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Role of Adiposity-Driven Inflammation in Depressive Morbidity
Open accessAbstract
Depression and metabolic disorders, including overweight and obesity, appear tightly interrelated. The prevalence of these conditions is concurrently growing worldwide, and both depression and overweight/obesity represent substantial risk factors for multiple medical complications. Moreover, there is now multiple evidence for a bidirectional relationship between depression and increased adiposity, with overweight/obesity being associated with an increased prevalence of depression, and in turn, depression augmenting the risk of weight gain and obesity. Although the reasons for this intricate link between depression and increased adiposity remain unclear, converging clinical and preclinical evidence points to a critical role for inflammatory processes and related alterations of brain functions. In support of this notion, increased adiposity leads to a chronic low-grade activation of inflammatory processes, which have been shown elsewhere to have a potent role in the pathophysiology of depression. It is therefore highly possible that adiposity-driven inflammation contributes to the development of depressive disorders and their growing prevalence worldwide. This review will present recent evidence in support of this hypothesis and will discuss the underlying mechanisms and potential therapeutic targets. Altogether, findings presented here should help to better understand the mechanisms linking adiposity to depression and facilitate the identification of new preventive and/or therapeutic strategies.
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“These findings are consistent with the hypothesis that adiposity-driven inflammation may contribute to MDD-related morbidity (55,56).”
From Peripheral cytokine and chemokine alterations in depression: a meta‐analysis of 82 studies (2017) · cites this paper as [55]
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Metadata
- Authors
- Capuron, L., Lasselin, J., & Castanon, N.
- Affiliations
- Université de Bordeaux (FR)
- Stockholm University (SE)
- Corresponding author
- Capuron, Lucile
- Venue
- Neuropsychopharmacology
- Published
- 2016-07-11
- Volume
- 42
- Issue
- 1
- Pages
- 115-128
- ISSN
- 0893-133X (ISSN-L)
- 1740-634X
- PMC
- PMC5143483
- OpenAlex
- W2469101786
- Cited by
- 182
- References
- 247
- Citations by year
- 2026: 15 · 2025: 20 · 2024: 18 · 2023: 14 · 2022: 25 · 2021: 23 · 2020: 23 · 2019: 18 · 2018: 15 · 2017: 9 · 2016: 2
- FWCI
- 0.91
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Neuropsychopharmacology (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- HAL (submittedVersion)
- Universitätsbibliographie, Universität Duisburg-Essen (submittedVersion)
- Oskar-Bordeaux (Universite de Bordeaux) (submittedVersion)
- Funders
- Agence Nationale de la Recherche (ANR-13-NEUR-0004, ANR-11-JSV1-0006)
- Institut National de la Recherche Agronomique
- Topics
- Life Sciences › Neuroscience › Biological Psychiatry › Tryptophan and brain disorders
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Adipokines, Inflammation, and Metabolic Diseases
- Life Sciences › Neuroscience › Behavioral Neuroscience › Stress Responses and Cortisol
- Keywords
- depression, adiposity, obesity, overweight, low-grade inflammation, neuroinflammation, brain function, therapeutic target, depression prevention
- MeSH terms
- Depressive Disorder, Humans, Inflammation, Overweight
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