[18F]FDG PET signal is driven by astroglial glutamate transport
Open accessAbstract
Contributions of glial cells to neuroenergetics have been the focus of extensive debate. Here we provide positron emission tomography evidence that activation of astrocytic glutamate transport via the excitatory amino acid transporter GLT-1 triggers widespread but graded glucose uptake in the rodent brain. Our results highlight the need for a reevaluation of the interpretation of [18 F]FDG positron emission tomography data, whereby astrocytes would be recognized as contributing to the [18 F]FDG signal.
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Astrocytes have been reported to contribute to the (18F)FDG-PET signal via EAAT2/GLT-1, encoded by SLC1A2.
“astrocytes have been reported to contribute to the (18F)fluoro-deoxy-glucose (FDG)–positron emission tomography (PET) signal via the glutamate transporter EAAT2/GLT-1, encoded by SLC1A2 (ref. 45)”
From Astrocyte transcriptomic changes along the spatiotemporal progression of Alzheimer’s disease (2024) · cites this paper as [45]
The paper’s Abstract (page unavailable) reports that astrocytic glutamate transport via GLT-1 contributes to the [18F]FDG PET signal. Our copy does not identify GLT-1 as EAAT2 or state that it is encoded by SLC1A2, so those identifiers are not supported by this source. (LLM, conf=0.84)
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- Authors
- Zimmer, E. R., Parent, M. J., Souza, D. G., Leuzy, A., Lecrux, C., Kim, H.-I., Gauthier, S., Pellerin, L., Hamel, E., & Rosa-Neto, P.
- Affiliations
- Universidade Federal do Rio Grande do Sul (BR)
- Douglas Mental Health University Institute (CA)
- Montreal Neurological Institute and Hospital (CA)
- Gwangju Institute of Science and Technology (KR)
- University of Lausanne (CH)
- ORCID
- Venue
- Nature Neuroscience
- Published
- 2017-01-30
- Volume
- 20
- Issue
- 3
- Pages
- 393-395
- ISSN
- 1097-6256 (ISSN-L)
- 1546-1726
- PMC
- PMC5378483
- OpenAlex
- W2581215498
- Cited by
- 343
- References
- 3
- Citations by year
- 2026: 28 · 2025: 35 · 2024: 45 · 2023: 48 · 2022: 51 · 2021: 37 · 2020: 34 · 2019: 26 · 2018: 26 · 2017: 13
- FWCI
- 13.25
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Nature Neuroscience (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- SERVAL (Université de Lausanne) (acceptedVersion, other-oa)
- IRIS (submittedVersion)
- Funders
- Alzheimer's Association (NIRG-08-92090)
- National Research Foundation
- Coordenação de Aperfeiçoamento de Pessoal de Nível Superior
- Conselho Nacional de Desenvolvimento Científico e Tecnológico
- National Research Foundation of Korea
- Fundação de Amparo à Pesquisa do Estado do Rio Grande do Sul
- Universidade Federal do Rio Grande do Sul
- Université de Lausanne
- Canadian Institutes of Health Research (#MOP-11-51-31, 92090, 142417_1, 115131_1)
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Health Sciences › Medicine › Radiology, Nuclear Medicine and Imaging › Medical Imaging Techniques and Applications
- Health Sciences › Medicine › Radiology, Nuclear Medicine and Imaging › Advanced MRI Techniques and Applications
- Keywords
- 18F-FDG PET, astrocytes, glutamate uptake, GLT-1, glutamate transporters, glucose uptake, glial cells, neuroenergetics, rodent brain
- MeSH terms
- Animals, Astrocytes, Biological Transport, Brain, Ceftriaxone, Cells, Cultured, Locomotion, Male, Vibrissae, Glutamic Acid, Fluorodeoxyglucose F18, Excitatory Amino Acid Transporter 1, Positron-Emission Tomography, Rats, Functional Neuroimaging
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