Got mutation? ‘Base editors’ fix genomes one nucleotide at a time.
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The rapid developing CRISPR/Cas9 base editing tools have promise in fixing the bugs in whole genome synthesis.
“The rapid developing CRISPR/Cas9 base editing tools, which has been widely used for correction of disease associated mutations, have promise in fixing the bugs”
From Large-Scale de Novo Oligonucleotide Synthesis for Whole-Genome Synthesis and Data Storage: Challenges and Opportunities (2021) · cites this paper as Ravindran, 2019
Cites
Programmable editing of a target base in genomic DNA without double-stranded DNA cleavage
Komor, A. C., Kim, Y. B., Packer, M. S., Zuris, J. A., & Liu, D. R. (2016) · Nature · doi:10.1038/nature17946 · Cited by 5,437 · see citing works
Search-and-replace genome editing without double-strand breaks or donor DNA
Anzalone, A. V., Randolph, P. B., Davis, J. R., Sousa, A. A., Koblan, L. W., Levy, J. M., Chen, P. J., Wilson, C., Newby, G. A., Raguram, A., et al. (2019) · Nature · doi:10.1038/s41586-019-1711-4 · Cited by 4,767 · see citing works
Programmable base editing of A•T to G•C in genomic DNA without DNA cleavage
Gaudelli, N. M., Komor, A. C., Rees, H. A., Packer, M. S., Badran, A. H., Bryson, D. I., & Liu, D. R. (2017) · Nature · doi:10.1038/nature24644 · Cited by 4,184 · see citing works
Efficient generation of mouse models of human diseases via ABE- and BE-mediated base editing
Liu, Z., Lu, Z., Yang, G., Huang, S., Li, G., Feng, S., Liu, Y., Li, J., Yu, W., Zhang, Y., et al. (2018) · Nature Communications · doi:10.1038/s41467-018-04768-7 · Cited by 2,103 · see citing works
Base editing: precision chemistry on the genome and transcriptome of living cells
Rees, H. A., & Liu, D. R. (2018) · Nature Reviews Genetics · doi:10.1038/s41576-018-0059-1 · Cited by 1,675 · see citing works
Cytosine base editor generates substantial off-target single-nucleotide variants in mouse embryos
Zuo, E., Sun, Y., Wei, W., Yuan, T., Ying, W., Sun, H., Yuan, L., Steinmetz, L. M., Li, Y., & Yang, H. (2019) · Science · doi:10.1126/science.aav9973 · Cited by 782 · see citing works
Kim, Y. B., Komor, A. C., Levy, J. M., Packer, M. S., Zhao, K. T., & Liu, D. R. (2017) · Nature Biotechnology · doi:10.1038/nbt.3803 · Cited by 756 · see citing works
Cytosine, but not adenine, base editors induce genome-wide off-target mutations in rice
Jin, S., Zong, Y., Gao, Q., Zhu, Z., Wang, Y., Qin, P., Liang, C., Wang, D., Qiu, J.-L., Zhang, F., et al. (2019) · Science · doi:10.1126/science.aaw7166 · Cited by 665 · see citing works
Transcriptome-wide off-target RNA editing induced by CRISPR-guided DNA base editors
Grünewald, J., Zhou, R., Garcia, S. P., Iyer, S., Lareau, C. A., Aryee, M. J., & Joung, J. K. (2019) · Nature · doi:10.1038/s41586-019-1161-z · Cited by 663 · see citing works
Adenine base editing in mouse embryos and an adult mouse model of Duchenne muscular dystrophy
Ryu, S.-M., Koo, T., Kim, K., Lim, K., Baek, G., Kim, S., Kim, H. S., Kim, D.-E., Lee, H., Chung, E., et al. (2018) · Nature Biotechnology · doi:10.1038/nbt.4148 · Cited by 442 · see citing works
Rees, H. A., Komor, A. C., Yeh, W.-H., Caetano‐Lopes, J., Warman, M. L., Edge, A. S. B., & Liu, D. R. (2017) · Nature Communications · doi:10.1038/ncomms15790 · Cited by 422 · see citing works
Highly efficient RNA-guided base editing in mouse embryos
Kim, K., Ryu, S.-M., Kim, S., Baek, G., Kim, D., Lim, K., Chung, E., Kim, S., & Kim, J. (2017) · Nature Biotechnology · doi:10.1038/nbt.3816 · Cited by 378 · see citing works
Billon, P., Bryant, E. E., Joseph, S. A., Nambiar, T. S., Hayward, S. B., Rothstein, R., & Ciccia, A. (2017) · Molecular Cell · doi:10.1016/j.molcel.2017.08.008 · Cited by 363 · see citing works
CRISPR-STOP: gene silencing through base-editing-induced nonsense mutations
Kuscu, C., Parlak, M., Tufan, T., Yang, J., Szlachta, K., Wei, X., Mammadov, R., & Adli, M. (2017) · Nature Methods · doi:10.1038/nmeth.4327 · Cited by 344 · see citing works
Highly efficient RNA-guided base editing in rabbit
Liu, Z., Chen, M., Chen, S., Deng, J., Song, Y., Lai, L., & Li, Z. (2018) · Nature Communications · doi:10.1038/s41467-018-05232-2 · Cited by 145 · see citing works
Adenine base editors catalyze cytosine conversions in human cells
Kim, H. S., Jeong, Y. K., Hur, J. K., Kim, J., & Bae, S. (2019) · Nature Biotechnology · doi:10.1038/s41587-019-0254-4 · Cited by 127 · see citing works
BE-PLUS: a new base editing tool with broadened editing window and enhanced fidelity
Jiang, W., Feng, S., Huang, S., Yu, W., Li, G., Yang, G., Liu, Y., Zhang, Y., Zhang, L., Hou, Y., et al. (2018) · Cell Research · doi:10.1038/s41422-018-0052-4 · Cited by 120 · see citing works
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1 of the 18 references couldn’t be matched to a known paper.
Cited by
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Song, L.-F., Deng, Z.-H., Gong, Z.-Y., Li, L.-L., & Li, B.-Z. (2021) · Frontiers in Bioengineering and Biotechnology · doi:10.3389/fbioe.2021.689797 · Cited by 74 · see citing works
Yang, A., Kantor, B., & Chiba‐Falek, O. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22031244 · Cited by 47 · see citing works
“This technology employs the deactivated Cas9 (dCas9) or nickase Cas9 (nCas9) fused with cytidine deaminase enzyme that allows the conversion of a C to T at single-base point mutations without the double-strand DNA backbone breaking, thereby increasing the editing efficiency and reducing additional unwanted insertions…”
MethodPrime editing primarily induces undesired outcomes in mice
Aida, T., Wilde, J. J., Yang, L., Hou, Y., Li, M., Xu, D., Lin, J., Qi, P., Lu, Z., & Feng, G. (2020) · doi:10.1101/2020.08.06.239723 · Cited by 43 · see citing works
“Currently, it is of great interest to understand whether PE broadly works in vivo for animal model production and therapeutic development (Cohen, 2019; Hampton, 2020; Ravindran, 2019; Urnov, 2020).”
BackgroundCornean, A., Gierten, J., Welz, B., Mateo, J. L., Thumberger, T., & Wittbrodt, J. (2022) · eLife · doi:10.7554/elife.72124 · Cited by 34 · see citing works
Current advances in overcoming obstacles of CRISPR/Cas9 off-target genome editing
Aquino‐Jarquín, G. (2021) · Molecular Genetics and Metabolism · doi:10.1016/j.ymgme.2021.08.002 · Cited by 32 · see citing works
Genome editing in cultured fishes
Hallerman, E. M. (2021) · CABI Agriculture and Bioscience · doi:10.1186/s43170-021-00066-3 · Cited by 32 · see citing works
“Improved base editors are being developed at a rapid rate, and are being applied to correct point mutations in cell lines and animal model systems, with an eye to eventual use for clinical use in human systems (Ravindran 2019).”
BackgroundAli, G., Tariq, M. A., Shahid, K., Ahmad, F. J., & Akram, J. (2020) · Gene Therapy · doi:10.1038/s41434-020-0153-9 · Cited by 20 · see citing works
“Obviously, that cannot be done by CRISPR/Cas9, so base editing could be a useful tool for correcting genetic diseases caused by single-letter mutations, including the most common form of sickle-cell anemia [78] and −175 mutation in γ-globin promotor resulted in silencing of the gene [79].”
BackgroundGenome and transcriptome engineering by compact and versatile CRISPR-Cas systems
Aquino‐Jarquín, G. (2023) · Drug Discovery Today · doi:10.1016/j.drudis.2023.103793 · Cited by 15 · see citing works
Genome Editing in Translational Medicine: An Inventory
Dobner, J., Ramachandran, H., & Rossi, A. (2022) · Frontiers in Bioscience-Landmark · doi:10.31083/j.fbl2708241 · Cited by 10 · see citing works
Moroi, K., Yamamoto, T., & Kurita, T. (2025) · Scientific Reports · doi:10.1038/s41598-025-26657-y · Cited by 5 · see citing works
Instance-based error correction for short reads of disease-associated genes
Zhang, X., Liu, Y., Yu, Z., Blumenstein, M., Hutvágner, G., & Li, J. (2021) · BMC Bioinformatics · doi:10.1186/s12859-021-04058-y · Cited by 3 · see citing works
Nanjappa, D. P., & Chakraborty, A. (2022) · Gene Reports · doi:10.1016/j.genrep.2022.101737 · Cited by 2 · see citing works
- Authors
- Ravindran, S.
- Corresponding author
- Ravindran, Sandeep
- Venue
- Nature
- Published
- 2019-11-18
- Volume
- 575
- Issue
- 7783
- Pages
- 553-555
- ISSN
- 0028-0836 (ISSN-L)
- 1476-4687
- OpenAlex
- W2989187010
- Cited by
- 12
- References
- 18
- Citations by year
- 2025: 1 · 2023: 1 · 2022: 3 · 2021: 5 · 2020: 2
- FWCI
- 0.83
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- Locations
- Nature (publishedVersion)
- PubMed (publishedVersion)
- RePEc: Research Papers in Economics (submittedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › CRISPR and Genetic Engineering
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › RNA regulation and disease
- Health Sciences › Medicine › Oncology › CAR-T cell therapy research
- Keywords
- base editors, CRISPR/Cas9, point mutation correction, genome editing, single-nucleotide editing, gene therapy, animal models, cell lines
- MeSH terms
- Gene Editing, Animals, Cell Line, Disease Models, Animal, DNA, Humans, Nucleotides, Substrate Specificity, Genome, Human, Point Mutation, Genetic Diseases, Inborn, Gene Knockout Techniques
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