systems: Origins and Their Impact on Functional Genomic
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99. Characterization and engineering of a type IV-A3 CRISPR–Cas system for genome editing in Escherichia coli
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100. Precision genetic manipulation: CRISPR toolkits reshape plant biology
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