The DOI matches its Crossref record; 31 of the 31 references it cites were found in a registry or an index.
Isotropic three-dimensional super-resolution imaging with a self-bending point spread function
Open accessAbstract
Airy beams maintain their intensity profiles over a large propagation distance without substantial diffraction and exhibit lateral bending during propagation1,2,3,4,5. This unique property has been exploited for the micromanipulation of particles6, the generation of plasma channels7 and the guidance of plasmonic waves8, but has not been explored for high-resolution optical microscopy. Here, we introduce a self-bending point spread function (SB-PSF) based on Airy beams for three-dimensional super-resolution fluorescence imaging. We designed a side-lobe-free SB-PSF and implemented a two-channel detection scheme to enable unambiguous three-dimensional localization of fluorescent molecules. The lack of diffraction and the propagation-dependent lateral bending make the SB-PSF well suited for precise three-dimensional localization of molecules over a large imaging depth. Using this method, we obtained super-resolution imaging with isotropic three-dimensional localization precision of 10–15 nm over a 3 µm imaging depth from ∼2,000 photons per localization. By exploiting a self-bending point spread function based on Airy beams, a three-dimensional super-resolution fluorescence imaging is realized. A three-dimensional localization precision in the range 10–15 nm was obtained at an imaging depth of 3 µm from ∼2,000 photons per localization.
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Cites
Imaging Intracellular Fluorescent Proteins at Nanometer Resolution
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Sub-diffraction-limit imaging by stochastic optical reconstruction microscopy (STORM)
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Self-citationHandbook Of Biological Confocal Microscopy
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Hess, S. T., Girirajan, T. P. K., & Mason, M. D. (2006) · Biophysical Journal · doi:10.1529/biophysj.106.091116 · Cited by 3,605
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Three-Dimensional Super-Resolution Imaging by Stochastic Optical Reconstruction Microscopy
Huang, B., Wang, W., Bates, M., & Zhuang, X. (2008) · Science · doi:10.1126/science.1153529 · Cited by 2,796
Self-citationObservation of Accelerating Airy Beams
Siviloglou, G. A., Broky, J., Dogariu, A., & Christodoulides, D. N. (2007) · Physical Review Letters · doi:10.1103/physrevlett.99.213901 · Cited by 2,411
Accelerating finite energy Airy beams
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Cited by
Fluorescence nanoscopy in cell biology
Sahl, S. J., Hell, S. W., & Jakobs, S. (2017) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm.2017.71 · Cited by 990
Visualizing and discovering cellular structures with super-resolution microscopy
Sigal, Y. M., Zhou, R., & Zhuang, X. (2018) · Science · doi:10.1126/science.aau1044 · Cited by 718
Self-citationOptimal Point Spread Function Design for 3D Imaging
Shechtman, Y., Sahl, S. J., Backer, A. S., & Moerner, W. E. (2014) · Physical Review Letters · doi:10.1103/physrevlett.113.133902 · Cited by 384
Single-cell transcriptomic evidence for dense intracortical neuropeptide networks
Smith, S. J., Sümbül, U., Graybuck, L. T., Collman, F., Seshamani, S., Gala, R., Gliko, O., Elabbady, L., Miller, J. A., Bakken, T. E., et al. (2019) · eLife · doi:10.7554/elife.47889 · Cited by 156
Single-molecule spectroscopy and imaging over the decades
Moerner, W. E., Shechtman, Y., & Wang, Q. (2015) · Faraday Discussions · doi:10.1039/c5fd00149h · Cited by 103
Metadata
- Authors
- Jia, S., Vaughan, J. C., & Zhuang, X.
- Venue
- Nature Photonics
- Published
- 2014-03-02
- Volume
- 8
- Issue
- 4
- Pages
- 302-306
- ISSN
- 1749-4885 (ISSN-L)
- 1749-4893
- OpenAlex
- W2037000609
- Cited by
- 542
- References
- 31
- FWCI
- 26.08
- Type
- journal article
- Language
- en
- Open access
- green
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