Cerebellar Purkinje cell activity drives motor learning
Open accessAbstract
The climbing fiber input to the cerebellar cortex is thought to provide instructive signals that drive the induction of motor skill learning. We found that optogenetic activation of Purkinje cells, the sole output neurons of the cerebellar cortex, can also drive motor learning in mice. This dual control over the induction of learning by climbing fibers and Purkinje cells can expand the learning capacity of motor circuits.
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There are multiple demonstrations of cerebellar learning that is independent of climbing fiber input.
“In addition there are multiple demonstrations of cerebellar learning that is independent of climbing fiber input (Boyden et al., 2004; Ke et al., 2009; Nguyen-Vu et al., 2013; Shin et al., 2014; Hewitt et al., 2015).”
From Cerebellum, Predictions and Errors (2019) · cites this paper as Nguyen-Vu et al., 2013
The paper reports that optogenetic Purkinje-cell activation induced motor learning in mice and suggests that it acts through a mechanism distinct from climbing-fiber activation (results and discussion, page unavailable). It does not report eliminating climbing-fiber input during that learning, so it does not establish independence from that input. (LLM, conf=0.83)
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- Authors
- Nguyen-Vu, T. D. B., Kimpo, R. R., Rinaldi, J. M., Kohli, A., Zeng, H., Deisseroth, K., & Raymond, J. L.
- Affiliations
- Stanford Medicine (US)
- Allen Institute for Brain Science (US)
- Howard Hughes Medical Institute (US)
- Corresponding author
- Raymond, Jennifer L
- Venue
- Nature Neuroscience
- Published
- 2013-10-27
- Volume
- 16
- Issue
- 12
- Pages
- 1734-1736
- ISSN
- 1097-6256 (ISSN-L)
- 1546-1726
- PMC
- PMC3966616
- OpenAlex
- W2040208273
- Cited by
- 140
- References
- 34
- Citations by year
- 2026: 6 · 2025: 9 · 2024: 8 · 2023: 6 · 2022: 10 · 2021: 11 · 2020: 16 · 2019: 12 · 2018: 13 · 2017: 13 · 2016: 11 · 2015: 16 · 2014: 9
- FWCI
- 6.56
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Nature Neuroscience (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institute of Mental Health (T32MH020016)
- National Institute on Deafness and Other Communication Disorders (F31DC010547, P30DC010363, R01 DC04154, P30 DC10363, R01DC004154)
- National Institute of Neurological Disorders and Stroke (R21NS057488, P30NS069375, K01NS069617, P01NS053862, R01NS072406)
- Topics
- Life Sciences › Neuroscience › Cognitive Neuroscience › Motor Control and Adaptation
- Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Keywords
- Purkinje cells, cerebellum, motor learning, optogenetic stimulation, climbing fibers, cerebellar cortex, motor circuits
- MeSH terms
- Channelrhodopsins, Acoustic Stimulation, Action Potentials, Dependovirus, Animals, Cerebellum, Gene Expression Regulation, Functional Laterality, Learning, Luminescent Proteins, Mice, Transgenic, Motor Activity, Motor Skills, Mutation, Photic Stimulation, Purkinje Cells, Transduction, Genetic, Vestibule, Labyrinth, Mice, Optogenetics
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