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Cited by 502Quantum Dots Synthesis And PropertiesNanoparticles: synthesis and applicationsHeavy Metal Exposure and Toxicity

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Meta-analysis of cellular toxicity for cadmium-containing quantum dots

Oh, Eunkeu, Liu, Rong, Nel, Andre, Gemill, Kelly Boeneman, Bilal, Muhammad, Cohen, Yoram, Medintz, Igor L.·2016·Nature Nanotechnology
DOI 10.1038/nnano.2015.338
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Abstract

Understanding the relationships between the physicochemical properties of engineered nanomaterials and their toxicity is critical for environmental and health risk analysis. However, this task is confounded by material diversity, heterogeneity of published data and limited sampling within individual studies. Here, we present an approach for analysing and extracting pertinent knowledge from published studies focusing on the cellular toxicity of cadmium-containing semiconductor quantum dots. From 307 publications, we obtain 1,741 cell viability-related data samples, each with 24 qualitative and quantitative attributes describing the material properties and experimental conditions. Using random forest regression models to analyse the data, we show that toxicity is closely correlated with quantum dot surface properties (including shell, ligand and surface modifications), diameter, assay type and exposure time. Our approach of integrating quantitative and categorical data provides a roadmap for interrogating the wide-ranging toxicity data in the literature and suggests that meta-analysis can help develop methods for predicting the toxicity of engineered nanomaterials.

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Metadata

Authors
Oh, E., Liu, R., Nel, A., Gemill, K. B., Bilal, M., Cohen, Y., & Medintz, I. L.
Affiliations
  • United States Naval Research Laboratory (US)
  • University of California, Los Angeles (US)
Corresponding author
  • Liu, Rong
  • Cohen, Yoram
  • Medintz, Igor L.
ORCID
Venue
Nature Nanotechnology
Publisher
Springer Science and Business Media LLC
Published
2016-02-29
Volume
11
Issue
5
Pages
479-486
ISSN
  • 1748-3387 (ISSN-L)
  • 1748-3395
DOI
10.1038/nnano.2015.338
OpenAlex
W2292437912
Cited by
502
References
0
Citations by year
2026: 24 · 2025: 36 · 2024: 39 · 2023: 40 · 2022: 62 · 2021: 53 · 2020: 78 · 2019: 44 · 2018: 56 · 2017: 48 · 2016: 22
FWCI
2.26
Type
journal article
Language
en
Open access
closed
Licence
www.springer.com/tdm (tdm)
Locations
  • Nature Nanotechnology (publishedVersion)
  • PubMed (publishedVersion)
  • eScholarship (California Digital Library) (submittedVersion)
Funders
  • National Science Foundation
  • Defense Threat Reduction Agency
  • U.S. Naval Research Laboratory
Topics
  • Physical Sciences › Materials Science › Materials Chemistry › Quantum Dots Synthesis And Properties
  • Physical Sciences › Materials Science › Materials Chemistry › Nanoparticles: synthesis and applications
  • Physical Sciences › Environmental Science › Health, Toxicology and Mutagenesis › Heavy Metal Exposure and Toxicity
Keywords
cadmium quantum dots, semiconductor quantum dots, cytotoxicity, engineered nanomaterials, nanoparticle toxicity, cell viability, surface modification, ligands, shells, particle diameter, toxicity prediction, physicochemical properties, random forest regression
MeSH terms
Animals, Cadmium, Cell Survival, Humans, Models, Theoretical, Inhibitory Concentration 50, Quantum Dots, Workflow

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