The DOI matches its Crossref record; 153 of the 153 references it cites were found in a registry or an index.
Challenges and opportunities for structural DNA nanotechnology
Open accessAbstract
DNA molecules have been used to build a variety of nanoscale structures and devices over the past 30 years, and potential applications have begun to emerge. But the development of more advanced structures and applications will require a number of issues to be addressed, the most significant of which are the high cost of DNA and the high error rate of self-assembly. Here we examine the technical challenges in the field of structural DNA nanotechnology and outline some of the promising applications that could be developed if these hurdles can be overcome. In particular, we highlight the potential use of DNA nanostructures in molecular and cellular biophysics, as biomimetic systems, in energy transfer and photonics, and in diagnostics and therapeutics for human health.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
The source backs part of the claim, not all of it — or backs it for a different population, condition or comparison.
In the citing paper
“The growing field of DNA (and RNA) origami provides many examples of compartments assembled from nucleic acids (for reviews, see Pinheiro et al. 2011;Hong et al. 2017).”
From Protocells and RNA Self-Replication (2018) · cites this paper as Pinheiro et al. 2011
Experimental — accuracy not yet measuredIn the citing paper
“DNA nanotechnology leverages the unparalleled molecular recognition motifs of the nitrogenous bases to create arbitrary two- and three-dimensional structures from the self-assembly of user-defined DNA strands.”
From Emerging Approaches to DNA Data Storage: Challenges and Prospects (2022) · cites this paper as [103]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
1 retracted
RETRACTED: Selective cell death mediated by small conditional RNAs
Venkataraman, S., Dirks, R. M., Ueda, C. T., & Pierce, N. A. (2010) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1006377107 · Cited by 89
RetractedFolding DNA to create nanoscale shapes and patterns
Rothemund, P. W. K. (2006) · Nature · doi:10.1038/nature04586 · Cited by 7,474
A DNA-based method for rationally assembling nanoparticles into macroscopic materials
Mirkin, C. A., Letsinger, R. L., Mucic, R. C., & Storhoff, J. J. (1996) · Nature · doi:10.1038/382607a0 · Cited by 6,693
Organization of 'nanocrystal molecules' using DNA
Alivisatos, A. P., Johnsson, K., Peng, X., Wilson, T. E., Loweth, C. J., Bruchez, M. P., & Schultz, P. G. (1996) · Nature · doi:10.1038/382609a0 · Cited by 2,963
Design and self-assembly of two-dimensional DNA crystals
Winfree, E., Liu, F., Wenzler, L. A., & Seeman, N. C. (1998) · Nature · doi:10.1038/28998 · Cited by 2,857
Self-assembly of DNA into nanoscale three-dimensional shapes
Douglas, S. M., Dietz, H., Liedl, T., Högberg, B., Graf, F., & Shih, W. M. (2009) · Nature · doi:10.1038/nature08016 · Cited by 2,617
Self-citationNucleic acid junctions and lattices
Seeman, N. C. (1982) · Journal of Theoretical Biology · doi:10.1016/0022-5193(82)90002-9 · Cited by 2,505
A DNA-fuelled molecular machine made of DNA
Yurke, B., Turberfield, A. J., Mills, A. P., Simmel, F. C., & Neumann, J. L. (2000) · Nature · doi:10.1038/35020524 · Cited by 2,426
Triggered amplification by hybridization chain reaction
Dirks, R. M., & Pierce, N. A. (2004) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0407024101 · Cited by 2,095
Dynamic DNA nanotechnology using strand-displacement reactions
Zhang, D. Y., & Seelig, G. (2011) · Nature Chemistry · doi:10.1038/nchem.957 · Cited by 1,785
DNA-Templated Self-Assembly of Protein Arrays and Highly Conductive Nanowires
Yan, H., Park, S. H., Finkelstein, G., Reif, J. H., & LaBean, T. H. (2003) · Science · doi:10.1126/science.1089389 · Cited by 1,765
Self-citationYan, R., Gargas, D. J., & Yang, P. (2009) · Nature Photonics · doi:10.1038/nphoton.2009.184 · Cited by 1,666
Self-assembly of a nanoscale DNA box with a controllable lid
Andersen, E. S., Dong, M., Nielsen, M. M., Jahn, K., Subramani, R., Mamdouh, W., Golas, M. M., Sander, B. O., Stark, H., Oliveira, C. L. P., et al. (2009) · Nature · doi:10.1038/nature07971 · Cited by 1,650
Programming biomolecular self-assembly pathways
Yin, P., Choi, H. M. T., Calvert, C. R., & Pierce, N. A. (2008) · Nature · doi:10.1038/nature06451 · Cited by 1,616
DNA-guided crystallization of colloidal nanoparticles
Nykypanchuk, D., Maye, M. M., van der Lelie, D., & Gang, O. (2008) · Nature · doi:10.1038/nature06560 · Cited by 1,534
A molecular ruler based on plasmon coupling of single gold and silver nanoparticles
Sönnichsen, C., Reinhard, B. M., Liphardt, J., & Alivisatos, A. P. (2005) · Nature Biotechnology · doi:10.1038/nbt1100 · Cited by 1,523
Synthesis from DNA of a molecule with the connectivity of a cube
Chen, J., & Seeman, N. C. (1991) · Nature · doi:10.1038/350631a0 · Cited by 1,394
Folding DNA into Twisted and Curved Nanoscale Shapes
Dietz, H., Douglas, S. M., & Shih, W. M. (2009) · Science · doi:10.1126/science.1174251 · Cited by 1,361
Self-citationWasielewski, M. R. (2009) · Accounts of Chemical Research · doi:10.1021/ar9001735 · Cited by 1,318
DNA Origami with Complex Curvatures in Three-Dimensional Space
Han, D., Pal, S., Nangreave, J., Deng, Z., Liu, Y., & Yan, H. (2011) · Science · doi:10.1126/science.1202998 · Cited by 1,243
Self-citationRapid Chiral Assembly of Rigid DNA Building Blocks for Molecular Nanofabrication
Goodman, R. P., Schaap, I. A. T., Tardin, C., Erben, C. M., Berry, R. M., Schmidt, C. F., & Turberfield, A. J. (2005) · Science · doi:10.1126/science.1120367 · Cited by 1,186
Photochemical Conversion of Solar Energy
Balzani, V., Credi, A., & Venturi, M. (2007) · ChemSusChem · doi:10.1002/cssc.200700087 · Cited by 1,164
From molecular to macroscopic via the rational design of a self-assembled 3D DNA crystal
Zheng, J., Birktoft, J. J., Chen, Y., Wang, T., Sha, R., Constantinou, P. E., Ginell, S. L., Mao, C., & Seeman, N. C. (2009) · Nature · doi:10.1038/nature08274 · Cited by 1,003
Seeman, N. C. (2010) · Annual Review of Biochemistry · doi:10.1146/annurev-biochem-060308-102244 · Cited by 992
A 1.7-kilobase single-stranded DNA that folds into a nanoscale octahedron
Shih, W. M., Quispe, J. D., & Joyce, G. F. (2004) · Nature · doi:10.1038/nature02307 · Cited by 989
Self-citationAssembling Materials with DNA as the Guide
Aldaye, F. A., Palmer, A. L., & Sleiman, H. F. (2008) · Science · doi:10.1126/science.1154533 · Cited by 989
A primer to scaffolded DNA origami
Castro, C. E., Kilchherr, F., Kim, D., Lin-Shiao, E., Wauer, T., Wortmann, P., Bathe, M., & Dietz, H. (2011) · Nature Methods · doi:10.1038/nmeth.1570 · Cited by 926
Lammers, T., Aime, S., Hennink, W. E., Storm, G., & Kiessling, F. M. (2011) · Accounts of Chemical Research · doi:10.1021/ar200019c · Cited by 906
Algorithmic Self-Assembly of DNA Sierpinski Triangles
Rothemund, P. W. K., Papadakis, N., & Winfree, E. (2004) · PLoS Biology · doi:10.1371/journal.pbio.0020424 · Cited by 860
A nanomechanical device based on the B–Z transition of DNA
Mao, C., Sun, W., Shen, Z., & Seeman, N. C. (1999) · Nature · doi:10.1038/16437 · Cited by 845
DNA double-crossover molecules
Fu, T. J., & Seeman, N. C. (1993) · Biochemistry · doi:10.1021/bi00064a003 · Cited by 831
A proximity-based programmable DNA nanoscale assembly line
Gu, H., Chao, J., Xiao, S., & Seeman, N. C. (2010) · Nature · doi:10.1038/nature09026 · Cited by 824
Building plasmonic nanostructures with DNA
Tan, S. J., Campolongo, M. J., Luo, D., & Cheng, W. (2011) · Nature Nanotechnology · doi:10.1038/nnano.2011.49 · Cited by 803
Long-Range Charge Transfer in DNA: Transient Structural Distortions Control the Distance Dependence
Schuster, G. B. (2000) · Accounts of Chemical Research · doi:10.1021/ar980059z · Cited by 778
Supramolecular fullerene chemistry
Diederich, F., & Gómez‐López, M. (1999) · Chemical Society Reviews · doi:10.1039/a804248i · Cited by 742
The emerging field of RNA nanotechnology
Guo, P. (2010) · Nature Nanotechnology · doi:10.1038/nnano.2010.231 · Cited by 726
Control of Self-Assembly of DNA Tubules Through Integration of Gold Nanoparticles
Sharma, J., Chhabra, R., Cheng, A., Brownell, J., Liu, Y., & Yan, H. (2009) · Science · doi:10.1126/science.1165831 · Cited by 720
Self-citationConstruction, Analysis, Ligation, and Self-Assembly of DNA Triple Crossover Complexes
LaBean, T. H., Yan, H., Kopatsch, J., Liu, F., Winfree, E., Reif, J. H., & Seeman, N. C. (2000) · Journal of the American Chemical Society · doi:10.1021/ja993393e · Cited by 704
Self-citationEnzyme cascades activated on topologically programmed DNA scaffolds
Wilner, O. I., Weizmann, Y., Gill, R., Lioubashevski, O., Freeman, R., & Willner, I. (2009) · Nature Nanotechnology · doi:10.1038/nnano.2009.50 · Cited by 701
A system for the continuous directed evolution of biomolecules
Esvelt, K. M., Carlson, J. C., & Liu, D. R. (2011) · Nature · doi:10.1038/nature09929 · Cited by 694
Long-Distance Charge Transport in DNA: The Hopping Mechanism
Giese, B. (2000) · Accounts of Chemical Research · doi:10.1021/ar990040b · Cited by 657
An immobile nucleic acid junction constructed from oligonucleotides
Kallenbach, N. R., Ma, R.-I., & Seeman, N. C. (1983) · Nature · doi:10.1038/305829a0 · Cited by 651
Organization of Intracellular Reactions with Rationally Designed RNA Assemblies
Delebecque, C. J., Lindner, A. B., Silver, P. A., & Aldaye, F. A. (2011) · Science · doi:10.1126/science.1206938 · Cited by 634
Self-assembly of carbon nanotubes into two-dimensional geometries using DNA origami templates
Maune, H., Han, S., Barish, R. D., Bockrath, M., Goddard, W. A., Rothemund, P. W. K., & Winfree, E. (2009) · Nature Nanotechnology · doi:10.1038/nnano.2009.311 · Cited by 622
Construction of a DNA-Truncated Octahedron
Zhang, Y., & Seeman, N. C. (1994) · Journal of the American Chemical Society · doi:10.1021/ja00084a006 · Cited by 591
Gold Nanoparticle Self-Similar Chain Structure Organized by DNA Origami
Ding, B., Deng, Z., Yan, H., Cabrini, S., Zuckermann, R. N., & Jeffrey Bokor, A. (2010) · Journal of the American Chemical Society · doi:10.1021/ja9101198 · Cited by 533
Self-citationGoodman, R. P., Berry, R. M., & Turberfield, A. J. (2004) · Chemical Communications · doi:10.1039/b402293a · Cited by 514
Design and Characterization of Programmable DNA Nanotubes
Rothemund, P. W. K., Ekani-Nkodo, A., Papadakis, N., Kumar, A., Fygenson, D. K., & Winfree, E. (2004) · Journal of the American Chemical Society · doi:10.1021/ja044319l · Cited by 512
Programming DNA Tube Circumferences
Yin, P., Hariadi, R. F., Sahu, S., Choi, H. M. T., Park, S. H., LaBean, T. H., & Reif, J. H. (2008) · Science · doi:10.1126/science.1157312 · Cited by 486
DNA-nanotube-induced alignment of membrane proteins for NMR structure determination
Douglas, S. M., Chou, J. J., & Shih, W. M. (2007) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0700930104 · Cited by 481
Self-citationDNA origami: a quantum leap for self-assembly of complex structures
Tørring, T., Voigt, N. V., Nangreave, J., Yan, H., & Gothelf, K. V. (2011) · Chemical Society Reviews · doi:10.1039/c1cs15057j · Cited by 477
Self-citationSelf-Assembly of Hexagonal DNA Two-Dimensional (2D) Arrays
He, Y., Chen, Y., Liu, H., Ribbe, A. E., & Mao, C. (2005) · Journal of the American Chemical Society · doi:10.1021/ja0541938 · Cited by 468
DNA-Templated Self-Assembly of Metallic Nanocomponent Arrays on a Surface
Le, J. D., Pinto, Y., Seeman, N. C., Musier‐Forsyth, K., Taton, T. A., & Kiehl, R. A. (2004) · Nano Letters · doi:10.1021/nl048635+ · Cited by 462
Energy Conversion in Natural and Artificial Photosynthesis
McConnell, I., Li, G., & Brudvig, G. W. (2010) · Chemistry & Biology · doi:10.1016/j.chembiol.2010.05.005 · Cited by 446
Two-Dimensional Nanoparticle Arrays Show the Organizational Power of Robust DNA Motifs
Zheng, J., Constantinou, P. E., Micheel, C., Alivisatos, A. P., Kiehl, R. A., & Seeman, N. C. (2006) · Nano Letters · doi:10.1021/nl060994c · Cited by 442
Hung, A. M., Micheel, C., Bozano, L. D., Osterbur, L. W., Wallraff, G. M., & Cha, J. N. (2009) · Nature Nanotechnology · doi:10.1038/nnano.2009.450 · Cited by 432
Crystalline Two‐Dimensional DNA‐Origami Arrays
Liu, W., Zhong, H., Wang, R., & Seeman, N. C. (2010) · Angewandte Chemie International Edition · doi:10.1002/anie.201005911 · Cited by 425
Multilayer DNA Origami Packed on a Square Lattice
Ke, Y., Douglas, S. M., Liu, M., Sharma, J., Cheng, A., Leung, A., Liu, Y., Shih, W. M., & Yan, H. (2009) · Journal of the American Chemical Society · doi:10.1021/ja906381y · Cited by 423
Self-citationÉchard, J., Bertrand, L., von Bohlen, A., Hô, A. L., Paris, C., Bellot‐Gurlet, L., Soulier, B., Lattuati‐Derieux, A., Heu-Thao, S., Robinet, L., et al. (2009) · Angewandte Chemie International Edition · doi:10.1002/anie.200906553 · Cited by 410
Free-standing nanoparticle superlattice sheets controlled by DNA
Cheng, W., Campolongo, M. J., Cha, J. J., Tan, S. J., Umbach, C. C., Muller, D. A., & Luo, D. (2009) · Nature Materials · doi:10.1038/nmat2440 · Cited by 404
Placement and orientation of individual DNA shapes on lithographically patterned surfaces
Kershner, R. J., Bozano, L. D., Micheel, C., Hung, A. M., Fornof, A. R., Cha, J. N., Rettner, C. T., Bersani, M., Frommer, J., Rothemund, P. W. K., et al. (2009) · Nature Nanotechnology · doi:10.1038/nnano.2009.220 · Cited by 394
Reconfigurable, braced, three-dimensional DNA nanostructures
Goodman, R. P., Heilemann, M., Doose, S., Erben, C. M., Kapanidis, A. N., & Turberfield, A. J. (2008) · Nature Nanotechnology · doi:10.1038/nnano.2008.3 · Cited by 390
Self-assembly of three-dimensional prestressed tensegrity structures from DNA
Liedl, T., Högberg, B., Tytell, J. D., Ingber, D. E., & Shih, W. M. (2010) · Nature Nanotechnology · doi:10.1038/nnano.2010.107 · Cited by 385
Self-citationProgrammable molecular recognition based on the geometry of DNA nanostructures
Woo, S., & Rothemund, P. W. K. (2011) · Nature Chemistry · doi:10.1038/nchem.1070 · Cited by 375
Mitochondrial uncoupling protein 2 structure determined by NMR molecular fragment searching
Berardi, M. J., Shih, W. M., Harrison, S. C., & Chou, J. J. (2011) · Nature · doi:10.1038/nature10257 · Cited by 373
Self-citationTensegrity: Construction of Rigid DNA Triangles with Flexible Four-Arm DNA Junctions
Liu, D., Wang, M., Deng, Z., Walulu, R., & Mao, C. (2004) · Journal of the American Chemical Society · doi:10.1021/ja031754r · Cited by 369
Scaffolded DNA Origami of a DNA Tetrahedron Molecular Container
Ke, Y., Sharma, J., Liu, M., Jahn, K., Liu, Y., & Yan, H. (2009) · Nano Letters · doi:10.1021/nl901165f · Cited by 351
Self-citationAn autonomous polymerization motor powered by DNA hybridization
Venkataraman, S., Dirks, R. M., Rothemund, P. W. K., Winfree, E., & Pierce, N. A. (2007) · Nature Nanotechnology · doi:10.1038/nnano.2007.225 · Cited by 340
DNA nanotubes self-assembled from triple-crossover tiles as templates for conductive nanowires
Liu, D., Park, S. H., Reif, J. H., & LaBean, T. H. (2004) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0305860101 · Cited by 336
Zhang, J., Liu, Y., Ke, Y., & Yan, H. (2006) · Nano Letters · doi:10.1021/nl052210l · Cited by 332
Self-citationDNA‐Templated Self‐Assembly of Two‐Dimensional and Periodical Gold Nanoparticle Arrays
Sharma, J., Chhabra, R., Liu, Y., Ke, Y., & Yan, H. (2005) · Angewandte Chemie International Edition · doi:10.1002/anie.200503208 · Cited by 332
Self-citationFolding and cutting DNA into reconfigurable topological nanostructures
Han, D., Pal, S., Liu, Y., & Yan, H. (2010) · Nature Nanotechnology · doi:10.1038/nnano.2010.193 · Cited by 329
Self-citationLoading and selective release of cargo in DNA nanotubes with longitudinal variation
Lo, P. K., Karam, P., Aldaye, F. A., McLaughlin, C. K., Hamblin, G. D., Cosa, G., & Sleiman, H. F. (2010) · Nature Chemistry · doi:10.1038/nchem.575 · Cited by 321
Six-Helix Bundles Designed from DNA
Mathieu, F., Liao, S., Kopatsch, J., Wang, T., Mao, C., & Seeman, N. C. (2005) · Nano Letters · doi:10.1021/nl050084f · Cited by 315
DNA‐Origami‐Directed Self‐Assembly of Discrete Silver‐Nanoparticle Architectures
Pal, S., Deng, Z., Ding, B., Yan, H., & Liu, Y. (2010) · Angewandte Chemie International Edition · doi:10.1002/anie.201000330 · Cited by 314
Self-citationDirected nucleation assembly of DNA tile complexes for barcode-patterned lattices
Yan, H., LaBean, T. H., Feng, L., & Reif, J. H. (2003) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1032954100 · Cited by 312
Self-citationStability of DNA Origami Nanoarrays in Cell Lysate
Mei, Q., Wei, X., Su, F., Liu, Y., Youngbull, C., Johnson, R. H., Lindsay, S., Yan, H., & Meldrum, D. (2011) · Nano letters (Print) · doi:10.1021/nl1040836 · Cited by 307
Self-citationSingle‐Molecule Protein Encapsulation in a Rigid DNA Cage
Erben, C. M., Goodman, R. P., & Turberfield, A. J. (2006) · Angewandte Chemie International Edition · doi:10.1002/anie.200603392 · Cited by 299
Modular Access to Structurally Switchable 3D Discrete DNA Assemblies
Aldaye, F. A., & Sleiman, H. F. (2007) · Journal of the American Chemical Society · doi:10.1021/ja075966q · Cited by 295
Orthogonal Protein Decoration of DNA Origami
Saccà, B., Meyer, R. L., Erkelenz, M., Kiko, K., Arndt, A., Schroeder, H., Rabe, K. S., & Niemeyer, C. M. (2010) · Angewandte Chemie International Edition · doi:10.1002/anie.201005931 · Cited by 291
Programmable DNA Self-Assemblies for Nanoscale Organization of Ligands and Proteins
Park, S. H., Yin, P., Liu, Y., Reif, J. H., LaBean, T. H., & Yan, H. (2005) · Nano Letters · doi:10.1021/nl050175c · Cited by 288
Self-citationFinite‐Size, Fully Addressable DNA Tile Lattices Formed by Hierarchical Assembly Procedures
Park, S. H., Pistol, C., Ahn, S. J., Reif, J. H., Lebeck, A. R., Dwyer, C. L., & LaBean, T. H. (2005) · Angewandte Chemie International Edition · doi:10.1002/anie.200503797 · Cited by 288
Spatially Addressable Multiprotein Nanoarrays Templated by Aptamer-Tagged DNA Nanoarchitectures
Chhabra, R., Sharma, J., Ke, Y., Liu, Y., Rinker, S. D., Lindsay, S. M., & Yan, H. (2007) · Journal of the American Chemical Society · doi:10.1021/ja072410u · Cited by 270
Self-citationStepwise surface encoding for high-throughput assembly of nanoclusters
Maye, M. M., Nykypanchuk, D., Cuisinier, M., van der Lelie, D., & Gang, O. (2009) · Nature Materials · doi:10.1038/nmat2421 · Cited by 266
Scalable gene synthesis by selective amplification of DNA pools from high-fidelity microchips
Kosuri, S., Eroshenko, N., LeProust, E. M., Super, M., Way, J. C., Li, J. B., & Church, G. M. (2010) · Nature Biotechnology · doi:10.1038/nbt.1716 · Cited by 266
Recent developments in oligonucleotide conjugation
Singh, Y., Murat, P., & Defrancq, É. (2010) · Chemical Society Reviews · doi:10.1039/b911431a · Cited by 263
Antiparallel DNA Double Crossover Molecules As Components for Nanoconstruction
Li, X., Yang, X., Qi, J., & Seeman, N. C. (1996) · Journal of the American Chemical Society · doi:10.1021/ja960162o · Cited by 260
Single-Molecule Four-Color FRET Visualizes Energy-Transfer Paths on DNA Origami
Stein, I. H., Steinhauer, C., & Tinnefeld, P. (2011) · Journal of the American Chemical Society · doi:10.1021/ja1105464 · Cited by 260
DNA-based programming of quantum dot valency, self-assembly and luminescence
Tikhomirov, G. A., Hoogland, S., Lee, P. E., Fischer, A., Sargent, E. H., & Kelley, S. O. (2011) · Nature Nanotechnology · doi:10.1038/nnano.2011.100 · Cited by 259
von Delius, M., & Leigh, D. A. (2011) · Chemical Society Reviews · doi:10.1039/c1cs15005g · Cited by 256
Programmable Periodicity of Quantum Dot Arrays with DNA Origami Nanotubes
Bui, H., Onodera, C., Kidwell, C., Tan, Y., Graugnard, E., Kuang, W., Lee, J., Knowlton, W. B., Yurke, B., & Hughes, W. L. (2010) · Nano Letters · doi:10.1021/nl101079u · Cited by 243
Highly Connected Two-Dimensional Crystals of DNA Six-Point-Stars
He, Y., Tian, Y., Ribbe, A. E., & Mao, C. (2006) · Journal of the American Chemical Society · doi:10.1021/ja0665141 · Cited by 222
Self-Assembly of Chiral DNA Nanotubes
Mitchell, J. C., Harris, J. R., Malo, J., Bath, J., & Turberfield, A. J. (2004) · Journal of the American Chemical Society · doi:10.1021/ja043890h · Cited by 215
Aptamer‐Directed Self‐Assembly of Protein Arrays on a DNA Nanostructure
Liu, Y., Lin, C., Li, H., & Yan, H. (2005) · Angewandte Chemie International Edition · doi:10.1002/anie.200501089 · Cited by 209
Self-citationEndo, M., Katsuda, Y., Hidaka, K., & Sugiyama, H. (2010) · Journal of the American Chemical Society · doi:10.1021/ja907649w · Cited by 205
Programmed Two-Dimensional Self-Assembly of Multiple DNA Origami Jigsaw Pieces
Rajendran, A., Endo, M., Katsuda, Y., Hidaka, K., & Sugiyama, H. (2010) · ACS Nano · doi:10.1021/nn1031627 · Cited by 202
Visualization of Dynamic Conformational Switching of the G-Quadruplex in a DNA Nanostructure
Sannohe, Y., Endo, M., Katsuda, Y., Hidaka, K., & Sugiyama, H. (2010) · Journal of the American Chemical Society · doi:10.1021/ja1058907 · Cited by 201
Sequential Self‐Assembly of a DNA Hexagon as a Template for the Organization of Gold Nanoparticles
Aldaye, F. A., & Sleiman, H. F. (2006) · Angewandte Chemie International Edition · doi:10.1002/anie.200502481 · Cited by 199
Metallization of Branched DNA Origami for Nanoelectronic Circuit Fabrication
Liu, J., Geng, Y., Pound, E., Gyawali, S., Ashton, J. R., Hickey, J. W., Woolley, A. T., & Harb, J. N. (2011) · ACS Nano · doi:10.1021/nn1035075 · Cited by 198
DNA origami: a history and current perspective
Nangreave, J., Han, D., Liu, Y., & Yan, H. (2010) · Current Opinion in Chemical Biology · doi:10.1016/j.cbpa.2010.06.182 · Cited by 196
Self-citationOrganizing DNA Origami Tiles into Larger Structures Using Preformed Scaffold Frames
Zhao, Z., Liu, Y., & Yan, H. (2011) · Nano Letters · doi:10.1021/nl201603a · Cited by 194
Self-citationOvercomingin vivobarriers to targeted nanodelivery
Chrastina, A., Massey, K. A., & Schnitzer, J. E. (2011) · Wiley Interdisciplinary Reviews Nanomedicine and Nanobiotechnology · doi:10.1002/wnan.143 · Cited by 192
Design and construction of a box-shaped 3D-DNA origami
Kuzuya, A., & Komiyama, M. (2009) · Chemical Communications · doi:10.1039/b907800b · Cited by 191
Bioorthogonal Chemistry for Site-Specific Labeling and Surface Immobilization of Proteins
Chen, Y., Triola, G., & Waldmann, H. (2011) · Accounts of Chemical Research · doi:10.1021/ar200046h · Cited by 182
Synthesis of crystals with a programmable kinetic barrier to nucleation
Schulman, R., & Winfree, E. (2007) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0701467104 · Cited by 178
Richter, J. (2003) · Physica E Low-dimensional Systems and Nanostructures · doi:10.1016/s1386-9477(02)00670-7 · Cited by 171
Evolution of Nitrate Reductase: Molecular and Structural Variations on a Common Function
Stolz, J. F., & Basu, P. (2002) · ChemBioChem · doi:10.1002/1439-7633(20020301)3:2/3 · Cited by 171
Yang, H. S., McLaughlin, C. K., Aldaye, F. A., Hamblin, G. D., Rys, A. Z., Rouiller, I., & Sleiman, H. F. (2009) · Nature Chemistry · doi:10.1038/nchem.290 · Cited by 168
DNA‐Tile‐Directed Self‐Assembly of Quantum Dots into Two‐Dimensional Nanopatterns
Sharma, J., Ke, Y., Lin, C., Chhabra, R., Wang, Q., Nangreave, J., Liu, Y., & Yan, H. (2008) · Angewandte Chemie International Edition · doi:10.1002/anie.200801485 · Cited by 162
Self-citationApproaching The Limit: Can One DNA Oligonucleotide Assemble into Large Nanostructures?
Liu, H., Chen, Y., He, Y., Ribbe, A. E., & Mao, C. (2006) · Angewandte Chemie International Edition · doi:10.1002/anie.200504022 · Cited by 161
A Self-Assembled DNA Bipyramid
Erben, C. M., Goodman, R. P., & Turberfield, A. J. (2007) · Journal of the American Chemical Society · doi:10.1021/ja071493b · Cited by 160
DNA Origami‐Templated Growth of Arbitrarily Shaped Metal Nanoparticles
Schreiber, R., Kempter, S., Holler, S., Schüller, V. J., Schiffels, D., Simmel, S. S., Nickels, P. C., & Liedl, T. (2011) · Small · doi:10.1002/smll.201100465 · Cited by 155
A Study of DNA Tube Formation Mechanisms Using 4-, 8-, and 12-Helix DNA Nanostructures
Ke, Y., Liu, Y., Zhang, J., & Yan, H. (2006) · Journal of the American Chemical Society · doi:10.1021/ja058145z · Cited by 153
Self-citationEncapsulation of Gold Nanoparticles in a DNA Origami Cage
Zhao, Z., Jacovetty, E. L., Liu, Y., & Yan, H. (2011) · Angewandte Chemie International Edition · doi:10.1002/anie.201006818 · Cited by 149
Self-citationDNA nanomachines and their functional evolution
Liu, H., & Liu, D. (2009) · Chemical Communications · doi:10.1039/b822719e · Cited by 145
DNA origami: Fold, stick, and beyond
Kuzuya, A., & Komiyama, M. (2009) · Nanoscale · doi:10.1039/b9nr00246d · Cited by 144
Self‐Assembled Peptide Nanoarrays: An Approach to Studying Protein–Protein Interactions
Williams, B. A. R., Lund, K., Liu, Y., Yan, H., & Chaput, J. C. (2007) · Angewandte Chemie International Edition · doi:10.1002/anie.200603919 · Cited by 142
Self-citationModular construction of DNA nanotubes of tunable geometry and single- or double-stranded character
Aldaye, F. A., Lo, P. K., Karam, P., McLaughlin, C. K., Cosa, G., & Sleiman, H. F. (2009) · Nature Nanotechnology · doi:10.1038/nnano.2009.72 · Cited by 139
A Route to Scale Up DNA Origami Using DNA Tiles as Folding Staples
Zhao, Z., Yan, H., & Liu, Y. (2010) · Angewandte Chemie International Edition · doi:10.1002/anie.200906225 · Cited by 137
Self-citationDNA Prism Structures Constructed by Folding of Multiple Rectangular Arms
Endo, M., Hidaka, K., Kato, T., Namba, K., & Sugiyama, H. (2009) · Journal of the American Chemical Society · doi:10.1021/ja904252e · Cited by 135
In vivo cloning of artificial DNA nanostructures
Lin, C., Rinker, S. D., Wang, X., Liu, Y., Seeman, N. C., & Yan, H. (2008) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0805416105 · Cited by 135
Self-citationSynergistic self-assembly of RNA and DNA molecules
Ko, S. H., Su, M., Zhang, C., Ribbe, A. E., Jiang, W., & Mao, C. (2010) · Nature Chemistry · doi:10.1038/nchem.890 · Cited by 135
Knitting complex weaves with DNA origami
Shih, W. M., & Lin, C. (2010) · Current Opinion in Structural Biology · doi:10.1016/j.sbi.2010.03.009 · Cited by 134
Self-citationMolecular Behavior of DNA Origami in Higher-Order Self-Assembly
Li, Z., Liu, M., Wang, L., Nangreave, J., Yan, H., & Liu, Y. (2010) · Journal of the American Chemical Society · doi:10.1021/ja106292x · Cited by 132
Self-citationSurface-Mediated DNA Self-Assembly
Sun, X., Ko, S. H., Zhang, C., Ribbe, A. E., & Mao, C. (2009) · Journal of the American Chemical Society · doi:10.1021/ja906475w · Cited by 132
Stephanopoulos, N., Liu, M., Tong, G. J., Li, Z., Liu, Y., Yan, H., & Francis, M. B. (2010) · Nano Letters · doi:10.1021/nl1018468 · Cited by 131
Self-citationSelf-Assembly of Symmetric Finite-Size DNA Nanoarrays
Liu, Y., Ke, Y., & Yan, H. (2005) · Journal of the American Chemical Society · doi:10.1021/ja055614o · Cited by 125
Self-citationAdvancing high-throughput gene synthesis technology
Tian, J., Ma, K.-S., & Saaem, I. (2009) · Molecular BioSystems · doi:10.1039/b822268c · Cited by 121
Self-Assembling a Molecular Pegboard
Lund, K., Liu, Y., Lindsay, S. M., & Yan, H. (2005) · Journal of the American Chemical Society · doi:10.1021/ja0568446 · Cited by 114
Self-citationA Replicable Tetrahedral Nanostructure Self-Assembled from a Single DNA Strand
Li, Z., Wei, B., Nangreave, J., Lin, C., Liu, Y., Mi, Y., & Yan, H. (2009) · Journal of the American Chemical Society · doi:10.1021/ja903768f · Cited by 110
Self-citationDNA-Templated Protein Arrays for Single-Molecule Imaging
Selmi, D. N., Adamson, R. J., Attrill, H. L., Goddard, A. D., Gilbert, R. J. C., Watts, A. G., & Turberfield, A. J. (2011) · Nano Letters · doi:10.1021/nl1037769 · Cited by 102
Interconnecting Gold Islands with DNA Origami Nanotubes
Ding, B., Wu, H., Xu, W., Zhao, Z., Liu, Y., Yu, H., & Yan, H. (2010) · Nano Letters · doi:10.1021/nl1033073 · Cited by 97
Self-citationDesign of Molecular Photonic Wires Based on Multistep Electronic Excitation Transfer
Tinnefeld, P., Heilemann, M., & Sauer, M. (2005) · ChemPhysChem · doi:10.1002/cphc.200400513 · Cited by 80
Two-dimensional DNA origami assemblies using a four-way connector
Endo, M., Sugita, T., Rajendran, A., Katsuda, Y., Emura, T., Hidaka, K., & Sugiyama, H. (2011) · Chemical Communications · doi:10.1039/c0cc05306f · Cited by 79
Rolling Circle Enzymatic Replication of a Complex Multi-Crossover DNA Nanostructure
Lin, C., Wang, X., Liu, Y., Seeman, N. C., & Yan, H. (2007) · Journal of the American Chemical Society · doi:10.1021/ja0760980 · Cited by 79
Self-citationAddressable Molecular Tweezers for DNA-Templated Coupling Reactions
Chhabra, R., Sharma, J., Liu, Y., & Yan, H. (2006) · Nano Letters · doi:10.1021/nl060212f · Cited by 71
Self-citationThree‐Step Synthesis of Sialic Acids and Derivatives
Hong, Z., Liu, L., Hsu, C., & Wong, C. (2006) · Angewandte Chemie International Edition · doi:10.1002/anie.200601555 · Cited by 68
Recent advances in DNA-based directed assembly on surfaces
Hung, A. M., Noh, H., & Cha, J. N. (2010) · Nanoscale · doi:10.1039/c0nr00430h · Cited by 65
Energy Transfer in Single‐Molecule Photonic Wires
Parajo, M. F. G., Hernando, J. C., SANCHEZ-MOSTEIRO, G., Hoogenboom, J. P., van Dijk, E. M. H. P., & van Hulst, N. F. (2005) · ChemPhysChem · doi:10.1002/cphc.200400630 · Cited by 63
Shaping up nucleic acid computation
Chen, X., & Ellington, A. D. (2010) · Current Opinion in Biotechnology · doi:10.1016/j.copbio.2010.05.003 · Cited by 60
A Structurally Tunable DNA-Based Extracellular Matrix
Aldaye, F. A., Senapedis, W. T., Silver, P. A., & Way, J. C. (2010) · Journal of the American Chemical Society · doi:10.1021/ja105431h · Cited by 60
DNA Scissors Device Used to Measure MutS Binding to DNA Mis-pairs
Gu, H., Yang, W., & Seeman, N. C. (2010) · Journal of the American Chemical Society · doi:10.1021/ja910188p · Cited by 59
Site‐Specific Assembly of DNA‐Based Photonic Wires by Using Programmable Polyamides
Su, W., Schuster, M., Bagshaw, C. R., Rant, U., & Burley, G. A. (2011) · Angewandte Chemie International Edition · doi:10.1002/anie.201006735 · Cited by 55
Li, H., LaBean, T. H., & Kenan, D. J. (2006) · Organic & Biomolecular Chemistry · doi:10.1039/b606391h · Cited by 52
Synthetic DNA knots and catenanes
Seeman, N. C., Chen, J. H., Du, S. M., Mueller, J., Zhang, Y. W., Fu, T.-J., Wang, H. H., Wang, Y. L., & Zhang, S. W. (1993) · New Journal of Chemistry · Cited by 48
Saccà, B., Meyer, R. L., Feldkamp, U., Schroeder, H., & Niemeyer, C. M. (2008) · Angewandte Chemie International Edition · doi:10.1002/anie.200704836 · Cited by 44
Studies of Thermal Stability of Multivalent DNA Hybridization in a Nanostructured System
Nangreave, J., Yan, H., & Liu, Y. (2009) · Biophysical Journal · doi:10.1016/j.bpj.2009.05.013 · Cited by 37
Self-citationSelf-assembling DNA templates for programmed artificial biomineralization
Sámano, E. C., Pilo‐Pais, M., Goldberg, S., Vogen, B. N., Finkelstein, G., & LaBean, T. H. (2011) · Soft Matter · doi:10.1039/c0sm01318h · Cited by 33
DNA Nanostructures as Models for Evaluating the Role of Enthalpy and Entropy in Polyvalent Binding
Nangreave, J., Yan, H., & Liu, Y. (2011) · Journal of the American Chemical Society · doi:10.1021/ja1103298 · Cited by 30
Self-citationMarton, S., Reyes-Darias, J. A., Sanchez-Luque, F. J., Romero‐López, C., & Berzal‐Herranz, A. (2010) · Molecules · doi:10.3390/molecules15074610 · Cited by 30
Some Experiments and Directions in Molecular Computing and Robotics
Stojanović, M. N. (2011) · Israel Journal of Chemistry · doi:10.1002/ijch.201000076 · Cited by 25
A Two-Dimensional DNA Array: The Three-Layer Logpile
Malo, J., Mitchell, J. C., & Turberfield, A. J. (2009) · Journal of the American Chemical Society · doi:10.1021/ja9042593 · Cited by 23
Kleinberg, J. M. (2006) · Nature · doi:10.1038/440279a · Cited by 7
Research works printed but not linked: 1
- Aldaye, F. A. & Sleiman, H. F. Modular access to structurally switchable 3D discrete DNA assemblies. J. Am. Chem. Soc. 129, 13376–13377 (2007). · DOI
Cited by
Sorted by citations
Review on nanoparticles and nanostructured materials: history, sources, toxicity and regulations
Jeevanandam, J., Barhoum, A., Chan, Y. S., Dufresne, A., & Danquah, M. K. (2018) · Beilstein Journal of Nanotechnology · doi:10.3762/bjnano.9.98 · Cited by 3,362
Self-Assembly of Colloidal Nanocrystals: From Intricate Structures to Functional Materials
Boles, M. A., Engel, M., & Talapin, D. V. (2016) · Chemical Reviews · doi:10.1021/acs.chemrev.6b00196 · Cited by 2,095
The History of Nanoscience and Nanotechnology: From Chemical–Physical Applications to Nanomedicine
Bayda, S., Adeel, M., Tuccinardi, T., Cordani, M., & Rizzolio, F. (2019) · Molecules · doi:10.3390/molecules25010112 · Cited by 2,098
Isothermal Amplification of Nucleic Acids
Zhao, Y., Chen, F., Li, Q., Wang, L., & Fan, C. (2015) · Chemical Reviews · doi:10.1021/acs.chemrev.5b00428 · Cited by 1,811
A DNA nanorobot functions as a cancer therapeutic in response to a molecular trigger in vivo
Li, S., Jiang, Q., Liu, S., Zhang, Y., Tian, Y., Song, C., Wang, J., Zou, Y., Anderson, G. J., Han, J.-Y., et al. (2018) · Nature Biotechnology · doi:10.1038/nbt.4071 · Cited by 1,481
Self-citation
Metadata
- Authors
- Pinheiro, A. V., Han, D., Shih, W. M., & Yan, H.
- Affiliations
- Arizona State University (US)
- Harvard University (US)
- Corresponding author
- Shih, William M.
- Yan, Hao
- Venue
- Nature Nanotechnology
- Published
- 2011-11-06
- Volume
- 6
- Issue
- 12
- Pages
- 763-772
- ISSN
- 1748-3387 (ISSN-L)
- 1748-3395
- PMC
- PMC3334823
- OpenAlex
- W2077850544
- Cited by
- 1,292
- References
- 153
- Citations by year
- 2026: 35 · 2025: 46 · 2024: 50 · 2023: 65 · 2022: 70 · 2021: 84 · 2020: 82 · 2019: 96 · 2018: 118 · 2017: 122 · 2016: 112 · 2015: 110 · 2014: 110 · 2013: 134 · 2012: 57
- FWCI
- 8.74
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Nature Nanotechnology (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Funders
- U.S. Department of Energy (DESC0001016)
- Arizona State University
- Hansjörg Wyss Institute for Biologically Inspired Engineering, Harvard University
- Office of Naval Research
- National Institute of General Medical Sciences (R01GM088818)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Advanced biosensing and bioanalysis techniques
- Physical Sciences › Mathematics › Theoretical Computer Science › DNA and Biological Computing
- Physical Sciences › Materials Science › Biomaterials › Supramolecular Self-Assembly in Materials
- Keywords
- DNA nanotechnology, DNA nanostructures, molecular biophysics, cellular biophysics, biomimetic systems, energy transfer, photonics, diagnostics, therapeutics
- MeSH terms
- DNA, Humans, Nucleic Acid Conformation, Nanotechnology, Biomimetic Materials, Nanostructures
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
