The DOI matches its Crossref record; 6 of the 6 references it cites were found in a registry or an index.
Optogenetic identification of a rapid eye movement sleep modulatory circuit in the hypothalamus
Open accessAbstract
Rapid-eye movement (REM) sleep correlates with neuronal activity in the brainstem, basal forebrain and lateral hypothalamus. Lateral hypothalamus melanin-concentrating hormone (MCH)-expressing neurons are active during sleep, but their effects on REM sleep remain unclear. Using optogenetic tools in newly generated Tg(Pmch-cre) mice, we found that acute activation of MCH neurons (ChETA, SSFO) at the onset of REM sleep extended the duration of REM, but not non-REM, sleep episodes. In contrast, their acute silencing (eNpHR3.0, archaerhodopsin) reduced the frequency and amplitude of hippocampal theta rhythm without affecting REM sleep duration. In vitro activation of MCH neuron terminals induced GABAA-mediated inhibitory postsynaptic currents in wake-promoting histaminergic neurons of the tuberomammillary nucleus (TMN), and in vivo activation of MCH neuron terminals in TMN or medial septum also prolonged REM sleep episodes. Collectively, these results suggest that activation of MCH neurons maintains REM sleep, possibly through inhibition of arousal circuits in the mammalian brain.
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Neural substrates of awakening probed with optogenetic control of hypocretin neurons
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Self-citationPhasic Firing in Dopaminergic Neurons Is Sufficient for Behavioral Conditioning
Tsai, H.-C., Zhang, F., Adamantidis, A., Stuber, G. D., Bonci, A., de Lecea, L., & Deisseroth, K. (2009) · Science · doi:10.1126/science.1168878 · Cited by 1,266
Self-citationThe Neurobiology of Sleep: Genetics, cellular physiology and subcortical networks
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Neuronal excitability modulation over the sleep cycle: a structural and mathematical model
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Wake–sleep circuitry: an overview
Saper, C. B., & Fuller, P. M. (2017) · Current Opinion in Neurobiology · doi:10.1016/j.conb.2017.03.021 · Cited by 383
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Identification of preoptic sleep neurons using retrograde labelling and gene profiling
Chung, S., Weber, F., Zhong, P., Tan, C. L., Nguyen, T. N., Beier, K. T., Hörmann, N., Chang, W.-C., Zhang, Z., Do, J. P., et al. (2017) · Nature · doi:10.1038/nature22350 · Cited by 317
Metadata
- Authors
- Jego, S., Glasgow, S. D., Herrera, C. G., Ekstrand, M., Reed, S. J., Boyce, R., Friedman, J., Burdakov, D., & Adamantidis, A. R.
- Venue
- Nature Neuroscience
- Published
- 2013-09-22
- Volume
- 16
- Issue
- 11
- Pages
- 1637-1643
- ISSN
- 1097-6256 (ISSN-L)
- 1546-1726
- OpenAlex
- W1985681303
- Cited by
- 452
- References
- 6
- FWCI
- 21.71
- Type
- journal article
- Language
- en
- Open access
- green
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