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Activation of transposable elements during aging and neuronal decline in Drosophila
Open accessAbstract
We found that several transposable elements were highly active in Drosophila brain during normal aging. In addition, we found that mutations in Drosophila Argonaute 2 (Ago2) resulted in exacerbated transposon expression in the brain, progressive and age-dependent memory impairment, and shortened lifespan. These findings suggest that transposon activation may contribute to age-dependent loss of neuronal function.
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“DNA damage-mediated cell death104 might thus be a predominant cause of deleterious effects exerted by retrotransposons in flies.”
From The role of retrotransposable elements in ageing and age-associated diseases (2021) · cites this paper as [104]
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“Sample sizes are similar to or greater than those reported in previous publications4,5,10.”
From Pathogenic tau-induced piRNA depletion promotes neuronal death through transposable element dysregulation in neurodegenerative tauopathies (2018) · cites this paper as [4]
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“studies in yeast, flies and mammals have noted an age-associated increase in the activation of transposable elements, contributing to genomic instability49–51.”
From Stem cell aging: mechanisms, regulators and therapeutic opportunities (2014) · cites this paper as [50]
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“with aging, the efficacy of these systems is known to be reduced, providing a genomic environment in which TEs may become activated and contribute to somatic mutagenesis [244, 245]”
From Genetic architecture of Alzheimer's disease (2020) · cites this paper as [245]
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“Neuropathologies such as tau have been observed to promote activation of TEs”
From Genetic architecture of Alzheimer's disease (2020) · cites this paper as [245]
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Metadata
- Authors
- Li, W., Prazak, L., Chatterjee, N., Grüninger, S., Krug, L., Theodorou, D., & Dubnau, J.
- Affiliations
- Cold Spring Harbor Laboratory (US)
- University of Zurich (CH)
- Sorbonne Paris Cité (FR)
- Corresponding author
- Dubnau, Josh
- ORCID
- Venue
- Nature Neuroscience
- Published
- 2013-04-07
- Volume
- 16
- Issue
- 5
- Pages
- 529-531
- ISSN
- 1097-6256 (ISSN-L)
- 1546-1726
- PMC
- PMC3821974
- OpenAlex
- W2089023364
- Cited by
- 346
- References
- 24
- Citations by year
- 2026: 15 · 2025: 25 · 2024: 30 · 2023: 22 · 2022: 32 · 2021: 39 · 2020: 38 · 2019: 27 · 2018: 23 · 2017: 22 · 2016: 22 · 2015: 25 · 2014: 20 · 2013: 6
- FWCI
- 8.63
- Type
- journal article
- Language
- en
- Open access
- green
- www.zora.uzh.ch
- Licence
- other-oa
- www.springer.com/tdm (tdm)
- Locations
- Nature Neuroscience (publishedVersion)
- PubMed (publishedVersion)
- Zurich Open Repository and Archive (University of Zurich) (acceptedVersion, other-oa)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Cold Spring Harbor Laboratory Institutional Repository (Cold Spring Harbor Laboratory) (acceptedVersion)
- Zurich Open Repository and Archive (University of Zurich) (submittedVersion, other-oa)
- Zurich Open Repository and Archive (University of Zurich)
- Funders
- National Institute of Neurological Disorders and Stroke (TR01 5R01NS067690-03, R01NS067690)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Aging › Genetics, Aging, and Longevity in Model Organisms
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Chromosomal and Genetic Variations
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurobiology and Insect Physiology Research
- Keywords
- transposable elements, transposon activation, aging, Argonaute 2, RNA interference, memory impairment, lifespan, Drosophila brain, age-related neurodegeneration
- MeSH terms
- Aging, Analysis of Variance, Animals, Avoidance Learning, Brain, Conditioning, Classical, DNA Transposable Elements, Drosophila, Longevity, Mutation, Neurons, Drosophila Proteins, Animals, Genetically Modified, Green Fluorescent Proteins, Argonaute Proteins
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