Neurogenic neuroinflammation: inflammatory CNS reactions in response to neuronal activity
Abstract
The CNS is endowed with an elaborated response repertoire termed 'neuroinflammation', which enables it to cope with pathogens, toxins, traumata and degeneration. On the basis of recent publications, we deduce that orchestrated actions of immune cells, vascular cells and neurons that constitute neuroinflammation are not only provoked by pathological conditions but can also be induced by increased neuronal activity. We suggest that the technical term 'neurogenic neuroinflammation' should be used for inflammatory reactions in the CNS in response to neuronal activity. We believe that neurogenic neuro-inflammation maintains homeostasis to enable the CNS to cope with enhanced metabolic demands and increases the computational power and plasticity of CNS neuronal networks. However, neurogenic neuroinflammation may also become maladaptive and aggravate the outcomes of pain, stress and epilepsy.
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In people living with HIV, the prevalence rate of self-reported sleep disturbances is about 60%, much higher than the prevalence rate of 10% in the general population.
“two recent systematic reviews revealed a prevalence rate of self-reported sleep disturbances of ~60% in people living with HIV, which is much higher than the prevalence rate of 10% in the general population (97, 591).”
From The Sleep-Immune Crosstalk in Health and Disease (2019) · cites this paper as [591]
Even after the initiation of antiretroviral therapy, HIV-positive patients continue to report lower sleep quality.
“even after the initiation of antiretroviral therapy, HIV-positive patients continue to report lower sleep quality (359, 539, 591)”
From The Sleep-Immune Crosstalk in Health and Disease (2019) · cites this paper as [591]
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- Authors
- Xanthos, D. N., & Sandkühler, J.
- Affiliations
- Medical University of Vienna (AT)
- Corresponding author
- Sandkühler, Jürgen
- ORCID
- Sandkühler, Jürgen
- Venue
- Nature Reviews Neuroscience
- Published
- 2013-11-27
- Volume
- 15
- Issue
- 1
- Pages
- 43-53
- ISSN
- 1471-003X (ISSN-L)
- 1471-0048
- OpenAlex
- W2052285428
- Cited by
- 580
- References
- 176
- Citations by year
- 2026: 20 · 2025: 44 · 2024: 39 · 2023: 47 · 2022: 54 · 2021: 56 · 2020: 44 · 2019: 56 · 2018: 63 · 2017: 53 · 2016: 40 · 2015: 41 · 2014: 23
- FWCI
- 3.37
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Nature reviews. Neuroscience (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Austrian Science Fund
- Topics
- Life Sciences › Neuroscience › Neurology › Neuroinflammation and Neurodegeneration Mechanisms
- Health Sciences › Medicine › Physiology › Pain Mechanisms and Treatments
- Life Sciences › Neuroscience › Biological Psychiatry › Tryptophan and brain disorders
- Keywords
- neuroinflammation, neuronal activity, central nervous system, immune cells, vascular cells, neurons, CNS homeostasis, neuroplasticity, pain, stress, epilepsy, neurodegeneration
- MeSH terms
- Animals, Central Nervous System, Central Nervous System Diseases, Humans, Inflammation, Neurons, Pain
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
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