The DOI matches its Crossref record; 12 of the 12 references it cites were found in a registry or an index.
Plasticity and Primary Motor Cortex
Abstract
One fundamental function of primary motor cortex (MI) is to control voluntary movements. Recent evidence suggests that this role emerges from distributed networks rather than discrete representations and that in adult mammals these networks are capable of modification. Neuronal recordings and activation patterns revealed with neuroimaging methods have shown considerable plasticity of MI representations and cell properties following pathological or traumatic changes and in relation to everyday experience, including motor-skill learning and cognitive motor actions. The intrinsic horizontal neuronal connections in MI are a strong candidate substrate for map reorganization: They interconnect large regions of MI, they show activity-dependent plasticity, and they modify in association with skill learning. These findings suggest that MI cortex is not simply a static motor control structure. It also contains a dynamic substrate that participates in motor learning and possibly in cognitive events as well.
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Cites
Habituation: a model phenomenon for the study of neuronal substrates of behavior
Thompson, R. F., & Spencer, W. A. (1966) · Psychological Review · doi:10.1037/h0022681 · Cited by 2,608 · cited 1×
“The mechanisms by which such changes may occur have been discussed above, but it also remains unclear whether the MI flexibility adheres to rules of behavioral or neural habituation (Thompson & Spencer 1966).”
BackgroundCORTICAL PLASTICITY: From Synapses to Maps
Buonomano, D. V., & Merzenich, M. M. (1998) · Annual Review of Neuroscience · doi:10.1146/annurev.neuro.21.1.149 · Cited by 2,083
Functional MRI evidence for adult motor cortex plasticity during motor skill learning
Kami, A., Meyer, G., Jezzard, P., Adams, M. M., Turner, R., & Ungerleider, L. G. (1995) · Nature · doi:10.1038/377155a0 · Cited by 1,883
Motor Areas of the Medial Wall: A Review of Their Location and Functional Activation
Picard, N., & Strick, P. L. (1996) · Cerebral Cortex · doi:10.1093/cercor/6.3.342 · Cited by 1,712
Synaptic plasticity: LTP and LTD
Bear, M. F., & Malenka, R. C. (1994) · Current Opinion in Neurobiology · doi:10.1016/0959-4388(94)90101-5 · Cited by 1,355
Rapid plasticity of human cortical movement representation induced by practice
Classen, J., Liepert, J., Wise, S. P., Hallett, M., & Cohen, L. G. (1998) · Journal of Neurophysiology · doi:10.1152/jn.1998.79.2.1117 · Cited by 1,156
Neural Correlates of Motor Memory Consolidation
Shadmehr, R., & Holcomb, H. H. (1997) · Science · doi:10.1126/science.277.5327.821 · Cited by 1,022
Porro, C. A., Francescato, M. P., Cettolo, V., Diamond, M. E., Baraldi, P., Zuiani, C., Bazzocchi, M., & di Prampero, P. E. (1996) · The Journal of Neuroscience · doi:10.1523/jneurosci.16-23-07688.1996 · Cited by 924
Functional anatomy of human procedural learning determined with regional cerebral blood flow and PET
Grafton, S., Mazziotta, J., Presty, S., Friston, K., Frackowiak, R., & Phelps, M. (1992) · The Journal of Neuroscience · doi:10.1523/jneurosci.12-07-02542.1992 · Cited by 607
Dynamic cortical involvement in implicit and explicit motor sequence learning. A PET study
Honda, M. (1998) · Brain · doi:10.1093/brain/121.11.2159 · Cited by 370
Cited by
Neuronal ensemble control of prosthetic devices by a human with tetraplegia
Hochberg, L. R., Serruya, M. D., Friehs, G. M., Mukand, J. A., Saleh, M., Caplan, A. H., Branner, A., Chen, D., Penn, R. D., & Donoghue, J. P. (2006) · Nature · doi:10.1038/nature04970 · Cited by 3,295
Self-citationPractice with Sleep Makes Perfect
Walker, M. P., Brakefield, T., Morgan, A., Hobson, J. A., & Stickgold, R. (2002) · Neuron · doi:10.1016/s0896-6273(02)00746-8 · Cited by 1,307
Rapid formation and selective stabilization of synapses for enduring motor memories
Xu, T., Yu, X., Perlik, A. J., Tobin, W. F., Zweig, J. A., Tennant, K., Jones, T., & Zuo, Y. (2009) · Nature · doi:10.1038/nature08389 · Cited by 1,193
Repairing the human brain after stroke: I. Mechanisms of spontaneous recovery
Cramer, S. C. (2008) · Annals of Neurology · doi:10.1002/ana.21393 · Cited by 875
Lee, H.-K., Takamiya, K., Han, J.-S., Man, H., Kim, C.-H., Rumbaugh, G., Yu, S., Ding, L., He, C., Petralia, R. S., et al. (2003) · Cell · doi:10.1016/s0092-8674(03)00122-3 · Cited by 802
Metadata
- Authors
- Sanes, J. N., & Donoghue, J. P.
- Venue
- Annual Review of Neuroscience
- Publisher
- Annual Reviews
- Published
- 2000-03
- Volume
- 23
- Issue
- 1
- Pages
- 393-415
- ISSN
- 0147-006X (ISSN-L)
- 1545-4126
- OpenAlex
- W2164535356
- Cited by
- 1,202
- References
- 12
- FWCI
- 2.36
- Type
- journal article
- Language
- en
- Open access
- closed
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
