Motor Learning Requires Purkinje Cell Synaptic Potentiation through Activation of AMPA-Receptor Subunit GluA3
Open accessAbstract
Accumulating evidence indicates that cerebellar long-term potentiation (LTP) is necessary for procedural learning. However, little is known about its underlying molecular mechanisms. Whereas AMPA receptor (AMPAR) subunit rules for synaptic plasticity have been extensively studied in relation to declarative learning, it is unclear whether these rules apply to cerebellum-dependent motor learning. Here we show that LTP at the parallel-fiber-to-Purkinje-cell synapse and adaptation of the vestibulo-ocular reflex depend not on GluA1- but on GluA3-containing AMPARs. In contrast to the classic form of LTP implicated in declarative memory formation, this form of LTP does not require GluA1-AMPAR trafficking but rather requires changes in open-channel probability of GluA3-AMPARs mediated by cAMP signaling and activation of the protein directly activated by cAMP (Epac). We conclude that vestibulo-cerebellar motor learning is the first form of memory acquisition shown to depend on GluA3-dependent synaptic potentiation by increasing single-channel conductance.
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Cerebellar LTP does not involve trafficking of GluA3; it relies on an increase in the open-probability of GluA3-containing receptors through a cAMP-dependent pathway.
“This form of cerebellar LTP does not appear to involve trafficking of GluA3, but rather relies on an increase in the open-probability of GluA3-containing receptors through a cAMP-dependent pathway (Gutierrez-Castellanos et al., 2017).”
From The AMPA Receptor Code of Synaptic Plasticity (2018) · cites this paper as Gutierrez-Castellanos et al., 2017
LTP in cerebellar Purkinje neurons and cerebellar-dependent adaptation of the vestibulo-ocular reflex both depend on GluA3- but not GluA1-containing AMPARs.
“Recently, it has been found that LTP in cerebellar Purkinje neurons as well as cerebellar-dependent adaptation of the vestibulo-ocular reflex both depend on GluA3- but not GluA1-containing AMPARs (Gutierrez-Castellanos et al., 2017).”
From The AMPA Receptor Code of Synaptic Plasticity (2018) · cites this paper as Gutierrez-Castellanos et al., 2017
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- Authors
- Gutierrez-Castellanos, N., Da Silva-Matos, C. M., Zhou, K., Canto, C. B., Renner, M. C., Koene, L. M. C., Ozyildirim, O., Sprengel, R., Kessels, H. W., & De Zeeuw, C. I.
- Affiliations
- Erasmus MC (NL)
- Netherlands Institute for Neuroscience (NL)
- Max Planck Institute for Medical Research (DE)
- Corresponding author
- Kessels, Helmut W.
- Venue
- Neuron
- Publisher
- Elsevier BV
- Published
- 2017-01
- Volume
- 93
- Issue
- 2
- Pages
- 409-424
- ISSN
- 0896-6273 (ISSN-L)
- PMC
- PMC5263704
- OpenAlex
- W2578571546
- Cited by
- 111
- References
- 73
- Citations by year
- 2026: 4 · 2025: 13 · 2024: 11 · 2023: 12 · 2022: 9 · 2021: 17 · 2020: 12 · 2019: 6 · 2018: 18 · 2017: 8 · 2016: 1
- FWCI
- 5.89
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Locations
- Neuron (publishedVersion, cc-by)
- Europe PMC (PubMed Central) (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- EUR Research Repository (Erasmus University Rotterdam) (publishedVersion, other-oa)
- KNAW Research Portal (The Royal Netherlands Academy of Arts and Sciences) (publishedVersion, cc-by)
- KNAW research portal (Royal Academy of Art and Sciences (KNAW)) (publishedVersion, cc-by)
- EUR Research Repository (Erasmus University Rotterdam) (submittedVersion, other-oa)
- RePub (Erasmus University Rotterdam) (submittedVersion, other-oa)
- Data Archiving and Networked Services (DANS) (submittedVersion, cc-by)
- Max Planck Digital Library (submittedVersion)
- MPG.PuRe (Max Planck Society) (submittedVersion)
- RePub (Erasmus University Rotterdam) (submittedVersion)
- Repository of Digital Objects for Teaching Research and Culture (University of Valencia) (submittedVersion, other-oa)
- Funders
- Dutch Organization for Medical Sciences
- Life Sciences
- Social and Behavioral Sciences
- ERC-adv
- ERC-POC
- CEREBNET
- C7
- Netherlands Organization for Scientific Research
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
- Life Sciences › Neuroscience › Cognitive Neuroscience › Motor Control and Adaptation
- Keywords
- motor learning, Purkinje cells, GluA3, AMPA receptor subunits, long-term potentiation, parallel fiber synapses, vestibulo-ocular reflex, cAMP signaling, Epac, synaptic potentiation, cerebellum, procedural learning
- MeSH terms
- Animals, Cerebellum, Learning, Motor Activity, Purkinje Cells, Long-Term Potentiation, Receptors, AMPA, Mice, Knockout, Patch-Clamp Techniques, Excitatory Postsynaptic Potentials, Long-Term Synaptic Depression, Mice, Eye Movement Measurements
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
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