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The P2Y12 receptor regulates microglial activation by extracellular nucleotides
Abstract
Microglia are primary immune sentinels of the CNS. Following injury, these cells migrate or extend processes toward sites of tissue damage. CNS injury is accompanied by release of nucleotides, serving as signals for microglial activation or chemotaxis. Microglia express several purinoceptors, including a G(i)-coupled subtype that has been implicated in ATP- and ADP-mediated migration in vitro. Here we show that microglia from mice lacking G(i)-coupled P2Y(12) receptors exhibit normal baseline motility but are unable to polarize, migrate or extend processes toward nucleotides in vitro or in vivo. Microglia in P2ry(12)(-/-) mice show significantly diminished directional branch extension toward sites of cortical damage in the living mouse. Moreover, P2Y(12) expression is robust in the 'resting' state, but dramatically reduced after microglial activation. These results imply that P2Y(12) is a primary site at which nucleotides act to induce microglial chemotaxis at early stages of the response to local CNS injury.
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“Thus, preservation of the CNS environment can delay loss of microglial signature gene expression ex vivo although microglial identity does eventually decay in cultured brain slices (Haynes et al., 2006).”
From Diverse Requirements for Microglial Survival, Specification, and Function Revealed by Defined-Medium Cultures (2017) · cites this paper as Haynes et al., 2006
Experimental — accuracy not yet measuredThe source backs part of the claim, not all of it — or backs it for a different population, condition or comparison.
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“Moreover, P2RY12 expression is decreased and lost in macrophages that exhibit an inflammatory phenotype [19, 31].”
From Loss of homeostatic microglial phenotype in CSF1R-related Leukoencephalopathy (2020) · cites this paper as [19]
Experimental — accuracy not yet measuredThe source backs part of the claim, not all of it — or backs it for a different population, condition or comparison.
In the citing paper
“Microglia express a broad spectrum of neurotransmitter receptors and ion channels that critically regulate microglial functions such as surveillance (Madry et al., 2018), cytokine release (Nguyen et al., 2017), chemotaxis, and phagocytosis (Haynes et al., 2006; Koizumi et al., 2007; Ohsawa et al., 2007).”
From Overexpressing low‐density lipoprotein receptor reduces tau‐associated neurodegeneration in relation to apoE‐linked mechanisms (2021) · cites this paper as Haynes et al., 2006
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“Mature pMGLs stained positive for markers of murine and human microglia 10,11,29,30, with both TMEM119 and P2RY12 displaying a broad membrane and punctate vesicular expression pattern”
From Efficient derivation of microglia-like cells from human pluripotent stem cells (2016) · cites this paper as [30]
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In the citing paper
“P2RY12 expression is lost upon microglia activation74, culture34”
From Genetic analysis of the human microglial transcriptome across brain regions, aging and disease pathologies (2022) · cites this paper as [74]
In the citing paper
“They use the products of nearly 100 genes to sense changes in their microenvironment (their sensome) including P2yr12, AXL, and MER4,7,19”
From Microglia in neurodegeneration (2018) · cites this paper as [4]
In the citing paper
“we focused on the P2Y12 purinergic receptor, which is selectively expressed in non-activated microglia and mediates process motility during early injury responses.”
From Microglial P2Y12 is necessary for synaptic plasticity in mouse visual cortex (2016) · cites this paper as [21]
In the citing paper
“we focused on the P2Y12 purinergic receptor, which is selectively expressed in non-activated microglia and mediates process motility during early injury responses.”
From Microglial P2Y12 is necessary for synaptic plasticity in mouse visual cortex (2016) · cites this paper as [21]
In the citing paper
“In addition, its expression correlates strongly with a ramified microglial morphology characteristic of healthy neurophysiology, indicating that it primarily functions during rapid responses to perturbations of brain homeostasis2123.”
From Microglial P2Y12 is necessary for synaptic plasticity in mouse visual cortex (2016) · cites this paper as [21]
In the citing paper
“P2Y12 is highly sensitive to adenosine diphosphate, abundantly and selectively expressed in homeostatic microglia, rapidly downregulated following the initiation of inflammation and elicits rapid and pronounced chemotactic responses of microglial processes2122.”
From Microglial P2Y12 is necessary for synaptic plasticity in mouse visual cortex (2016) · cites this paper as [21]
In the citing paper
“The microglial expression of most of these receptors has been demonstrated in vitro, but activation of the Gi/o-coupled purinergic receptor, P2Y12, has been shown to powerfully alter microglial dynamics in vivo21.”
From Microglial P2Y12 is necessary for synaptic plasticity in mouse visual cortex (2016) · cites this paper as [21]
In the citing paper
“P2Y12 is highly sensitive to adenosine diphosphate, abundantly and selectively expressed in homeostatic microglia, rapidly downregulated following the initiation of inflammation and elicits rapid and pronounced chemotactic responses of microglial processes2122.”
From Microglial P2Y12 is necessary for synaptic plasticity in mouse visual cortex (2016) · cites this paper as [21]
In the citing paper
“P2Y12 is highly sensitive to adenosine diphosphate, abundantly and selectively expressed in homeostatic microglia, rapidly downregulated following the initiation of inflammation and elicits rapid and pronounced chemotactic responses of microglial processes2122.”
From Microglial P2Y12 is necessary for synaptic plasticity in mouse visual cortex (2016) · cites this paper as [21]
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Citations
Cites
The capsaicin receptor: a heat-activated ion channel in the pain pathway
Caterina, M. J., Schumacher, M. A., Tominaga, M., Rosen, T. A., Levine, J. D., & Julius, D. J. (1997) · Nature · doi:10.1038/39807 · Cited by 9,132
Self-citationResting microglial cells are highly dynamic surveillants of brain parenchyma in vivo
Nimmerjahn, A., Kirchhoff, F., & Helmchen, F. (2005) · Science · doi:10.1126/science.1110647 · Cited by 5,827
Microglia: a sensor for pathological events in the CNS
Kreutzberg, G. W. (1996) · Trends in Neurosciences · doi:10.1016/0166-2236(96)10049-7 · Cited by 4,396
ATP mediates rapid microglial response to local brain injury in vivo
Davalos, D., Grutzendler, J., Yang, G., Kim, J. V., Zuo, Y., Jung, S., Littman, D. R., Dustin, M. L., & Gan, W.-B. (2005) · Nature Neuroscience · doi:10.1038/nn1472 · Cited by 3,913
Self-citationJung, S., Aliberti, J., Graemmel, P., Sunshine, M. J., Kreutzberg, G. W., Sher, A., & Littman, D. R. (2000) · Molecular and Cellular Biology · doi:10.1128/mcb.20.11.4106-4114.2000 · Cited by 2,632
BDNF from microglia causes the shift in neuronal anion gradient underlying neuropathic pain
Coull, J. A. M., Beggs, S., Boudreau, D., Boivin, D., Tsuda, M., Inoue, K., Gravel, C., Salter, M. W., & De Koninck, Y. (2005) · Nature · doi:10.1038/nature04223 · Cited by 1,965
P2X4 receptors induced in spinal microglia gate tactile allodynia after nerve injury
Tsuda, M., Shigemoto‐Mogami, Y., Koizumi, S., Mizokoshi, A., Kohsaka, S., Salter, M. W., & Inoue, K. (2003) · Nature · doi:10.1038/nature01786 · Cited by 1,567
Identification of the platelet ADP receptor targeted by antithrombotic drugs
Hollopeter, G., Jantzen, H., Vincent, D., Li, G., England, L. J., Ramakrishnan, V., Yang, R., Nurden, P., Nurden, A. T., Julius, D. J., et al. (2001) · Nature · doi:10.1038/35051599 · Cited by 1,421
Self-citationCharacterization of ameboid microglia isolated from developing mammalian brain
Giulian, D., & Baker, T. J. (1986) · Journal of Neuroscience · doi:10.1523/jneurosci.06-08-02163.1986 · Cited by 1,300
Activated microglia mediate neuronal cell injury via a nitric oxide mechanism
Chao, C. C., Hu, S., Molitor, T. W., Shaskan, E. G., & Peterson, P. K. (1992) · The Journal of Immunology · doi:10.4049/jimmunol.149.8.2736 · Cited by 1,138
Research works printed but not linked: 1
- Burnstock, G. in P2 Purinoceptors: Localization, Funciton, and Transduction Mechanisms (eds. Chadwick, D. & Goode, J.) 1–34 (Wiley, New York, 1996).
Cited by
Sorted by citations
Items 901–1,000 of 1,005
Arseni, L., Sharma, R., Mack, N. L., Nagalla, D., Ohl, S., Hielscher, T., Singhal, M., Pilz, R., Augustin, H. G., Sandhoff, R., et al. (2023) · Cancers · doi:10.3390/cancers15020479 · Cited by 19
Weilinger, N. L., Yang, K., Choi, H. B., Groten, C. J., Wendt, S., Murugan, M., Wicki‐Stordeur, L. E., Bernier, L., Velayudhan, P. S., Zheng, J., et al. (2023) · Cell Reports · doi:10.1016/j.celrep.2023.113128 · Cited by 20
Bobotis, B. C., Halvorson, T., Carrier, M., & Tremblay, M. (2024) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2024.1317125 · Cited by 22
Wang, W., Luo, J., Fang, X., Liu, X., Jiang, M., Liao, L., & Hu, J. (2014) · PLoS ONE · doi:10.1371/journal.pone.0110101 · Cited by 18
Zhao, K., Yang, M., Lu, Y., Sun, S., Li, W., Li, X., & Zhao, Z. (2018) · Drug Research · doi:10.1055/a-0622-8110 · Cited by 18
Kwankaew, N., Okuda, H., Aye‐Mon, A., Ishikawa, T., Hori, K., Sonthi, P., Kozakai, Y., & Ozaki, N. (2021) · European Journal of Pain · doi:10.1002/ejp.1790 · Cited by 20
Zhang, P., Schlecht, A., Wolf, J., Boneva, S., Laich, Y., Koch, J., Ludwig, F., Boeck, M., Thien, A., Härdtner, C., et al. (2021) · Journal of Neuroinflammation · doi:10.1186/s12974-021-02230-y · Cited by 18
17β-estradiol attenuates injury-induced microglia activation in the oculomotor nucleus
Gyenes, A., Hoyk, Z., Csakvari, E., Siklós, L., & Párducz, Á. (2010) · Neuroscience · doi:10.1016/j.neuroscience.2010.09.033 · Cited by 18
Erythropoietin Dampens Injury-Induced Microglial Motility
Mitkovski, M., Dahm, L., Heinrich, R., Monnheimer, M., Gerhart, S., Stegmüller, J., Hanisch, U., Nave, K., & Ehrenreich, H. (2015) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1038/jcbfm.2015.100 · Cited by 18
Persistent Gliosis Interferes with Neurogenesis in Organotypic Hippocampal Slice Cultures
Gerlach, J., Donkels, C., Münzner, G., & Haas, C. A. (2016) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2016.00131 · Cited by 17
Brain endothelial dysfunction following pyrithiamine induced thiamine deficiency in the rat
Sarkar, S., Liachenko, S. M., Paule, M. G., Bowyer, J. F., & Hanig, J. P. (2016) · NeuroToxicology · doi:10.1016/j.neuro.2016.10.014 · Cited by 18
Yasuda, T., Kamahori, M., Nagata, K., Watanabe‐Asaka, T., Suzuki, M., Funayama, T., Mitani, H., & Oda, S. (2017) · International Journal of Molecular Sciences · doi:10.3390/ijms18071428 · Cited by 18
Inflammation on the Mind: Visualizing Immunity in the Central Nervous System
Kang, S. S., & McGavern, D. B. (2009) · Current topics in microbiology and immunology · doi:10.1007/978-3-540-93864-4_10 · Cited by 18
Role of Microglia in Central Nervous System Development and PlasticityPreprint
Schafer, D. P., Stevens, B., Bennett, M. L., & Bennett, F. C. (2024) · Cold Spring Harbor Perspectives in Biology · doi:10.1101/cshperspect.a041810 · Cited by 19
Regulation of microglial process elongation, a featured characteristic of microglial plasticity
Yang, R., Wang, H., Wen, J., Ma, K., Chen, D., Chen, Z., & Huang, C. (2018) · Pharmacological Research · doi:10.1016/j.phrs.2018.11.028 · Cited by 16
Calovi, S., Mut-Arbona, P., Tod, P., Iring, A., Nicke, A., Mato, S., Vizi, E. S., Tønnesen, J., & Sperlágh, B. (2020) · Frontiers in Molecular Neuroscience · doi:10.3389/fnmol.2020.566251 · Cited by 18
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Neely, S. A., & Lyons, D. A. (2021) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2021.754606 · Cited by 18
Dorion, M., Yaqubi, M., Murdoch, H. J., Hall, J. A., Dudley, R., Antel, J. P., Durcan, T. M., & Healy, L. M. (2023) · Glia · doi:10.1002/glia.24338 · Cited by 17
Bace1 Deletion in the Adult Reverses Epileptiform Activity and Sleep–wake Disturbances in AD Mice
Yao, A. Y., Halloran, P. J., Ge, Y., Singh, N., Zhou, J., Galske, J., He, W., Yan, R., & Hu, X. (2023) · Journal of Neuroscience · doi:10.1523/jneurosci.2124-22.2023 · Cited by 17
Sepulveda, J., Kim, J. Y., Binder, J., Vicini, S., & Rebeck, G. W. (2024) · Molecular Neurodegeneration · doi:10.1186/s13024-024-00714-y · Cited by 19
Chidambaram, H., Desale, S. E., & Chinnathambi, S. (2024) · Methods in molecular biology · doi:10.1007/978-1-0716-3629-9_2 · Cited by 17
Kawamura, M., Yamasaki, R., Kawamura, N., Tateishi, T., Nagara, Y., Matsushita, T., Ohyagi, Y., & Kira, J. (2012) · Experimental Neurology · doi:10.1016/j.expneurol.2012.01.015 · Cited by 17
Purinergic signaling: a novel mechanism in immune surveillance
Mei, L., Du, W., Gao, W. D., & Mei, Q. (2010) · Acta Pharmacologica Sinica · doi:10.1038/aps.2010.128 · Cited by 17
Plasticity of microglia in remote regions after focal brain injury
Bisicchia, E., Sasso, V., Molinari, M., & Viscomi, M. T. (2019) · Seminars in Cell and Developmental Biology · doi:10.1016/j.semcdb.2019.01.011 · Cited by 17
The role of adenosine and P2Y receptors expressed by multiple cell types in pain transmission
Magni, G., & Ceruti, S. (2019) · Brain Research Bulletin · doi:10.1016/j.brainresbull.2019.02.011 · Cited by 17
Sepulveda‐Rodriguez, A., Li, P., Khan, T., Ma, J. D., Carlone, C. A., Bozzelli, P. L., Conant, K. E., Forcelli, P. A., & Vicini, S. (2019) · eNeuro · doi:10.1523/eneuro.0056-19.2019 · Cited by 18
Elmadany, N., Logiacco, F., Buonfiglioli, A., Haage, V. C., Wright-Jin, E. C., Schattenberg, A., Papawassiliou, R. M., Kettenmann, H., Semtner, M., & Gutmann, D. H. (2020) · Neurobiology of Disease · doi:10.1016/j.nbd.2020.105030 · Cited by 16
Lopes, K. P., Snijders, G. J. L., Humphrey, J., de Witte, L. D., & Raj, T. (2021) · Alzheimer s & Dementia · doi:10.1002/alz.050942 · Cited by 18
Guo, X., Liu, Y., Morgan, D., & Zhao, L. (2020) · Aging and Disease · doi:10.14336/ad.2020.0201 · Cited by 16
Akter, S., Sharma, R. K., Sharma, S., Rastogi, S., Fiebich, B. L., & Akundi, R. S. (2021) · Journal of Leukocyte Biology · doi:10.1002/jlb.3a1219-697rr · Cited by 17
Reichenbach, A., & Bringmann, A. (2015) · Colloquium Series on Neuroglia in Biology and Medicine From Physiology to Disease · doi:10.4199/c00122ed1v01y201412ngl003 · Cited by 18
McIlvain, H. B., Ma, L., Ludwig, B., Manners, M. T., Martone, R. L., Dunlop, J., Kaftan, E. J., Kennedy, J. D., & Whiteside, G. T. (2010) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2010.06.046 · Cited by 19
Alkylindole-sensitive receptors modulate microglial cell migration and proliferation
Fung, S., Cherry, A. E., Xu, C., & Stella, N. (2015) · Glia · doi:10.1002/glia.22845 · Cited by 17
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Audinat, É., & Arnoux, I. (2014) · médecine/sciences · doi:10.1051/medsci/20143002012 · Cited by 17
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Astell, K. R., & Sieger, D. (2016) · Methods in cell biology · doi:10.1016/bs.mcb.2016.10.001 · Cited by 17
Receptor webs: Can the chunking theory tell us more about it?
Volonté, C., Amadio, S., & D’Ambrosi, N. (2008) · Brain Research Reviews · doi:10.1016/j.brainresrev.2008.04.004 · Cited by 17
GM1 induces p38 and microtubule dependent ramification of rat primary microglia in vitro
Park, J., Kim, H. Y., Jou, I., & Park, S. M. (2008) · Brain Research · doi:10.1016/j.brainres.2008.09.072 · Cited by 17
Gras, S., Blasco, A., Mòdol‐Caballero, G., Tarabal, O., Casanovas, A., Piedrafita, L., Barranco, A., Das, T., Rueda, R., Pereira, S. L., et al. (2021) · Aging · doi:10.18632/aging.203336 · Cited by 17
Antiplatelet Agents Affecting GPCR Signaling Implicated in Tumor Metastasis
Rovati, G. E., Contursi, A., Bruno, A., Tacconelli, S., Ballerini, P., & Patrignani, P. (2022) · Cells · doi:10.3390/cells11040725 · Cited by 16
Jackson, I. M., Buccino, P. J., Azevedo, E. C., Carlson, M. L., Luo, A., Deal, E. M., Kalita, M., Reyes, S. T., Shao, X., Beinat, C., et al. (2022) · Nuclear Medicine and Biology · doi:10.1016/j.nucmedbio.2022.05.001 · Cited by 17
Physiologic roles of P2 receptors in leukocytes
Alberto, A. V. P., Ferreira, N. C. D. S., Bonavita, A. G. C., Nihei, O. K., de Farias, F. P., Bisaggio, R. D. C., Albuquerque, C., Savino, W., Coutinho‐Silva, R., Persechini, P. M., et al. (2022) · Journal of Leukocyte Biology · doi:10.1002/jlb.2ru0421-226rr · Cited by 19
Smith, G. T., Chen, T. J., Shah, N. M., Agrest, B., & Grotticelli, J. (2024) · Frontiers in Anesthesiology · doi:10.3389/fanes.2024.1281034 · Cited by 17
Zhao, S., Wang, L., Kleidonas, D., Qi, F., Liang, Y., Zheng, J., Umpierre, A. D., & Wu, L. (2025) · Science Advances · doi:10.1126/sciadv.ado7829 · Cited by 16
Antal, M. (2025) · International Journal of Molecular Sciences · doi:10.3390/ijms26052356 · Cited by 21
Overview of the pharmacology and physiological roles of P2Y receptors
Boeynaems, J., Communi, D., & Robaye, B. (2012) · Wiley Interdisciplinary Reviews Membrane Transport and Signalling · doi:10.1002/wmts.44 · Cited by 16
Riquier, A. J., & Sollars, S. I. (2017) · Neuroscience · doi:10.1016/j.neuroscience.2017.04.037 · Cited by 16
Quarta, A., Berneman, Z. N., & Ponsaerts, P. (2020) · Journal of Leukocyte Biology · doi:10.1002/jlb.3ru0820-536r · Cited by 17
Koike-Kumagai, M., Fujimoto, M., & Wataya‐Kaneda, M. (2022) · Neuropharmacology · doi:10.1016/j.neuropharm.2022.109203 · Cited by 16
Pathological Potential of Astroglial Purinergic Receptors
Franke, H., & Illés, P. (2014) · Advances in neurobiology · doi:10.1007/978-3-319-08894-5_11 · Cited by 16
Sumitani, M., Nishizawa, D., Nagashima, M., Ikeda, K., Abe, H., Kato, R., Ueda, H., & Yamada, Y. (2017) · Pain Medicine · doi:10.1093/pm/pnx102 · Cited by 16
Hallmarks of NLRP3 inflammasome activation are observed in organotypic hippocampal slice culture
Hoyle, C., Redondo‐Castro, E., Cook, J., Tzeng, T.-C. J., Allan, S. M., Brough, D., & Lemarchand, E. (2020) · Immunology · doi:10.1111/imm.13221 · Cited by 17
Yashiro, K., Matsumoto, Y., Ihara, H., Suzuki, Y., Kondo, K., Urano, T., & Umemura, K. (2009) · Transplantation · doi:10.1097/tp.0b013e318196305a · Cited by 16
MAVS signaling shapes microglia responses to neurotropic virus infection
Gern, O. L., Pavlou, A., Mulenge, F., Busker, L. M., Ghita, L., Aringo, A., Costa, B., Spanier, J., Waltl, I., Stangel, M., et al. (2024) · Journal of Neuroinflammation · doi:10.1186/s12974-024-03258-6 · Cited by 15
Naffaa, M. M. (2025) · Exploration of neuroscience · doi:10.37349/en.2025.100676 · Cited by 20
Isaković, J., Gorup, D., & Mitrečić, D. (2019) · Croatian Medical Journal · doi:10.3325/cmj.2019.60.127 · Cited by 14
Positron Emission Tomography of Neuroimmune Responses in Humans: Insights and Intricacies
Raval, N. R., Wetherill, R. R., Wiers, C. E., Dubroff, J. G., & Hillmer, A. T. (2022) · Seminars in Nuclear Medicine · doi:10.1053/j.semnuclmed.2022.08.008 · Cited by 15
Circadian cycle and neuroinflammation
Xu, X., Wang, J., & Chen, G. (2023) · Open Life Sciences · doi:10.1515/biol-2022-0712 · Cited by 16
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Nusraty, S., Boddeti, U., Zaghloul, K. A., & Brown, D. A. (2024) · Cancers · doi:10.3390/cancers16111972 · Cited by 15
Yang, T., Tang, Y., Liu, X., Gong, S., & Yao, E. (2024) · IUBMB Life · doi:10.1002/iub.2903 · Cited by 15
Physiological Implications of Microglia–Synapse Interactions
Wake, H., Horiuchi, H., Kato, D., Moorhouse, A. J., & Nabekura, J. (2019) · Methods in molecular biology · doi:10.1007/978-1-4939-9658-2_6 · Cited by 15
Microglia Modulate Cortical Spreading Depolarizations After Ischemic Stroke: A Narrative Review
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Sahara, N., Maeda, J., Ishikawa, A., Tokunaga, M., Suhara, T., & Higuchi, M. (2018) · Journal of Alzheimer s Disease · doi:10.3233/jad-179933 · Cited by 16
Glial cells in intracerebral transplantation for Parkinson’s disease
Tomov, N. (2020) · Neural Regeneration Research · doi:10.4103/1673-5374.270296 · Cited by 15
Estrogen and P2 Purinergic Receptor Systems in Microglia: Therapeutic Targets for Neuroprotection.
Crain, J. M., & Watters, J. J. (2010) · PubMed · doi:10.2174/1877381801002010148 · Cited by 15
Yi, Y., Zhu, X., Jia, P., Cai, W., & Liu, L. (2025) · International Immunopharmacology · doi:10.1016/j.intimp.2025.115250 · Cited by 16
Cranial irradiation acutely and persistently impairs injury-induced microglial proliferation
Belcher, E. K., Sweet, T. B., Karaahmet, B., Dionisio-Santos, D. A., Owlett, L. D., Leffler, K. A., Janelsins, M. C., Williams, J. P., Olschowka, J. A., & O’Banion, M. K. (2020) · Brain Behavior & Immunity - Health · doi:10.1016/j.bbih.2020.100057 · Cited by 13
Wang, P., Mi, Y., Yu, H. N., Teng, X., Jin, S., Xiao, L., Xue, H., Tian, D., Guo, Q., & Wu, Y. (2024) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2024.116549 · Cited by 15
Sapio, M. R., Staedtler, E. S., King, D. M., Maric, D., Jahanipour, J., Ghetti, A., Jacobson, K. A., Mannes, A. J., & Iadarola, M. J. (2024) · Pain · doi:10.1097/j.pain.0000000000003242 · Cited by 14
Francistiová, L., Vörös, K., Lovász, Z., Dinnyés, A., & Kobolák, J. (2022) · Frontiers in Molecular Neuroscience · doi:10.3389/fnmol.2021.793769 · Cited by 14
Vargas, P., Scheffel, T. B., Diz, F. M., Rockenbach, L., Grave, N., Cappellari, A. R., Kist, L. W., Bogo, M. R., Thomé, M. P. M., Leal, G. F., et al. (2022) · Purinergic Signalling · doi:10.1007/s11302-022-09888-w · Cited by 14
Peña‐Ortega, F. (2016) · Current Neuropharmacology · doi:10.2174/1570159x14666160928151546 · Cited by 14
Swayne, L. A., & Boyce, A. K. J. (2017) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2017.00230 · Cited by 15
Generating tissue-resident macrophages from pluripotent stem cells: Lessons learned from microglia
Claes, C., Daele, J. V. D., & Verfaillie, C. M. (2018) · Cellular Immunology · doi:10.1016/j.cellimm.2018.01.019 · Cited by 13
Protein cooperation: From neurons to networks
Volonté, C., D’Ambrosi, N., & Amadio, S. (2008) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2008.07.001 · Cited by 14
Prostaglandin E2 reduces extracellular ATP-induced migration in cultured rat microglia
Nagano, T., Kimura, S. H., & Takemura, M. (2008) · Brain Research · doi:10.1016/j.brainres.2008.05.018 · Cited by 14
Optical Window Preparation for Two-Photon Imaging of Microglia in Mice: Figure 1.Preprint
Nimmerjahn, A. (2012) · Cold Spring Harbor Protocols · doi:10.1101/pdb.prot069286 · Cited by 14
Huang, T., Wu, J., Mu, J., & Gao, J. (2022) · Molecular Pharmaceutics · doi:10.1021/acs.molpharmaceut.2c00605 · Cited by 13
Adenosine A2A receptor and glia
Gao, Z. (2023) · International review of neurobiology · doi:10.1016/bs.irn.2023.08.002 · Cited by 14
Zhang, Y., Tang, Y., & Illés, P. (2024) · Molecular Neurobiology · doi:10.1007/s12035-024-04531-8 · Cited by 14
Sex differences in the microglial response to stress and chronic alcohol exposure in mice
Soares, A. R., Garcia‐Rivas, V., Fai, C., Thomas, M. A., Zheng, X., Picciotto, M. R., & Mineur, Y. S. (2025) · Biology of Sex Differences · doi:10.1186/s13293-025-00701-y · Cited by 15
Zyma, M., & Pawliczak, R. (2020) · International Reviews of Immunology · doi:10.1080/08830185.2020.1723582 · Cited by 13
Xiang, W., Yang, Z., Xue, H., Wang, J., Niu, F., Wang, J., Chen, C., Wang, Y., Pang, J., & Wang, B. (2021) · Aging · doi:10.18632/aging.202607 · Cited by 13
Tricarico, P. M., Piscianz, E., Monasta, L., Kleiner, G., Crovella, S., & Marcuzzi, A. (2015) · APOPTOSIS · doi:10.1007/s10495-015-1139-8 · Cited by 13
Zhao, S., Zheng, J., Wang, L., Umpierre, A. D., Parusel, S., Xie, M., Dheer, A., Ayasoufi, K., Johnson, A. J., Richardson, J. R., et al. (2023) · Molecular Psychiatry · doi:10.1038/s41380-023-02128-6 · Cited by 13
Sarkar, S., & Schmued, L. C. (2010) · Brain Research · doi:10.1016/j.brainres.2010.07.011 · Cited by 12
Does ATP act through P2X1 receptors to regulate platelet activation and thrombus formation?
Nurden, A. T. (2007) · Journal of Thrombosis and Haemostasis · doi:10.1111/j.1538-7836.2007.02456.x · Cited by 13
AAV vectors for specific and efficient gene expression in microglia
Aoki, R., Konno, A., Hosoi, N., Kawabata, H., & Hirai, H. (2025) · Cell Reports Methods · doi:10.1016/j.crmeth.2025.101116 · Cited by 12
P2Y receptors (version 2019.4) in the IUPHAR/BPS Guide to Pharmacology Database
Abbracchio, M. P., Boeynaems, J., Boyer, J. L., Burnstock, G., Ceruti, S., Fumagalli, M., Gachet, C., Hills, R., Humphries, R. G., Inoue, K., et al. (2019) · IUPHAR/BPS Guide to Pharmacology CITE · doi:10.2218/gtopdb/f52/2019.4 · Cited by 12
G protein-coupled purinergic P2Y receptors in infectious diseases
Carvalho, M. L., Alves, V. S., Coutinho‐Silva, R., & Savio, L. E. B. (2025) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2025.108796 · Cited by 12
Stowell, R. D., & Wang, K. H. (2025) · Nature Communications · doi:10.1038/s41467-025-63314-4 · Cited by 14
Comparative Anatomy of Glial Cells in Mammals
Reichenbach, A., & Bringmann, A. (2016) · Elsevier eBooks · doi:10.1016/b978-0-12-804042-3.00050-6 · Cited by 12
Yuan, F., Pan, X., Zeng, T., Zhang, Y., Chen, L., Gan, Z., Huang, T., & Cai, Y. (2020) · Frontiers in Bioengineering and Biotechnology · doi:10.3389/fbioe.2020.00350 · Cited by 12
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Eguchi, T., & Taha, E. A. (2020) · Heat shock proteins · doi:10.1007/7515_2020_25 · Cited by 10
Maes, M. E., Wögenstein, G. M., Colombo, G., Casado-Polanco, R., & Siegert, S. (2021) · Molecular Therapy — Methods & Clinical Development · doi:10.1016/j.omtm.2021.09.006 · Cited by 12
Astrocytes and Microglia Exhibit Cell-Specific Ca2+ Signaling Dynamics in the Murine Spinal Cord
Rieder, P., Gobbo, D., Stopper, G., Welle, A., Damo, E., Kirchhoff, F., & Scheller, A. (2022) · Frontiers in Molecular Neuroscience · doi:10.3389/fnmol.2022.840948 · Cited by 11
Purinergic signaling systems across comparative models of spinal cord injury
Stefanova, E. E., & Scott, A. L. (2022) · Neural Regeneration Research · doi:10.4103/1673-5374.338993 · Cited by 12
Lou, L., Yu, T., Dai, Y., Zhao, S., Feng, S., Xu, J., & Wen, Z. (2022) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2203273119 · Cited by 13
Chen, X.-T., Chen, L., Fan, L.-J., Kan, H., Wang, Z.-Z., Qian, B., Pan, Z., & Shen, W. (2023) · Journal of Pain · doi:10.1016/j.jpain.2023.01.005 · Cited by 12
Babiec, L., Wilkaniec, A., Matuszewska, M., Pałasz, E., Cieślik, M., & Adamczyk, A. (2023) · Brain Sciences · doi:10.3390/brainsci13071088 · Cited by 12
Invariant NKT Cells Regulate the CD8 T Cell Response during Theiler's Virus Infection
Mars, L. T., Mas, M., Beaudoin, L., Bauer, J., Leite‐de‐Moraes, M., Lehuen, A., Bureau, J., & Liblau, R. (2014) · PLoS ONE · doi:10.1371/journal.pone.0087717 · Cited by 13
Metadata
- Authors
- Haynes, S. E., Hollopeter, G., Yang, G., Kurpius, D., Dailey, M. E., Gan, W.-B., & Julius, D.
- Affiliations
- University of California, San Francisco (US)
- New York University (US)
- University of Iowa (US)
- Corresponding author
- Julius, David
- Venue
- Nature Neuroscience
- Published
- 2006-11-19
- Volume
- 9
- Issue
- 12
- Pages
- 1512-1519
- ISSN
- 1097-6256 (ISSN-L)
- 1546-1726
- OpenAlex
- W2131686384
- Cited by
- 1,542
- References
- 34
- Citations by year
- 2026: 91 · 2025: 80 · 2024: 126 · 2023: 94 · 2022: 122 · 2021: 138 · 2020: 104 · 2019: 93 · 2018: 80 · 2017: 71 · 2016: 63 · 2015: 68 · 2014: 64 · 2013: 67 · 2012: 69
- FWCI
- 19.53
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Nature Neuroscience (publishedVersion)
- PubMed (publishedVersion)
- eScholarship (California Digital Library) (submittedVersion)
- Funders
- University of California, San Francisco
- National Institute of Neurological Disorders and Stroke (R01NS043468, NS434468)
- National Center for Research Resources (S10RR017941)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Physiology › Adenosine and Purinergic Signaling
- Life Sciences › Neuroscience › Neurology › Neuroinflammation and Neurodegeneration Mechanisms
- Health Sciences › Medicine › Clinical Neurology › Traumatic Brain Injury and Neurovascular Disturbances
- Keywords
- P2Y12 receptor, microglial activation, extracellular nucleotides, microglial chemotaxis, microglial polarization, microglial motility, purinergic signaling, G protein-coupled receptors, central nervous system injury, cortical injury
- MeSH terms
- Adenosine Diphosphate, Adenosine Triphosphate, Animals, Brain Injuries, Central Nervous System, Chemotaxis, Membrane Proteins, Microglia, Receptors, Purinergic P2, Mice, Knockout, Mice, Receptors, Purinergic P2Y12
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