The DOI matches its Crossref record; 3 of the 3 references it cites were found in a registry or an index.
Magneto-aerotactic bacteria deliver drug-containing nanoliposomes to tumour hypoxic regions
Open accessAbstract
Oxygen depleted hypoxic regions in the tumour are generally resistant to therapies1. Although nanocarriers have been used to deliver drugs, the targeting ratios have been very low. Here, we show that the magneto-aerotactic migration behaviour2 of magnetotactic bacteria3, Magnetococcus marinus strain MC-14, can be used to transport drug-loaded nanoliposomes into hypoxic regions of the tumour. In their natural environment, MC-1 cells, each containing a chain of magnetic iron-oxide nanocrystals5, tend to swim along local magnetic field lines and towards low oxygen concentrations6 based on a two-state aerotactic sensing system2. We show that when MC-1 cells bearing covalently bound drug-containing nanoliposomes were injected near the tumour in SCID Beige mice and magnetically guided, up to 55% of MC-1 cells penetrated into hypoxic regions of HCT116 colorectal xenografts. Approximately 70 drug-loaded nanoliposomes were attached to each MC-1 cell. Our results suggest that harnessing swarms of microorganisms exhibiting magneto-aerotactic behaviour can significantly improve the therapeutic index of various nanocarriers in tumour hypoxic regions.
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Cites
Targeting hypoxia in cancer therapy
Wilson, W. R., & Hay, M. P. (2011) · Nature Reviews Cancer · doi:10.1038/nrc3064 · Cited by 3,172
Exploiting tumour hypoxia in cancer treatment
Brown, J. M., & Wilson, W. R. (2004) · Nature Reviews Cancer · doi:10.1038/nrc1367 · Cited by 2,828
High Interstitial Fluid Pressure - an Obstacle in Cancer Therapy
Heldin, C.-H., Rubin, K., Pietras, K., & Östman, A. (2004) · Nature reviews. Cancer · doi:10.1038/nrc1456 · Cited by 2,222
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Artificial intelligence in medicine
Hamet, P., & Tremblay, J. (2017) · Metabolism · doi:10.1016/j.metabol.2017.01.011 · Cited by 2,334
The grand challenges of Science Robotics
Yang, G.-Z., Bellingham, J., Dupont, P. E., Fischer, P., Floridi, L., Full, R., Jacobstein, N., Kumar, V., McNutt, M., Merrifield, R., et al. (2018) · Science Robotics · doi:10.1126/scirobotics.aar7650 · Cited by 1,177
Multifunctional Biohybrid Magnetite Microrobots for Imaging-Guided Therapy
Yan, X., Zhou, Q., Vincent, M., Deng, Y., Yu, J., Xu, J., Xu, T., Tang, T., Bian, L., Wang, Y.-X. J., et al. (2017) · Science Robotics · doi:10.1126/scirobotics.aaq1155 · Cited by 893
The Use of Alternative Strategies for Enhanced Nanoparticle Delivery to Solid Tumors
Izci, M., Maksoudian, C., Manshian, B. B., & Soenen, S. J. (2021) · Chemical Reviews · doi:10.1021/acs.chemrev.0c00779 · Cited by 506
Soft erythrocyte-based bacterial microswimmers for cargo delivery
Alapan, Y., Yasa, O., Schauer, O., Giltinan, J., Tabak, A. F., Sourjik, V., & Sitti, M. (2018) · Science Robotics · doi:10.1126/scirobotics.aar4423 · Cited by 420
Metadata
- Authors
- Felfoul, O., Mohammadi, M., Taherkhani, S., de Lanauze, D., Zhong Xu, Y., Loghin, D., Essa, S., Jancik, S., Houle, D., Lafleur, M., Gaboury, L., Tabrizian, M., Kaou, N., Atkin, M., Vuong, T., Batist, G., Beauchemin, N., Radzioch, D., & Martel, S.
- Venue
- Nature Nanotechnology
- Published
- 2016-08-15
- Volume
- 11
- Issue
- 11
- Pages
- 941-947
- ISSN
- 1748-3387 (ISSN-L)
- 1748-3395
- OpenAlex
- W2515051096
- Cited by
- 1,106
- References
- 3
- FWCI
- 56.33
- Type
- journal article
- Language
- en
- Open access
- green
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- Felfoul, O., Mohammadi, M., Taherkhani, S., de Lanauze, D., Zhong Xu, Y., Loghin, D., Essa, S., Jancik, S., Houle, D., Lafleur, M., Gaboury, L., Tabrizian, M., Kaou, N., Atkin, M., Vuong, T., Batist, G., Beauchemin, N., Radzioch, D., & Martel, S. (2016). Magneto-aerotactic bacteria deliver drug-containing nanoliposomes to tumour hypoxic regions. Nature Nanotechnology. https://doi.org/10.1038/nnano.2016.137
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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