Identification of preoptic sleep neurons using retrograde labelling and gene profiling

A robust and high-throughput Cre reporting and characterization system for the whole mouse brain

Madisen, L., Zwingman, T. A., Sunkin, S. M., Oh, S. W., Zariwala, H. A., Gu, H., Ng, L. L., Palmiter, R. D., Hawrylycz, M. J., Jones, A. R., et al. (2010) · Nature Neuroscience · doi:10.1038/nn.2467 · Cited by 6,907 · see citing works

Large-scale gene function analysis with the PANTHER classification system

Mi, H., Muruganujan, A., Casagrande, J. T., & Thomas, P. D. (2013) · Nature Protocols · doi:10.1038/nprot.2013.092 · Cited by 2,422 · see citing works

A resource of Cre driver lines for genetic targeting of GABAergic neurons in cerebral cortex

Taniguchi, H., He, M., Wu, P., Kim, S., Paik, R., Sugino, K., Kvitsani, D., Fu, Y., Lu, J., Lin, Y., et al. (2011) · Neuron · doi:10.1016/j.neuron.2011.07.026 · Cited by 1,828 · see citing works

Adult mouse cortical cell taxonomy revealed by single cell transcriptomics

Tasic, B., Menon, V., Nguyen, T. N., Kim, T. K., Jarsky, T., Yao, Z., Levi, B., Gray, L. T., Sorensen, S. A., Dolbeare, T., et al. (2016) · Nature Neuroscience · doi:10.1038/nn.4216 · Cited by 1,714 · see citing works

Leptin Action on GABAergic Neurons Prevents Obesity and Reduces Inhibitory Tone to POMC Neurons

Vong, L., Ye, C., Yang, Z., Choi, B. J., Chua, S. C., & Lowell, B. B. (2011) · Neuron · doi:10.1016/j.neuron.2011.05.028 · Cited by 1,238 · see citing works

A translational profiling approach for the molecular characterization of CNS cell types

Heiman, M., Schaefer, A., Gong, S., Peterson, J. D., Day, M., Ramsey, K. E., Suárez-Fariñas, M., Schwarz, C., Stephan, D. A., Surmeier, D. J., et al. (2008) · Cell · doi:10.1016/j.cell.2008.10.028 · Cited by 1,134 · see citing works

Activation of ventrolateral preoptic neurons during sleep

Sherin, J. E., Shiromani, P. J., McCarley, R. W., & Saper, C. B. (1996) · Science · doi:10.1126/science.271.5246.216 · Cited by 1,111 · see citing works

Circuit architecture of VTA dopamine neurons revealed by systematic input-output mapping

Beier, K. T., Steinberg, E. E., DeLoach, K. E., Xie, S., Miyamichi, K., Schwarz, L., Gao, X. J., Kremer, E. J., Malenka, R. C., & Luo, L. (2015) · Cell · doi:10.1016/j.cell.2015.07.015 · Cited by 1,068 · see citing works

Long-range and local circuits for top-down modulation of visual cortex processing

Zhang, S., Xu, M., Kamigaki, T., Hoang Do, J. P., Chang, W.-C., Jenvay, S., Miyamichi, K., Luo, L., & Dan, Y. (2014) · Science · doi:10.1126/science.1254126 · Cited by 804 · see citing works

Innervation of Histaminergic Tuberomammillary Neurons by GABAergic and Galaninergic Neurons in the Ventrolateral Preoptic Nucleus of the Rat

Sherin, J. E., Elmquist, J. K., Torrealba, F., & Saper, C. B. (1998) · Journal of Neuroscience · doi:10.1523/jneurosci.18-12-04705.1998 · Cited by 746 · see citing works

SLEEP AS A PROBLEM OF LOCALIZATION

von Economo, C. (1930) · The Journal of Nervous and Mental Disease · doi:10.1097/00005053-193003000-00001 · Cited by 687 · see citing works

HYPOTHALAMIC REGULATION OF SLEEP IN RATS. AN EXPERIMENTAL STUDY

Nauta, W. J. H. (1946) · Journal of Neurophysiology · doi:10.1152/jn.1946.9.4.285 · Cited by 668 · see citing works

Effect of Lesions of the Ventrolateral Preoptic Nucleus on NREM and REM Sleep

Lu, J., Greco, M. A., Shiromani, P. J., & Saper, C. B. (2000) · Journal of Neuroscience · doi:10.1523/jneurosci.20-10-03830.2000 · Cited by 667 · see citing works

Quantitative measures of cluster quality for use in extracellular recordings

Schmitzer-Torbert, N. C., Jackson, J. C., Henze, D. A., Harris, K., & Redish, A. D. (2005) · Neuroscience · doi:10.1016/j.neuroscience.2004.09.066 · Cited by 642 · see citing works

An excitatory paraventricular nucleus to AgRP neuron circuit that drives hunger

Krashes, M. J., Shah, B. P., Madara, J. C., Olson, D. P., Strochlic, D. E., Garfield, A. S., Vong, L., Pei, H., Watabe-Uchida, M., Uchida, N., et al. (2014) · Nature · doi:10.1038/nature12956 · Cited by 603 · see citing works

AMPA receptor subunits expressed by single purkinje cells

Lambolez, B., Audinat, É., Bochet, P., Crépel, F., & Rossier, J. (1992) · Neuron · doi:10.1016/0896-6273(92)90164-9 · Cited by 544 · see citing works

Molecular taxonomy of major neuronal classes in the adult mouse forebrain

Sugino, K., Hempel, C. M., Miller, M. N., Hattox, A. M., Shapiro, P., Wu, C., Huang, Z. J., & Nelson, S. B. (2006) · Nature Neuroscience · doi:10.1038/nn1618 · Cited by 521 · see citing works

Basal forebrain circuit for sleep-wake control

Xu, M., Chung, S., Zhang, S., Zhong, P., Ma, C., Chang, W.-C., Weissbourd, B., Sakai, N., Luo, L., Nishino, S., et al. (2015) · Nature Neuroscience · doi:10.1038/nn.4143 · Cited by 514 · see citing works

Chemogenetic Tools to Interrogate Brain Functions

Sternson, S. M., & Roth, B. L. (2014) · Annual Review of Neuroscience · doi:10.1146/annurev-neuro-071013-014048 · Cited by 506 · see citing works

Sleep–waking discharge patterns of ventrolateral preoptic/anterior hypothalamic neurons in rats

Szymusiak, R. S., Alam, N., Steininger, T. L., & McGinty, D. (1998) · Brain Research · doi:10.1016/s0006-8993(98)00631-3 · Cited by 458 · see citing works

Optogenetic identification of a rapid eye movement sleep modulatory circuit in the hypothalamus

Jego, S., Glasgow, S. D., Herrera, C. G., Ekstrand, M. I., Reed, S. J., Boyce, R., Friedman, J. M., Burdakov, D., & Adamantidis, A. (2013) · Nature Neuroscience · doi:10.1038/nn.3522 · Cited by 454 · see citing works

Sleep Suppression after Basal Forebrain Lesions in the Cat

McGinty, D., & Sterman, M. B. (1968) · Science · doi:10.1126/science.160.3833.1253 · Cited by 430 · see citing works

Optetrode: a multichannel readout for optogenetic control in freely moving mice

Anikeeva, P., Andalman, A. S., Witten, I. B., Warden, M. R., Goshen, I., Grosenick, L., Gunaydin, L. A., Frank, L. M., & Deisseroth, K. A. (2011) · Nature Neuroscience · doi:10.1038/nn.2992 · Cited by 381 · see citing works

Effect of sleep deprivation on sleep and EEG power spectra in the rat

Borbély, A. A., Tobler, I., & Hanagasioglu, M. (1984) · Behavioural Brain Research · doi:10.1016/0166-4328(84)90186-4 · Cited by 340 · see citing works

The GABAergic parafacial zone is a medullary slow wave sleep–promoting center

Anaclet, C., Ferrari, L. L., Arrigoni, E., Bass, C. E., Saper, C. B., Lu, J., & Fuller, P. M. (2014) · Nature Neuroscience · doi:10.1038/nn.3789 · Cited by 329 · see citing works

Molecular Profiling of Activated Neurons by Phosphorylated Ribosome Capture

Knight, Z. A., Tan, K., Birsoy, K., Schmidt, S. F., Garrison, J. L., Wysocki, R. W., Emiliano, A. B., Ekstrand, M. I., & Friedman, J. M. (2012) · Cell · doi:10.1016/j.cell.2012.10.039 · Cited by 312 · see citing works

Optogenetic activation of cholinergic neurons in the PPT or LDT induces REM sleep

Van Dort, C. J., Zachs, D. P., Kenny, J. D., Zheng, S., Goldblum, R. R., Gelwan, N. A., Ramos, D. M., Nolan, M. A., Wang, K., Weng, F.-J., et al. (2015) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1423136112 · Cited by 296 · see citing works

Control of REM sleep by ventral medulla GABAergic neurons

Weber, F., Chung, S., Beier, K. T., Xu, M., Luo, L., & Dan, Y. (2015) · Nature · doi:10.1038/nature14979 · Cited by 296 · see citing works

Ventrolateral preoptic nucleus contains sleep-active, galaninergic neurons in multiple mammalian species

Gaus, S. E., Strecker, R. E., Tate, B. A., Parker, R. A., & Saper, C. B. (2002) · Neuroscience · doi:10.1016/s0306-4522(02)00308-1 · Cited by 288 · see citing works

Neuronal ensembles sufficient for recovery sleep and the sedative actions of α2 adrenergic agonists

Zhang, Z., Ferretti, V., Güntan, İ., Moro, A., Steinberg, E. A., Ye, Z., Zecharia, A. Y., Yu, X., Vyssotski, A. L., Brickley, S. G., et al. (2015) · Nature Neuroscience · doi:10.1038/nn.3957 · Cited by 275 · see citing works

Subregional organization of preoptic area /anterior hypothalamic projections to arousal-related monoaminergic cell groups

Steininger, T. L., Gong, H., McGinty, D., & Szymusiak, R. S. (2000) · The Journal of Comparative Neurology · doi:10.1002/1096-9861(20010122)429:4 · Cited by 240 · see citing works

Long-lasting insomnia induced by preoptic neuron lesions and its transient reversal by muscimol injection into the posterior hypothalamus in the cat

Sallanon, M. M., Denoyer, M., Kitahama, K., Aubert, C., Gay, N., & Jouvet, M. (1989) · Neuroscience · doi:10.1016/0306-4522(89)90289-3 · Cited by 235 · see citing works

Structural foundations of optogenetics: Determinants of channelrhodopsin ion selectivity

Berndt, A., Lee, S. Y., Wietek, J., Ramakrishnan, C., Steinberg, E. E., Rashid, A. J., Kim, H., Park, S., Santoro, A., Frankland, P. W., et al. (2015) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1523341113 · Cited by 216 · see citing works

Activation of c‐ fos in GABAergic neurones in the preoptic area during sleep and in response to sleep deprivation

Gong, H., McGinty, D., Guzmán-Marı́n, R., Chew, K., Stewart, D., & Szymusiak, R. S. (2004) · The Journal of Physiology · doi:10.1113/jphysiol.2003.056622 · Cited by 215 · see citing works

Cells of a common developmental origin regulate REM/non-REM sleep and wakefulness in mice

Hayashi, Y., Kashiwagi, M., Yasuda, K., Ando, R., Kanuka, M., Sakai, K., & Itohara, S. (2015) · Science · doi:10.1126/science.aad1023 · Cited by 191 · see citing works

Characterization and mapping of sleep–waking specific neurons in the basal forebrain and preoptic hypothalamus in mice

Takahashi, K., Lin, J., & Sakai, K. (2009) · Neuroscience · doi:10.1016/j.neuroscience.2009.02.075 · Cited by 142 · see citing works

A manual method for the purification of fluorescently labeled neurons from the mammalian brain

Hempel, C. M., Sugino, K., & Nelson, S. B. (2007) · Nature Protocols · doi:10.1038/nprot.2007.416 · Cited by 124 · see citing works

Conditional corticotropin-releasing hormone overexpression in the mouse forebrain enhances rapid eye movement sleep

Kimura, M., Müller-Preuss, P., Lu, A., Wiesner, E., Flachskamm, C., Wurst, W., Holsboer, F., & Deussing, J. M. (2009) · Molecular Psychiatry · doi:10.1038/mp.2009.46 · Cited by 111 · see citing works

A Quantitative Comparison of Cell-Type-Specific Microarray Gene Expression Profiling Methods in the Mouse Brain

Okaty, B. W., Sugino, K., & Nelson, S. B. (2011) · PLoS ONE · doi:10.1371/journal.pone.0016493 · Cited by 104 · see citing works

Region-specific changes in immediate early gene expression in response to sleep deprivation and recovery sleep in the mouse brain

Terao, A., Greco, M. A., Davis, R. W., Heller, H. C., & Kilduff, T. S. (2003) · Neuroscience · doi:10.1016/s0306-4522(03)00395-6 · Cited by 93 · see citing works

Opioidergic projections to sleep-active neurons in the ventrolateral preoptic nucleus

Greco, M.-A., Fuller, P. M., Jhou, T. C., Martin‐Schild, S., Zadina, J. E., Hu, Z., Shiromani, P. J., & Lu, J. (2008) · Brain Research · doi:10.1016/j.brainres.2008.09.043 · Cited by 76 · see citing works

Cholecystokinin (CCK-8) elicits prandial sleep in rats

Mansbach, R. S., & LORENZ, D. (1983) · Physiology & Behavior · doi:10.1016/0031-9384(83)90002-1 · Cited by 68 · see citing works

Substance P promotes sleep in the ventrolateral preoptic area of rats

Zhang, G., Wang, L., Liu, H., & Zhang, J. (2004) · Brain Research · doi:10.1016/j.brainres.2004.09.017 · Cited by 34 · see citing works

Optical control of retrogradely infected neurons using drug-regulated “TLoop” lentiviral vectors

Cetin, A. H., & Callaway, E. M. (2014) · Journal of Neurophysiology · doi:10.1152/jn.00495.2013 · Cited by 24 · see citing works

Molecular, spatial, and functional single-cell profiling of the hypothalamic preoptic region

Moffitt, J. R., Bambah-Mukku, D., Eichhorn, S. W., Vaughn, E., Shekhar, K., Perez, J. D., Rubinstein, N. D., Hao, J., Regev, A., Dulac, C., et al. (2018) · Science · doi:10.1126/science.aau5324 · Cited by 1,365 · see citing works

Neural circuit mechanisms of social behavior

Chen, P., & Hong, W. (2018) · Neuron · doi:10.1016/j.neuron.2018.02.026 · Cited by 527 · see citing works

Biological and clinical insights from genetics of insomnia symptoms

Sleep, H. A. I., Lane, J. M., Jones, S. E., Dashti, H. S., Wood, A. R., Aragam, K. G., van Hees, V. T., Strand, L. B., Winsvold, B. S., Wang, H., et al. (2019) · Nature Genetics · doi:10.1038/s41588-019-0361-7 · Cited by 397 · see citing works

Silencing Neurons: Tools, Applications, and Experimental Constraints

Wiegert, J. S., Mahn, M., Prigge, M., Printz, Y., & Yizhar, O. (2017) · Neuron · doi:10.1016/j.neuron.2017.06.050 · Cited by 306 · see citing works

GABA and glutamate neurons in the VTA regulate sleep and wakefulness

Yu, X., Li, W., Ma, Y., Tossell, K., Harris, J. J., Harding, E. C., Ba, W., Miracca, G., Wang, D., Li, L., et al. (2018) · Nature Neuroscience · doi:10.1038/s41593-018-0288-9 · Cited by 317 · see citing works

Sleep deprivation and stress: a reciprocal relationship

Nollet, M., Wisden, W., & Franks, N. P. (2020) · Interface Focus · doi:10.1098/rsfs.2019.0092 · Cited by 307 · see citing works

Neurons that regulate mouse torpor

Hrvatin, S., Sun, S., Wilcox, O. F., Yao, H., Lavin-Peter, A. J., Cicconet, M., Assad, E. G., Palmer, M. E., Aronson, S., Banks, A. S., et al. (2020) · Nature · doi:10.1038/s41586-020-2387-5 · Cited by 291 · see citing works

Designing cell function: assembly of synthetic gene circuits for cell biology applications

Xie, M., & Fussenegger, M. (2018) · Nature Reviews Molecular Cell Biology · doi:10.1038/s41580-018-0024-z · Cited by 290 · see citing works

Oscillating circuitries in the sleeping brain

Adamantidis, A. R., Gutierrez Herrera, C., & Gent, T. C. (2019) · Nature Reviews Neuroscience · doi:10.1038/s41583-019-0223-4 · Cited by 281 · see citing works

Galanin neurons in the ventrolateral preoptic area promote sleep and heat loss in mice

Kroeger, D., Absi, G., Gagliardi, C., Bandaru, S. S., Madara, J. C., Ferrari, L. L., Arrigoni, E., Münzberg, H., Scammell, T. E., Saper, C. B., et al. (2018) · Nature Communications · doi:10.1038/s41467-018-06590-7 · Cited by 276 · see citing works

Arousal and sleep circuits

Jones, B. E. (2019) · Neuropsychopharmacology · doi:10.1038/s41386-019-0444-2 · Cited by 265 · see citing works

A Hypothalamic Midbrain Pathway Essential for Driving Maternal Behaviors

Fang, Y., Yamaguchi, T., Song, S. C., Tritsch, N. X., & Lin, D. (2018) · Neuron · doi:10.1016/j.neuron.2018.02.019 · Cited by 266 · see citing works

The Corticotropin-Releasing Factor Family: Physiology of the Stress Response.

Deussing, J., & Chen, A. (2018) · Physiological Reviews · doi:10.1152/physrev.00042.2017 · Cited by 234 · see citing works

Medial preoptic area in mice is capable of mediating sexually dimorphic behaviors regardless of gender

Wei, Y., Wang, S.-R., Jiao, Z., Zhang, W., Lin, J.-K., Li, X., Li, S., Zhang, X., & Xu, X. (2018) · Nature Communications · doi:10.1038/s41467-017-02648-0 · Cited by 248 · see citing works

Lhx6-positive GABA-releasing neurons of the zona incerta promote sleep

Liu, K., Kim, J., Kim, D. W., Zhang, Y. S., Bao, H., Denaxa, M., Lim, S.-A., Kim, E. S., Liu, C., Wickersham, I. R., et al. (2017) · Nature · doi:10.1038/nature23663 · Cited by 227 · see citing works

Neuropathologic Correlates of Psychiatric Symptoms in Alzheimer’s Disease

Ehrenberg, A. J., Suemoto, C. K., Resende, E. D. P. F., Petersen, C., Leite, R. E. P., Rodriguez, R. D., Ferretti‐Rebustini, R. E. D. L., You, M. Y., Oh, J. Y., Nitríni, R., et al. (2018) · Journal of Alzheimer s Disease · doi:10.3233/jad-180688 · Cited by 218 · see citing works

A Motor Theory of Sleep-Wake Control: Arousal-Action Circuit

Liu, D., & Dan, Y. (2019) · Annual Review of Neuroscience · doi:10.1146/annurev-neuro-080317-061813 · Cited by 190 · see citing works

Advances in Achieving Opioid Analgesia Without Side Effects

Machelska, H., & Celik, M. Ö. (2018) · Frontiers in Pharmacology · doi:10.3389/fphar.2018.01388 · Cited by 180 · see citing works

Two genetically, anatomically and functionally distinct cell types segregate across anteroposterior axis of paraventricular thalamus

Gao, C., Leng, Y., Ma, J., Rooke, V., Rodriguez-Gonzalez, S., Ramakrishnan, C., Deisseroth, K. A., & Penzo, M. A. (2020) · Nature Neuroscience · doi:10.1038/s41593-019-0572-3 · Cited by 180 · see citing works

Nontoxic, double-deletion-mutant rabies viral vectors for retrograde targeting of projection neurons

Chatterjee, S., Sullivan, H. A., MacLennan, B. J., Xu, R., Hou, Y., Lavin, T. K., Lea, N. E., Michalski, J. E., Babcock, K. R., Dietrich, S., et al. (2018) · Nature Neuroscience · doi:10.1038/s41593-018-0091-7 · Cited by 172 · see citing works

A common neuroendocrine substrate for diverse general anesthetics and sleep

Jiang-Xie, L.-F., Yin, L., Zhao, S., Prevosto, V., Han, B.-X., Dzirasa, K., & Wang, F. (2019) · Neuron · doi:10.1016/j.neuron.2019.03.033 · Cited by 173 · see citing works

The Neural Circuits Underlying General Anesthesia and Sleep

Moody, O. A., Zhang, E. R., Vincent, K. F., Kato, R., Melonakos, E. D., Nehs, C. J., & Solt, K. (2021) · Anesthesia & Analgesia · doi:10.1213/ane.0000000000005361 · Cited by 165 · see citing works

The Case for TAAR1 as a Modulator of Central Nervous System Function

Rutigliano, G., Accorroni, A., & Zucchi, R. (2018) · Frontiers in Pharmacology · doi:10.3389/fphar.2017.00987 · Cited by 166 · see citing works

Sleep-wake control and the thalamus

Gent, T. C., Bassetti, C. L., & Adamantidis, A. (2018) · Current Opinion in Neurobiology · doi:10.1016/j.conb.2018.08.002 · Cited by 165 · see citing works

FGF21 Signals to Glutamatergic Neurons in the Ventromedial Hypothalamus to Suppress Carbohydrate Intake

Jensen-Cody, S. O., Flippo, K. H., Claflin, K. E., Yavuz, Y., Sapouckey, S. A., Walters, G. C., Usachev, Y. M., Atasoy, D., Gillum, M. P., & Potthoff, M. J. (2020) · Cell Metabolism · doi:10.1016/j.cmet.2020.06.008 · Cited by 166 · see citing works

Neuro-orchestration of sleep and wakefulness

Sulaman, B. A., Wang, S., Tyan, J., & Eban-Rothschild, A. (2022) · Nature Neuroscience · doi:10.1038/s41593-022-01236-w · Cited by 160 · see citing works

Medial preoptic area antagonistically mediates stress-induced anxiety and parental behavior

Zhang, G., Shen, L., Tao, C., Jung, A.-H., Peng, B., Li, Z., Zhang, L. I., & Tao, H. W. (2021) · Nature Neuroscience · doi:10.1038/s41593-020-00784-3 · Cited by 158 · see citing works

The Biology of General Anesthesia from Paramecium to Primate

Kelz, M. B., & Mashour, G. A. (2019) · Current Biology · doi:10.1016/j.cub.2019.09.071 · Cited by 151 · see citing works

Histamine: neural circuits and new medications

Scammell, T. E., Jackson, A. C., Franks, N. P., Wisden, W., & Dauvilliers, Y. A. (2018) · SLEEP · doi:10.1093/sleep/zsy183 · Cited by 144 · see citing works

A Hypothalamic Switch for REM and Non-REM Sleep

Chen, K.-S., Xu, M., Zhang, Z., Chang, W.-C., Gaj, T., Schaffer, D. V., & Dan, Y. (2018) · Neuron · doi:10.1016/j.neuron.2018.02.005 · Cited by 137 · see citing works

A neuronal hub binding sleep initiation and body cooling in response to a warm external stimulus

Harding, E. C., Yu, X., Miao, A., Andrews, N., Ma, Y., Ye, Z., Lignos, L., Miracca, G., Ba, W., Yustos, R., et al. (2018) · Current Biology · doi:10.1016/j.cub.2018.05.054 · Cited by 136 · see citing works

Neural control of parental behaviors

Kohl, J., & Dulac, C. (2018) · Current Opinion in Neurobiology · doi:10.1016/j.conb.2018.02.002 · Cited by 136 · see citing works

Galanin Neurons Unite Sleep Homeostasis and α2-Adrenergic Sedation

Ma, Y., Miracca, G., Yu, X., Harding, E. C., Miao, A., Yustos, R., Vyssotski, A. L., Franks, N. P., & Wisden, W. (2019) · Current Biology · doi:10.1016/j.cub.2019.07.087 · Cited by 126 · see citing works

Orexin neurons inhibit sleep to promote arousal

De Luca, R., Nardone, S., Grace, K. P., Venner, A., Cristofolini, M., Bandaru, S. S., Sohn, L. T., Kong, D., Mochizuki, T., Viberti, B., et al. (2022) · Nature Communications · doi:10.1038/s41467-022-31591-y · Cited by 130 · see citing works

To eat or to sleep: That is a lateral hypothalamic question

Arrigoni, E., Chee, M. J. S., & Fuller, P. M. (2018) · Neuropharmacology · doi:10.1016/j.neuropharm.2018.11.017 · Cited by 124 · see citing works

Muscarinic Acetylcholine Receptors Chrm1 and Chrm3 Are Essential for REM Sleep

Niwa, Y., Kanda, G. N., Yamada, R. G., Shi, S., Sunagawa, G. A., Ukai‐Tadenuma, M., Fujishima, H., Matsumoto, N., Masumoto, K., Nagano, M., et al. (2018) · Cell Reports · doi:10.1016/j.celrep.2018.07.082 · Cited by 111 · see citing works

Gating and the Need for Sleep: Dissociable Effects of Adenosine A1 and A2A Receptors

Lazarus, M., Oishi, Y., Bjorness, T. E., & Greene, R. W. (2019) · Frontiers in Neuroscience · doi:10.3389/fnins.2019.00740 · Cited by 110 · see citing works

Genomic mosaicism in the developing and adult brain

Rohrback, S., Siddoway, B. A., Liu, C. S., & Chun, J. J. M. (2018) · Developmental Neurobiology · doi:10.1002/dneu.22626 · Cited by 103 · see citing works

Complementary contributions of non-REM and REM sleep to visual learning

Tamaki, M., Wang, Z., Barnes-Diana, T., Guo, D., Berard, A. V., Walsh, E. G., Watanabe, T., & Sasaki, Y. (2020) · Nature Neuroscience · doi:10.1038/s41593-020-0666-y · Cited by 103 · see citing works

The mammalian circadian pacemaker regulates wakefulness via CRF neurons in the paraventricular nucleus of the hypothalamus

Ono, D., Mukai, Y., Hung, C. J., Chowdhury, S., Sugiyama, T., & Yamanaka, A. (2020) · Science Advances · doi:10.1126/sciadv.abd0384 · Cited by 102 · see citing works

Single cell transcriptomics in neuroscience: cell classification and beyond

Tasic, B. (2018) · Current Opinion in Neurobiology · doi:10.1016/j.conb.2018.04.021 · Cited by 83 · see citing works

Bidirectional Relationship between Opioids and Disrupted Sleep: Putative Mechanisms

Eacret, D., Veasey, S. C., & Blendy, J. A. (2020) · Molecular Pharmacology · doi:10.1124/mol.119.119107 · Cited by 95 · see citing works

Role of the Preoptic Area in Sleep and Thermoregulation

Rothhaas, R., & Chung, S. (2021) · Frontiers in Neuroscience · doi:10.3389/fnins.2021.664781 · Cited by 98 · see citing works

Activation of Preoptic GABAergic or Glutamatergic Neurons Modulates Sleep-Wake Architecture, but Not Anesthetic State Transitions

Vanini, G., Bassana, M., Mast, M., Mondino, A., Cerda, I. H., Phyle, M., Chen, V., Colmenero, A. V., Hambrecht‐Wiedbusch, V. S., & Mashour, G. A. (2020) · Current Biology · doi:10.1016/j.cub.2019.12.063 · Cited by 96 · see citing works

Kinase signalling in excitatory neurons regulates sleep quantity and depth

Kim, S. J., Hotta-Hirashima, N., Asano, F., Kitazono, T., Iwasaki, K., Nakata, S., Komiya, H., Asama, N., Matsuoka, T., Fujiyama, T., et al. (2022) · Nature · doi:10.1038/s41586-022-05450-1 · Cited by 96 · see citing works

Structural mechanisms of selectivity and gating in anion channelrhodopsins

KATO, H. E., Kim, Y. S., Paggi, J. M., Evans, K. E., Allen, W. E., Richardson, C. E., Inoue, K., Ito, S., Ramakrishnan, C., Fenno, L. E., et al. (2018) · Nature · doi:10.1038/s41586-018-0504-5 · Cited by 93 · see citing works

Sleep Regulation by Neurotensinergic Neurons in a Thalamo-Amygdala Circuit

Ma, C., Zhong, P., Liu, D., Barger, Z., Zhou, L., Chang, W.-C., Kim, B., & Dan, Y. (2019) · Neuron · doi:10.1016/j.neuron.2019.05.015 · Cited by 94 · see citing works

Differential regulation of the Drosophila sleep homeostat by circadian and arousal inputs

Ni, J. D., Gurav, A. S., Liu, W., Ogunmowo, T. H., Hackbart, H., Elsheikh, A., Verdegaal, A. A., & Montell, C. (2019) · eLife · doi:10.7554/elife.40487 · Cited by 93 · see citing works

Control of Non-REM Sleep by Midbrain Neurotensinergic Neurons

Zhong, P., Zhang, Z., Barger, Z., Ma, C., Liu, D., Ding, X., & Dan, Y. (2019) · Neuron · doi:10.1016/j.neuron.2019.08.026 · Cited by 93 · see citing works

A noradrenergic-hypothalamic neural substrate for stress-induced sleep disturbances

Antila, H., Kwak, I., Choi, A., Pisciotti, A., Covarrubias, I., Baik, J., Eisch, A. J., Beier, K. T., THOMAS, S. A., Weber, F., et al. (2022) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2123528119 · Cited by 91 · see citing works

A Rare Mutation of β1-Adrenergic Receptor Affects Sleep/Wake Behaviors

Shi, G., Xing, L., Wu, D., Bhattacharyya, B. J., Jones, C. R., McMahon, T., Chong, S. Y. C., Chen, J., Coppola, G., Geschwind, D. H., et al. (2019) · Neuron · doi:10.1016/j.neuron.2019.07.026 · Cited by 90 · see citing works

The Neuropeptide Galanin Is Required for Homeostatic Rebound Sleep following Increased Neuronal Activity

Reichert, S., Arocas, O. P., & Rihel, J. (2019) · Neuron · doi:10.1016/j.neuron.2019.08.010 · Cited by 89 · see citing works

Non‐invasive transcutaneous auricular vagus nerve stimulation prevents postoperative ileus and endotoxemia in mice

Hong, G., Zillekens, A., Schneiker, B., Pantelis, D., de Jonge, W. J., Schaefer, N., Kalff, J. C., & Wehner, S. (2018) · Neurogastroenterology & Motility · doi:10.1111/nmo.13501 · Cited by 87 · see citing works

GABA Receptors and the Pharmacology of Sleep

Wisden, W., Yu, X., & Franks, N. P. (2017) · Handbook of experimental pharmacology · doi:10.1007/164_2017_56 · Cited by 83 · see citing works

The role of co-neurotransmitters in sleep and wake regulation

Oh, J. Y., Petersen, C., Walsh, C. M., Bittencourt, J. C., Neylan, T. C., & Grinberg, L. T. (2018) · Molecular Psychiatry · doi:10.1038/s41380-018-0291-2 · Cited by 87 · see citing works

Dynamic Network Activation of Hypothalamic MCH Neurons in REM Sleep and Exploratory Behavior

Blanco‐Centurion, C., Luo, S., Spergel, D. J., Vidal-Ortiz, A., Oprisan, S. A., van den Pol, A. N., Liu, M., & Shiromani, P. J. (2019) · Journal of Neuroscience · doi:10.1523/jneurosci.0305-19.2019 · Cited by 85 · see citing works

Control of locomotor speed, arousal, and hippocampal theta rhythms by the nucleus incertus

Lu, L., Ren, Y., Yu, T., Liu, Z., Wang, S., Tan, L., Zeng, J., Feng, Q., Lin, R., Liu, Y., et al. (2020) · Nature Communications · doi:10.1038/s41467-019-14116-y · Cited by 84 · see citing works

Hypothalamic Tuberomammillary Nucleus Neurons: Electrophysiological Diversity and Essential Role in Arousal Stability

Fujita, A., Bonnavion, P., Wilson, M. H., Mickelsen, L. E., Bloit, J., de Lecea, L., & Jackson, A. C. (2017) · Journal of Neuroscience · doi:10.1523/jneurosci.0580-17.2017 · Cited by 82 · see citing works

Genetic and neuronal regulation of sleep by neuropeptide VF

Lee, D. A., Andreev, A., Truong, T. V., Chen, A., Hill, A. J., Oikonomou, G., Pham, U., Hong, Y. K., Tran, S., Glass, L., et al. (2017) · eLife · doi:10.7554/elife.25727 · Cited by 89 · see citing works

Sleep and the hypothalamus

Adamantidis, A., & de Lecea, L. (2023) · Science · doi:10.1126/science.adh8285 · Cited by 83 · see citing works

A hypothalamic circuit underlying the dynamic control of social homeostasis

Liu, D., Rahman, M., Johnson, A., Amo, R., Tsutsui‐Kimura, I., Sullivan, Z. A., Pena, N., Talay, M., Logeman, B. L., Finkbeiner, S., et al. (2025) · Nature · doi:10.1038/s41586-025-08617-8 · Cited by 83 · see citing works

Medial preoptic circuit induces hunting-like actions to target objects and prey

Park, S.-G., Jeong, Y., Kim, D., Lee, M.-H., Shin, A., Park, G., Ryoo, J., Hong, J., Bae, S., Kim, C.-H., et al. (2018) · Nature Neuroscience · doi:10.1038/s41593-018-0072-x · Cited by 82 · see citing works

Neurogenetic basis for circadian regulation of metabolism by the hypothalamusPreprint

Cedernaes, J., Waldeck, N. J., & Bass, J. T. (2019) · Genes & Development · doi:10.1101/gad.328633.119 · Cited by 84 · see citing works

An Excitatory Circuit in the Perioculomotor Midbrain for Non-REM Sleep Control

Zhang, Z., Zhong, P., Hu, F., Barger, Z., Ren, Y., Ding, X., Li, S., Weber, F., Chung, S., Palmiter, R. D., et al. (2019) · Cell · doi:10.1016/j.cell.2019.03.041 · Cited by 79 · see citing works

Sleep in autism: A biomolecular approach to aetiology and treatment

Ballester, P., Richdale, A. L., Baker, E. K., & Peiró, A. M. (2020) · Sleep Medicine Reviews · doi:10.1016/j.smrv.2020.101357 · Cited by 81 · see citing works

The Effects of Light and the Circadian System on Rhythmic Brain Function

von Gall, C. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23052778 · Cited by 79 · see citing works

Monoamines Inhibit GABAergic Neurons in Ventrolateral Preoptic Area That Make Direct Synaptic Connections to Hypothalamic Arousal Neurons

Saito, Y. C., Maejima, T., Nishitani, M., Hasegawa, E., Yanagawa, Y., Mieda, M., & Sakurai, T. (2018) · Journal of Neuroscience · doi:10.1523/jneurosci.2835-17.2018 · Cited by 78 · see citing works

The retinal iprgc-preoptic circuit mediates the acute effect of light on sleep

Zhang, Z., Beier, C., Weil, T., & Hattar, S. (2021) · Nature Communications · doi:10.1038/s41467-021-25378-w · Cited by 75 · see citing works

Thermoregulation via Temperature-Dependent PGD2 Production in Mouse Preoptic Area

Wang, T. A., Teo, C. F., Åkerblom, M., Chen, C., Fontaine, M. T.-L., Greiner, V. J., Diaz, A. A., McManus, M. T., Jan, Y. N., & Jan, L. Y. (2019) · Neuron · doi:10.1016/j.neuron.2019.04.035 · Cited by 74 · see citing works

AGRP Neurons Project to the Medial Preoptic Area and Modulate Maternal Nest-Building

Li, X., Han, Y., Zhang, W., Wang, S.-R., Wei, Y., Li, S., Lin, J.-K., Yan, J.-J., Chen, A.-X., Zhang, X., et al. (2018) · Journal of Neuroscience · doi:10.1523/jneurosci.0958-18.2018 · Cited by 71 · see citing works

Reassessing the Role of Histaminergic Tuberomammillary Neurons in Arousal Control

Venner, A., Mochizuki, T., De Luca, R., Anaclet, C., Scammell, T. E., Saper, C. B., Arrigoni, E., & Fuller, P. M. (2019) · The Journal of Neuroscience · doi:10.1523/jneurosci.1032-19.2019 · Cited by 70 · see citing works

Sleep and Sedative States Induced by Targeting the Histamine and Noradrenergic Systems

Yu, X., Franks, N. P., & Wisden, W. (2018) · Frontiers in Neural Circuits · doi:10.3389/fncir.2018.00004 · Cited by 68 · see citing works

Sleep-Active Neurons: Conserved Motors of Sleep

Bringmann, H. (2018) · Genetics · doi:10.1534/genetics.117.300521 · Cited by 72 · see citing works

An Inhibitory Lateral Hypothalamic-Preoptic Circuit Mediates Rapid Arousals from Sleep

Venner, A., Luca, R. D., Sohn, L. T., Bandaru, S. S., Verstegen, A. M. J., Arrigoni, E., & Fuller, P. M. (2019) · Current Biology · doi:10.1016/j.cub.2019.10.026 · Cited by 66 · see citing works

The Sleep-Promoting Ventrolateral Preoptic Nucleus: What Have We Learned over the Past 25 Years?

Arrigoni, E., & Fuller, P. M. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23062905 · Cited by 66 · see citing works

Understanding the Neural Mechanisms of General Anesthesia from Interaction with Sleep–Wake State: A Decade of Discovery

Bao, W., Jiang, S., Qu, W., Li, W., Miao, C., & Huang, Z. (2023) · Pharmacological Reviews · doi:10.1124/pharmrev.122.000717 · Cited by 68 · see citing works

The Histaminergic System in Neuropsychiatric Disorders

Li, C., Liu, J., & Chen, Z. (2021) · Biomolecules · doi:10.3390/biom11091345 · Cited by 60 · see citing works

Precise Mapping of Single Neurons by Calibrated 3D Reconstruction of Brain Slices Reveals Topographic Projection in Mouse Visual Cortex

Song, J. H., Choi, W., Song, Y.-H., Kim, J., Jeong, D., Lee, S., & Paik, S. (2020) · Cell Reports · doi:10.1016/j.celrep.2020.107682 · Cited by 61 · see citing works

The medial preoptic area mediates depressive-like behaviors induced by ovarian hormone withdrawal through distinct GABAergic projections

Tao, C., Zhang, G., Huang, J., Li, Z., Tao, H. W., & Zhang, L. I. (2023) · Nature Neuroscience · doi:10.1038/s41593-023-01397-2 · Cited by 60 · see citing works

Cellular Composition of the Preoptic Area Regulating Sleep, Parental, and Sexual Behavior

Tsuneoka, Y., & Funato, H. (2021) · Frontiers in Neuroscience · doi:10.3389/fnins.2021.649159 · Cited by 57 · see citing works

Disorders of Body Weight, Sleep and Circadian Rhythm as Manifestations of Hypothalamic Dysfunction in Alzheimer’s Disease

Hiller, A. J., & Ishii, M. (2018) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2018.00471 · Cited by 57 · see citing works

Sensory input, sex and function shape hypothalamic cell type development

Kaplan, H. S., Logeman, B. L., Zhang, K., Yawitz, T. A., Santiago, C., Sohail, N., Talay, M., Seo, C., Naumenko, S., Sui, S. J. H., et al. (2025) · Nature · doi:10.1038/s41586-025-08603-0 · Cited by 53 · see citing works

Glutamatergic Neurons in the Preoptic Hypothalamus Promote Wakefulness, Destabilize NREM Sleep, Suppress REM Sleep, and Regulate Cortical Dynamics

Mondino, A., Hambrecht‐Wiedbusch, V. S., Li, D., York, A. K., Pal, D., González, J., Torterolo, P., Mashour, G. A., & Vanini, G. (2021) · Journal of Neuroscience · doi:10.1523/jneurosci.2718-20.2021 · Cited by 52 · see citing works

Genetic sleep deprivation: using sleep mutants to study sleep functions

Bringmann, H. (2019) · EMBO Reports · doi:10.15252/embr.201846807 · Cited by 49 · see citing works

Neural Substrates for the Regulation of Sleep and General Anesthesia

Yang, Q., Zhou, F., Li, A., & Dong, H. (2021) · Current Neuropharmacology · doi:10.2174/1570159x19666211214144639 · Cited by 50 · see citing works

NMDA Receptors in the Lateral Preoptic Hypothalamus Are Essential for Sustaining NREM and REM Sleep

Miracca, G., Soto, B. A., Tossell, K., Yustos, R., Vyssotski, A. L., Franks, N. P., & Wisden, W. (2022) · Journal of Neuroscience · doi:10.1523/jneurosci.0350-21.2022 · Cited by 54 · see citing works

Cellular populations and thermosensing mechanisms of the hypothalamic thermoregulatory center

Siemens, J., & Kamm, G. B. (2018) · Pflügers Archiv - European Journal of Physiology · doi:10.1007/s00424-017-2101-0 · Cited by 50 · see citing works

GABAergic modulation of sleep-wake states

Oishi, Y., Saito, Y. C., & Sakurai, T. (2023) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2023.108505 · Cited by 49 · see citing works

Anion-conducting channelrhodopsins with tuned spectra and modified kinetics engineered for optogenetic manipulation of behavior

Wietek, J., Rodriguez-Rozada, S., Tutas, J., Tenedini, F. M., Grimm, C., Oertner, T. G., Soba, P., Hegemann, P., & Wiegert, J. S. (2017) · Scientific Reports · doi:10.1038/s41598-017-14330-y · Cited by 48 · see citing works

A common neuronal ensemble in nucleus accumbens regulates pain-like behaviour and sleep

Sun, H., Li, Z., Qiu, Z., Shen, Y., Guo, Q., Hu, S.-W., Ding, H., An, S., & Cao, J. (2023) · Nature Communications · doi:10.1038/s41467-023-40450-3 · Cited by 49 · see citing works

Activation of Preoptic Tachykinin 1 Neurons Promotes Wakefulness over Sleep and Volatile Anesthetic-Induced Unconsciousness

Reitz, S. L., Wasilczuk, A. Z., Beh, G. H., Proekt, A., & Kelz, M. B. (2020) · Current Biology · doi:10.1016/j.cub.2020.10.050 · Cited by 46 · see citing works

Regulation of stress-induced sleep fragmentation by preoptic glutamatergic neurons

Smith, J., Honig-Frand, A., Antila, H., Choi, A., Kim, H., Beier, K. T., Weber, F., & Chung, S. (2023) · Current Biology · doi:10.1016/j.cub.2023.11.035 · Cited by 45 · see citing works

The hypothalamic link between arousal and sleep homeostasis in mice

Yamagata, T., Kahn, M. C., Prius-Mengual, J., Meijer, E. J., Šabanović, M., Guillaumin, M. C. C., van der Vinne, V., Huang, Y., McKillop, L. E., Jagannath, A., et al. (2021) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2101580118 · Cited by 45 · see citing works

Widely Distributed Neurotensinergic Neurons in the Brainstem Regulate NREM Sleep in Mice

Kashiwagi, M., Kanuka, M., Tatsuzawa, C., Suzuki, H., Morita, M., Tanaka, K., Kawano, T., Shin, J. W., Suzuki, H., Itohara, S., et al. (2020) · Current Biology · doi:10.1016/j.cub.2020.01.047 · Cited by 44 · see citing works

The stress of losing sleep: Sex-specific neurobiological outcomes

Wright, C. J., Milosavljevic, S., & Pocivavsek, A. (2023) · Neurobiology of Stress · doi:10.1016/j.ynstr.2023.100543 · Cited by 45 · see citing works

Excitation-inhibition imbalance in medial preoptic area circuits underlies chronic stress-induced depression-like states

Tao, C., Zhang, G.-W., Sun, W.-J., Huang, J. J., Zhang, L. I., & Tao, H. W. (2024) · Nature Communications · doi:10.1038/s41467-024-52727-2 · Cited by 42 · see citing works

Dim light in the evening causes coordinated realignment of circadian rhythms, sleep, and short-term memory

Tam, S. K. E., Brown, L. A., Wilson, T. S., Tir, S., Fisk, A. S., Pothecary, C. A., van der Vinne, V., Foster, F., Vyazovskiy, V. V., Bannerman, D. M., et al. (2021) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2101591118 · Cited by 40 · see citing works

Activation of locus coeruleus noradrenergic neurons rapidly drives homeostatic sleep pressure

Silverman, D., Chen, C., Chang, S., Bui, L., Zhang, Y., Raghavan, R., Jiang, A., Le, A. N., Darmohray, D. M., Sima, J., et al. (2025) · Science Advances · doi:10.1126/sciadv.adq0651 · Cited by 39 · see citing works

Genome-epigenome interactions associated with Myalgic Encephalomyelitis/Chronic Fatigue Syndrome

Herrera, S., de Vega, W. C., Ashbrook, D. G., Vernon, S. D., & McGowan, P. O. (2018) · Epigenetics · doi:10.1080/15592294.2018.1549769 · Cited by 38 · see citing works

Yin-and-yang bifurcation of opioidergic circuits for descending analgesia at the midbrain of the mouse

Kim, J., Gangadharan, G., Byun, J., Choi, E., Lee, C. J., & Shin, H. (2018) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1806082115 · Cited by 39 · see citing works

Labelling sleep generators

Yates, D. M. (2017) · Nature reviews. Neuroscience · doi:10.1038/nrn.2017.77 · Cited by 1 · see citing works

Hypothalamic control of sleep

Szymusiak, R. S., Gvilia, I., & McGinty, D. (2007) · Sleep Medicine · doi:10.1016/j.sleep.2007.03.013 · Cited by 200 · see citing works

Brain structures and mechanisms involved in the generation of NREM sleep: focus on the preoptic hypothalamus

McGinty, D., & Szymusiak, R. S. (2001) · Sleep Medicine Reviews · doi:10.1053/smrv.2001.0170 · Cited by 122 · see citing works

Preoptic area sleep-regulating mechanisms.

Szymusiak, R. S., Steininger, T. L., Alam, N., & McGinty, D. (2001) · PubMed · Cited by 82 · see citing works

Neurochemistry of the preoptic hypothalamic hypnogenic mechanism

McGinty, D., Alam, M. N., Gong, H., Methippara, M. M., Suntsova, N., Guzmán-Marı́n, R., & Szymusiak, R. S. (2008) · Cambridge University Press eBooks · doi:10.1017/cbo9780511541674.002 · Cited by 1 · see citing works