The DOI matches its Crossref record; 3 of the 3 references it cites were found in a registry or an index.
Biological measurement beyond the quantum limit
Open accessAbstract
Dynamic biological measurements require low light levels to avoid damaging the specimen. With this constraint on optical power, quantum noise fundamentally limits the measurement sensitivity. This limit can only be surpassed by extracting more information per photon by using quantum correlations. Here, we experimentally demonstrate that the quantum shot noise limit can be overcome for measurements of living systems. Quantum-correlated light with amplitude noise squeezed 75% below the vacuum level is used to perform microrheology experiments within Saccharomyces cerevisiae yeast cells. Naturally occurring lipid granules are tracked in real time as they diffuse through the cytoplasm, and the quantum noise limit is surpassed by 42%. The laser-based microparticle tracking technique used is compatible with non-classical light and is immune to low-frequency noise, leading the way to achieving a broad range of quantum-enhanced measurements in biology. Researchers use squeezed light to track the constituents of yeast cells with a performance that overcomes the quantum noise limit. This approach allows for the utilization of low optical power, which helps to minimize cell damage.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Direct observation of kinesin stepping by optical trapping interferometry
Svoboda, K., Schmidt, C. F., Schnapp, B. J., & Block, S. M. (1993) · Nature · doi:10.1038/365721a0 · Cited by 1,910
A gravitational wave observatory operating beyond the quantum shot-noise limit
The LIGO Scientific Collaboration, Abadie, J., Abbott, B. P., Abbott, R., Abbott, T. D., Abernathy, M., Adams, C., Adhikari, R., Affeldt, C., Allen, B., et al. (2011) · Nature Physics · doi:10.1038/nphys2083 · Cited by 921
Self-citationThe elusive Heisenberg limit in quantum-enhanced metrology
Demkowicz-Dobrzański, R., Kołodyński, J., & Guţă, M. (2012) · Nature Communications · doi:10.1038/ncomms2067 · Cited by 773
Cited by
Degen, C. L., Reinhard, F., & Cappellaro, P. (2017) · Reviews of Modern Physics · doi:10.1103/revmodphys.89.035002 · Cited by 4,045
Plasmonic Biosensing: Focus Review
Mejía-Salazar, J. R., & Oliveira, O. N. (2018) · Chemical Reviews · doi:10.1021/acs.chemrev.8b00359 · Cited by 544
Squeezed states of light and their applications in laser interferometers
Schnabel, R. (2017) · Physics Reports · doi:10.1016/j.physrep.2017.04.001 · Cited by 513
Quantum theory of superresolution for two incoherent optical point sources
Tsang, M., Nair, R., & Lu, X.-M. (2016) · Physical Review X · doi:10.1103/physrevx.6.031033 · Cited by 482
An entanglement-enhanced microscope
Ono, T., Okamoto, R., & Takeuchi, S. (2013) · Nature Communications · doi:10.1038/ncomms3426 · Cited by 323
Metadata
- Authors
- Taylor, M. A., Janousek, J., Daria, V., Knittel, J., Hage, B., Bachor, H.-A., & Bowen, W. P.
- Venue
- Nature Photonics
- Published
- 2013-02-03
- Volume
- 7
- Issue
- 3
- Pages
- 229-233
- ISSN
- 1749-4885 (ISSN-L)
- 1749-4893
- OpenAlex
- W2037633090
- Cited by
- 572
- References
- 3
- FWCI
- 53.37
- Type
- journal article
- Language
- en
- Open access
- green
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
How to cite
Cite CoChat for the checks on this page, and the paper for its own findings.
- This page
- CoChat. (2026). Citation check: Biological measurement beyond the quantum limit. https://app.cochat.ai/papers/10.1038/nphoton.2012.346
- The paper
- Taylor, M. A., Janousek, J., Daria, V., Knittel, J., Hage, B., Bachor, H.-A., & Bowen, W. P. (2013). Biological measurement beyond the quantum limit. Nature Photonics. https://doi.org/10.1038/nphoton.2012.346
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
