Cited by 260Neurotransmitter Receptor Influence on BehaviorAttention Deficit Hyperactivity DisorderSubstance Abuse Treatment and Outcomes

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Altered responsiveness to cocaine in rats exposed to methylphenidate during development

Andersen, Susan L., Arvanitogiannis, Andreas, Pliakas, Andrea M., LeBlanc, Celeste, Carlezon, William A.·2002·Nature Neuroscience

DOI 10.1038/nn777

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Abstract

Evidence in laboratory animals indicates that exposure to stimulants produces sensitization to their rewarding effects, a process that in humans would be expected to increase the risk of substance abuse. However, therapeutic administration of stimulants such as methylphenidate (MPH) in children with attention deficit hyperactivity disorder reportedly reduces the risk of substance abuse. Here we show in rats that exposure to MPH during pre-adolescence causes behavioral and neurobiological adaptations that endure into adulthood, and that are consistent with increased sensitivity to the aversive effects of cocaine.

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Authors: Andersen, S. L., Arvanitogiannis, A., Pliakas, A. M., LeBlanc, C., & Carlezon, W. A.
Affiliations: Harvard University (US)
Corresponding author: Andersen, Susan L.
ORCID: Andersen, Susan L.
Carlezon, William A.
Venue: Nature Neuroscience
Publisher: Springer Science and Business Media LLC
Published: 2001-12-03
Volume: 5
Issue: 1
Pages: 13-14
ISSN: 1097-6256 (ISSN-L)
1546-1726
DOI: 10.1038/nn777
OpenAlex: W1964751335
Cited by: 259
References: 15
Citations by year: 2026: 1 · 2025: 5 · 2024: 2 · 2022: 2 · 2021: 7 · 2020: 2 · 2019: 4 · 2018: 5 · 2017: 7 · 2016: 8 · 2015: 8 · 2014: 15 · 2013: 14 · 2012: 12
FWCI: 4.42
Type: journal article
Language: en
Open access: closed
Licence: www.springer.com/tdm (tdm)
Locations: Nature Neuroscience (publishedVersion)
PubMed (publishedVersion)
Funders: National Institute on Drug Abuse (R01DA012736, DA12736)
Topics: Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
Health Sciences › Medicine › Psychiatry and Mental health › Attention Deficit Hyperactivity Disorder
Health Sciences › Medicine › Epidemiology › Substance Abuse Treatment and Outcomes
Keywords: methylphenidate, cocaine sensitivity, late childhood, attention deficit hyperactivity disorder, substance abuse risk, behavioral adaptation
MeSH terms: Adaptation, Physiological, Adult, Aging, Central Nervous System Stimulants, Animals, Child, Cocaine, Conditioning, Classical, Humans, Methylphenidate, Nucleus Accumbens, Reward, Time Factors, Cyclic AMP Response Element-Binding Protein, Receptors, AMPA, Rats

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Altered responsiveness to cocaine in rats exposed to methylphenidate during development

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