The DOI matches its Crossref record; 6 of the 6 references it cites were found in a registry or an index.
Leptin regulates the reward value of nutrient
Open accessAbstract
We developed an assay for quantifying the reward value of nutrient and used it to analyze the effects of metabolic state and leptin. In this assay, mice chose between two sippers, one of which dispensed water and was coupled to optogenetic activation of dopaminergic (DA) neurons and the other of which dispensed natural or artificial sweeteners. This assay measured the reward value of sweeteners relative to lick-induced optogenetic activation of DA neurons. Mice preferred optogenetic stimulation of DA neurons to sucralose, but not to sucrose. However, the mice preferred sucralose plus optogenetic stimulation versus sucrose. We found that food restriction increased the value of sucrose relative to sucralose plus optogenetic stimulation, and that leptin decreased it. Our data suggest that leptin suppresses the ability of sucrose to drive taste-independent DA neuronal activation and provide new insights into the mechanism of leptin's effects on food intake.
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Cites
Neurons in the orbitofrontal cortex encode economic value
Padoa-Schioppa, C., & Assad, J. A. (2006) · Nature · doi:10.1038/nature04676 · Cited by 1,598
Phasic Firing in Dopaminergic Neurons Is Sufficient for Behavioral Conditioning
Tsai, H.-C., Zhang, F., Adamantidis, A., Stuber, G. D., Bonci, A., de Lecea, L., & Deisseroth, K. (2009) · Science · doi:10.1126/science.1168878 · Cited by 1,266
Self-citationAbizaid, A., Liu, Z.-W., Andrews, Z. B., Shanabrough, M., Borok, E., Elsworth, J. D., Roth, R. H., Sleeman, M. W., Picciotto, M. R., Tschöp, M. H., et al. (2006) · Journal of Clinical Investigation · doi:10.1172/jci29867 · Cited by 984 · cited 1×
“This assay is generally applicable and can be used to establish the reward value of other nutrients and the effects of other hormone”
Berridge, K. (2000) · Neuroscience & Biobehavioral Reviews · doi:10.1016/s0149-7634(99)00072-x · Cited by 721
Effects of deprivation on hedonics and reinforcing value of food
Epstein, L. H., Truesdale, R., Wojcik, A., Paluch, R. A., & Raynor, H. A. (2003) · Physiology & Behavior · doi:10.1016/s0031-9384(02)00978-2 · Cited by 267
Intense sweeteners, energy intake and the control of body weight.
Bellisle, F., & Drewnowski, A. (2007) · European Journal of Clinical Nutrition · doi:10.1038/sj.ejcn.1602649 · Cited by 200
Cited by
Neurons for hunger and thirst transmit a negative-valence teaching signal
Betley, J. N., Xu, S., Cao, Z. F. H., Gong, R., Magnus, C. J., Yu, Y., & Sternson, S. M. (2015) · Nature · doi:10.1038/nature14416 · Cited by 704
Leptin and the endocrine control of energy balance
Friedman, J. M. (2019) · Nature Metabolism · doi:10.1038/s42255-019-0095-y · Cited by 661
Self-citationSympathetic Neuro-adipose Connections Mediate Leptin-Driven Lipolysis
Zeng, W., Pirzgalska, R. M., Pereira, M. M. A., Kubasova, N., Barateiro, A., Seixas, E., Lu, Y.-H., Kozlova, A., Voss, H., Martins, G. G., et al. (2015) · Cell · doi:10.1016/j.cell.2015.08.055 · Cited by 490
Self-citationDorsal raphe neurons signal reward through 5-HT and glutamate
Liu, Z., Zhou, J., Li, Y., Hu, F., Lu, Y., Ma, M., Feng, Q., Zhang, J.-E., Wang, D., Zeng, J., et al. (2014) · Neuron · doi:10.1016/j.neuron.2014.02.010 · Cited by 469
Overlapping Brain Circuits for Homeostatic and Hedonic Feeding
Rossi, M. A., & Stuber, G. D. (2018) · Cell Metabolism · doi:10.1016/j.cmet.2017.09.021 · Cited by 415
Metadata
- Authors
- Domingos, A. I., Vaynshteyn, J., Voss, H. U., Ren, X., Gradinaru, V., Zang, F., Deisseroth, K., de Araujo, I. E., & Friedman, J.
- Venue
- Nature Neuroscience
- Published
- 2011-11-13
- Volume
- 14
- Issue
- 12
- Pages
- 1562-1568
- ISSN
- 1097-6256 (ISSN-L)
- 1546-1726
- OpenAlex
- W1997098169
- Cited by
- 230
- References
- 6
- FWCI
- 7.95
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Domingos, A. I., Vaynshteyn, J., Voss, H. U., Ren, X., Gradinaru, V., Zang, F., Deisseroth, K., de Araujo, I. E., & Friedman, J. (2011). Leptin regulates the reward value of nutrient. Nature Neuroscience. https://doi.org/10.1038/nn.2977
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
