Activation of transposable elements during aging and neuronal decline in Drosophila

Somatic mosaicism in neuronal precursor cells mediated by L1 retrotransposition

Muotri, A. R., Chu, V. T., Marchetto, M. C. N., Deng, W., Moran, J. V., & Gage, F. H. (2005) · Nature · doi:10.1038/nature03663 · Cited by 942

Genetic dissection of consolidated memory in Drosophila

Tully, T., Preat, T., Boynton, S. C., & Del Vecchio, M. (1994) · Cell · doi:10.1016/0092-8674(94)90398-0 · Cited by 924

L1 retrotransposition in human neural progenitor cells

Coufal, N. G., Garcia-Perez, J. L., Peng, G. E., Yeo, G. W., Mu, Y., Lovci, M. T., Morell, M., O’Shea, K. S., Moran, J. V., & Gage, F. H. (2009) · Nature · doi:10.1038/nature08248 · Cited by 814

Somatic retrotransposition alters the genetic landscape of the human brain

Baillie, J. K., Barnett, M. W., Upton, K. R., Gerhardt, D. J., Richmond, T. A., De Sapio, F., Brennan, P. M., Rizzu, P., Smith, S., Fell, M., et al. (2011) · Nature · doi:10.1038/nature10531 · Cited by 684

Retrotransposons Revisited: The Restraint and Rehabilitation of Parasites

Goodier, J. L., & Kazazian, H. H. (2008) · Cell · doi:10.1016/j.cell.2008.09.022 · Cited by 659

L1 retrotransposition in neurons is modulated by MeCP2

Muotri, A. R., Marchetto, M. C. N., Coufal, N. G., Oefner, R., Yeo, G., Nakashima, K., & Gage, F. H. (2010) · Nature · doi:10.1038/nature09544 · Cited by 626

Small RNA sorting: matchmaking for Argonautes

Czech, B., & Hannon, G. J. (2011) · Nature Reviews Genetics · doi:10.1038/nrg2916 · Cited by 605

DICER1 deficit induces Alu RNA toxicity in age-related macular degeneration

Kaneko, H., Dridi, S., Tarallo, V., Gelfand, B. D., Fowler, B. J., Cho, W. G., Kleinman, M. E., Ponicsan, S. L., Hauswirth, W. W., Chiodo, V. A., et al. (2011) · Nature · doi:10.1038/nature09830 · Cited by 601

The microRNA miR-34 modulates ageing and neurodegeneration in Drosophila

Liu, N., Landreh, M., Cao, K., Abe, M., Hendriks, G.-J., Kennerdell, J. R., Zhu, Y., Wang, L.-S., & Bonini, N. M. (2012) · Nature · doi:10.1038/nature10810 · Cited by 356

Identification of active loci of a human endogenous retrovirus in neurons of patients with amyotrophic lateral sclerosis

Douville, R. N., Liu, J., Rothstein, J., & Nath, A. (2010) · Annals of Neurology · doi:10.1002/ana.22149 · Cited by 327

Resveratrol Blocks Retrotransposition of LINE-1 Through PPAR α and Sirtuin-6Preprint

Okudaira, N., Ishizaka, Y., & Tamamori‐Adachi, M. (2021) · Research Square · doi:10.21203/rs.3.rs-860434/v1

Transcriptional and mutational signatures of the aging germlinePreprint

Witt, E., Langer, C. B., Svetec, N., & Zhao, L. (2021) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2021.11.22.469565

RNAi and miRNA pathways in arthropods

Svoboda, P. (2020) · Karolinum Press eBooks · doi:10.14712/9788024643724.7

Epigenomic and transcriptomic analysis of developing, adult and aging brain: mechanisms of brain folding, neuronal function and finding novel therapy for dementia

Sakib, M. S. (2021) · eDiss (Georg-August-Universität Göttingen) · doi:10.53846/goediss-8870 · Cited by 1

Faculty Opinions recommendation of A somatic piRNA pathway in the Drosophila fat body ensures metabolic homeostasis and normal lifespan.

Kapahi, P. (2020) · Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature · doi:10.3410/f.727132533.793573768

Faculty Opinions recommendation of Pathogenic tau-induced piRNA depletion promotes neuronal death through transposable element dysregulation in neurodegenerative tauopathies.

Ryoo, H. D. (2018) · Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature · doi:10.3410/f.733685711.793549102

Processus morphogénétiques

Prochiantz, A. (2015) · L’annuaire du Collège de France · doi:10.4000/annuaire-cdf.11906

IRescue: uncertainty-aware quantification of transposable elements expression at single cell levelPreprint

Polimeni, B., Marasca, F., Ranzani, V., & Bodega, B. (2022) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2022.09.16.508229

Endogenous retrovirus expression during fruitfly metamorphosis enhances adult viral immunity

Botto, J. M., & Faulkner, G. J. (2022) · Nature Genetics · doi:10.1038/s41588-022-01209-6

JUN upregulation drives aberrant transposable element mobilization, associated innate immune response, and impaired neurogenesis in Alzheimer’s diseasePreprint

Scopa, C., Barnada, S. M., Cicardi, M. E., Singer, M., Trotti, D., & Trizzino, M. (2022) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2022.11.24.517794

Influence of induced transpositional activity of p elements on age-dependent changes in the reproductive system and embryo survival of Drosophila melanogaster

Александровна, Ю. Е. (2022) · Proceedings of the Komi Science Centre of the Ural Division of the Russian Academy of Sciences · doi:10.19110/1994-5655-2022-4-82-91

Diurnal small RNA expression and post-transcriptional regulation in young and old Drosophila melanogaster heads

Fey, R. M., Chow, E. S., Gvakharia, B. O., Giebultowicz, J. M., & Hendrix, D. A. (2022) · F1000Research · doi:10.12688/f1000research.124724.1

Genetic analysis of spermatogenesis and aging in Drosophila

Bouska, M. J. (2021) · doi:10.31274/td-20240329-363

Changes in Lifespan as an Integral Response to the Organism’s Immune Status and Mobile Elements Activity

Trostnikov, M. V., Malyshev, D. R., & PASYUKOVA, E. G. (2023) · Генетика · doi:10.31857/s0016675823110140

The Role of Transposable Elements in Long-Term Memory Formation

Mustafin, R. N., & Хуснутдинова, Э. К. (2024) · Russian Journal of Genetics · doi:10.1134/s1022795424040094

Transposable element small and long RNAs in aging brains and implications in Huntington’s and Parkinson’s diseasePreprint

Dayama, G., Gupta, S., Connizzo, B. K., Labadorf, A. T., Myers, R. H., & Lau, N. C. (2024) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2024.10.22.619758

Exploring the role of transposable elements to sex gap in longevity in Drosophila speciesPreprint

Merenciano, M., Janillon, S., Mermet‐Bouvier, C., Burlet, N., Rodriguez-Rada, V., Ronget, V., Gibert, P., Gaillard, J., Lemaître, J., Marais, G. A. B., et al. (2025) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2025.01.22.634250

Horizontally transferred cell-free chromatin particles function as autonomous satellite genomes and vehicles for transposable elements within host cellsPreprint

Banerjee, S., Shende, S., Kata, L., Lopes, R., Praveen, S., Joshi, R., Khare, N. K., Raghuram, G. V., Shabrish, S., & Mittra, I. (2025) · eLife · doi:10.7554/elife.103771.2 · Cited by 1

Ago2-Mediated Recruitment of HP1a on Transposable Elements in Drosophila Brain

Olenkina, O. M., Simonov, R. A., Ivannikova, A. Y., Abramov, Y. A., Sivkina, A. L., Ulianov, S. V., & Shevelyov, Y. Y. (2025) · Cells · doi:10.3390/cells14171361

Long-read sequencing-based analyses of the adult Drosophila brain transcriptome in physiological and pathological settings

Ramirez, P., Zuniga, G., Ochoa, E., & Frost, B. E. (2025) · BMC Genomics · doi:10.1186/s12864-025-12111-w

The Role of Transposable Elements in Therapeutics

Howe, K. E., & Doucet-O’Hare, T. T. (2025) · Epigenetics and human health · doi:10.1007/978-3-032-04125-8_13

Transposable Elements as Drivers of Age-Related Neurodegenerative Disease

Scopa, C., Muench, M., & Trotti, D. (2025) · Epigenetics and human health · doi:10.1007/978-3-032-04125-8_11

Transposable elements in aging: From biomarkers to effectors

Fuentes-Iglesias, A., García-Vílchez, R., & Guallar, D. (2025) · Advances in genetics · doi:10.1016/bs.adgen.2025.11.001

Retrotransposons as both “architects” and “saboteurs” in the nervous system

Izquierdo‐Useros, N., Dierssen, M., Clotet, B., Elizalde‐Torrent, A., & Carriba, P. (2025) · Advances in genetics · doi:10.1016/bs.adgen.2025.11.002 · Cited by 2

Additional file 1 of TDP-43 prevents retrotransposon activation in the Drosophila motor system through regulation of Dicer-2 activity

Romano, G., Klima, R., & Feiguin, F. M. (2020) · Figshare · doi:10.6084/m9.figshare.12610199

Additional file 6 of TDP-43 prevents retrotransposon activation in the Drosophila motor system through regulation of Dicer-2 activity

Romano, G., Klima, R., & Feiguin, F. M. (2020) · Figshare · doi:10.6084/m9.figshare.12610214

Additional file 3 of TDP-43 prevents retrotransposon activation in the Drosophila motor system through regulation of Dicer-2 activity

Romano, G., Klima, R., & Feiguin, F. M. (2020) · Figshare · doi:10.6084/m9.figshare.12610205

Additional file 2 of TDP-43 prevents retrotransposon activation in the Drosophila motor system through regulation of Dicer-2 activity

Romano, G., Klima, R., & Feiguin, F. M. (2020) · Figshare · doi:10.6084/m9.figshare.12610202

Additional file 1 of Daphnia magna egg piRNA cluster expression profiles change as mothers age

Hearn, J., & Little, T. J. (2022) · Figshare · doi:10.6084/m9.figshare.20025061

Additional file 5 of TDP-43 prevents retrotransposon activation in the Drosophila motor system through regulation of Dicer-2 activity

Romano, G., Klima, R., & Feiguin, F. M. (2020) · Figshare · doi:10.6084/m9.figshare.12610211

Additional file 4 of TDP-43 prevents retrotransposon activation in the Drosophila motor system through regulation of Dicer-2 activity

Romano, G., Klima, R., & Feiguin, F. M. (2020) · Figshare · doi:10.6084/m9.figshare.12610208

Metformin-induced longevity is associated with retrotransposon dynamics in yeast chronological aging

Meneses-Plascencia, J., Moreno‐Méndez, E., Ascencio, D., Pérez-Aguilar, C., Munguía-Figueroa, M., Abreu-Goodger, C., Funes, S., & DeLuna, A. (2026) · Mechanisms of Ageing and Development · doi:10.1016/j.mad.2026.112162 · Cited by 1

Régulations épigénétiques des éléments transposables au cours de l’ovogenèse de Drosophila melanogaster

Théron, E. (2017) · theses.fr (ABES) · doi:10.70675/d76b18c1zc2c1z4748z9fc2zcc393afc2a86

Regulation of wing growth in vivo by the histone demethylase dLSD1

Texier, M. (2018) · theses.fr (ABES) · doi:10.70675/39466764za985z4be7z8494z3c0281e77b30

Caractérisation des interactions entre les défenses antivirales et le contrôle génomique des éléments transposables chez Drosophila

Roy, M. (2019) · theses.fr (ABES) · doi:10.70675/131ed218z9059z4573zbe9cz51797ce2d6f6

Study of neuronal networks and mechanisms implicated in locomotor reactivity and Parkinson's disease pathogenesis in the Drosophila model

Sun, J. (2018) · theses.fr (ABES) · doi:10.70675/ab1bac8ezd1d7z4faczafedzd5f7efbfe78c

Genome instability : from genome content variations to gene expression plasticity

Goupil, A. (2021) · theses.fr (ABES) · doi:10.70675/73c5ad47z37c8z4114zaf3ez3ddd10007a35

Local SNP-explained methylation variation reveals genetically anchored and exposure-associated methylation architecture in the human brainPreprint

Bennett, A., Johnson, E. K., Terry, N. N., Hemphill, J., & Benjamin, K. J. (2026) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.64898/2026.06.05.730443

mRNA-LNP delivery of individual longevity genes mitigates doxorubicin-induced progeroid phenotypes

Ju, Y., Zhang, Y., Zhao, X., Lin, J., & Wei, Y. (2026) · Protein & Cell · doi:10.1093/procel/pwag044

Small Noncoding RNAs: Small Interfering RNAs and Piwi-interacting RNAs

Haseltine, W. A., & Patarca, R. (2026) · Springer eBooks · doi:10.1007/978-3-032-30270-0_7

Aging and Reproductive Cancers: An Integrative View on Cell-Free DNA and Transposable Elements

Cecati, M., Vaiasicca, S., Cianfruglia, L., Fumarola, S., Campagna, R., Marchegiani, F., & Cardelli, M. (2026) · Frontiers in Bioscience-Landmark · doi:10.31083/fbl50970

The lncRNA Statera regulates synaptogenesis by repressing the retrotransposon copia in DrosophilaPreprint

Wang, S., M'angale, P. G., Xiao, C., Alegre, G., Simkin, A., Malinkevich, A., & Thomson, T. (2026) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.64898/2026.09.01.748680

Protein-driven colloid-osmotic pressure controls nuclear size, organization, and functionPreprint

Ohsawa, S., Sáncho-Andrés, G., Narduzzi, G., Zhao, W., Lakhe, D., Estrada, M. E., Biswas, A., Moriizumi, H., Zatulovskiy, E. A., Reber, S., et al. (2026) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.64898/2026.09.03.749057

The therapeutic potential of transposable element activity modulation

Morelli, G., D’Onghia, M., Mangiavacchi, A., & Orlando, V. (2026) · EMBO Molecular Medicine · doi:10.1038/s44321-026-00528-z

Effect of aging on neutrophil function in humans

Galang, J. N., Sumpter, N. A., Schlüter, T., Asmann, N., Pich, L. M. M., Sarlea, A., van de Veerdonk, F., Ziogas, A., & Netea, M. G. (2026) · Cellular Immunology · doi:10.1016/j.cellimm.2026.105166

ACTIVATION OF TRANSPOSABLE ELEMENTS AS A MOLECULAR CAUSE OF AGING

Helfand, S. L., Wood, J., Jones, B. C., & Taylor, J. (2017) · Innovation in Aging · doi:10.1093/geroni/igx004.4889

Transposable Elements as a Factor in the Aging of Drosophila melanogaster

Driver, C., & McKechnie, S. W. (1992) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.1992.tb27439.x · Cited by 49

Artificially stimulating retrotransposon activity increases mortality and accelerates a subset of aging phenotypes in Drosophila

Rigal, J., Anduaga, A. M., Bitman, E., Rivellese, E., Kadener, S., & Marr, M. T. (2022) · eLife · doi:10.7554/elife.80169 · Cited by 21

Chromatin-modifying genetic interventions suppress age-associated transposable element activation and extend life span in Drosophila

Wood, J. G., Jones, B. C., Jiang, N., Chang, C., Hosier, S., Wickremesinghe, P., Garcia, M., Hartnett, D. A., Burhenn, L., Neretti, N., et al. (2016) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1604621113 · Cited by 214

The ‘moving target’ of transposon landscape changes in aging Drosophila

Yang, N., Srivastav, S. P., Ma, Q., Rahman, R., Chinen, M., Lei, E., & Lau, N. C. (2020) · Figshare · doi:10.6084/m9.figshare.12145884