The DOI matches its Crossref record; 42 of the 42 references it cites were found in a registry or an index.
Distinct timing in the activity of cannabinoid-sensitive and cannabinoid-insensitive basket cells
Open accessAbstract
Cannabinoids are powerful modulators of inhibition, yet the precise spike timing of cannabinoid receptor (CB1R)-expressing inhibitory neurons in relation to other neurons in the circuit is poorly understood. Here we found that the spike timing of CB1R-expressing basket cells, a major target for cannabinoids in the rat hippocampus, was distinct from the other main group of basket cells, the CB1R-negative. Despite receiving the same afferent inputs, the synaptic and biophysical properties of the two cell types were tuned to detect different features of activity. CB1R-negative basket cells responded reliably and immediately to subtle and repetitive excitation. In contrast, CB1R-positive basket cells responded later and did not follow repetitive activity, but were better suited to integrate the consecutive excitation of independent afferents. This temporal separation in the activity of the two basket cell types generated distinct epochs of somatic inhibition that were differentially affected by endocannabinoids.
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“As a result of slow facilitation, these interneurons [presumably SST-containing O-LM cells, BiCs and CB1R-positive CCK-containing cells (404)] are engaged in a later inhibitory epoch reflecting an integration mode that drives distal dendritic inhibitory inputs proportional to spike rates late in the series.”
From Hippocampal GABAergic Inhibitory Interneurons (2017) · cites this paper as [404]
In the citing paper
“In most cortical networks, the dynamic between excitatory and inhibitory inputs is strongly modulated by the short-term plasticity properties of the respective components, such that progressive changes in the excitation:inhibition ratio results in a progressive degradation of the excitation and inhibition balance (372, 404).”
From Hippocampal GABAergic Inhibitory Interneurons (2017) · cites this paper as [404]
Citations
Cites
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Endogenous cannabinoids mediate retrograde signalling at hippocampal synapses
Wilson, R. I., & Nicoll, R. A. (2001) · Nature · doi:10.1038/35069076 · Cited by 1,607
Synchronization of neuronal activity in hippocampus by individual GABAergic interneurons
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Brain-state- and cell-type-specific firing of hippocampal interneurons in vivo
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Enforcement of Temporal Fidelity in Pyramidal Cells by Somatic Feed-Forward Inhibition
Pouille, F., & Scanziani, M. (2001) · Science · doi:10.1126/science.1060342 · Cited by 1,097
Self-citationMechanisms of Gamma Oscillations in the Hippocampus of the Behaving Rat
Csicsvari, J., Jamieson, B. G., Wise, K. D., & Buzsáki, G. (2003) · Neuron · doi:10.1016/s0896-6273(02)01169-8 · Cited by 1,031
Differences between somatic and dendritic inhibition in the hippocampus
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The effects of cannabinoids on the brain
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Hippocampal CA1 interneurons: an in vivo intracellular labeling study
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Mechanisms of Gamma Oscillations
Buzsáki, G., & Wang, X.-J. (2012) · Annual Review of Neuroscience · doi:10.1146/annurev-neuro-062111-150444 · Cited by 2,796
Neuronal Diversity and Temporal Dynamics: The Unity of Hippocampal Circuit Operations
Klausberger, T., & Somogyi, P. (2008) · Science · doi:10.1126/science.1149381 · Cited by 2,050
GABAergic Interneurons in the Neocortex: From Cellular Properties to Circuits
Tremblay, R., Lee, S., & Rudy, B. (2016) · Neuron · doi:10.1016/j.neuron.2016.06.033 · Cited by 2,033
“They have been studied in the hippocampus and neocortex, where their properties have been contrasted with those of PV FS basket cells (Freund and Katona, 2007; Glickfeld and Scanziani, 2006; Klausberger et al., 2005).”
How Inhibition Shapes Cortical Activity
Isaacson, J. S., & Scanziani, M. (2011) · Neuron · doi:10.1016/j.neuron.2011.09.027 · Cited by 1,678
Self-citationPfeffer, C. K., Xue, M., He, M., Huang, Z. J., & Scanziani, M. (2013) · Nature Neuroscience · doi:10.1038/nn.3446 · Cited by 1,353
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Metadata
- Authors
- Glickfeld, L. L., & Scanziani, M.
- Affiliations
- University of California San Diego (US)
- Corresponding author
- Scanziani, Massimo
- Venue
- Nature Neuroscience
- Published
- 2006-04-30
- Volume
- 9
- Issue
- 6
- Pages
- 807-815
- ISSN
- 1097-6256 (ISSN-L)
- 1546-1726
- PMC
- PMC3509385
- OpenAlex
- W2119343718
- Cited by
- 222
- References
- 42
- Citations by year
- 2026: 2 · 2025: 8 · 2024: 6 · 2023: 7 · 2022: 6 · 2021: 7 · 2020: 11 · 2019: 3 · 2018: 8 · 2017: 5 · 2016: 10 · 2015: 7 · 2014: 18 · 2013: 19 · 2012: 13
- FWCI
- 9.20
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Nature Neuroscience (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institutes of Health (5t32da007315-11)
- National Institute of Mental Health (MH 70058, MH71401, R01MH071401, R01MH070058)
- National Institute on Drug Abuse (T32-DA-007315, 5T32DA007315)
- Topics
- Health Sciences › Medicine › Pharmacology (medical) › Cannabis and Cannabinoid Research
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Life Sciences › Neuroscience › Cognitive Neuroscience › Neural dynamics and brain function
- Keywords
- CB1 receptor, basket cells, inhibitory interneurons, spike timing, hippocampus, endocannabinoids, somatic inhibition, synaptic integration, afferent input, inhibitory circuits
- MeSH terms
- Animals, Cannabinoids, Dendrites, Hippocampus, Interneurons, Male, Nerve Net, Neural Inhibition, Neural Pathways, Synaptic Transmission, Organ Culture Techniques, Reaction Time, Synapses, Time Factors, Rats, Wistar, Pyramidal Cells, Patch-Clamp Techniques, Excitatory Postsynaptic Potentials, Receptor, Cannabinoid, CB1, Cell Shape, Rats
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