The DOI matches its Crossref record; 15 of the 15 references it cites were found in a registry or an index.
Orexigen-sensitive NPY/AgRP pacemaker neurons in the hypothalamic arcuate nucleus
Abstract
The hypothalamic arcuate nucleus (ARC) integrates and responds to satiety and hunger signals and forms the origins of the central neural response to perturbations in energy balance. Here we show that rat ARC neurons containing neuropeptide Y (NPY) and agouti-related protein (AgRP), which are conditional pacemakers, are activated by orexigens and inhibited by the anorexigen leptin. We propose a neuron-specific signaling mechanism through which central and peripheral signals engage the central neural anabolic drive.
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In the citing paper
“Regulation of spontaneous firing of AgRP neurons can be achieved by synaptic and intrinsic mechanisms [54, 58–61].”
From Chronic unpredictable stress induces depression-related behaviors by suppressing AgRP neuron activity (2021) · cites this paper as [61]
In the citing paper
“ATP-sensitive potassium channels were also detected in AgRP neurons [61].”
From Chronic unpredictable stress induces depression-related behaviors by suppressing AgRP neuron activity (2021) · cites this paper as [61]
In the citing paper
“Projections from orexin neurons in the lateral hypothalamus activate NPY neurons in the arcuate nucleus.80”
From Interacting epidemics? Sleep curtailment, insulin resistance, and obesity (2012) · cites this paper as [80]
In the citing paper
“Orexin neurons are active during waking and quiescent during sleep; consistently, orexin levels in the CSF are maximal at the end of the waking period.80,81”
From Interacting epidemics? Sleep curtailment, insulin resistance, and obesity (2012) · cites this paper as [80]
In the citing paper
“leptin inhibits the firing rate of NPY/AgRP neurons (189), while simultaneously depolarizing POMC neurons (42), and also activates PI3K signaling in the latter cells (204).”
From Leptin and the Central Nervous System Control of Glucose Metabolism (2011) · cites this paper as [189]
In the citing paper
“Consistent with this, AgRP neurons are inhibited by leptin (van den Top et al., 2004).”
From Leptin-Dependent Control of Glucose Balance and Locomotor Activity by POMC Neurons (2009) · cites this paper as van den Top et al., 2004
Citations
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A role for ghrelin in the central regulation of feeding
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Electrophysiology of hypothalamic magnocellular neurones secreting oxytocin and vasopressin
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Low-Threshold Calcium Currents in Central Nervous System Neurons
Huguenard, J. R. (1996) · Annual Review of Physiology · doi:10.1146/annurev.ph.58.030196.001553 · Cited by 767
Leptin inhibits hypothalamic neurons by activation of ATP-sensitive potassium channels
Spanswick, D., Smith, M. A., Groppi, V. E., Logan, S. D., & Ashford, M. L. J. (1997) · Nature · doi:10.1038/37379 · Cited by 628
Self-citationInsulin activates ATP-sensitive K+ channels in hypothalamic neurons of lean, but not obese rats
Spanswick, D., Smith, M. A., Mirshamsi, S., Routh, V. H., & Ashford, M. L. J. (2000) · Nature Neuroscience · doi:10.1038/77660 · Cited by 495
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Phasic firing enhances vasopressin release from the rat neurohypophysis
Dutton, A. A. C., & Dyball, R. E. J. (1979) · The Journal of Physiology · doi:10.1113/jphysiol.1979.sp012781 · Cited by 367
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Jovanovic, V. M., Narisu, N., Bonnycastle, L. L., Castellano, D., Ryu, S., Tharakan, R., Mesch, K. T., Chen, Q., Erol, F. M. B., Glover, H. J., et al. (2026) · Stem Cell Reports · doi:10.1016/j.stemcr.2026.102958
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Metadata
- Authors
- van den Top, M., Lee, K., Whyment, A. D., Blanks, A. M., & Spanswick, D.
- Affiliations
- University of Warwick (GB)
- Corresponding author
- Spanswick, David
- Venue
- Nature Neuroscience
- Published
- 2004-04-18
- Volume
- 7
- Issue
- 5
- Pages
- 493-494
- ISSN
- 1097-6256 (ISSN-L)
- 1546-1726
- OpenAlex
- W1974743256
- Cited by
- 435
- References
- 15
- Citations by year
- 2026: 9 · 2025: 10 · 2024: 11 · 2023: 10 · 2022: 12 · 2021: 16 · 2020: 19 · 2019: 22 · 2018: 25 · 2017: 23 · 2016: 28 · 2015: 20 · 2014: 28 · 2013: 33 · 2012: 18
- FWCI
- 7.98
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Nature Neuroscience (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Regulation of Appetite and Obesity
- Health Sciences › Medicine › Reproductive Medicine › Hypothalamic control of reproductive hormones
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuropeptides and Animal Physiology
- Keywords
- neuropeptide Y, agouti-related protein, arcuate nucleus, hypothalamus, leptin, pacemaker neurons, energy balance, satiety, hunger
- MeSH terms
- Orexins, Anesthetics, Local, Animals, Arcuate Nucleus of Hypothalamus, Carrier Proteins, Drug Interactions, Male, Membrane Potentials, Neurons, Neuropeptide Y, Neuropeptides, Nickel, Proteins, Receptors, Cell Surface, RNA, Messenger, Tetrodotoxin, 4-Aminopyridine, Rats, Wistar, Receptors, Neuropeptide, Patch-Clamp Techniques, Reverse Transcriptase Polymerase Chain Reaction, Leptin, Potassium Channel Blockers, Intercellular Signaling Peptides and Proteins, Peptide Hormones, Receptors, G-Protein-Coupled, Intracellular Signaling Peptides and Proteins, Rats, Agouti-Related Protein, Receptors, Leptin, Ghrelin, Orexin Receptors, In Vitro Techniques
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