The DOI matches its Crossref record; 47 of the 47 references it cites were found in a registry or an index.
Subtype-specific plasticity of inhibitory circuits in motor cortex during motor learning
Open accessAbstract
Motor skill learning induces long-lasting reorganization of dendritic spines, principal sites of excitatory synapses, in the motor cortex. However, mechanisms that regulate these excitatory synaptic changes remain poorly understood. Here, using in vivo two-photon imaging in awake mice, we found that learning-induced spine reorganization of layer (L) 2/3 excitatory neurons occurs in the distal branches of their apical dendrites in L1 but not in the perisomatic dendrites. This compartment-specific spine reorganization coincided with subtype-specific plasticity of local inhibitory circuits. Somatostatin-expressing inhibitory neurons (SOM-INs), which mainly inhibit distal dendrites of excitatory neurons, showed a decrease in axonal boutons immediately after the training began, whereas parvalbumin-expressing inhibitory neurons (PV-INs), which mainly inhibit perisomatic regions of excitatory neurons, exhibited a gradual increase in axonal boutons during training. Optogenetic enhancement and suppression of SOM-IN activity during training destabilized and hyperstabilized spines, respectively, and both manipulations impaired the learning of stereotyped movements. Our results identify SOM inhibition of distal dendrites as a key regulator of learning-related changes in excitatory synapses and the acquisition of motor skills.
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Metadata
- Authors
- Chen, S. X., Kim, A. N., Peters, A. J., & Komiyama, T.
- Venue
- Nature Neuroscience
- Published
- 2015-06-22
- Volume
- 18
- Issue
- 8
- Pages
- 1109-1115
- ISSN
- 1097-6256 (ISSN-L)
- 1546-1726
- OpenAlex
- W808307776
- Cited by
- 321
- References
- 47
- FWCI
- 12.10
- Type
- journal article
- Language
- en
- Open access
- green
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