The DOI matches its Crossref record; 15 of the 15 references it cites were found in a registry or an index.
Altered responsiveness to cocaine in rats exposed to methylphenidate during development
Abstract
Evidence in laboratory animals indicates that exposure to stimulants produces sensitization to their rewarding effects, a process that in humans would be expected to increase the risk of substance abuse. However, therapeutic administration of stimulants such as methylphenidate (MPH) in children with attention deficit hyperactivity disorder reportedly reduces the risk of substance abuse. Here we show in rats that exposure to MPH during pre-adolescence causes behavioral and neurobiological adaptations that endure into adulthood, and that are consistent with increased sensitivity to the aversive effects of cocaine.
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“Specifically, later preference for cocaine in rats is decreased by early, compared to later methylphenidate administration (16, 17), suggesting that age at exposure may modulate long-term drug effects on the brain, at least in rats.”
From Age of methylphenidate treatment initiation in children with ADHD and later substance abuse: prospective follow-up into adulthood. (2008) · cites this paper as [16]
In the citing paper
“Specifically, later preference for cocaine in rats is decreased by early, compared to later methylphenidate administration (16, 17), suggesting that age at exposure may modulate long-term drug effects on the brain, at least in rats.”
From Age of methylphenidate treatment initiation in children with ADHD and later substance abuse: prospective follow-up into adulthood. (2008) · cites this paper as [16]
In the citing paper
“Although findings are consistent with animal data that later preference for cocaine in rats is relatively decreased by exposure to methylphenidate early rather than late in development (16, 17), the relevance of animal neurodevelopmental models of stimulant exposure is not straightforward.”
From Age of methylphenidate treatment initiation in children with ADHD and later substance abuse: prospective follow-up into adulthood. (2008) · cites this paper as [16]
Citations
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Self-citationExpression of the transcription factor ΔFosB in the brain controls sensitivity to cocaine
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Cited by
Sorted by citations
Neuroscience of attention-deficit/hyperactivity disorder: the search for endophenotypes
Castellanos, F. X., & Tannock, R. (2002) · Nature Reviews Neuroscience · doi:10.1038/nrn896 · Cited by 1,827
Trajectories of brain development: point of vulnerability or window of opportunity?
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Metadata
- Authors
- Andersen, S. L., Arvanitogiannis, A., Pliakas, A. M., LeBlanc, C., & Carlezon, W. A.
- Affiliations
- Harvard University (US)
- Corresponding author
- Andersen, Susan L.
- Venue
- Nature Neuroscience
- Published
- 2001-12-03
- Volume
- 5
- Issue
- 1
- Pages
- 13-14
- ISSN
- 1097-6256 (ISSN-L)
- 1546-1726
- OpenAlex
- W1964751335
- Cited by
- 259
- References
- 15
- Citations by year
- 2026: 1 · 2025: 5 · 2024: 2 · 2022: 2 · 2021: 7 · 2020: 2 · 2019: 4 · 2018: 5 · 2017: 7 · 2016: 8 · 2015: 8 · 2014: 15 · 2013: 14 · 2012: 12
- FWCI
- 4.42
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Nature Neuroscience (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institute on Drug Abuse (R01DA012736, DA12736)
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
- Health Sciences › Medicine › Psychiatry and Mental health › Attention Deficit Hyperactivity Disorder
- Health Sciences › Medicine › Epidemiology › Substance Abuse Treatment and Outcomes
- Keywords
- methylphenidate, cocaine sensitivity, late childhood, attention deficit hyperactivity disorder, substance abuse risk, behavioral adaptation
- MeSH terms
- Adaptation, Physiological, Adult, Aging, Central Nervous System Stimulants, Animals, Child, Cocaine, Conditioning, Classical, Humans, Methylphenidate, Nucleus Accumbens, Reward, Time Factors, Cyclic AMP Response Element-Binding Protein, Receptors, AMPA, Rats
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