Insulin activates ATP-sensitive K+ channels in hypothalamic neurons of lean, but not obese rats
Abstract
Insulin and leptin receptors are present in hypothalamic regions that control energy homeostasis, and these hormones reduce food intake and body weight in lean, but not obese, Zucker rats. Here we demonstrate that insulin, like leptin, hyperpolarizes lean rat hypothalamic glucose-responsive (GR) neurons by opening KATP channels. These findings suggest hypothalamic K ATP channel function is crucial to physiological regulation of food intake and body weight.
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Leptin and insulin hyperpolarize a subset of glucose-responsive neurons in the ARC via activation of KATP channels, a mechanism blocked by a PI3K inhibitor.
“leptin and insulin were shown to hyperpolarize a subset of “glucose-responsive” neurons in the ARC via activation of the ATP-sensitive potassium channel (KATP) (176, 177) via a mechanism that was blocked by a PI3K inhibitor (116, 177).”
From Leptin and the Central Nervous System Control of Glucose Metabolism (2011) · cites this paper as [177]
Insulin and leptin activate ATP-sensitive potassium channels and hyperpolarize a subset of glucose-responsive neurons via a mechanism requiring PI3K.
“both insulin and leptin activate ATP-sensitive potassium channels and thereby hyperpolarize a subset of “glucose-responsive” neurons via a mechanism that requires PI3K (176, 177).”
From Leptin and the Central Nervous System Control of Glucose Metabolism (2011) · cites this paper as [177]
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- Authors
- Spanswick, D., Smith, M. A., Mirshamsi, S., Routh, V. H., & Ashford, M. L. J.
- Affiliations
- University of Aberdeen (GB)
- Corresponding author
- Ashford, M. L. J.
- Venue
- Nature Neuroscience
- Published
- 2000-08
- Volume
- 3
- Issue
- 8
- Pages
- 757-758
- ISSN
- 1097-6256 (ISSN-L)
- 1546-1726
- OpenAlex
- W1866620858
- Cited by
- 495
- References
- 15
- Citations by year
- 2026: 2 · 2025: 2 · 2024: 6 · 2023: 13 · 2022: 3 · 2021: 14 · 2020: 8 · 2019: 11 · 2018: 12 · 2017: 16 · 2016: 16 · 2015: 18 · 2014: 26 · 2013: 21 · 2012: 22
- FWCI
- 8.86
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Nature Neuroscience (publishedVersion)
- PubMed (publishedVersion)
- Discovery Research Portal (University of Dundee) (publishedVersion)
- Topics
- Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Regulation of Appetite and Obesity
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Ion channel regulation and function
- Health Sciences › Medicine › Surgery › Pancreatic function and diabetes
- Keywords
- insulin, ATP-sensitive potassium channels, hypothalamic neurons, leptin, food intake regulation, body weight regulation, energy homeostasis, obesity, Zucker rats, neuronal hyperpolarization
- MeSH terms
- Adenosine Triphosphate, Animals, Arcuate Nucleus of Hypothalamus, Glucose, Hypothalamus, Insulin, Membrane Potentials, Neurons, Obesity, Rats, Zucker, Thinness, Tolbutamide, Potassium Channels, Patch-Clamp Techniques, Phosphatidylinositol 3-Kinases, Leptin, Rats, In Vitro Techniques
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