Cited by 435Regulation of Appetite and ObesityHypothalamic control of reproductive hormonesNeuropeptides and Animal Physiology

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Orexigen-sensitive NPY/AgRP pacemaker neurons in the hypothalamic arcuate nucleus

van den Top, Marco, Lee, Kevin, Whyment, Andrew D, Blanks, Andrew M, Spanswick, David·2004·Nature Neuroscience

DOI 10.1038/nn1226

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Abstract

The hypothalamic arcuate nucleus (ARC) integrates and responds to satiety and hunger signals and forms the origins of the central neural response to perturbations in energy balance. Here we show that rat ARC neurons containing neuropeptide Y (NPY) and agouti-related protein (AgRP), which are conditional pacemakers, are activated by orexigens and inhibited by the anorexigen leptin. We propose a neuron-specific signaling mechanism through which central and peripheral signals engage the central neural anabolic drive.

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Authors: van den Top, M., Lee, K., Whyment, A. D., Blanks, A. M., & Spanswick, D.
Affiliations: University of Warwick (GB)
Corresponding author: Spanswick, David
ORCID: Lee, Kevin
Blanks, Andrew M
Spanswick, David
Venue: Nature Neuroscience
Publisher: Springer Science and Business Media LLC
Published: 2004-04-18
Volume: 7
Issue: 5
Pages: 493-494
ISSN: 1097-6256 (ISSN-L)
1546-1726
DOI: 10.1038/nn1226
OpenAlex: W1974743256
Cited by: 435
References: 15
Citations by year: 2026: 9 · 2025: 10 · 2024: 11 · 2023: 10 · 2022: 12 · 2021: 16 · 2020: 19 · 2019: 22 · 2018: 25 · 2017: 23 · 2016: 28 · 2015: 20 · 2014: 28 · 2013: 33 · 2012: 18
FWCI: 7.98
Type: journal article
Language: en
Open access: closed
Licence: www.springer.com/tdm (tdm)
Locations: Nature Neuroscience (publishedVersion)
PubMed (publishedVersion)
Topics: Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Regulation of Appetite and Obesity
Health Sciences › Medicine › Reproductive Medicine › Hypothalamic control of reproductive hormones
Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuropeptides and Animal Physiology
Keywords: neuropeptide Y, agouti-related protein, arcuate nucleus, hypothalamus, leptin, pacemaker neurons, energy balance, satiety, hunger
MeSH terms: Orexins, Anesthetics, Local, Animals, Arcuate Nucleus of Hypothalamus, Carrier Proteins, Drug Interactions, Male, Membrane Potentials, Neurons, Neuropeptide Y, Neuropeptides, Nickel, Proteins, Receptors, Cell Surface, RNA, Messenger, Tetrodotoxin, 4-Aminopyridine, Rats, Wistar, Receptors, Neuropeptide, Patch-Clamp Techniques, Reverse Transcriptase Polymerase Chain Reaction, Leptin, Potassium Channel Blockers, Intercellular Signaling Peptides and Proteins, Peptide Hormones, Receptors, G-Protein-Coupled, Intracellular Signaling Peptides and Proteins, Rats, Agouti-Related Protein, Receptors, Leptin, Ghrelin, Orexin Receptors, In Vitro Techniques

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Orexigen-sensitive NPY/AgRP pacemaker neurons in the hypothalamic arcuate nucleus

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