Cited by 919Neural dynamics and brain functionMemory and Neural MechanismsNeuroscience and Neuropharmacology Research

Theta-gamma coupling increases during the learning of item-context associations

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Tort, Adriano B. L., Komorowski, Robert W., Manns, Joseph R., Kopell, Nancy J., Eichenbaum, Howard·2009·Proceedings of the National Academy of Sciences

Abstract

Phase-amplitude cross-frequency coupling (CFC) between theta (4-12 Hz) and gamma (30-100 Hz) oscillations occurs frequently in the hippocampus. However, it still remains unclear whether theta-gamma coupling has any functional significance. To address this issue, we studied CFC in local field potential oscillations recorded from the CA3 region of the dorsal hippocampus of rats as they learned to associate items with their spatial context. During the course of learning, the amplitude of the low gamma subband (30-60 Hz) became more strongly modulated by theta phase in CA3, and higher levels of theta-gamma modulation were maintained throughout overtraining sessions. Furthermore, the strength of theta-gamma coupling was directly correlated with the increase in performance accuracy during learning sessions. These findings suggest a role for hippocampal theta-gamma coupling in memory recall.

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  • Theta/gamma coupling is functionally relevant for long-term memory processes and contributes to recall of stored information in rats and humans.

    “The theta/gamma coupling has been shown to be functionally relevant for long-term memory processes (Tort et al., 2009) contributing to the recall of stored information both in rats (Shirvalkar et al., 2010) and in humans (Friese et al., 2013).”

    From The Functional Role of Dreaming in Emotional Processes (2019) · cites this paper as Tort et al., 2009

  • Theta-phase gamma-amplitude coupling in the dorsal hippocampus has been implicated in cognitive function.

    “Specifically, theta-phase gamma-amplitude coupling in the dorsal hippocampus has been implicated in cognitive function (57)”
  • The model network displayed gamma oscillations (25-80 Hz).

    “In addition to theta rhythm, the model network displayed gamma oscillations (25–80 Hz; Figures 3B and 4D), as expected based on in vivo data (Soltesz and Deschênes, 1993; Tort et al., 2009; Colgin and Moser, 2010) and in vitro slice data showing 65–75 Hz gamma oscillations arising in response to theta rhythmic network stimulation (Butler et al., 2016).”

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Authors
Tort, A. B. L., Komorowski, R. W., Manns, J. R., Kopell, N. J., & Eichenbaum, H.
Affiliations
  • Universidade Federal do Rio Grande do Sul (BR)
  • Boston University (US)
  • Emory University (US)
  • Center for BioDynamics,
Venue
Proceedings of the National Academy of Sciences
Published
2009-12-08
Volume
106
Issue
49
Pages
20942-20947
ISSN
  • 0027-8424 (ISSN-L)
  • 1091-6490
OpenAlex
W1975221291
Cited by
919
References
35
Citations by year
2026: 39 · 2025: 50 · 2024: 59 · 2023: 61 · 2022: 88 · 2021: 80 · 2020: 63 · 2019: 63 · 2018: 55 · 2017: 61 · 2016: 73 · 2015: 47 · 2014: 56 · 2013: 41 · 2012: 24
FWCI
12.44
Type
journal article
Language
en
Open access
Locations
  • Proceedings of the National Academy of Sciences (publishedVersion)
  • Europe PMC (PubMed Central) (publishedVersion)
  • PubMed Central (publishedVersion)
  • PubMed (publishedVersion)
Funders
  • National Science Foundation (MH71702)
  • Burroughs Wellcome Fund
  • National Institutes of Health
  • National Institute of Mental Health (MH-71702, R01MH051570, MH051570, P50MH071702)
Topics
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Neural dynamics and brain function
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
Keywords
theta-gamma coupling, hippocampus, CA3, spatial learning, memory retrieval, local field potentials, low gamma oscillations
MeSH terms
Animals, Association Learning, Hippocampus, Locomotion, Physical Stimulation, Task Performance and Analysis, Theta Rhythm, Rats

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