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Biomimetic enzyme nanocomplexes and their use as antidotes and preventive measures for alcohol intoxication
Open accessAbstract
Organisms have sophisticated subcellular compartments containing enzymes that function in tandem. These confined compartments ensure effective chemical transformation and transport of molecules, and the elimination of toxic metabolic wastes1,2. Creating functional enzyme complexes that are confined in a similar way remains challenging. Here we show that two or more enzymes with complementary functions can be assembled and encapsulated within a thin polymer shell to form enzyme nanocomplexes. These nanocomplexes exhibit improved catalytic efficiency and enhanced stability when compared with free enzymes. Furthermore, the co-localized enzymes display complementary functions, whereby toxic intermediates generated by one enzyme can be promptly eliminated by another enzyme. We show that nanocomplexes containing alcohol oxidase and catalase could reduce blood alcohol levels in intoxicated mice, offering an alternative antidote and prophylactic for alcohol intoxication.
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Wanders, R. J. A., & Waterham, H. R. (2006) · Annual Review of Biochemistry · doi:10.1146/annurev.biochem.74.082803.133329 · Cited by 995
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Gou, M., Qu, X., Zhu, W., Xiang, M., Yang, J., Zhang, K., Wei, Y., & Chen, S. (2014) · Nature Communications · doi:10.1038/ncomms4774 · Cited by 323
Site-selective photoinduced cleavage and profiling of DNA by chiral semiconductor nanoparticles
Sun, M., Xu, L., Qu, A., Zhao, P., Hao, T., Ma, W., Hao, C., Wen, X., Colombari, F. M., de Moura, A. F., et al. (2018) · Nature Chemistry · doi:10.1038/s41557-018-0083-y · Cited by 298
Metadata
- Authors
- Liu, Y., Du, J., Yan, M., Lau, M. Y., Hu, J., Han, H., Yang, O. O., Liang, S., Wei, W., Wang, H., Li, J., Zhu, X., Shi, L., Chen, W., Ji, C., & Lu, Y.
- Venue
- Nature Nanotechnology
- Published
- 2013-02-17
- Volume
- 8
- Issue
- 3
- Pages
- 187-192
- ISSN
- 1748-3387 (ISSN-L)
- 1748-3395
- OpenAlex
- W2034915366
- Cited by
- 339
- References
- 2
- FWCI
- 11.43
- Type
- journal article
- Language
- en
- Open access
- green
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- Liu, Y., Du, J., Yan, M., Lau, M. Y., Hu, J., Han, H., Yang, O. O., Liang, S., Wei, W., Wang, H., Li, J., Zhu, X., Shi, L., Chen, W., Ji, C., & Lu, Y. (2013). Biomimetic enzyme nanocomplexes and their use as antidotes and preventive measures for alcohol intoxication. Nature Nanotechnology. https://doi.org/10.1038/nnano.2012.264
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