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Cited by 285

The DOI matches its Crossref record; 45 of the 45 references it cites were found in a registry or an index.

Antibiotics as a selective driver for conjugation dynamics

Open access
Lopatkin, Allison J., Huang, Shuqiang, Smith, Robert P., Srimani, Jaydeep K., Sysoeva, Tatyana A., Bewick, Sharon, Karig, David K., You, Lingchong·2016·Nature Microbiology
DOI 10.1038/nmicrobiol.2016.44
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Abstract

It is generally assumed that antibiotics can promote horizontal gene transfer. However, because of a variety of confounding factors that complicate the interpretation of previous studies, the mechanisms by which antibiotics modulate horizontal gene transfer remain poorly understood. In particular, it is unclear whether antibiotics directly regulate the efficiency of horizontal gene transfer, serve as a selection force to modulate population dynamics after such gene transfer has occurred, or both. Here, we address this question by quantifying conjugation dynamics in the presence and absence of antibiotic-mediated selection. Surprisingly, we find that sublethal concentrations of antibiotics from the most widely used classes do not significantly increase the conjugation efficiency. Instead, our modelling and experimental results demonstrate that conjugation dynamics are dictated by antibiotic-mediated selection, which can both promote and suppress conjugation dynamics. Our findings suggest that the contribution of antibiotics to the promotion of horizontal gene transfer may have been overestimated. These findings have implications for designing effective antibiotic treatment protocols and for assessing the risks of antibiotic use.

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Metadata

Authors
Lopatkin, A. J., Huang, S., Smith, R. P., Srimani, J. K., Sysoeva, T. A., Bewick, S., Karig, D. K., & You, L.
Venue
Nature Microbiology
Publisher
Springer Science and Business Media LLC
Published
2016-04-11
Volume
1
Issue
6
Pages
16044-16044
ISSN
2058-5276 (ISSN-L)
DOI
10.1038/nmicrobiol.2016.44
OpenAlex
W2331140546
Cited by
285
References
45
FWCI
15.17
Type
journal article
Language
en
Open access
green

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