The DOI matches its Crossref record; 50 of the 51 references it cites were found in a registry or an index.
Vertebrate neurogenesis is counteracted by Sox1–3 activity
Abstract
The generation of neurons from stem cells involves the activity of proneural basic helix-loop-helix (bHLH) proteins, but the mechanism by which these proteins irreversibly commit stem cells to neuronal differentiation is not known. Here we report that expression of the transcription factors Sox1, Sox2 and Sox3 (Sox1-3) is a critical determinant of neurogenesis. Using chick in ovo electroporation, we found that Sox1-3 transcription factors keep neural cells undifferentiated by counteracting the activity of proneural proteins. Conversely, the capacity of proneural bHLH proteins to direct neuronal differentiation critically depends on their ability to suppress Sox1-3 expression in CNS progenitors. These data suggest that the generation of neurons from stem cells depends on the inhibition of Sox1-3 expression by proneural proteins.
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“Members of SoxB1 and SoxB2 subgroups are especially important during neurogenesis [68,69].”
From Evolution of eumetazoan nervous systems: insights from cnidarians (2015) · cites this paper as [68]
Citations
Cites
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Wegner, M. (1999) · Nucleic Acids Research · doi:10.1093/nar/27.6.1409 · Cited by 890
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Kamachi, Y., Uchikawa, M., & Kondoh, H. (2000) · Trends in Genetics · doi:10.1016/s0168-9525(99)01955-1 · Cited by 641
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Sox21 homeologs autoregulate expression levels to control progression through neurogenesis
Damuth, D. L., Cunningham, D. D., & Casey, E. S. (2024) · genesis · doi:10.1002/dvg.23612
Anophthalmia, Microphthalmia, and Uveal Coloboma
Brooks, P. M., & Brooks, B. P. (2024) · Elsevier eBooks · doi:10.1016/b978-0-12-815234-8.00006-9
Amyloid precursor protein mediates deficits in corticogenesis in Down syndrome cortical organoidsPreprint
Rakowiecki, K., Patel, D., Cofresi, L. A., & Lazarov, O. (2025) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2025.07.26.666926
SOX Family Members Expression in Canine Oral Melanoma: Role of the SOX3 in Tumor Aggressiveness
Costa, R. F., de Carvalho, B. A., Lima, B. M., Veloso, É. S., Nakagaki, K. Y. R., Gonçalves, I. N. N., Puerto, H. L. D., & Ferreira, E. F. (2025) · Veterinary Sciences · doi:10.3390/vetsci12090851
Sánchez-Petidier, M., Guerri, C., & Moreno‐Manzano, V. (2022) · Figshare · doi:10.6084/m9.figshare.19396041
Lin, Z., Huang, Y., Liu, S., Huang, Q., Zhang, B., Wang, T., Zhang, Z., Zhu, X., Liao, C., & Han, Q. (2023) · Figshare · doi:10.6084/m9.figshare.23292063
Lin, Z., Huang, Y., Liu, S., Huang, Q., Zhang, B., Wang, T., Zhang, Z., Zhu, X., Liao, C., & Han, Q. (2023) · Figshare · doi:10.6084/m9.figshare.23292072
Spatially Precise Neuron Formation via Hydrogel-Mediated Modulation of the Host Astrocyte Response
Mahmoudi, N., Harvey, A. R., Moriarty, N., Mahmoudi, M., Tong, W., Goris, T., Reynolds, N., Ahmed, N. Y., Dehorter, N., Lisowski, L., et al. (2026) · ACS Nano · doi:10.1021/acsnano.6c03424
Cherednychenko, M., Gajewska, N. A., & Mitchell, J. A. (2026) · Biochemistry and Cell Biology · doi:10.1139/bcb-2025-0375
Pan, Y., Su, Y., Li, X., & Yao, M. (2026) · Frontiers in Genetics · doi:10.3389/fgene.2026.1786528
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Cruces‐Salguero, S., Jordán‐Pla, A., Domingo-Muelas, A., Morante‐Redolat, J. M., Rizzoti, K., Matheu, A., Fariñas, I., Lovell-Badge, R. H., & Moncho-Amor, V. (2026) · Genome biology · doi:10.1186/s13059-026-04126-7
LINE-1 Retrotransposons and Amyotrophic Lateral Sclerosis
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Αντωνίου, Δ., Xilouri, M., Gkikas, D., Vlachakis, D., Tsampoula, M., Malissovas, N., Mastori, K., Kaltezioti, V., Ninou, E., Kyrousi, C., et al. (2026) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-026-06330-x
Boyling, A., Cutrupi, A. N., Li, D., Crossett, B., Danon, J. J., Harvey-Latham, E. D., Nicholson, G. A., Vucic, S., & Kennerson, M. L. (2026) · Human Mutation · doi:10.1155/humu/4225263
Spatiotemporal expression of Sox2 in chick embryo tongue development
Al-Beladi, A., & Al-Qudsi, F. (2026) · Journal of Biosciences · doi:10.1007/s12038-026-00615-w
Kirk, R. G., Liwei, S., Xiao, R., Clark, E., & Nelson, S. B. (2026) · eLife · doi:10.7554/elife.106510.2
Sox3 stabilizes the actin core of hair cell stereocilia essential for hearing
Wang, W., Zhou, L., Zhu, Y., Wu, H., & Du, T. (2026) · EMBO Reports · doi:10.1038/s44319-026-00943-w
Auditory progenitor stem cell biology and therapy
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Metadata
- Authors
- Bylund, M., Andersson, E., Novitch, B. G., & Muhr, J.
- Affiliations
- Karolinska Institutet (SE)
- Howard Hughes Medical Institute (US)
- Corresponding author
- Muhr, Jonas
- Venue
- Nature Neuroscience
- Published
- 2003-09-28
- Volume
- 6
- Issue
- 11
- Pages
- 1162-1168
- ISSN
- 1097-6256 (ISSN-L)
- 1546-1726
- OpenAlex
- W2031683488
- Cited by
- 825
- References
- 51
- Citations by year
- 2026: 15 · 2025: 12 · 2024: 27 · 2023: 28 · 2022: 27 · 2021: 23 · 2020: 35 · 2019: 27 · 2018: 39 · 2017: 23 · 2016: 32 · 2015: 51 · 2014: 45 · 2013: 55 · 2012: 54
- FWCI
- 7.72
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Nature Neuroscience (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Neuroscience › Developmental Neuroscience › Neurogenesis and neuroplasticity mechanisms
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Developmental Biology and Gene Regulation
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Congenital heart defects research
- Keywords
- neurogenesis, SOX1, SOX2, SOX3, neuronal differentiation, neural stem cells, transcriptional repression, chick embryo, in ovo electroporation
- MeSH terms
- Animals, Bromodeoxyuridine, Cell Differentiation, Chick Embryo, DNA-Binding Proteins, Drosophila, Embryonic Induction, Eye Proteins, High Mobility Group Proteins, Membrane Glycoproteins, Nerve Tissue Proteins, Neurons, Neuropeptides, Nuclear Proteins, Phosphopyruvate Hydratase, Spinal Cord, Stem Cells, Time Factors, Transcription Factors, Tubulin, Vertebrates, Proto-Oncogene Proteins c-myc, Neurofilament Proteins, Helix-Loop-Helix Motifs, Electroporation, Homeodomain Proteins, Gene Expression Regulation, Developmental, HMGB Proteins, Drosophila Proteins, Avian Proteins, Mice, PAX7 Transcription Factor, Basic Helix-Loop-Helix Proteins, SOXB1 Transcription Factors, LIM-Homeodomain Proteins
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