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Cited by 261

The DOI matches its Crossref record; 10 of the 10 references it cites were found in a registry or an index.

An FKBP destabilization domain modulates protein levels in Plasmodium falciparum

Open access
Armstrong, Christopher M, Goldberg, Daniel E·2007·Nature Methods

Abstract

To enhance the repertoire of molecular tools for studying malaria parasite biology, we adapted a ligand-regulatable FKBP protein destabilization domain (ddFKBP) for use in P. falciparum. We destabilized the reporter yellow fluorescent protein (YFP) and the P. falciparum protease falcipain-2 in a ligand-reversible manner by tagging with ddFKBP. The swollen food vacuole phenotype of falcipain-2 knockout parasites could be rescued in a Shld1 ligand–dependent fashion by falcipain-2–ddFKBP expression.

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Metadata

Authors
Armstrong, C. M., & Goldberg, D. E.
Venue
Nature Methods
Published
2007-11-11
Volume
4
Issue
12
Pages
1007-1009
ISSN
  • 1548-7091 (ISSN-L)
  • 1548-7105
OpenAlex
W2016728754
Cited by
261
References
10
FWCI
13.45
Type
journal article
Language
en
Open access
green

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