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Cited by 224Cannabis and Cannabinoid ResearchNeuroscience and Neuropharmacology ResearchNeural dynamics and brain function

The DOI matches its Crossref record; 42 of the 42 references it cites were found in a registry or an index.

Distinct timing in the activity of cannabinoid-sensitive and cannabinoid-insensitive basket cells

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Glickfeld, Lindsey L, Scanziani, Massimo·2006·Nature Neuroscience
DOI 10.1038/nn1688PMC PMC3509385
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Abstract

Cannabinoids are powerful modulators of inhibition, yet the precise spike timing of cannabinoid receptor (CB1R)-expressing inhibitory neurons in relation to other neurons in the circuit is poorly understood. Here we found that the spike timing of CB1R-expressing basket cells, a major target for cannabinoids in the rat hippocampus, was distinct from the other main group of basket cells, the CB1R-negative. Despite receiving the same afferent inputs, the synaptic and biophysical properties of the two cell types were tuned to detect different features of activity. CB1R-negative basket cells responded reliably and immediately to subtle and repetitive excitation. In contrast, CB1R-positive basket cells responded later and did not follow repetitive activity, but were better suited to integrate the consecutive excitation of independent afferents. This temporal separation in the activity of the two basket cell types generated distinct epochs of somatic inhibition that were differentially affected by endocannabinoids.

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Metadata

Authors
Glickfeld, L. L., & Scanziani, M.
Affiliations
University of California San Diego (US)
Corresponding author
Scanziani, Massimo
ORCID
Venue
Nature Neuroscience
Publisher
Springer Science and Business Media LLC
Published
2006-04-30
Volume
9
Issue
6
Pages
807-815
ISSN
  • 1097-6256 (ISSN-L)
  • 1546-1726
DOI
10.1038/nn1688
PMC
PMC3509385
OpenAlex
W2119343718
Cited by
222
References
42
Citations by year
2026: 2 · 2025: 8 · 2024: 6 · 2023: 7 · 2022: 6 · 2021: 7 · 2020: 11 · 2019: 3 · 2018: 8 · 2017: 5 · 2016: 10 · 2015: 7 · 2014: 18 · 2013: 19 · 2012: 13
FWCI
9.20
Type
journal article
Language
en
Open access
Licence
www.springer.com/tdm (tdm)
Locations
  • Nature Neuroscience (publishedVersion)
  • PubMed (publishedVersion)
  • PubMed Central (acceptedVersion)
Funders
  • National Institutes of Health (5t32da007315-11)
  • National Institute of Mental Health (MH 70058, MH71401, R01MH071401, R01MH070058)
  • National Institute on Drug Abuse (T32-DA-007315, 5T32DA007315)
Topics
  • Health Sciences › Medicine › Pharmacology (medical) › Cannabis and Cannabinoid Research
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Neural dynamics and brain function
Keywords
CB1 receptor, basket cells, inhibitory interneurons, spike timing, hippocampus, endocannabinoids, somatic inhibition, synaptic integration, afferent input, inhibitory circuits
MeSH terms
Animals, Cannabinoids, Dendrites, Hippocampus, Interneurons, Male, Nerve Net, Neural Inhibition, Neural Pathways, Synaptic Transmission, Organ Culture Techniques, Reaction Time, Synapses, Time Factors, Rats, Wistar, Pyramidal Cells, Patch-Clamp Techniques, Excitatory Postsynaptic Potentials, Receptor, Cannabinoid, CB1, Cell Shape, Rats

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