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Methylomic profiling implicates cortical deregulation of ANK1 in Alzheimer's disease
Open accessAbstract
Alzheimer's disease (AD) is a chronic neurodegenerative disorder that is characterized by progressive neuropathology and cognitive decline. We performed a cross-tissue analysis of methylomic variation in AD using samples from four independent human post-mortem brain cohorts. We identified a differentially methylated region in the ankyrin 1 (ANK1) gene that was associated with neuropathology in the entorhinal cortex, a primary site of AD manifestation. This region was confirmed as being substantially hypermethylated in two other cortical regions (superior temporal gyrus and prefrontal cortex), but not in the cerebellum, a region largely protected from neurodegeneration in AD, or whole blood obtained pre-mortem from the same individuals. Neuropathology-associated ANK1 hypermethylation was subsequently confirmed in cortical samples from three independent brain cohorts. This study represents, to the best of our knowledge, the first epigenome-wide association study of AD employing a sequential replication design across multiple tissues and highlights the power of this approach for identifying methylomic variation associated with complex disease.
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“Importantly, alterations of DNA methylation levels have also been implicated in multiple neurological disorders including AD [18–22]”
From Sex-specific DNA methylation differences in Alzheimer’s disease pathology (2021) · cites this paper as [19]
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“Consistent with previous studies [18, 19, 86, 87], we observed the majority of these sex-specific differences were hyper-methylated in samples with AD neuropathology, for which methylation levels increased as the AD Braak stage increased”
From Sex-specific DNA methylation differences in Alzheimer’s disease pathology (2021) · cites this paper as [19]
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“Alterations of DNA methylation levels have been shown to be involved in many diseases, including AD [19–24].”
From Distinct sex-specific DNA methylation differences in Alzheimer’s disease (2022) · cites this paper as [20]
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“consistent with previous studies in AD that also found DNA methylation variations in the blood, by and large, did not recapitulate those in the brain [20, 22, 93].”
From Distinct sex-specific DNA methylation differences in Alzheimer’s disease (2022) · cites this paper as [20]
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“DNA methylation is an important epigenetic modification that regulates gene transcription and is known to be involved in AD”
From Sex-specific DNA methylation differences in Alzheimer’s disease pathology (2021) · cites this paper as [19]
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“Notably, none of the 14 CpGs detected in our interaction analysis was identified in previous large-scale DNA methylation studies [18–22]”
From Sex-specific DNA methylation differences in Alzheimer’s disease pathology (2021) · cites this paper as [19]
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“and two independent genome-wide studies recently identified a differentially methylated region in the ANK1 gene as associated with the burden of AD pathology [198, 199].”
From Genetic architecture of Alzheimer's disease (2020) · cites this paper as [198]
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Citations
Cites
R: A Language and Environment for Statistical Computing
R Core Team (2000) · doi:10.32614/r.manuals · Cited by 355,893
An integrated encyclopedia of DNA elements in the human genome
The ENCODE Project Consortium (2012) · Nature · doi:10.1038/nature11247 · Cited by 18,072
Neuropathological stageing of Alzheimer-related changes.
Braak, H., & Braak, E. (1991) · Acta Neuropathologica · doi:10.1007/bf00308809 · Cited by 16,123
The Amyloid Hypothesis of Alzheimer’s Disease: Progress and Problems on the Road to Therapeutics
Hardy, J., & Selkoe, D. J. (2002) · Science · doi:10.1126/science.1072994 · Cited by 13,864
Bioconductor: open software development for computational biology and bioinformatics
Gentleman, R. C., Carey, V. J., Bates, D. M., Bolstad, B., Dettling, M., Dudoit, S., Ellis, B., Gautier, L., Ge, Y., Gentry, J., et al. (2004) · Genome biology · doi:10.1186/gb-2004-5-10-r80 · Cited by 12,082
Amyloid oligomers exacerbate tau pathology in a mouse model of tauopathy
Selenica, M.-L. B., Brownlow, M., Jimenez, J. P., Lee, D. C., Pena, G., Dickey, C. A., Gordon, M. N., & Morgan, D. (2013) · Neurodegenerative Diseases · doi:10.1159/000337230 · Cited by 10,359
Alzheimer's disease: the amyloid cascade hypothesis
Hardy, J. A., & Higgins, G. A. (1992) · Science · doi:10.1126/science.1566067 · Cited by 7,484
Meta-Analysis of 74,046 Individuals Identifies 11 New Susceptibility Loci for Alzheimer’s Disease
(EADI), E. A. D. I., Lambert, J.-C., (GERAD), G. A. E. R. I. A. D., Alzheimer's Disease Genetic Consortium (ADGC), (CHARGE), C. F. H. A. A. R. I. G. E., Ibrahim-Verbaas, C. A., Harold, D., Naj, A. C., Sims, R., Bellenguez, C., et al. (2013) · Nature Genetics · doi:10.1038/ng.2802 · Cited by 4,336
Self-citationForecasting the global burden of Alzheimer's disease
Brookmeyer, R., Johnson, E., Ziegler‐Graham, K., & Arrighi, H. M. (2007) · Alzheimer's & Dementia · doi:10.1016/j.jalz.2007.04.381 · Cited by 3,370
The projected effect of risk factor reduction on Alzheimer's disease prevalence
Barnes, D. E., & Yaffe, K. S. (2011) · The Lancet Neurology · doi:10.1016/s1474-4422(11)70072-2 · Cited by 2,846
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Bougea, A. M., Debasa‐Mouce, M., Gulkarov, S., Castro‐Mosquera, M., Reiss, A. B., & Ouro, A. (2025) · Medicina · doi:10.3390/medicina61081462 · Cited by 5
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González-Molina, L. A., Dolga, A. M., Rots, M. G., & Sarno, F. (2025) · Sub-cellular biochemistry/Subcellular biochemistry · doi:10.1007/978-3-031-75980-2_4 · Cited by 5
Chaar, D., Li, Z., Shang, L., Ratliff, S. M., Mosley, T. H., Kardia, S. L. R., Zhao, W., Zhou, X., & Smith, J. A. (2025) · International Journal of Molecular Sciences · doi:10.3390/ijms26062443 · Cited by 7
The late-onset Alzheimer’s disease risk factor RHBDF2 is a modifier of microglial TREM2 proteolysis
Jocher, G., Müller, S. A., Hsia, H., Osua, M. L., Özcelik, G., Hofmann, L. I., Aßfalg, M., Dinkel, L., Feng, X. M., Schlepckow, K., et al. (2025) · Life Science Alliance · doi:10.26508/lsa.202403080 · Cited by 6
Epigenetic analysis of human postmortem brain tissue
Islam, S. A., Lussier, A. A., & Kobor, M. S. (2018) · Handbook of clinical neurology · doi:10.1016/b978-0-444-63639-3.00017-7 · Cited by 6
SNP-by-CpG Site Interactions in ABCA7 Are Associated with Cognition in Older African Americans
Chaar, D., Nguyen, K. A., Wang, Y.-Z., Ratliff, S. M., Mosley, T. H., Kardia, S. L. R., Smith, J. A., & Zhao, W. (2022) · Genes · doi:10.3390/genes13112150 · Cited by 5
Neuropsychiatric Manifestations in Alzheimer’s Disease Patients: Genetics and Treatment Options
Singh, A. K., Malviya, R., Prakash, A., & Verma, S. (2023) · CNS & Neurological Disorders - Drug Targets · doi:10.2174/1871527322666230301111216 · Cited by 5
Fernández, R., Zubiaurre‐Elorza, L., Santisteban, A., Ojeda, N., Collet, S., Kiyar, M., T'Sjoen, G. G., Mueller, S. C., Guillamón, A., & Pásaro, E. (2023) · Scientific Reports · doi:10.1038/s41598-023-48782-2 · Cited by 5
Nurkolis, F., Utami, T. W., Alatas, A. I., Wicaksono, D., Kurniawan, R., Ratmandhika, S. R., Sukarno, K. T., Pahu, Y. G. P., Kim, B., Tallei, T. E., et al. (2024) · Frontiers in Aging · doi:10.3389/fragi.2024.1462569 · Cited by 5
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Alami, M., Fülöp, T., Boumezough, K., Khalil, A., Zerif, E., & Berrougui, H. (2024) · Springer eBooks · doi:10.1007/978-3-031-69962-7_4 · Cited by 6
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Ueda, J., Murata, Y., Bundo, M., Oh‐Nishi, A., Kassai, H., Ikegame, T., Zhao, Z., Jinde, S., Aiba, A., Suhara, T., et al. (2017) · Neuroscience Research · doi:10.1016/j.neures.2017.02.005 · Cited by 5
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Shen, X., Barbu, M. C., Caramaschi, D., Arathimos, R., Czamara, D., David, F. S., Dearman, A., Dilkes, E., Herrera-Rivero, M., Huider, F., et al. (2023) · medRxiv · doi:10.1101/2023.10.27.23297630 · Cited by 5
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Kumar, V., Shukla, R., Gangani, S., Joseph, R., Jain, S., & Yadav, H. (2026) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1016/j.jpet.2026.104299 · Cited by 5
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Sattarov, R., Toresson, H., Orbjörn, C., & Mattsson-Carlgren, N. (2023) · Journal of Alzheimer’s Disease · doi:10.3233/jad-230119 · Cited by 4
Wang, Z., Fu, G.-P., Ma, G.-J., Wang, C.-Y., Wang, Q., Lu, C.-L., Fu, L.-H., Zhang, X.-J., Cong, B., & Li, S.-J. (2024) · Human Genetics · doi:10.1007/s00439-024-02659-0 · Cited by 4
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Weymouth, L. S., Smith, A. R., & Lunnon, K. (2024) · Current topics in behavioral neurosciences · doi:10.1007/7854_2024_530 · Cited by 4
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Shankarappa, B. M., Mahadevan, J., Murthy, P., Purushottam, M., Viswanath, B., Jain, S., Devarbhavi, H. C., & Visweswariah, A. M. (2023) · DNA and Cell Biology · doi:10.1089/dna.2022.0669 · Cited by 4
Nazarian, A., Yashin, A. I., & Kulminski, A. M. (2018) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/322503 · Cited by 3
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Zhu, B., Ghosh, A., Wang, Z., Liao, Z., Appiah, M. G., Li, J., Zhang, M., Tullio, F. D., Kurowski, A., Fullard, J. F., et al. (2026) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.64898/2026.01.30.702946 · Cited by 4
Liu, J., Yan, M., Chen, L., Yu, W., & Lü, Y. (2025) · Scientific Reports · doi:10.1038/s41598-025-89980-4 · Cited by 3
Fodder, K., Smith, H. M. G., Yaman, Ü., Piras, I. S., Murthy, M. N., Hardy, J., Lashley, T., de Silva, R., Salih, D. A. M., & Bettencourt, C. (2026) · Molecular Psychiatry · doi:10.1038/s41380-026-03686-1 · Cited by 4
Dimeji, I. Y., Sanni, M. O., Abass, K. S., Samson, A. O., & Harrath, A. H. (2026) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2026.1791177 · Cited by 3
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Khan, Y., Rekha, A., Ballal, S., Maharana, L., Maqbool, M., Goyal, K., Mishra, R., Uniyal, P., Alam, P., Aljarba, T. M., et al. (2026) · Metabolic Brain Disease · doi:10.1007/s11011-026-01873-1 · Cited by 3
Krunic, A., Bellio, T. A., Cohen, B. Z., Labadorf, A. T., Stein, T. D., Lin, H., Mellott, T. J., & Blusztajn, J. K. (2025) · Aging Cell · doi:10.1111/acel.70241 · Cited by 5
Kraus, T. F. J., Langwieder, C. K., Hölzl, D., Hutarew, G., Schlicker, H. U., Alinger-Scharinger, B., Schwartz, C., & Sotlar, K. (2023) · Cancers · doi:10.3390/cancers15133525 · Cited by 3
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Han, S., Hwang, J., Park, T., Pyun, J., Lee, J., Park, J. S., Bice, P. J., Liu, S., Yun, S., Jeong, J., et al. (2025) · Alzheimer s & Dementia · doi:10.1002/alz.14563 · Cited by 2
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Xia, Y., Long, H., Zeng, R., & Zhang, G. (2025) · Electronics · doi:10.3390/electronics14132655 · Cited by 3
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Shea, T. B. (2021) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2021.07.039 · Cited by 3
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Lill, C. M., & Bertram, L. (2015) · Movement Disorders · doi:10.1002/mds.26143 · Cited by 3
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Rani, H., & Mahadevan, V. (2019) · RNA technologies · doi:10.1007/978-3-030-14792-1_4 · Cited by 3
Zolezzi, J. M., Candia, S. B., & Inestrosa, N. C. (2019) · IntechOpen eBooks · doi:10.5772/intechopen.86167 · Cited by 3
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Hannon, E. J., Dempster, E. L., Chioza, B. A., Davies, J. P., Blake, G. E. T., Burrage, J., Policicchio, S. S. S., Franklin, A., Walker, E., Bamford, R. A., et al. (2023) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2023.06.23.545974 · Cited by 3
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Lukacsovich, D., Young, J. I., Gomez, L., Schmidt, M. A., Zhang, W. Y., Kunkle, B. W., Chen, X. S., Martin, E. R., Wang, L., & Initiative, A. D. N. (2026) · Genome Medicine · doi:10.1186/s13073-026-01698-8 · Cited by 2
Wang, Z., Chen, F., He, B., Wang, F., Cha, J., Song, Y., Meng, W., Zou, W., Fu, Y., Sun, S., et al. (2025) · Advanced Science · doi:10.1002/advs.202507843 · Cited by 2
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Zhang, Y., Mao, Y., Fu, Q.-Q., Zhang, X., Zhang, D., Yue, Y., & Yang, C. (2024) · Frontiers in Neuroscience · doi:10.3389/fnins.2024.1414603 · Cited by 2
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Gao, Q., Wang, J., Fang, R., Sun, H., & Wang, T. (2025) · BMC Medical Research Methodology · doi:10.1186/s12874-025-02488-3 · Cited by 2
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Chacón, T., & Hernández, H. G. (2025) · Journal of Alzheimer s Disease Reports · doi:10.1177/25424823251341176 · Cited by 2
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Lee, S., Lee, J. H., Lee, R. H., Shin, Y. P., Kim, I.-W., Seo, M., Kim, M.-A., Hwang, J. S., Shin, D., & Lee, H. (2020) · Gene · doi:10.1016/j.gene.2020.145188 · Cited by 2
Garg, P., Joshi, R. S., Watson, C. T., & Sharp, A. J. (2017) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/189704 · Cited by 2
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Gerlando, R. D., Dragoni, F., Rizzo, B., Ferrari, R. R., Zardini, E., Ramusino, M. C., Perini, G., Costa, A. C., Poloni, T. E., Pansarasa, O., et al. (2024) · Aging and Disease · doi:10.14336/ad.2024.0350 · Cited by 1
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Jian, L., Liu, Y., & Peng, W. (2026) · Ageing Research Reviews · doi:10.1016/j.arr.2026.103099 · Cited by 1
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Roy, A., & Bhattacharyya, M. (2016) · Gene Reports · doi:10.1016/j.genrep.2016.04.006 · Cited by 1
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Hlady, R. A., & Robertson, K. D. (2016) · Elsevier eBooks · doi:10.1016/b978-0-12-802389-1.00022-8 · Cited by 1
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Mur, J., McCartney, D. L., Walker, R. M., Campbell, A. I., Bermingham, M. L., Morris, S. W., Porteous, D. J., McIntosh, A. M., Deary, I. J., Evans, K. L., et al. (2019) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/811224 · Cited by 1
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Wang, Y., Grant, O. A., Zhai, X., McDonald-Maier, K. D., & Schalkwyk, L. C. (2022) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2022.05.16.492116 · Cited by 1
Self-citationZhang, W., Young, J. I., Gomez, L., Schmidt, M. A., Lukacsovich, D., Varma, A., Chen, X. S., Kunkle, B. W., Martin, E. R., & Wang, L. (2023) · Research Square · doi:10.21203/rs.3.rs-3068938/v2 · Cited by 1
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Lewis, S. (2014) · Nature reviews. Neuroscience · doi:10.1038/nrn3825
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Satterlee, J. S. (2015) · Springer eBooks · doi:10.1007/978-1-4614-6434-1_148-1
Discovery of problematic probes in illumina DNA methylation microarrays
Chen, Y. A. (2015) · TSpace (University of Toronto)
Metadata
- Authors
- Lunnon, K., Smith, R., Hannon, E., De Jager, P. L., Srivastava, G., Volta, M., Troakes, C., Al-Sarraj, S., Burrage, J., Macdonald, R., Condliffe, D., Harries, L. W., Katsel, P., Haroutunian, V., Kaminsky, Z., Joachim, C., Powell, J., Lovestone, S., Bennett, D. A., Schalkwyk, L. C., & Mill, J.
- Affiliations
- University of Exeter (GB)
- King's College London (GB)
- Broad Institute (US)
- Icahn School of Medicine at Mount Sinai (US)
- Johns Hopkins University (US)
- John Radcliffe Hospital (GB)
- Rush University Medical Center (US)
- Corresponding author
- Mill, Jonathan
- ORCID
- Venue
- Nature Neuroscience
- Published
- 2014-08-17
- Volume
- 17
- Issue
- 9
- Pages
- 1164-1170
- ISSN
- 1097-6256 (ISSN-L)
- 1546-1726
- PMC
- PMC4410018
- OpenAlex
- W1991244004
- Cited by
- 574
- References
- 47
- Citations by year
- 2026: 26 · 2025: 38 · 2024: 43 · 2023: 46 · 2022: 49 · 2021: 56 · 2020: 65 · 2019: 46 · 2018: 56 · 2017: 41 · 2016: 56 · 2015: 37 · 2014: 15
- FWCI
- 20.38
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Nature Neuroscience (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Open Access at Essex (University of Essex) (acceptedVersion)
- Digital Access to Scholarship at Harvard (DASH) (Harvard University) (submittedVersion, cc-by)
- Figshare (submittedVersion)
- Research Portal (King's College London) (submittedVersion, other-oa)
- Open Research Exeter (University of Exeter) (submittedVersion)
- Funders
- Medical Research Council (MR/L022656/1)
- National Institute on Aging (R01AG017917, P30-AG 10161, K25AG041906, R01AG036039, AG-02219, R01‐AG17917, R01 AG15819, R01AG018023, R01AG036836, AG 05138, P50AG005138, R01-AG18023, R01AG036042, R01AG015819, P30AG010161, RC2AG036547, R01AG032990, P01AG002219, RF1AG036042, P50AG016574)
- National Institute of Mental Health (R01MH064673, MH-064673)
- National Institute of Environmental Health Sciences (U01ES017155)
- National Center for Research Resources (KL2RR024151)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Epigenetics and DNA Methylation
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Alzheimer's disease research and treatments
- Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
- Keywords
- Alzheimer's disease, ANK1, DNA methylation, hypermethylation, differentially methylated regions, entorhinal cortex, superior temporal gyrus, prefrontal cortex, cerebellum, epigenome-wide association study, postmortem brain
- MeSH terms
- Aged, Aged, 80 and over, Alzheimer Disease, Cerebral Cortex, Female, Humans, Male, Middle Aged, Temporal Lobe, Prefrontal Cortex, Ankyrins, Entorhinal Cortex, DNA Methylation, Epigenesis, Genetic, Genome-Wide Association Study, Transcriptome
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