Practice Parameter for the Use of Stimulant Medications in the Treatment of Children, Adolescents, and Adults
Abstract
This practice parameter describes treatment with stimulant medication. It uses an evidence-based medicine approach derived from a detailed literature review and expert consultation. Stimulant medications in clinical use include methylphenidate, dextroamphetamine, mixed-salts amphetamine, and pemoline. It carries FDA indications for treatment of attention-deficit/hyperactivity disorder and narcolepsy.
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Psychostimulants are the most widely researched medications for ADHD alone, but findings on their efficacy and safety in co-occurring ADHD and ASD conflict.
“Psychostimulants are the most widely researched medications used to treat ADHD alone [26], but conflicting findings have been reported regarding the efficacy and safety of stimulants in cases of co-occurring ADHD and ASD.”
From Treatment for Co-Occurring Attention Deficit/Hyperactivity Disorder and Autism Spectrum Disorder (2012) · cites this paper as [26]
Pharmacological treatment for ADHD reduces impairment from core ADHD symptoms and improves functioning in children and adults.
“Pharmacological treatment for ADHD is effective for reducing impairment associated with core ADHD symptoms (i.e., inattention, hyperactivity, impulsivity) and improving functioning in children and adults [25,26].”
From Treatment for Co-Occurring Attention Deficit/Hyperactivity Disorder and Autism Spectrum Disorder (2012) · cites this paper as [26]
Several studies indicate that combining medication with psychosocial treatment works especially well for managing ADHD symptoms.
“Multiple studies have demonstrated that combination pharmacological and psychosocial treatments are particularly effective for ADHD symptom management [26,62].”
From Treatment for Co-Occurring Attention Deficit/Hyperactivity Disorder and Autism Spectrum Disorder (2012) · cites this paper as [26]
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- Authors
- Greenhill, L. L., Pliszka, S., & Dulcan, M. K.
- Venue
- Journal of the American Academy of Child & Adolescent Psychiatry
- Publisher
- Elsevier BV
- Published
- 2002-02
- Volume
- 41
- Issue
- 2
- Pages
- 26S-49S
- ISSN
- 0890-8567 (ISSN-L)
- OpenAlex
- W2062714266
- Semantic Scholar
- ceaa70e97dbbecf204e6c78e84f580e56b6eeec0
- Cited by
- 927
- References
- 172
- Citations by year
- 2026: 3 · 2025: 11 · 2024: 15 · 2023: 8 · 2022: 11 · 2021: 17 · 2020: 172 · 2019: 14 · 2018: 15 · 2017: 22 · 2016: 30 · 2015: 22 · 2014: 43 · 2013: 31 · 2012: 34
- FWCI
- 30.71
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Journal of the American Academy of Child & Adolescent Psychiatry (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Psychiatry and Mental health › Attention Deficit Hyperactivity Disorder
- Health Sciences › Medicine › Pediatrics, Perinatology and Child Health › Pharmaceutical studies and practices
- Life Sciences › Neuroscience › Cognitive Neuroscience › Neuroethics, Human Enhancement, Biomedical Innovations
- Keywords
- stimulant medication, attention deficit hyperactivity disorder, narcolepsy, methylphenidate, d-amphetamine, amphetamine salts, pemoline, pediatric treatment, adolescents, adults
- MeSH terms
- Contraindications, Adolescent, Adult, Amphetamines, Central Nervous System Stimulants, Attention Deficit Disorder with Hyperactivity, Brain, Child, Child, Preschool, Humans, Methylphenidate, Narcolepsy, Pemoline, Psychopharmacology, Psychotropic Drugs, United States, Drug Monitoring, Evidence-Based Medicine
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
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