Cited by 580Neuroinflammation and Neurodegeneration MechanismsPain Mechanisms and TreatmentsTryptophan and brain disorders

Neurogenic neuroinflammation: inflammatory CNS reactions in response to neuronal activity

Xanthos, Dimitris N., Sandkühler, Jürgen·2014·Nature Reviews Neuroscience

Abstract

The CNS is endowed with an elaborated response repertoire termed 'neuroinflammation', which enables it to cope with pathogens, toxins, traumata and degeneration. On the basis of recent publications, we deduce that orchestrated actions of immune cells, vascular cells and neurons that constitute neuroinflammation are not only provoked by pathological conditions but can also be induced by increased neuronal activity. We suggest that the technical term 'neurogenic neuroinflammation' should be used for inflammatory reactions in the CNS in response to neuronal activity. We believe that neurogenic neuro-inflammation maintains homeostasis to enable the CNS to cope with enhanced metabolic demands and increases the computational power and plasticity of CNS neuronal networks. However, neurogenic neuroinflammation may also become maladaptive and aggravate the outcomes of pain, stress and epilepsy.

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Crossref · 10.1038/nrn3617

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  • In people living with HIV, the prevalence rate of self-reported sleep disturbances is about 60%, much higher than the prevalence rate of 10% in the general population.

    “two recent systematic reviews revealed a prevalence rate of self-reported sleep disturbances of ~60% in people living with HIV, which is much higher than the prevalence rate of 10% in the general population (97, 591).”

    From The Sleep-Immune Crosstalk in Health and Disease (2019) · cites this paper as [591]

  • Even after the initiation of antiretroviral therapy, HIV-positive patients continue to report lower sleep quality.

    “even after the initiation of antiretroviral therapy, HIV-positive patients continue to report lower sleep quality (359, 539, 591)”

    From The Sleep-Immune Crosstalk in Health and Disease (2019) · cites this paper as [591]

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Authors
Xanthos, D. N., & Sandkühler, J.
Affiliations
Medical University of Vienna (AT)
Corresponding author
Sandkühler, Jürgen
Venue
Nature Reviews Neuroscience
Published
2013-11-27
Volume
15
Issue
1
Pages
43-53
ISSN
  • 1471-003X (ISSN-L)
  • 1471-0048
OpenAlex
W2052285428
Cited by
580
References
176
Citations by year
2026: 20 · 2025: 44 · 2024: 39 · 2023: 47 · 2022: 54 · 2021: 56 · 2020: 44 · 2019: 56 · 2018: 63 · 2017: 53 · 2016: 40 · 2015: 41 · 2014: 23
FWCI
3.37
Type
journal article
Language
en
Open access
closed
Locations
  • Nature reviews. Neuroscience (publishedVersion)
  • PubMed (publishedVersion)
Funders
Austrian Science Fund
Topics
  • Life Sciences › Neuroscience › Neurology › Neuroinflammation and Neurodegeneration Mechanisms
  • Health Sciences › Medicine › Physiology › Pain Mechanisms and Treatments
  • Life Sciences › Neuroscience › Biological Psychiatry › Tryptophan and brain disorders
Keywords
neuroinflammation, neuronal activity, central nervous system, immune cells, vascular cells, neurons, CNS homeostasis, neuroplasticity, pain, stress, epilepsy, neurodegeneration
MeSH terms
Animals, Central Nervous System, Central Nervous System Diseases, Humans, Inflammation, Neurons, Pain

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