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The P2Y12 receptor regulates microglial activation by extracellular nucleotides
Abstract
Microglia are primary immune sentinels of the CNS. Following injury, these cells migrate or extend processes toward sites of tissue damage. CNS injury is accompanied by release of nucleotides, serving as signals for microglial activation or chemotaxis. Microglia express several purinoceptors, including a G(i)-coupled subtype that has been implicated in ATP- and ADP-mediated migration in vitro. Here we show that microglia from mice lacking G(i)-coupled P2Y(12) receptors exhibit normal baseline motility but are unable to polarize, migrate or extend processes toward nucleotides in vitro or in vivo. Microglia in P2ry(12)(-/-) mice show significantly diminished directional branch extension toward sites of cortical damage in the living mouse. Moreover, P2Y(12) expression is robust in the 'resting' state, but dramatically reduced after microglial activation. These results imply that P2Y(12) is a primary site at which nucleotides act to induce microglial chemotaxis at early stages of the response to local CNS injury.
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“Thus, preservation of the CNS environment can delay loss of microglial signature gene expression ex vivo although microglial identity does eventually decay in cultured brain slices (Haynes et al., 2006).”
From Diverse Requirements for Microglial Survival, Specification, and Function Revealed by Defined-Medium Cultures (2017) · cites this paper as Haynes et al., 2006
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“Moreover, P2RY12 expression is decreased and lost in macrophages that exhibit an inflammatory phenotype [19, 31].”
From Loss of homeostatic microglial phenotype in CSF1R-related Leukoencephalopathy (2020) · cites this paper as [19]
Experimental — accuracy not yet measuredThe source backs part of the claim, not all of it — or backs it for a different population, condition or comparison.
In the citing paper
“Microglia express a broad spectrum of neurotransmitter receptors and ion channels that critically regulate microglial functions such as surveillance (Madry et al., 2018), cytokine release (Nguyen et al., 2017), chemotaxis, and phagocytosis (Haynes et al., 2006; Koizumi et al., 2007; Ohsawa et al., 2007).”
From Overexpressing low‐density lipoprotein receptor reduces tau‐associated neurodegeneration in relation to apoE‐linked mechanisms (2021) · cites this paper as Haynes et al., 2006
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In the citing paper
“P2RY12 expression is lost upon microglia activation74, culture34”
From Genetic analysis of the human microglial transcriptome across brain regions, aging and disease pathologies (2022) · cites this paper as [74]
In the citing paper
“They use the products of nearly 100 genes to sense changes in their microenvironment (their sensome) including P2yr12, AXL, and MER4,7,19”
From Microglia in neurodegeneration (2018) · cites this paper as [4]
In the citing paper
“Mature pMGLs stained positive for markers of murine and human microglia 10,11,29,30, with both TMEM119 and P2RY12 displaying a broad membrane and punctate vesicular expression pattern”
From Efficient derivation of microglia-like cells from human pluripotent stem cells (2016) · cites this paper as [30]
In the citing paper
“we focused on the P2Y12 purinergic receptor, which is selectively expressed in non-activated microglia and mediates process motility during early injury responses.”
From Microglial P2Y12 is necessary for synaptic plasticity in mouse visual cortex (2016) · cites this paper as [21]
In the citing paper
“we focused on the P2Y12 purinergic receptor, which is selectively expressed in non-activated microglia and mediates process motility during early injury responses.”
From Microglial P2Y12 is necessary for synaptic plasticity in mouse visual cortex (2016) · cites this paper as [21]
In the citing paper
“In addition, its expression correlates strongly with a ramified microglial morphology characteristic of healthy neurophysiology, indicating that it primarily functions during rapid responses to perturbations of brain homeostasis2123.”
From Microglial P2Y12 is necessary for synaptic plasticity in mouse visual cortex (2016) · cites this paper as [21]
In the citing paper
“P2Y12 is highly sensitive to adenosine diphosphate, abundantly and selectively expressed in homeostatic microglia, rapidly downregulated following the initiation of inflammation and elicits rapid and pronounced chemotactic responses of microglial processes2122.”
From Microglial P2Y12 is necessary for synaptic plasticity in mouse visual cortex (2016) · cites this paper as [21]
In the citing paper
“The microglial expression of most of these receptors has been demonstrated in vitro, but activation of the Gi/o-coupled purinergic receptor, P2Y12, has been shown to powerfully alter microglial dynamics in vivo21.”
From Microglial P2Y12 is necessary for synaptic plasticity in mouse visual cortex (2016) · cites this paper as [21]
In the citing paper
“P2Y12 is highly sensitive to adenosine diphosphate, abundantly and selectively expressed in homeostatic microglia, rapidly downregulated following the initiation of inflammation and elicits rapid and pronounced chemotactic responses of microglial processes2122.”
From Microglial P2Y12 is necessary for synaptic plasticity in mouse visual cortex (2016) · cites this paper as [21]
In the citing paper
“P2Y12 is highly sensitive to adenosine diphosphate, abundantly and selectively expressed in homeostatic microglia, rapidly downregulated following the initiation of inflammation and elicits rapid and pronounced chemotactic responses of microglial processes2122.”
From Microglial P2Y12 is necessary for synaptic plasticity in mouse visual cortex (2016) · cites this paper as [21]
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Citations
Cites
The capsaicin receptor: a heat-activated ion channel in the pain pathway
Caterina, M. J., Schumacher, M. A., Tominaga, M., Rosen, T. A., Levine, J. D., & Julius, D. J. (1997) · Nature · doi:10.1038/39807 · Cited by 9,132
Self-citationResting microglial cells are highly dynamic surveillants of brain parenchyma in vivo
Nimmerjahn, A., Kirchhoff, F., & Helmchen, F. (2005) · Science · doi:10.1126/science.1110647 · Cited by 5,827
Microglia: a sensor for pathological events in the CNS
Kreutzberg, G. W. (1996) · Trends in Neurosciences · doi:10.1016/0166-2236(96)10049-7 · Cited by 4,396
ATP mediates rapid microglial response to local brain injury in vivo
Davalos, D., Grutzendler, J., Yang, G., Kim, J. V., Zuo, Y., Jung, S., Littman, D. R., Dustin, M. L., & Gan, W.-B. (2005) · Nature Neuroscience · doi:10.1038/nn1472 · Cited by 3,913
Self-citationJung, S., Aliberti, J., Graemmel, P., Sunshine, M. J., Kreutzberg, G. W., Sher, A., & Littman, D. R. (2000) · Molecular and Cellular Biology · doi:10.1128/mcb.20.11.4106-4114.2000 · Cited by 2,632
BDNF from microglia causes the shift in neuronal anion gradient underlying neuropathic pain
Coull, J. A. M., Beggs, S., Boudreau, D., Boivin, D., Tsuda, M., Inoue, K., Gravel, C., Salter, M. W., & De Koninck, Y. (2005) · Nature · doi:10.1038/nature04223 · Cited by 1,965
P2X4 receptors induced in spinal microglia gate tactile allodynia after nerve injury
Tsuda, M., Shigemoto‐Mogami, Y., Koizumi, S., Mizokoshi, A., Kohsaka, S., Salter, M. W., & Inoue, K. (2003) · Nature · doi:10.1038/nature01786 · Cited by 1,567
Identification of the platelet ADP receptor targeted by antithrombotic drugs
Hollopeter, G., Jantzen, H., Vincent, D., Li, G., England, L. J., Ramakrishnan, V., Yang, R., Nurden, P., Nurden, A. T., Julius, D. J., et al. (2001) · Nature · doi:10.1038/35051599 · Cited by 1,421
Self-citationCharacterization of ameboid microglia isolated from developing mammalian brain
Giulian, D., & Baker, T. J. (1986) · Journal of Neuroscience · doi:10.1523/jneurosci.06-08-02163.1986 · Cited by 1,300
Activated microglia mediate neuronal cell injury via a nitric oxide mechanism
Chao, C. C., Hu, S., Molitor, T. W., Shaskan, E. G., & Peterson, P. K. (1992) · The Journal of Immunology · doi:10.4049/jimmunol.149.8.2736 · Cited by 1,138
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Research works printed but not linked: 1
- Burnstock, G. in P2 Purinoceptors: Localization, Funciton, and Transduction Mechanisms (eds. Chadwick, D. & Goode, J.) 1–34 (Wiley, New York, 1996).
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Sorted by citations
Items 401–500 of 1,005
Molecular pharmacology of P2Y receptor subtypes
von Kügelgen, I. (2020) · Biochemical Pharmacology · doi:10.1016/j.bcp.2020.114361 · Cited by 90
Role of the P2Y12 Receptor in the Modulation of Murine Dendritic Cell Function by ADP
Addi, A. B., Cammarata, D., Conley, P. B., Boeynaems, J., & Robaye, B. (2010) · The Journal of Immunology · doi:10.4049/jimmunol.0901799 · Cited by 93
Altered morphological dynamics of activated microglia after induction of status epilepticus
Avignone, E., Lepleux, M., Angibaud, J., & Nägerl, U. V. (2015) · Journal of Neuroinflammation · doi:10.1186/s12974-015-0421-6 · Cited by 95
STIM1, STIM2, and Orai1 regulate store‐operated calcium entry and purinergic activation of microglia
Michaelis, M., Nieswandt, B., Stegner, D., Eilers, J., & Kraft, R. (2014) · Glia · doi:10.1002/glia.22775 · Cited by 91
Ataka, K., Asakawa, A., Nagaishi, K., Kaimoto, K., Sawada, A., Hayakawa, Y., Tatezawa, R., Inui, A., & Fujimiya, M. (2013) · PLoS ONE · doi:10.1371/journal.pone.0081744 · Cited by 89
von Kügelgen, I. (2019) · Brain Research Bulletin · doi:10.1016/j.brainresbull.2019.03.010 · Cited by 93
Chang, C., Wu, K.-C., Lin, C., & Chern, Y. (2021) · Journal of Biomedical Science · doi:10.1186/s12929-021-00766-y · Cited by 90
Guzman, S. J., & Gerevich, Z. (2016) · Neural Plasticity · doi:10.1155/2016/1207393 · Cited by 99
Dorand, R. D., Barkauskas, D. S., Evans, T. A., Petrošiūtė, A., & Huang, A. Y.-C. (2014) · IntraVital · doi:10.4161/intv.29728 · Cited by 88
Rapid manifestation of reactive astrogliosis in acute hippocampal brain slices
Takano, T., He, W. J., Han, X., Wang, F., Xu, Q., Wang, X., Bush, N. A. O., Cruz, N. F., Dienel, G. A., & Nedergaard, M. (2013) · Glia · doi:10.1002/glia.22588 · Cited by 96
Purinergic Signaling During Immune Cell Trafficking
Ferrari, D., McNamee, E. N., Idzko, M., Gambari, R., & Eltzschig, H. K. (2016) · Trends in Immunology · doi:10.1016/j.it.2016.04.004 · Cited by 89
Microglia communication: parallels between aging and Alzheimer's disease
Udeochu, J. C., Shea, J. M., & Villeda, S. A. (2016) · Clinical and Experimental Neuroimmunology · doi:10.1111/cen3.12307 · Cited by 87
Neurovascular dysfunction in glaucoma
Alarcón-Martínez, L., Shiga, Y., Villafranca‐Baughman, D., Vargas, J. L. C., Vidal-Paredes, I. A., Quintero, H., Fortune, B. A., Danesh-Meyer, H. V., & Polo, A. D. (2023) · Progress in Retinal and Eye Research · doi:10.1016/j.preteyeres.2023.101217 · Cited by 89
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Zhu, H., Guan, A., Liu, J., Li, P., Zhang, Z., & Wang, S. (2023) · Journal of Neuroinflammation · doi:10.1186/s12974-023-02901-y · Cited by 91
Maeda, M., Tsuda, M., Tozaki‐Saitoh, H., Inoue, K., & Kiyama, H. (2010) · Glia · doi:10.1002/glia.21053 · Cited by 87
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Tsuda, M., & Inoue, K. (2015) · Neuropharmacology · doi:10.1016/j.neuropharm.2015.08.042 · Cited by 88
Recent Advances in the Study of Bipolar/Rod-Shaped Microglia and their Roles in Neurodegeneration
Au, N. P. B., & Ma, C. H. E. (2017) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2017.00128 · Cited by 87
Zhan, L., Fan, L., Kodama, L., Sohn, P., Wong, M. Y., Mousa, G. A., Zhou, Y., Li, Y., & Gan, L. (2020) · eLife · doi:10.7554/elife.51796 · Cited by 80
Altered synaptic connectivity and brain function in mice lacking microglial adapter protein Iba1
Lituma, P. J., Woo, E., O’Hara, B. F., Castillo, P. E., Sibinga, N. E. S., & Nandi, S. (2021) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2115539118 · Cited by 87
Pannell, M., Szulzewsky, F., Matyash, V., Wolf, S. A., & Kettenmann, H. (2014) · Glia · doi:10.1002/glia.22633 · Cited by 86
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Andoh, M., Shibata, K., Okamoto, K., Onodera, J., Morishita, K., Miura, Y., Ikegaya, Y., & Koyama, R. (2019) · Cell Reports · doi:10.1016/j.celrep.2019.05.015 · Cited by 87
Can we switch microglia's phenotype to foster neuroprotection? Focus on multiple sclerosis
Giunti, D., Parodi, B., Cordano, C., Uccelli, A., & de Rosbo, N. K. (2013) · Immunology · doi:10.1111/imm.12177 · Cited by 87
Gelosa, P., Lecca, D., Fumagalli, M., Wypych, D., Pignieri, A., Cimino, M., Verderio, C., Enerbäck, M., Nikookhesal, E., Tremoli, E., et al. (2014) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1038/jcbfm.2014.45 · Cited by 88
Weisman, G. A., Camden, J. M., Peterson, T. S., Ajit, D., Woods, L. T., & Erb, L. (2012) · Molecular Neurobiology · doi:10.1007/s12035-012-8263-z · Cited by 87
Microglia toxicity in preterm brain injury
Baburamani, A. A., Supramaniam, V. G., Hagberg, H., & Mallard, C. E. (2014) · Reproductive Toxicology · doi:10.1016/j.reprotox.2014.04.002 · Cited by 90
Matyash, M., Zabiegalov, O., Wendt, S., Matyash, V., & Kettenmann, H. (2017) · PLoS ONE · doi:10.1371/journal.pone.0175012 · Cited by 86
Microglia and Macrophages in the Pathological Central and Peripheral Nervous Systems
Abe, N., Nishihara, T., Yorozuya, T., & Tanaka, J. (2020) · Cells · doi:10.3390/cells9092132 · Cited by 88
Expression of ATP receptors in the rat dorsal root ganglion and spinal cord
Kobayashi, K., Yamanaka, H., & Noguchi, K. (2012) · Anatomical Science International · doi:10.1007/s12565-012-0163-9 · Cited by 84
Simon, E., Obst, J., & Gomez-Nicola, D. (2019) · Neuroscience · doi:10.1016/j.neuroscience.2018.01.059 · Cited by 83
Minocycline decreases in vitro microglial motility, β1‐integrin, and Kv1.3 channel expression
Nutile‐McMenemy, N., Elfenbein, A., & DeLeo, J. A. (2007) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2007.04889.x · Cited by 83
Kurpius, D., Nolley, E. P., & Dailey, M. E. (2007) · Glia · doi:10.1002/glia.20509 · Cited by 83
Self-citationJurcău, M. C., Jurcău, A., Cristian, A., Hogea, V. O., Diaconu, R. G., & Nunkoo, V. S. (2024) · International Journal of Molecular Sciences · doi:10.3390/ijms251910535 · Cited by 100
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Malm, T. M., Jay, T. R., & Landreth, G. E. (2015) · Neurotherapeutics · doi:10.1007/s13311-014-0316-8 · Cited by 85
Zhu, C., Kros, J. M., van der Weiden, M., Zheng, P., Cheng, C., & Mustafa, D. A. M. (2017) · Acta Neuropathologica Communications · doi:10.1186/s40478-016-0405-5 · Cited by 81
Glial Modulators as Potential Treatments of Psychostimulant Abuse
Beardsley, P. M., & Hauser, K. F. (2014) · Advances in pharmacology · doi:10.1016/b978-0-12-420118-7.00001-9 · Cited by 84
Chen, S.-W., Hung, Y.-S., Fuh, J., Chen, N.-J., Chu, Y., Chen, S.-C., Fann, M., & Wong, Y. (2021) · Stem Cell Reports · doi:10.1016/j.stemcr.2021.03.010 · Cited by 83
Calcium dyshomeostasis in white matter pathology
Matute, C. (2009) · Cell Calcium · doi:10.1016/j.ceca.2009.12.004 · Cited by 81
Ahlers‐Dannen, K. E., Karaçay, B., Fuller, L. C., Bonthius, D. J., & Dailey, M. E. (2015) · Glia · doi:10.1002/glia.22835 · Cited by 85
Self-citationBerger, J. V., Knaepen, L., Janssen, S. P. M., Jaken, R. J. P., Marcus, M. A. E., Joosten, E. A. J., & Deumens, R. (2011) · Brain Research Reviews · doi:10.1016/j.brainresrev.2011.03.003 · Cited by 83
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Takeda, A., Shinozaki, Y., Kashiwagi, K., Ohno, N., Eto, K., Wake, H., Nabekura, J., & Koizumi, S. (2018) · Glia · doi:10.1002/glia.23475 · Cited by 77
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Adenosine A3 receptor is involved in ADP‐induced microglial process extension and migration
Ohsawa, K., Sanagi, T., Nakamura, Y., Suzuki, E., Inoue, K., & Kohsaka, S. (2012) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2012.07693.x · Cited by 79
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Plesnila, N. (2015) · Current Opinion in Pharmacology · doi:10.1016/j.coph.2015.10.008 · Cited by 85
Fernández‐Albarral, J. A., Ramirez, A. I., de Hoz, R., López-Villarín, N., Salobrar‐García, E., López‐Cuenca, I., Licastro, E., Inarejos-García, A. M., Almodóvar, P., Pinazo-Durán, M. D., et al. (2019) · International Journal of Molecular Sciences · doi:10.3390/ijms20174110 · Cited by 78
York, E. M., Zhang, J., Choi, H. B., & MacVicar, B. A. (2020) · Glia · doi:10.1002/glia.23913 · Cited by 81
Myeloid cell responses after spinal cord injury
David, S., Kroner, A., Greenhalgh, A. D., Zarruk, J. G., & López‐Vales, R. (2018) · Journal of Neuroimmunology · doi:10.1016/j.jneuroim.2018.06.003 · Cited by 81
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Kempthorne, L., Yoon, H., Madore, C., Smith, S., Wszolek, Z. K., Rademakers, R., Kim, J., Butovsky, O., & Dickson, D. W. (2020) · Acta Neuropathologica Communications · doi:10.1186/s40478-020-00947-0 · Cited by 77
Swiatkowski, P., Murugan, M., Eyo, U. B., Wāng, Y., Rangaraju, S., Oh, S. B., & Wu, L. (2016) · Neuroscience · doi:10.1016/j.neuroscience.2016.01.008 · Cited by 75
Fujita, R., Ma, Y., & Ueda, H. (2008) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2008.05599.x · Cited by 77
Qiao, S., Qian, Y., Xu, G., Luo, Q., & Zhang, Z. (2019) · Journal of Neuroinflammation · doi:10.1186/s12974-018-1389-9 · Cited by 77
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Abdipranoto, A., Park, J., Croucher, D. R., Daniel, J. A., Henshall, S. M., Galbraith, S., Mervin, K., & Vissel, B. (2009) · Stem Cells · doi:10.1002/stem.80 · Cited by 79
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Inoue, K., & Tsuda, M. (2011) · Experimental Neurology · doi:10.1016/j.expneurol.2011.09.016 · Cited by 74
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Pineau, I., & Lacroix, S. (2008) · Glia · doi:10.1002/glia.20763 · Cited by 78
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Corriden, R., & Insel, P. A. (2012) · Purinergic Signalling · doi:10.1007/s11302-012-9311-x · Cited by 78
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Klaver, D., & Thurnher, M. (2021) · Cells · doi:10.3390/cells10051098 · Cited by 74
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Deierborg, T., Roybon, L., Inácio, A. R. L., Pesic, J., & Brundin, P. (2010) · Neuroscience · doi:10.1016/j.neuroscience.2010.09.045 · Cited by 77
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Kluge, M. G., Abdolhoseini, M., Zalewska, K., Ong, L. K., Johnson, S. J., Nilsson, M., & Walker, F. R. (2018) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1177/0271678x18797346 · Cited by 74
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Tsuda, M. (2016) · Journal of Neuroscience Research · doi:10.1002/jnr.23816 · Cited by 72
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Rahimian, R., Belliveau, C., Chen, R., & Mechawar, N. (2022) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2022.871997 · Cited by 77
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Huo, A., Wang, J., Li, Q., Li, M., Qi, Y., Yin, Q., Luo, W., Shi, J., & Cong, Q. (2023) · Neural Regeneration Research · doi:10.4103/1673-5374.385854 · Cited by 76
Kettenmann, H. (2007) · Nature · doi:10.1038/nature05713 · Cited by 73
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Li, H.-Q., Chen, C., Dou, Y., Wu, H.-J., Liu, Y.-J., Lou, H.-F., Zhang, J.-M., Li, X.-M., Wang, H., & Duan, S. (2013) · Molecular and Cellular Biology · doi:10.1128/mcb.00544-13 · Cited by 73
Kaur, T., Clayman, A. C., Nash, A. J., Schrader, A. D., Warchol, M. E., & Ohlemiller, K. K. (2019) · Frontiers in Neuroscience · doi:10.3389/fnins.2019.00620 · Cited by 73
Delbridge, A. R. D., Huh, D., Brickelmaier, M., Burns, J. C., Roberts, C., Challa, R., Raymond, N., Cullen, P., Carlile, T. M., Ennis, K. A., et al. (2020) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2020.592005 · Cited by 72
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Kyrargyri, V., Madry, C., Rifat, A., Arancibia‐Cárcamo, I. L., Jones, S. P., Chan, V. T. T., Xu, Y., Robaye, B., & Attwell, D. (2019) · Glia · doi:10.1002/glia.23719 · Cited by 69
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Roles of white matter in central nervous system pathophysiologies
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OʼShea, T. M., Wollenberg, A. L., Kim, J. H., Ao, Y., Deming, T. J., & Sofroniew, M. V. (2020) · Nature Communications · doi:10.1038/s41467-020-19906-3 · Cited by 70
Apolloni, S., Fabbrizio, P., Parisi, C., Amadio, S., & Volonté, C. (2014) · Molecular Neurobiology · doi:10.1007/s12035-014-9019-8 · Cited by 72
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Wendt, S., Maricos, M., Vana, N., Meyer, N., Guneykaya, D., Semtner, M., & Kettenmann, H. (2017) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2017.05.027 · Cited by 69
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Milior, G., Morin‐Brureau, M., Chali, F., Duigou, C. L., Savary, E., Huberfeld, G., Rouach, N., Pallud, J., Capelle, L., Navarro, V., et al. (2020) · Journal of Neuroscience · doi:10.1523/jneurosci.0218-19.2019 · Cited by 69
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Johansson, J., Tabor, V., Wikell, A., Jalkanen, S., & Fuxe, J. (2015) · Frontiers in Oncology · doi:10.3389/fonc.2015.00003 · Cited by 67
Metadata
- Authors
- Haynes, S. E., Hollopeter, G., Yang, G., Kurpius, D., Dailey, M. E., Gan, W.-B., & Julius, D.
- Affiliations
- University of California, San Francisco (US)
- New York University (US)
- University of Iowa (US)
- Corresponding author
- Julius, David
- Venue
- Nature Neuroscience
- Published
- 2006-11-19
- Volume
- 9
- Issue
- 12
- Pages
- 1512-1519
- ISSN
- 1097-6256 (ISSN-L)
- 1546-1726
- OpenAlex
- W2131686384
- Cited by
- 1,542
- References
- 34
- Citations by year
- 2026: 91 · 2025: 80 · 2024: 126 · 2023: 94 · 2022: 122 · 2021: 138 · 2020: 104 · 2019: 93 · 2018: 80 · 2017: 71 · 2016: 63 · 2015: 68 · 2014: 64 · 2013: 67 · 2012: 69
- FWCI
- 19.53
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Nature Neuroscience (publishedVersion)
- PubMed (publishedVersion)
- eScholarship (California Digital Library) (submittedVersion)
- Funders
- University of California, San Francisco
- National Institute of Neurological Disorders and Stroke (R01NS043468, NS434468)
- National Center for Research Resources (S10RR017941)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Physiology › Adenosine and Purinergic Signaling
- Life Sciences › Neuroscience › Neurology › Neuroinflammation and Neurodegeneration Mechanisms
- Health Sciences › Medicine › Clinical Neurology › Traumatic Brain Injury and Neurovascular Disturbances
- Keywords
- P2Y12 receptor, microglial activation, extracellular nucleotides, microglial chemotaxis, microglial polarization, microglial motility, purinergic signaling, G protein-coupled receptors, central nervous system injury, cortical injury
- MeSH terms
- Adenosine Diphosphate, Adenosine Triphosphate, Animals, Brain Injuries, Central Nervous System, Chemotaxis, Membrane Proteins, Microglia, Receptors, Purinergic P2, Mice, Knockout, Mice, Receptors, Purinergic P2Y12
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