The DOI matches its Crossref record; 50 of the 50 references it cites were found in a registry or an index.
An age-related sprouting transcriptome provides molecular control of axonal sprouting after stroke
Open accessAbstract
Stroke is an age-related disease. Recovery after stroke is associated with axonal sprouting in cortex adjacent to the infarct. The molecular program that induces a mature cortical neuron to sprout a new connection after stroke is not known. We selectively isolated neurons that sprout a new connection in cortex after stroke and compared their whole-genome expression profile to that of adjacent, non-sprouting neurons. This 'sprouting transcriptome' identified a neuronal growth program that consists of growth factor, cell adhesion, axonal guidance and cytoskeletal modifying molecules that differed by age and time point. Gain and loss of function in three distinct functional classes showed new roles for these proteins in epigenetic regulation of axonal sprouting, growth factor-dependent survival of neurons and, in the aged mouse, paradoxical upregulation of myelin and ephrin receptors in sprouting neurons. This neuronal growth program may provide new therapeutic targets and suggest mechanisms for age-related differences in functional recovery.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
The source backs part of the claim, not all of it — or backs it for a different population, condition or comparison.
In the citing paper
“In rodent and primate models of stroke, axonal sprouting and the formation of new connections occurs in motor, somatosensory and premotor areas1–4.”
From GDF10 is a signal for axonal sprouting and functional recovery after stroke (2015) · cites this paper as [3]
Experimental — accuracy not yet measuredThe source backs part of the claim, not all of it — or backs it for a different population, condition or comparison.
In the citing paper
“Within the post-stroke axonal sprouting transcriptome, Growth and Differentiation Factor 10 (GDF10) is one of the most highly upregulated genes during the initiation of axonal sprouting in peri-infarct cortical neurons in the aged brain.”
From GDF10 is a signal for axonal sprouting and functional recovery after stroke (2015) · cites this paper as [3]
Experimental — accuracy not yet measuredThe source backs part of the claim, not all of it — or backs it for a different population, condition or comparison.
In the citing paper
“Stroke induces axonal sprouting and the formation of new connections in peri-infarct cortex that link premotor, motor, somatosensory and association areas1–4.”
From GDF10 is a signal for axonal sprouting and functional recovery after stroke (2015) · cites this paper as [3]
Experimental — accuracy not yet measuredThe source backs part of the claim, not all of it — or backs it for a different population, condition or comparison.
In the citing paper
“GDF10 is induced in sprouting neurons from aged rats during the initiation phase of axonal sprouting, 7 days after stroke3: 1.32× with microarray and 3× with confirmatory qPCR (p<0.0009) at 7d after stroke3.”
From GDF10 is a signal for axonal sprouting and functional recovery after stroke (2015) · cites this paper as [3]
Experimental — accuracy not yet measuredThe source backs part of the claim, not all of it — or backs it for a different population, condition or comparison.
In the citing paper
“As previously shown in other gene systems3,4, nucleotide-modified siRNA delivered directly into the infarct core produces protein knockdown over at least 2 weeks after stroke with GDF10 (Supplementary Fig. 3a).”
From GDF10 is a signal for axonal sprouting and functional recovery after stroke (2015) · cites this paper as [3]
Experimental — accuracy not yet measured
The source backs part of the claim, not all of it — or backs it for a different population, condition or comparison.
In the citing paper
“To test this hypothesis, GDF10 gain and loss of function was produced directly from the stroke through sustained release via biopolymer hydrogel, which produces release over 2–3 weeks from the stroke site3,4,28 without altering local inflammation, gliosis, neuronal or vascular structure4.”
From GDF10 is a signal for axonal sprouting and functional recovery after stroke (2015) · cites this paper as [3]
Experimental — accuracy not yet measuredThe source backs part of the claim, not all of it — or backs it for a different population, condition or comparison.
In the citing paper
“Stroke normally produces a limited pattern of axonal sprouting from motor or somatosensory cortex posteriorly to areas adjacent to or caudal to the stroke2–4,28,29.”
From GDF10 is a signal for axonal sprouting and functional recovery after stroke (2015) · cites this paper as [3]
Experimental — accuracy not yet measuredThe source backs part of the claim, not all of it — or backs it for a different population, condition or comparison.
In the citing paper
“After stroke, axonal sprouting has been demonstrated in mice, rats and non-human primates1–4,10,38.”
From GDF10 is a signal for axonal sprouting and functional recovery after stroke (2015) · cites this paper as [3]
Experimental — accuracy not yet measuredThe source backs part of the claim, not all of it — or backs it for a different population, condition or comparison.
In the citing paper
“This biopolymer hydrogel releases both small and large molecules over a 3 week period from the infarct core3,4,29.”
From GDF10 is a signal for axonal sprouting and functional recovery after stroke (2015) · cites this paper as [3]
Experimental — accuracy not yet measuredThe cited source says what the claim attributes to it.
In the citing paper
“As reported previously3,4,28,29, stroke alone modestly but significantly induces axonal sprouting in the motor cortex adjacent to the stroke site compared to normal motor system connections (Supplementary Fig. 6b).”
From GDF10 is a signal for axonal sprouting and functional recovery after stroke (2015) · cites this paper as [3]
The cited source says what the claim attributes to it.
In the citing paper
“This experimental design has been validated by other groups conducting similar behavioral4 or tissue outcomes experiments3,4,28,29.”
From GDF10 is a signal for axonal sprouting and functional recovery after stroke (2015) · cites this paper as [3]
The cited source says what the claim attributes to it.
In the citing paper
“Animal number in in vivo quantitative cortical mapping studies utilizes spatial correlation statistics, so sample size was estimated from previous publications with similar mechanistic studies3,4,28,29.”
From GDF10 is a signal for axonal sprouting and functional recovery after stroke (2015) · cites this paper as [3]
In the citing paper
“The spatial orientation and distribution of fibres were shown to be controlled by leucine-rich repeat and IgG domain containing protein 1 (Lingo1) and Nogo receptor 1, which directed the newly formed axons to cortical areas that were otherwise not targeted.72”
From Promoting brain remodelling and plasticity for stroke recovery: therapeutic promise and potential pitfalls of clinical translation (2012) · cites this paper as [72]
In the citing paper
“In the rat somatosensory whisker barrel field, the ATP-dependent DNA-modifying enzyme α-thalassaemia/mental retardation syndrome X-linked (ATRX) protein, which controls neuronal survival and migration during brain development, contributes to the formation of axonal growth cones, which are stabilised by insulin-like growth factor 1.72”
From Promoting brain remodelling and plasticity for stroke recovery: therapeutic promise and potential pitfalls of clinical translation (2012) · cites this paper as [72]
In the citing paper
“Indeed, the expression of plasticity-related proteins in neurons differs between young and old animals.”
From Promoting brain remodelling and plasticity for stroke recovery: therapeutic promise and potential pitfalls of clinical translation (2012) · cites this paper as [72]
In the citing paper
“Lingo1 immuno staining, by contrast, was stronger in neurons of old rats (2 years of age) than in young rats (2 months of age).72”
From Promoting brain remodelling and plasticity for stroke recovery: therapeutic promise and potential pitfalls of clinical translation (2012) · cites this paper as [72]
In the citing paper
“Thus, insulin-like growth factor 1 was localised mainly to astrocytes in the periinfarct cortex of 2-month-old rats, but exhibited predominantly neuronal labelling in 2-year-old rats.72”
From Promoting brain remodelling and plasticity for stroke recovery: therapeutic promise and potential pitfalls of clinical translation (2012) · cites this paper as [72]
In the citing paper
“Although evidence is limited to a rather small number of studies, the preserved neurological recovery in old animals argues against specific age limits for neurorestorative treatments.”
From Promoting brain remodelling and plasticity for stroke recovery: therapeutic promise and potential pitfalls of clinical translation (2012) · cites this paper as [72]
In the citing paper
“Although restorative treat ments can promote neurological recovery in old ani mals,17,26,72,76–79 specific findings in ageing animals72,77–79 and in animals with vascular risk factors80,82,86,87 suggest that the efficacy of new therapeutics might be compromised in elderly patients with risk factors.”
From Promoting brain remodelling and plasticity for stroke recovery: therapeutic promise and potential pitfalls of clinical translation (2012) · cites this paper as [72]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
The Mouse Brain in Stereotaxic Coordinates
Paxinos, G. (2001) · Cited by 12,859
The Classical Complement Cascade Mediates CNS Synapse Elimination
Stevens, B., Allen, N. J., Vazquez, L. E., Howell, G. R., Christopherson, K. S., Nouri, N., Micheva, K. D., Mehalow, A. K., Huberman, A. D., Stafford, B., et al. (2007) · Cell · doi:10.1016/j.cell.2007.10.036 · Cited by 3,313
Ischemic Cell Death in Brain Neurons
Lipton, P. (1999) · Physiological Reviews · doi:10.1152/physrev.1999.79.4.1431 · Cited by 3,043
Use of within-array replicate spots for assessing differential expression in microarray experiments
Smyth, G. K., Michaud, J., & Scott, H. S. (2005) · Computer applications in the biosciences · doi:10.1093/bioinformatics/bti270 · Cited by 1,406
The subcellular organization of neocortical excitatory connections
Petreanu, L., Mao, T., Sternson, S. M., & Svoboda, K. (2009) · Nature · doi:10.1038/nature07709 · Cited by 1,047
Fitch, M. T., & Silver, J. (2008) · Experimental Neurology · doi:10.1016/j.expneurol.2007.05.014 · Cited by 1,007
A Neurovascular Niche for Neurogenesis after Stroke
Ohab, J. J., Fleming, S., Blesch, A., & Carmichael, S. T. (2006) · The Journal of Neuroscience · doi:10.1523/jneurosci.4323-06.2006 · Cited by 878 · cited 1×
“Focal cortical strokes on young (2–4 months old) and aged adult (22–24 months old) F344 or C57BL/6 male rats and mice (Charles River Laboratories) were produced as previously describe”
Self-citationCortical rewiring and information storage
Chklovskii, D. B., Mel, B. W., & Svoboda, K. (2004) · Nature · doi:10.1038/nature03012 · Cited by 717
Extensive Cortical Rewiring after Brain Injury
Dancause, N., Barbay, S., Frost, S. B., Plautz, E. J., Chen, D., Zoubina, E. V., Stowe, A. M., & Nudo, R. J. (2005) · The Journal of Neuroscience · doi:10.1523/jneurosci.3256-05.2005 · Cited by 704
Cellular and molecular mechanisms of neural repair after stroke: making waves
Carmichael, S. T. (2006) · Annals of Neurology · doi:10.1002/ana.20845 · Cited by 595
Self-citation
Cited by
Sorted by citations
Items 201–300 of 328
Wang, Y., & Cai, Y. (2016) · Scientific Reports · doi:10.1038/srep29693 · Cited by 20
Li, L., Yang, J., Li, C., Zhou, H., Yu, L., Wu, X., Lu, Y.-H., He, Y. T., & Wan, H. (2023) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2023.114887 · Cited by 19
Kluge, M. G., Jones, K., Ong, L. K., Gowing, E. K., Nilsson, M., Clarkson, A. N., & Walker, F. R. (2018) · Neuroscience · doi:10.1016/j.neuroscience.2018.07.034 · Cited by 19
Shi, C.-S., Hu, Q., Fang, S.-L., Sun, C.-X., & Shao, D.-H. (2023) · ACS Chemical Neuroscience · doi:10.1021/acschemneuro.3c00047 · Cited by 17
Au, N. P. B., Wu, T., Kumar, G., Jin, Y., Li, Y. Y. T., Chan, S. L., Lai, J. H. C., Chan, K. W. Y., Yu, K. N., Wang, X., et al. (2023) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2023.09.015 · Cited by 21
Monitoring Brain Repair in Stroke Using Advanced Magnetic Resonance Imaging
Sztriha, L., Tuura, R., Modo, M., Barker, G. J., Williams, S., & Kalra, L. (2012) · Stroke · doi:10.1161/strokeaha.111.649244 · Cited by 17
Phosphodiesterase 10A Inhibition Leads to Brain Region-Specific Recovery Based on Stroke Type
Birjandi, S. Z., Abduljawad, N., Nair, S., Dehghani, M., Suzuki, K., Kimura, H., & Carmichael, S. T. (2020) · Translational Stroke Research · doi:10.1007/s12975-020-00819-8 · Cited by 19
Self-citationAge-Dependent Modulation of Cortical Transcriptomes in Spinal Cord Injury and Repair
Järve, A., Kruse, F., Malik, K., Hartung, H., & Müller, H. W. (2012) · PLoS ONE · doi:10.1371/journal.pone.0049812 · Cited by 17
Effect of age and gender on recovery after stroke in rats treated with bone marrow mononuclear cells
Coelho, B. P., & Giraldi‐Guimarães, A. (2014) · Neuroscience Research · doi:10.1016/j.neures.2014.08.007 · Cited by 17
Gennaro, M., Mattiello, A., Mazziotti, R. M., Antonelli, C., Gherardini, L. M., Guzzetta, A., Berardi, N., Cioni, G., & Pizzorusso, T. (2017) · Frontiers in Neural Circuits · doi:10.3389/fncir.2017.00047 · Cited by 18
Qin, L., Actor-Engel, H. S., Woo, M.-S., Shakil, F., Chen, Y.-W., Cho, S., & Aoki, C. J. (2019) · Neurorehabilitation and neural repair · doi:10.1177/1545968319872997 · Cited by 16
Optogenetic modulation in stroke recovery
Pendharkar, A. V., Levy, S. L., Ho, A. L., Sussman, E. S., Cheng, M., & Steinberg, G. K. (2016) · Neurosurgical FOCUS · doi:10.3171/2016.2.focus163 · Cited by 16
Profiling neuron-autonomous lncRNA changes upon ischemia/reperfusion injury
Li, H., Wu, Y., Suo, G., Shen, F., Zhen, Y., Chen, X., & Lv, H. (2017) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2017.10.157 · Cited by 16
Bandet, M. V., & Winship, I. R. (2023) · eLife · doi:10.7554/elife.90080 · Cited by 20
Promoting Neurological Recovery in the Post-Acute Stroke Phase: Benefits and Challenges
Hermann, D. M., & Chopp, M. (2014) · European Neurology · doi:10.1159/000365171 · Cited by 14
Heredia, M., Palomero, J., de la Fuente, A., Criado, J. M., Yajeya, J., Devesa, J., Devesa, P., Villardón, J. L. V., & Riolobos, A. S. (2018) · Neural Plasticity · doi:10.1155/2018/6125901 · Cited by 15
Overexpression of kynurenic acid and 3-hydroxyanthranilic acid after rat traumatic brain injury
Mangas, A., Heredia, M., Riolobos, A., de la Fuente, A. M., Criado, J., Yajeya, J., Geffard, M., & Coveñas, R. (2018) · European Journal of Histochemistry · doi:10.4081/ejh.2018.2985 · Cited by 15
Parker, K., Berretta, A., Saenger, S., Sivaramakrishnan, M., Shirley, S. A., Metzger, F., & Clarkson, A. N. (2017) · Scientific Reports · doi:10.1038/s41598-017-00336-z · Cited by 16
Materials to promote recovery after stroke
Erning, K., & Segura, T. (2020) · Current Opinion in Biomedical Engineering · doi:10.1016/j.cobme.2020.04.002 · Cited by 16
Feng, Y., Xu, Z., Wang, Y., Xiong, Y., Xie, W., He, Y., Chen, L., Liu, G.-Y., Li, X., Liu, J., et al. (2022) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2022.876342 · Cited by 15
de Boer, A., Storm, A., Gómez‐Soler, M., Smolders, S., Rué, L., Poppe, L., Pasquale, E. B., Robberecht, W., & Lemmens, R. (2019) · Human Molecular Genetics · doi:10.1093/hmg/ddz288 · Cited by 14
Du, X., Gao, F., Chen, S.-J., Botchway, B. O. A., Amin, N., Hu, Z.-Y., & Fang, M.-R. (2020) · Mediators of Inflammation · doi:10.1155/2020/8796103 · Cited by 13
EPO promotes axonal sprouting via upregulating GDF10
Li, S., Cui, K., Fu, J.-J., Fu, X., Gao, Y., Zhang, D., Lu, Z., Zhang, Y., Yu, L., & Wang, J. (2019) · Neuroscience Letters · doi:10.1016/j.neulet.2019.134412 · Cited by 13
Self-citationSato, T., Itokazu, T., Osaki, H., Ohtake, M., Yamamoto, T., Sohya, K., Maki, T., & Sato, T. K. (2019) · eLife · doi:10.7554/elife.50855 · Cited by 14
Sánchez-Mendoza, E. H., & Hermann, D. M. (2016) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2016.00196 · Cited by 13
Altered Hippocampal–Prefrontal Dynamics Following Medial Prefrontal Stroke in Mouse
Hillman, K. L., Wall, H. J., Matthews, L. O., Gowing, E. K., & Clarkson, A. N. (2019) · NeuroMolecular Medicine · doi:10.1007/s12017-019-08557-3 · Cited by 14
Early seizures and risk of epilepsy and death after intracerebral haemorrhage: The MUCH Italy
Pezzini, A., Tarantino, B., Zedde, M., Marcheselli, S., Silvestrelli, G., Ciccone, A., DeLodovici, M. L., Cariddi, L. P., Vidale, S., Paciaroni, M., et al. (2024) · European Stroke Journal · doi:10.1177/23969873241247745 · Cited by 12
Learning and Stroke Recovery: Parallelism of Biological Substrates
Joy, M. T., & Carmichael, S. T. (2021) · Seminars in Neurology · doi:10.1055/s-0041-1725136 · Cited by 12
Self-citationAxonal Regeneration Mediated by a Novel Axonal Guidance Pair, Galectin-1 and Secernin-1
Yang, X., & Tohda, C. (2022) · Molecular Neurobiology · doi:10.1007/s12035-022-03125-6 · Cited by 12
Dual effect of C–C motif chemokine receptor 5 on ischemic stroke: More harm than benefit?
Jing, K., Chen, F., Shi, X., Guo, J., & Liu, X. (2023) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2023.175857 · Cited by 12
Sato, T., Nakamura, Y., Takeda, A., & Ueno, M. (2021) · Frontiers in Neuroscience · doi:10.3389/fnins.2021.737034 · Cited by 11
Complement C3a: Shaping the Plasticity of the Post-stroke Brain
Stokowska, A., & Pekna, M. (2017) · Springer series in translational stroke research · doi:10.1007/978-3-319-66679-2_26 · Cited by 11
Han, K., Mun, S., Sohn, S., Piao, X., Park, I., & Chang, M. Y. (2019) · International Journal of Molecular Medicine · doi:10.3892/ijmm.2019.4316 · Cited by 11
Modeling poststroke epilepsy and preclinical development of drugs for poststroke epilepsy
Leo, A., Caro, C. D., Nesci, V., Tallarico, M., Sarro, G. D., Russo, E., & Citraro, R. (2019) · Epilepsy & Behavior · doi:10.1016/j.yebeh.2019.106472 · Cited by 11
Heredia, M., Rodríguez, N., Sánchez‐Robledo, V., Criado, J. M., de la Fuente, A., Devesa, J., Devesa, P., & Riolobos, A. S. (2019) · International Journal of Molecular Sciences · doi:10.3390/ijms20225770 · Cited by 10
Treating Cerebral Ischemia: Novel Therapeutic Strategies from Experimental Stroke Research
Zheng, X., Haupt, M., Bähr, M., Tatenhorst, L., & Doeppner, T. R. (2021) · Exon Publications eBooks · doi:10.36255/exonpublications.cerebralischemia.2021.therapy · Cited by 10
Neurobiology of Stroke Recovery
Kane, E., & Ward, N. (2021) · Springer eBooks · doi:10.1007/978-3-030-58505-1_1 · Cited by 12
Antons, M. J., Lindner, M. J., Grosch, M., Oos, R., Palumbo, G., Brendel, M., Ziegler, S. I., Bartenstein, P., Dieterich, M., & Zwergal, A. (2022) · Scientific Reports · doi:10.1038/s41598-022-09936-w · Cited by 9
Li, K., Peng, L., Xing, Q., Zuo, X., Huang, W., Zhan, L., Li, H., Sun, W., Zhong, X., Zhu, T., et al. (2023) · Stem Cells Translational Medicine · doi:10.1093/stcltm/szad037 · Cited by 9
Expansion of plasma MicroRNAs over the first month following human stroke
Edwardson, M. A., Shivapurkar, N., Li, J., Khan, M., Smith, J., Giannetti, M. L., Fan, R., & Dromerick, A. W. (2023) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1177/0271678x231196982 · Cited by 9
Considering Context-Specific microRNAs in Ischemic Stroke with Three “W”: Where, When, and What
Chang, C., Wang, Y., Wang, R., & Bao, X. (2024) · Molecular Neurobiology · doi:10.1007/s12035-024-04051-5 · Cited by 10
Schwab, M. E. (2010) · Nature Neuroscience · doi:10.1038/nn1210-1444 · Cited by 9
Chen, G., Zhang, K., Sun, M., Xie, N., Wu, L., Zhang, G., Guo, B., Huang, C., Hoi, M. P. M., Zhang, Z., et al. (2025) · Neuropharmacology · doi:10.1016/j.neuropharm.2025.110410 · Cited by 8
Brain-wide microstrokes affect the stability of memory circuits in the hippocampus
Heiser, H., Kiessler, F., Roggenbach, A., Ibañez, V., Wieckhorst, M., Helmchen, F., Gjorgjieva, J., & Wahl, A.-S. (2025) · Nature Communications · doi:10.1038/s41467-025-58688-4 · Cited by 8
Gleichman, A. J., Kawaguchi, R., Rathbun, E. M., Sofroniew, M. V., & Carmichael, S. T. (2025) · Neuron · doi:10.1016/j.neuron.2025.09.023 · Cited by 8
Self-citationHyStem®: A Unique Clinical Grade Hydrogel for Present and Future Medical Applications
Zarembinski, T. I., & Skardal, A. (2019) · IntechOpen eBooks · doi:10.5772/intechopen.81344 · Cited by 8
Bu, F., Min, J., Razzaque, A. M., Hamamy, A. E., Patrizz, A., Li, Q., Urayama, A., & Li, J. (2023) · Neural Regeneration Research · doi:10.4103/1673-5374.382256 · Cited by 8
Kang, J., Luo, W., Zhang, C., Ren, Y., Cao, L., Wu, J. H., & Li, H. (2021) · Journal of Stroke and Cerebrovascular Diseases · doi:10.1016/j.jstrokecerebrovasdis.2021.105790 · Cited by 8
Pregabalin improves axon regeneration and motor outcome in a rodent stroke model
Kugler, C., Blank-Stein, N., Matušková, H., Thielscher, C., Reichenbach, N., Lin, T.-C., Bradke, F., & Petzold, G. C. (2022) · Brain Communications · doi:10.1093/braincomms/fcac170 · Cited by 8
Wahl, A.-S. (2018) · Neural Plasticity · doi:10.1155/2018/3846593 · Cited by 8
Shimogawa, T., Sakaguchi, H., Kikuchi, T., Tsuchimochi, R., Sano, N., Torikoshi, S., Ito, A., Aoyama, T., Iihara, K., & Takahashi, J. B. (2019) · npj Regenerative Medicine · doi:10.1038/s41536-019-0075-6 · Cited by 8
Ishii, D., Osaki, H., Yozu, A., Ishibashi, K., Kawamura, K., Yamamoto, S., Miyata, M., & Kohno, Y. (2020) · Behavioural Brain Research · doi:10.1016/j.bbr.2020.113097 · Cited by 8
Lagging, C., Klasson, S., Pedersén, A., Nilsson, S., Jood, K., Stanne, T. M., & Jern, C. (2022) · Scientific Reports · doi:10.1038/s41598-022-23288-5 · Cited by 8
Long-range axon branching: contributions to brain network plasticity and repair
Richards, L. J., Huang, C., Bauer, A. Q., & Lee, J. (2026) · Nature reviews. Neuroscience · doi:10.1038/s41583-025-01008-y · Cited by 9
Liao, H., Zou, Z., Liu, W., Guo, X., Xie, J., Li, L., Li, X., Gan, X., Huang, X., Liu, J., et al. (2022) · PubMed Central · Cited by 6
Temporal and Spatial Gene Expression Profile of Stroke Recovery Genes in Mice
Götz, J., Wieters, F., Fritz, V. J., Käsgen, O., Kalantari, A., Fink, G. R., & Aswendt, M. (2023) · Genes · doi:10.3390/genes14020454 · Cited by 5
Adult neurogenesis and brain remodelling after brain injury: From bench to bedside?
Quintard, H., Heurteaux, C., & Ichaï, C. (2015) · Anaesthesia Critical Care & Pain Medicine · doi:10.1016/j.accpm.2015.02.008 · Cited by 6
Elfouly, A., Awny, M. M., Ibrahim, M. K., Aboelsaad, M., Tian, J., & Sayed, M. (2021) · Neurochemical Research · doi:10.1007/s11064-021-03357-3 · Cited by 6
Strecker, J., Schmidt‐Pogoda, A., Diederich, K., Zaremba, D., Wieters, F., Beuker, C., Koecke, M. H. M., Straeten, F. A., Wiendl, H., & Minnerup, J. (2024) · Brain Pathology · doi:10.1111/bpa.13280 · Cited by 5
Eggers, B., Steinbach, S., Aldea, I. G., Keers, S. M., Molina, M., Grinberg, L. T., Heinsen, H., Leite, R. E. P., Attems, J., May, C., et al. (2025) · Advanced Biology · doi:10.1002/adbi.202400814 · Cited by 5
Eom, Y. I., Kim, M., & Joo, I. S. (2016) · Journal of Spinal Cord Medicine · doi:10.1080/10790268.2016.1209888 · Cited by 5
Wang, H., Cheng, X., Yu, H., Zhang, X., Guan, M., Zhao, L., Liu, Y., Linag, Y., Luo, Y., & Zhao, C. (2019) · Restorative Neurology and Neuroscience · doi:10.3233/rnn-180827 · Cited by 5
Stroke: Pathophysiology and Therapy
Minnerup, J., Schmidt, A., Albert-Weißenberger, C., & Kleinschnitz, C. (2013) · Colloquium Series on Integrated Systems Physiology From Molecule to Function · doi:10.4199/c00088ed1v01y201308isp042 · Cited by 5
Invasive Neurostimulation for Poststroke Motor Recovery
Wathen, C. A., Baker, K. B., & Machado, A. G. (2018) · Elsevier eBooks · doi:10.1016/b978-0-12-805353-9.00095-4 · Cited by 4
Alionte, C., Notte, C., & Strubakos, C. D. (2021) · Life Sciences · doi:10.1016/j.lfs.2021.120161 · Cited by 4
Kim, H. S., Seo, H. G., Jhee, J. H., Park, C.-H., Lee, H. W., Park, B., & Kim, B. G. (2023) · Experimental Neurobiology · doi:10.5607/en23016 · Cited by 4
Activity-dependent transcriptional programs in memory regulate motor recovery after stroke
Joy, M. T., & Carmichael, S. T. (2024) · Communications Biology · doi:10.1038/s42003-024-06723-3 · Cited by 4
Self-citationMitochondrial Regulators of Synaptic Plasticity in the Ischemic Brain
Park, H., & Jonas, E. A. (2017) · InTech eBooks · doi:10.5772/67126 · Cited by 4
Heterozygous Deletion of EphrinA5 Does Not Improve Functional Recovery After Experimental Stroke
de Boer, A., Storm, A., Rué, L., Poppe, L., Robberecht, W., & Lemmens, R. (2019) · Stroke · doi:10.1161/strokeaha.118.023857 · Cited by 4
A compartmentalized culture device for studying the axons of CNS neurons
Cheng, M.-Y., Ho, H.-H., Huang, T.-K., Chuang, C.-F., Hui-yu, C., Chung, H.-W., Leong, W.-C., Yang, W., Fu, C., Hsu, Y.-H., et al. (2017) · Analytical Biochemistry · doi:10.1016/j.ab.2017.09.013 · Cited by 4
Sharma, P., Gupta, P., Gill, A. R., Kumar, S., Kumar, P., Singhal, P., Gupta, M., Singh, R. B., Sharma, V., Sharun, K., et al. (2024) · Indian Journal of Clinical Biochemistry · doi:10.1007/s12291-024-01281-1 · Cited by 3
Wang, X., Zang, J., Yang, Y., Li, K., Ye, D., Wang, Z., Wang, Q., Wu, Y., & Luan, Z. (2024) · Cytotherapy · doi:10.1016/j.jcyt.2024.07.012 · Cited by 3
Sampaio, M. D. F. D. S., Boechat, M. S. B., Cunha, I. A. G., Pereira, M. G., Coimbra, N. C., & Giraldi‐Guimarães, A. (2021) · Brain Research · doi:10.1016/j.brainres.2021.147292 · Cited by 3
A Review of Neuroinflammatory Mechanisms in Ischemic Stroke: Background and Therapeutic Approaches
Sas, A., Horváth, L., Oláh, C., & Valikovics, A. (2017) · InTech eBooks · doi:10.5772/intechopen.69234 · Cited by 3
Molecular Mechanisms of Inflammation in Stroke
Tabeshmehr, P., Hosseini, S. M., Karimi, A., & Ziaee, S. M. (2017) · Translational medicine research · doi:10.1007/978-981-10-5804-2_11 · Cited by 3
Endothelin B receptor inhibition rescues aging-dependent neuronal regenerative declinePreprint
Feng, R., Rosen, S. F., Ansari, I., John, S., Thomsen, M. B., Avraham, O., Geoffroy, C. G., & Cavalli, V. (2024) · eLife · doi:10.7554/elife.100217 · Cited by 3
Mechanisms of Plasticity Remodeling and Recovery
Zheng, Z., Chen, J., & Chopp, M. (2021) · Elsevier eBooks · doi:10.1016/b978-0-323-69424-7.00011-9 · Cited by 2
Oey, N. E., Zhou, L., Chan, C. H. S., VanDongen, A. M. J., & Tan, E. K. (2023) · Biomedicines · doi:10.3390/biomedicines11020486 · Cited by 2
Mechanism of Post-stroke Axonal Outgrowth and Functional Recovery
Ueno, Y. (2023) · Juntendō Igaku/Juntendo igaku · doi:10.14789/jmj.jmj23-0025-r · Cited by 2
Research status and future perspectives of IL‑27 in the treatment of stroke (Review)
Liu, W., Zou, Z., Li, W., Yang, G., Zhang, J., Zhang, Z., & Yao, H. (2025) · International Journal of Molecular Medicine · doi:10.3892/ijmm.2025.5557 · Cited by 3
Weisz, H. A., Boone, D. R., Sell, S. L., & Hellmich, H. L. (2018) · Neuromethods · doi:10.1007/978-1-4939-8564-7_11 · Cited by 2
Single-cell mapping links neurogenesis and angiogenesis in aggressive breast cancerPreprint
Wik, E., Aziz, S. M., Finne, K., Kleftogiannis, D., Askeland, C., Knutsvik, G., Krüger, K., Svanøe, A. A., Birkeland, E., Kjølle, S., et al. (2022) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2022.01.28.477898 · Cited by 3
Joy, M. T., Bridges, S. P., & Carmichael, S. T. (2023) · Methods in molecular biology · doi:10.1007/978-1-0716-2926-0_13 · Cited by 1
Self-citationReorganizing Therapy: Changing the Clinical Approach to Upper Limb Recovery Post-Stroke
Hubbard, I. J., Carey, L. M., Budd, T. W., & Parsons, M. W. (2014) · Occupational Therapy International · doi:10.1002/oti.1381 · Cited by 1
Cell Therapy and Structural Plasticity Following Cerebral Ischemia
Hoang, S., Jung, H., Bliss, T. M., & Steinberg, G. K. (2012) · Springer eBooks · doi:10.1007/978-3-7091-1175-8_1 · Cited by 1
Identifying Therapeutic Targets in Cerebrovascular Diseases Using Wholegenome Transcriptomics
Popa‐Wagner, A., & Bugă, A. M. (2012) · Biochemistry & Analytical Biochemistry · doi:10.4172/2161-1009.1000e104 · Cited by 1
Identification of New Therapeutic Targets for Cerebral Ischemia by Genome-Wide Analysis
Popa‐Wagner, A. (2016) · Biochemistry & Analytical Biochemistry · doi:10.4172/2161-1009.1000e162 · Cited by 1
Methods for the analysis of neuronal plasticity and brain connectivity during neurological recovery
Sánchez-Mendoza, E. H., de Carvalho, T. S., & Hermann, D. M. (2016) · Neural Regeneration Research · doi:10.4103/1673-5374.194704 · Cited by 1
Xu, R., Ghori, A., Schneider, U. C., & Vajkoczy, P. (2017) · Translational medicine research · doi:10.1007/978-981-10-5804-2_13 · Cited by 1
Sadowska, M., Mehlhorn, C., Średniawa, W., Szewczyk, Ł. M., Szlachcic, A., Urban, P., Winiarski, M. J., & Jablonka, J. (2020) · Neuroscience · doi:10.1016/j.neuroscience.2020.10.032 · Cited by 1
Endothelin B receptor inhibition rescues aging-dependent neuronal regenerative decline
Feng, R., Rosen, S. F., Ansari, I., John, S., Thomsen, M. B., Avraham, O., Geoffroy, C. G., & Cavalli, V. (2025) · eLife · doi:10.7554/elife.100217.3 · Cited by 1
Interhemispheric axonal sprouting occurs after pial removal in mice
Nikouei, K., Garma, L. D., Memic, F., Hjerling‐Leffler, J., & Goldschmidt, E. (2024) · Scientific Reports · doi:10.1038/s41598-024-75278-4 · Cited by 1
Napoli, M. D., Smith, C. J., Hopkins, S. J., Popa‐Wagner, A., Bugă, A. M., & SLEVIN, M. A. (2014) · Springer eBooks · doi:10.1007/978-1-4939-1071-7_11 · Cited by 1
Wiersma, A. M. (2017) · ERA: Education and Research Archive (University of Alberta) · doi:10.7939/r3v698s16 · Cited by 1
Bandet, M. V., & Winship, I. R. (2023) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2023.06.13.544847 · Cited by 1
Brain Function, Stroke, and Medicinal Herbs
Ezzat, S. M., Marghany, R., Mahdi, N. E., & Salem, M. A. (2023) · Wiley eBooks · doi:10.1002/9781119794127.ch6 · Cited by 3
Sato, T., Nakamura, Y., Hoshina, K., Inoue, K., Takada, M., Yano, M., Matsuzawa, H., & Ueno, M. (2025) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2025.01.21.634186 · Cited by 1
High-dose high-intensity arm neurorehabilitation in chronic stroke improves general motor controlPreprint
Dawson, A., Galea, J. M., Sporn, S., Krakauer, J. W., Bestmann, S., & Ward, N. (2025) · medRxiv · doi:10.1101/2025.11.18.25340491 · Cited by 1
Plasticity after injury to the central nervous system
Selzer, M. A., Clarke, S., Cohen, L. G., Kwakkel, G., & Miller, R. H. (2014) · Cambridge University Press eBooks · doi:10.1017/cbo9780511995583.014
Cellular mechanisms of plasticity after brain lesions
Carmichael, S. T. (2014) · Cambridge University Press eBooks · doi:10.1017/cbo9780511995583.016
Self-citation
Metadata
- Authors
- Li, S., Overman, J. J., Katsman, D., Kozlov, S. V., Donnelly, C. J., Twiss, J. L., Giger, R. J., Coppola, G., Geschwind, D. H., & Carmichael, S. T.
- Affiliations
- University of California, Los Angeles (US)
- Drexel University (US)
- University of Michigan (US)
- Corresponding author
- Carmichael, S Thomas
- ORCID
- Venue
- Nature Neuroscience
- Published
- 2010-11-07
- Volume
- 13
- Issue
- 12
- Pages
- 1496-1504
- ISSN
- 1097-6256 (ISSN-L)
- 1546-1726
- PMC
- PMC3059556
- OpenAlex
- W1981596049
- Cited by
- 329
- References
- 50
- Citations by year
- 2026: 7 · 2025: 14 · 2024: 15 · 2023: 28 · 2022: 17 · 2021: 20 · 2020: 16 · 2019: 34 · 2018: 21 · 2017: 27 · 2016: 20 · 2015: 18 · 2014: 20 · 2013: 20 · 2012: 27
- FWCI
- 9.17
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Nature Neuroscience (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- eScholarship (California Digital Library) (submittedVersion)
- Funders
- National Institutes of Health
- National Institute of Neurological Disorders and Stroke (NS049041, R01NS045729, NS045729, R01NS041596, NS04733, R01NS049041)
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Nerve injury and regeneration
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Axon Guidance and Neuronal Signaling
- Life Sciences › Neuroscience › Developmental Neuroscience › Neurogenesis and neuroplasticity mechanisms
- Keywords
- axonal sprouting, stroke, epigenetic regulation, growth factors, cell adhesion, axon guidance, cytoskeletal proteins, Eph receptors, neuronal survival, cortical neurons, functional recovery
- MeSH terms
- Aging, Animals, Axons, Cells, Cultured, Male, Mice, Inbred C57BL, Rats, Inbred F344, Sensory Receptor Cells, Up-Regulation, Recovery of Function, Stroke, Gene Expression Profiling, Mice, Rats
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
