Cited by 719Regulation of Appetite and ObesityHypothalamic control of reproductive hormonesAdipokines, Inflammation, and Metabolic Diseases

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Decreasing hypothalamic insulin receptors causes hyperphagia and insulin resistance in rats

Obici, Silvana, Feng, Zhaohui, Karkanias, George, Baskin, Denis G., Rossetti, Luciano·2002·Nature Neuroscience

DOI 10.1038/nn0602-861

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Abstract

We investigated the role of hypothalamic insulin signaling in the regulation of energy balance and insulin action in rats through selective decreases in insulin receptor expression in discrete hypothalamic nuclei. We generated an antisense oligodeoxynucleotide directed against the insulin receptor precursor protein and administered this directly into the third cerebral ventricle. Immunostaining of rat brains after 7-day administration of the oligodeoxynucleotide showed a selective decrease of insulin receptor protein within cells in the medial portion of the arcuate nucleus (decreased by approximately 80% as compared to rats treated with a control oligodeoxynucleotide). Insulin receptors in other hypothalamic and extra-hypothalamic areas were not affected. This selective decrease in hypothalamic insulin receptor protein was accompanied by rapid onset of hyperphagia and increased fat mass. During insulin-clamp studies, physiological hyperinsulinemia decreased glucose production by 55% in rats treated with control oligodeoxynucleotides but by only 25% in rats treated with insulin receptor antisense oligodeoxynucleotides. Thus, insulin receptors in discrete areas of the hypothalamus have a physiological role in the control of food intake, fat mass and hepatic action of insulin.

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The rat brain in stereotaxic coordinates
Palkovits, M. (1983) · Neuropeptides · doi:10.1016/0143-4179(83)90049-5 · Cited by 28,959
Positional cloning of the mouse obese gene and its human homologue
Zhang, Y., Proenca, R., Maffei, M., Barone, M., Leopold, L., & Friedman, J. M. (1994) · Nature · doi:10.1038/372425a0 · Cited by 13,419
Central nervous system control of food intake
Schwartz, M. W., Woods, S. C., Porte, D., Seeley, R. J., & Baskin, D. G. (2000) · Nature · doi:10.1038/35007534 · Cited by 6,451
Self-citation
Recombinant Mouse OB Protein: Evidence for a Peripheral Signal Linking Adiposity and Central Neural Networks
Campfield, L. A., Smith, F. J., Guisez, Y., Devos, R., & Burn, P. (1995) · Science · doi:10.1126/science.7624778 · Cited by 3,243
Role of Brain Insulin Receptor in Control of Body Weight and Reproduction
Brüning, J. C., Gautam, D., Burks, D. J., Gillette, J., Schubert, M., Orban, P. C., Klein, R., Krone, W., Müller-Wieland, D., & Kahn, C. R. (2000) · Science · doi:10.1126/science.289.5487.2122 · Cited by 2,235
Leptin levels reflect body lipid content in mice: Evidence for diet-induced resistance to leptin action
Frederich, R. C., Hamann, A., Anderson, S., Löllmann, B., Lowell, B. B., & Flier, J. S. (1995) · Nature Medicine · doi:10.1038/nm1295-1311 · Cited by 1,660
The role of depot fat in the hypothalamic control of food intake in the rat
Gc, K. (1953) · Proceedings of the Royal Society B Biological Sciences · doi:10.1098/rspb.1953.0009 · Cited by 1,432
Isolated removal of hypothalamic or other brain nuclei of the rat
Palkovits, M. (1973) · Brain Research · doi:10.1016/0006-8993(73)90290-4 · Cited by 1,431
Obese and diabetes: Two mutant genes causing diabetes-obesity syndromes in mice
Coleman, D. L. (1978) · Diabetologia · doi:10.1007/bf00429772 · Cited by 1,307
Insulin receptors are widely distributed in the central nervous system of the rat
Havránková, J., Roth, J., & Brownstein, M. (1978) · Nature · doi:10.1038/272827a0 · Cited by 1,116

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Authors: Obici, S., Feng, Z., Karkanias, G., Baskin, D. G., & Rossetti, L.
Affiliations: Albert Einstein College of Medicine (US)
University of Washington (US)
Corresponding author: Rossetti, Luciano
ORCID: Feng, Zhaohui
Karkanias, George
Rossetti, Luciano
Venue: Nature Neuroscience
Publisher: Springer Science and Business Media LLC
Published: 2002-05-20
Volume: 5
Issue: 6
Pages: 566-572
ISSN: 1097-6256 (ISSN-L)
1546-1726
DOI: 10.1038/nn0602-861
OpenAlex: W1997565232
Cited by: 719
References: 36
Citations by year: 2026: 9 · 2025: 6 · 2024: 5 · 2023: 16 · 2022: 22 · 2021: 29 · 2020: 27 · 2019: 37 · 2018: 26 · 2017: 37 · 2016: 33 · 2015: 29 · 2014: 38 · 2013: 37 · 2012: 44
FWCI: 10.72
Type: journal article
Language: en
Open access: closed
Licence: www.springer.com/tdm (tdm)
Locations: Nature Neuroscience (publishedVersion)
PubMed (publishedVersion)
Funders: National Institute of Diabetes and Digestive and Kidney Diseases (DK-48321, DK-17047, DK20541, DK-45024, P30DK017047)
Topics: Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Regulation of Appetite and Obesity
Health Sciences › Medicine › Reproductive Medicine › Hypothalamic control of reproductive hormones
Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Adipokines, Inflammation, and Metabolic Diseases
Keywords: hyperphagia, insulin resistance, arcuate nucleus, antisense oligodeoxynucleotides, energy balance, food intake regulation, fat mass, hepatic insulin action, glucose production, insulin signaling
MeSH terms: Adipose Tissue, Animals, Arcuate Nucleus of Hypothalamus, Eating, Glucose, Hyperphagia, Hypothalamus, Injections, Intraventricular, Insulin, Insulin Resistance, Liver, Male, Neuropeptide Y, Proteins, Receptor, Insulin, Oligonucleotides, Antisense, Rats, Sprague-Dawley, Intercellular Signaling Peptides and Proteins, Rats, Agouti-Related Protein

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Decreasing hypothalamic insulin receptors causes hyperphagia and insulin resistance in rats

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