Theta-gamma coupling increases during the learning of item-context associations
Open accessAbstract
Phase-amplitude cross-frequency coupling (CFC) between theta (4-12 Hz) and gamma (30-100 Hz) oscillations occurs frequently in the hippocampus. However, it still remains unclear whether theta-gamma coupling has any functional significance. To address this issue, we studied CFC in local field potential oscillations recorded from the CA3 region of the dorsal hippocampus of rats as they learned to associate items with their spatial context. During the course of learning, the amplitude of the low gamma subband (30-60 Hz) became more strongly modulated by theta phase in CA3, and higher levels of theta-gamma modulation were maintained throughout overtraining sessions. Furthermore, the strength of theta-gamma coupling was directly correlated with the increase in performance accuracy during learning sessions. These findings suggest a role for hippocampal theta-gamma coupling in memory recall.
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Theta/gamma coupling is functionally relevant for long-term memory processes and contributes to recall of stored information in rats and humans.
“The theta/gamma coupling has been shown to be functionally relevant for long-term memory processes (Tort et al., 2009) contributing to the recall of stored information both in rats (Shirvalkar et al., 2010) and in humans (Friese et al., 2013).”
From The Functional Role of Dreaming in Emotional Processes (2019) · cites this paper as Tort et al., 2009
Theta-phase gamma-amplitude coupling in the dorsal hippocampus has been implicated in cognitive function.
“Specifically, theta-phase gamma-amplitude coupling in the dorsal hippocampus has been implicated in cognitive function (57)”
From Perineuronal nets, inhibitory interneurons and anxiety-related ventral hippocampal neuronal oscillations are altered by early life adversity (2019) · cites this paper as [57]
The model network displayed gamma oscillations (25-80 Hz).
“In addition to theta rhythm, the model network displayed gamma oscillations (25–80 Hz; Figures 3B and 4D), as expected based on in vivo data (Soltesz and Deschênes, 1993; Tort et al., 2009; Colgin and Moser, 2010) and in vitro slice data showing 65–75 Hz gamma oscillations arising in response to theta rhythmic network stimulation (Butler et al., 2016).”
From Interneuronal mechanisms of hippocampal theta oscillations in a full-scale model of the rodent CA1 circuit (2016) · cites this paper as Tort et al., 2009
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- Authors
- Tort, A. B. L., Komorowski, R. W., Manns, J. R., Kopell, N. J., & Eichenbaum, H.
- Affiliations
- Universidade Federal do Rio Grande do Sul (BR)
- Boston University (US)
- Emory University (US)
- Center for BioDynamics,
- Venue
- Proceedings of the National Academy of Sciences
- Publisher
- National Academy of Sciences
- Published
- 2009-12-08
- Volume
- 106
- Issue
- 49
- Pages
- 20942-20947
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- PMC
- PMC2791641
- OpenAlex
- W1975221291
- Cited by
- 919
- References
- 35
- Citations by year
- 2026: 39 · 2025: 50 · 2024: 59 · 2023: 61 · 2022: 88 · 2021: 80 · 2020: 63 · 2019: 63 · 2018: 55 · 2017: 61 · 2016: 73 · 2015: 47 · 2014: 56 · 2013: 41 · 2012: 24
- FWCI
- 12.44
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Proceedings of the National Academy of Sciences (publishedVersion)
- Europe PMC (PubMed Central) (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Science Foundation (MH71702)
- Burroughs Wellcome Fund
- National Institutes of Health
- National Institute of Mental Health (MH-71702, R01MH051570, MH051570, P50MH071702)
- Topics
- Life Sciences › Neuroscience › Cognitive Neuroscience › Neural dynamics and brain function
- Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Keywords
- theta-gamma coupling, hippocampus, CA3, spatial learning, memory retrieval, local field potentials, low gamma oscillations
- MeSH terms
- Animals, Association Learning, Hippocampus, Locomotion, Physical Stimulation, Task Performance and Analysis, Theta Rhythm, Rats
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