Cited by 182Tryptophan and brain disordersAdipokines, Inflammation, and Metabolic DiseasesStress Responses and Cortisol

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Role of Adiposity-Driven Inflammation in Depressive Morbidity

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Capuron, Lucile, Lasselin, Julie, Castanon, Nathalie·2017·Neuropsychopharmacology

DOI 10.1038/npp.2016.123PMC PMC5143483

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Abstract

Depression and metabolic disorders, including overweight and obesity, appear tightly interrelated. The prevalence of these conditions is concurrently growing worldwide, and both depression and overweight/obesity represent substantial risk factors for multiple medical complications. Moreover, there is now multiple evidence for a bidirectional relationship between depression and increased adiposity, with overweight/obesity being associated with an increased prevalence of depression, and in turn, depression augmenting the risk of weight gain and obesity. Although the reasons for this intricate link between depression and increased adiposity remain unclear, converging clinical and preclinical evidence points to a critical role for inflammatory processes and related alterations of brain functions. In support of this notion, increased adiposity leads to a chronic low-grade activation of inflammatory processes, which have been shown elsewhere to have a potent role in the pathophysiology of depression. It is therefore highly possible that adiposity-driven inflammation contributes to the development of depressive disorders and their growing prevalence worldwide. This review will present recent evidence in support of this hypothesis and will discuss the underlying mechanisms and potential therapeutic targets. Altogether, findings presented here should help to better understand the mechanisms linking adiposity to depression and facilitate the identification of new preventive and/or therapeutic strategies.

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See all 182

Authors: Capuron, L., Lasselin, J., & Castanon, N.
Affiliations: Université de Bordeaux (FR)
Stockholm University (SE)
Corresponding author: Capuron, Lucile
ORCID: Capuron, Lucile
Lasselin, Julie
Castanon, Nathalie
Venue: Neuropsychopharmacology
Publisher: Springer Science and Business Media LLC
Published: 2016-07-11
Volume: 42
Issue: 1
Pages: 115-128
ISSN: 0893-133X (ISSN-L)
1740-634X
DOI: 10.1038/npp.2016.123
PMC: PMC5143483
OpenAlex: W2469101786
Cited by: 182
References: 247
Citations by year: 2026: 15 · 2025: 20 · 2024: 18 · 2023: 14 · 2022: 25 · 2021: 23 · 2020: 23 · 2019: 18 · 2018: 15 · 2017: 9 · 2016: 2
FWCI: 0.91
Type: journal article
Language: en
Open access: bronze
doi.org
Licence: www.springer.com/tdm (tdm)
Locations: Neuropsychopharmacology (publishedVersion)
PubMed Central (publishedVersion)
PubMed (publishedVersion)
HAL (submittedVersion)
Universitätsbibliographie, Universität Duisburg-Essen (submittedVersion)
Oskar-Bordeaux (Universite de Bordeaux) (submittedVersion)
Funders: Agence Nationale de la Recherche (ANR-13-NEUR-0004, ANR-11-JSV1-0006)
Institut National de la Recherche Agronomique
Topics: Life Sciences › Neuroscience › Biological Psychiatry › Tryptophan and brain disorders
Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Adipokines, Inflammation, and Metabolic Diseases
Life Sciences › Neuroscience › Behavioral Neuroscience › Stress Responses and Cortisol
Keywords: depression, adiposity, obesity, overweight, low-grade inflammation, neuroinflammation, brain function, therapeutic target, depression prevention
MeSH terms: Depressive Disorder, Humans, Inflammation, Overweight

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Role of Adiposity-Driven Inflammation in Depressive Morbidity

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