The DOI matches its Crossref record; 45 of the 45 references it cites were found in a registry or an index.
Antibiotics as a selective driver for conjugation dynamics
Open accessAbstract
It is generally assumed that antibiotics can promote horizontal gene transfer. However, because of a variety of confounding factors that complicate the interpretation of previous studies, the mechanisms by which antibiotics modulate horizontal gene transfer remain poorly understood. In particular, it is unclear whether antibiotics directly regulate the efficiency of horizontal gene transfer, serve as a selection force to modulate population dynamics after such gene transfer has occurred, or both. Here, we address this question by quantifying conjugation dynamics in the presence and absence of antibiotic-mediated selection. Surprisingly, we find that sublethal concentrations of antibiotics from the most widely used classes do not significantly increase the conjugation efficiency. Instead, our modelling and experimental results demonstrate that conjugation dynamics are dictated by antibiotic-mediated selection, which can both promote and suppress conjugation dynamics. Our findings suggest that the contribution of antibiotics to the promotion of horizontal gene transfer may have been overestimated. These findings have implications for designing effective antibiotic treatment protocols and for assessing the risks of antibiotic use.
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Cited by
Horizontal transfer of antibiotic resistance genes in clinical environments
Lerminiaux, N. A., & Cameron, A. D. S. (2019) · Canadian Journal of Microbiology · doi:10.1139/cjm-2018-0275 · Cited by 802
Wang, Y., Lu, J., Mao, L., Li, J., Yuan, Z., Bond, P. L., & Guo, J. (2019) · The ISME Journal · doi:10.1038/s41396-018-0275-x · Cited by 441
Antibiotic perturbations to the gut microbiome
Fishbein, S. R. S., Mahmud, B., & Dantas, G. (2023) · Nature Reviews Microbiology · doi:10.1038/s41579-023-00933-y · Cited by 440
The Ecology and Evolution of Pangenomes
Brockhurst, M. A., Harrison, E., Hall, J. P. J., Richards, T., McNally, A., & MacLean, C. (2019) · Current Biology · doi:10.1016/j.cub.2019.08.012 · Cited by 385
Jutkina, J., Marathe, N. P., Flach, C.-F., & Larsson, D. G. J. (2018) · Science of The Total Environment · doi:10.1016/j.scitotenv.2017.10.312 · Cited by 381
Metadata
- Authors
- Lopatkin, A. J., Huang, S., Smith, R. P., Srimani, J. K., Sysoeva, T. A., Bewick, S., Karig, D. K., & You, L.
- Venue
- Nature Microbiology
- Published
- 2016-04-11
- Volume
- 1
- Issue
- 6
- Pages
- 16044-16044
- ISSN
- 2058-5276 (ISSN-L)
- OpenAlex
- W2331140546
- Cited by
- 285
- References
- 45
- FWCI
- 15.17
- Type
- journal article
- Language
- en
- Open access
- green
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- Lopatkin, A. J., Huang, S., Smith, R. P., Srimani, J. K., Sysoeva, T. A., Bewick, S., Karig, D. K., & You, L. (2016). Antibiotics as a selective driver for conjugation dynamics. Nature Microbiology. https://doi.org/10.1038/nmicrobiol.2016.44
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
