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Role of Adiposity-Driven Inflammation in Depressive Morbidity
Open accessAbstract
Depression and metabolic disorders, including overweight and obesity, appear tightly interrelated. The prevalence of these conditions is concurrently growing worldwide, and both depression and overweight/obesity represent substantial risk factors for multiple medical complications. Moreover, there is now multiple evidence for a bidirectional relationship between depression and increased adiposity, with overweight/obesity being associated with an increased prevalence of depression, and in turn, depression augmenting the risk of weight gain and obesity. Although the reasons for this intricate link between depression and increased adiposity remain unclear, converging clinical and preclinical evidence points to a critical role for inflammatory processes and related alterations of brain functions. In support of this notion, increased adiposity leads to a chronic low-grade activation of inflammatory processes, which have been shown elsewhere to have a potent role in the pathophysiology of depression. It is therefore highly possible that adiposity-driven inflammation contributes to the development of depressive disorders and their growing prevalence worldwide. This review will present recent evidence in support of this hypothesis and will discuss the underlying mechanisms and potential therapeutic targets. Altogether, findings presented here should help to better understand the mechanisms linking adiposity to depression and facilitate the identification of new preventive and/or therapeutic strategies.
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“These findings are consistent with the hypothesis that adiposity-driven inflammation may contribute to MDD-related morbidity (55,56).”
From Peripheral cytokine and chemokine alterations in depression: a meta‐analysis of 82 studies (2017) · cites this paper as [55]
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Selenica, M.-L. B., Brownlow, M., Jimenez, J. P., Lee, D. C., Pena, G., Dickey, C. A., Gordon, M. N., & Morgan, D. (2013) · Neurodegenerative Diseases · doi:10.1159/000337230 · Cited by 10,359
Inflammation and metabolic disorders
Hotamisligil, G. S. (2006) · Nature · doi:10.1038/nature05485 · Cited by 9,199
Child abuse: Adolescent records vs. adult recall
Femina, D. D., Yeager, C. A., & Lewis, D. O. (1990) · Child Abuse & Neglect · doi:10.1016/0145-2134(90)90033-p · Cited by 8,820
Molecular Mechanisms of Depression: Perspectives on New Treatment Strategies
Lang, U. E., & Borgwardt, S. (2013) · Cellular Physiology and Biochemistry · doi:10.1159/000350094 · Cited by 8,526
The metabolic phenotype in obesity: Fat mass, body fat distribution, and adipose tissue function
Goossens, G. H. (2017) · Obesity Facts · doi:10.1159/000471488 · Cited by 8,481
Diversity of the Human Intestinal Microbial Flora
Eckburg, P. B., Bik, E. M., Bernstein, C. N., Purdom, E., Dethlefsen, L., Sargent, M., Gill, S. R., Nelson, K. E., & Relman, D. A. (2005) · Science · doi:10.1126/science.1110591 · Cited by 7,913
A core gut microbiome in obese and lean twins
Turnbaugh, P. J., Hamady, M., Yatsunenko, T., Cantarel, B. L., Duncan, A., Ley, R. E., Sogin, M. L., Jones, W. J., Roe, B. A., Affourtit, J. P., et al. (2009) · Nature · doi:10.1038/nature07540 · Cited by 7,823
Genetics of Food Intake Self-Regulation in Childhood: Literature Review and Research Opportunities
Faith, M. S., Carnell, S., & Kral, T. V. E. (2013) · Human Heredity · doi:10.1159/000353879 · Cited by 7,633
From inflammation to sickness and depression: when the immune system subjugates the brain
Dantzer, R., O'Connor, J. C., Freund, G. G., Johnson, R. W., & Kelley, K. W. (2008) · Nature Reviews Neuroscience · doi:10.1038/nrn2297 · Cited by 7,395
Xu, H., Barnes, G. T., Yang, Q., Tan, G., Yang, D., Chou, C. J., Sole, J., Nichols, A., Ross, J. S., Tartaglia, L. A., et al. (2003) · Journal of Clinical Investigation · doi:10.1172/jci200319451 · Cited by 6,760
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Kandola, A., Ashdown-Franks, G., Hendrikse, J., Sabiston, C. M., & Stubbs, B. (2019) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2019.09.040 · Cited by 1,309
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Felger, J. C., Haroon, E., Patel, T. A., Goldsmith, D. R., Wommack, E. C., Woolwine, B. J., Le, N.-A., Feinberg, R., Tansey, M. G., & Miller, A. H. (2020) · Molecular Psychiatry · doi:10.1038/s41380-018-0096-3 · Cited by 448
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Diabesity and mood disorders: Multiple links through the microbiota-gut-brain axis
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Bekhbat, M., Treadway, M. T., Goldsmith, D. R., Woolwine, B. J., Haroon, E., Miller, A. H., & Felger, J. C. (2020) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2020.03.015 · Cited by 80
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Rahimian, R., Belliveau, C., Chen, R., & Mechawar, N. (2022) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2022.871997 · Cited by 77
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Verhaegen, A. A., & Gaal, L. F. V. (2017) · Journal of Endocrinological Investigation · doi:10.1007/s40618-017-0719-6 · Cited by 75
Leyrolle, Q., Cserjési, R., Mulders, M. D. G. H., Zamariola, G., Hiel, S., Gianfrancesco, M. A., Portheault, D., Amadieu, C., Bindels, L. B., Leclercq, S., et al. (2021) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2021.01.014 · Cited by 68
Sen, Z. D., Danyeli, L. V., Woelfer, M., Lamers, F., Wagner, G., Sobanski, T., & Walter, M. (2021) · Brain, Behavior, and Immunity · doi:10.1016/j.bbi.2020.12.020 · Cited by 65
Bekhbat, M., Chu, K., Le, N., Woolwine, B. J., Haroon, E., Miller, A. H., & Felger, J. C. (2018) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2018.09.004 · Cited by 66
Lasselin, J., Karshikoff, B., Axelsson, J., Åkerstedt, T., Benson, S., Engler, H., Schedlowski, M., Jones, M., Lekander, M., & Andréasson, A. (2019) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2019.10.020 · Cited by 59
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Verhaegen, A. A., & Van Gaal, L. F. (2021) · Current Obesity Reports · doi:10.1007/s13679-020-00419-5 · Cited by 53
Demers, G., Roy, J., Machuca-Parra, A. I., Dashtehei pour, Z., Bairamian, D., Daneault, C., Rosiers, C. D., Ferreira, G., Alquier, T., Fulton, S., et al. (2020) · International Journal of Obesity · doi:10.1038/s41366-020-0623-6 · Cited by 53
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Shen, X., Zhao, Z., Wang, H., Guo, Z., Hu, B., & Zhang, G. (2017) · Mediators of Inflammation · doi:10.1155/2017/3709874 · Cited by 48
Chu, K., Cadar, D., Iob, E., & Frank, P. (2022) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2022.11.016 · Cited by 48
Goldsmith, D. R., Bekhbat, M., Le, N., Chen, X., Woolwine, B. J., Li, Z., Haroon, E., & Felger, J. C. (2020) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2020.05.013 · Cited by 46
Zagaria, A., Fiori, V., Vacca, M., Lombardo, C., Pariante, C. M., & Ballesio, A. (2024) · Journal of Affective Disorders · doi:10.1016/j.jad.2024.04.072 · Cited by 45
Sominsky, L., O’Hely, M., Drummond, K. D., Cao, S., Collier, F., Dhar, P., Loughman, A., Dawson, S. L., Tang, M. L. K., Mansell, T., et al. (2023) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2023.07.005 · Cited by 38
Delgado, I., Cussotto, S., Anesi, A., Dexpert, S., Aubert, A., Aouizerate, B., Beau, C., Forestier, D., Ledaguenel, P., Magne, E., et al. (2022) · International Journal of Obesity · doi:10.1038/s41366-021-01049-0 · Cited by 42
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Huet, L., Delgado, I., Dexpert, S., Sauvant, J., Aouizerate, B., Beau, C., Forestier, D., Ledaguenel, P., Magne, E., & Capuron, L. (2021) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2021.02.031 · Cited by 33
Self-citationCardinal, P., de Oliveira, C. M., Sauvant, J., Foury, A., Darnaudéry, M., Vancassel, S., Castanon, N., & Capuron, L. (2021) · Journal of Neuroinflammation · doi:10.1186/s12974-021-02330-9 · Cited by 31
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Navinés, R., Oriolo, G., Horrillo, I., Cavero, M., Aouizerate, B., Schaefer, M., Capuron, L., Meana, J. J., & Martín‐Santos, R. (2022) · The International Journal of Neuropsychopharmacology · doi:10.1093/ijnp/pyac016 · Cited by 28
Self-citationSchmitter, M., Spijker, J., Smit, F., Tendolkar, I., Derksen, A.-M., Oostelbos, P., Wijnen, B. F. M., van Doesum, T., Smits, J. A. J., & Vrijsen, J. N. (2020) · BMC Psychiatry · doi:10.1186/s12888-020-02989-z · Cited by 27
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Self-citationSuárez, J., Rivera, P., Rey, A. A., Pérez‐Martín, M., Arrabal, S., de Fonseca, F. R., de Azúa, I. R., & Lutz, B. (2019) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2019.104418 · Cited by 25
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do Bonfim, T. H. F., Tavares, R. L., de Vasconcelos, M. H. A., Gouveia, M., Nunes, P. C., Soares, N. L., Alves, R. C., de Carvalho, J. L. P., Alves, A. F., Pereira, R. D. A., et al. (2020) · Journal of Affective Disorders · doi:10.1016/j.jad.2020.10.034 · Cited by 25
Moisan, M., Foury, A., Dexpert, S., Cole, S. W., Beau, C., Forestier, D., Ledaguenel, P., Magne, E., & Capuron, L. (2021) · Translational Psychiatry · doi:10.1038/s41398-021-01323-9 · Cited by 22
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Teixeira, A. L., Martins, L. B., Berk, M., & Bauer, M. E. (2022) · Clinical Science · doi:10.1042/cs20211106 · Cited by 22
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Werneck, A. O., Owen, N. G., Araújo, R. H. D. O., da Silva, D. R. P., & Hallgren, M. Å. (2023) · Journal of Affective Disorders · doi:10.1016/j.jad.2023.07.053 · Cited by 23
de Oliveira, C. M., Smedt, V. D., Morael, J., Vancassel, S., Capuron, L., Gaudout, D., Pourtau, L., & Castanon, N. (2021) · Pharmaceutics · doi:10.3390/pharmaceutics13122155 · Cited by 22
Self-citationLeyrolle, Q., Cserjési, R., Demeure, R., Neyrinck, A. M., Amadieu, C., Rodriguez, J., Kärkkäinen, O. K., Hanhineva, K., Paquot, N., Cnop, M., et al. (2021) · Nutrients · doi:10.3390/nu14010147 · Cited by 19
Kohn, J. N., Cabrera, Y., Dimitrov, S., Guay-Ross, N., Pruitt, C., Shaikh, F., & Hong, S. (2019) · International Journal of Obesity · doi:10.1038/s41366-019-0375-3 · Cited by 19
Liu, H., Dong, H., Zhou, Y., Jin, M., Hao, H., Yuan, Y., & Jia, H. (2024) · Frontiers in Endocrinology · doi:10.3389/fendo.2024.1482003 · Cited by 18
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Meshkat, S., Liu, Y., Jung, H. J., Tassone, V. K., Pang, H. Y. M., Janssen‐Aguilar, R., Lou, W. Y. W., & Bhat, V. (2024) · Psychiatry Research · doi:10.1016/j.psychres.2023.115709 · Cited by 18
Perna, L., Trares, K., Perneczky, R., Tatò, M., Stocker, H. R., Möllers, T., Holleczek, B., Schöttker, B., & Brenner, H. (2021) · American Journal of Geriatric Psychiatry · doi:10.1016/j.jagp.2021.12.001 · Cited by 20
Simpson, S., Taylor, K. L., Jelinek, G. A., Livera, A. M. D., Brown, C. R., O’Kearney, E., Neate, S. L., Bevens, W., & Weiland, T. J. (2019) · Multiple Sclerosis and Related Disorders · doi:10.1016/j.msard.2019.02.014 · Cited by 18
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Veibäck, G. S., Lindahl, J., Suneson, K., Tjernberg, J., Ståhl, D., Landberg, R., Asp, M., Kjellberg, A., Falknäs, F., Sjöberg, K., et al. (2025) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2025.06.002 · Cited by 21
Nicolas, S., Chabry, J., Guyon, A., Zarif, H., Heurteaux, C., & Petit-Paitel, A. (2018) · médecine/sciences · doi:10.1051/medsci/20183405014 · Cited by 17
Verbiest, I., Michels, N., Tanghe, A., & Braet, C. (2021) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2021.07.020 · Cited by 23
Christensen, S. M., Varney, C., Gupta, V., Wenz, L., & Bays, H. E. (2022) · Obesity Pillars · doi:10.1016/j.obpill.2022.100041 · Cited by 16
Kotlęga, D., Zembroń-Łacny, A., Gołąb-Janowska, M., Nowacki, P., & Szczuko, M. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21155220 · Cited by 17
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Metadata
- Authors
- Capuron, L., Lasselin, J., & Castanon, N.
- Affiliations
- Université de Bordeaux (FR)
- Stockholm University (SE)
- Corresponding author
- Capuron, Lucile
- Venue
- Neuropsychopharmacology
- Published
- 2016-07-11
- Volume
- 42
- Issue
- 1
- Pages
- 115-128
- ISSN
- 0893-133X (ISSN-L)
- 1740-634X
- PMC
- PMC5143483
- OpenAlex
- W2469101786
- Cited by
- 182
- References
- 247
- Citations by year
- 2026: 15 · 2025: 20 · 2024: 18 · 2023: 14 · 2022: 25 · 2021: 23 · 2020: 23 · 2019: 18 · 2018: 15 · 2017: 9 · 2016: 2
- FWCI
- 0.91
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Neuropsychopharmacology (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- HAL (submittedVersion)
- Universitätsbibliographie, Universität Duisburg-Essen (submittedVersion)
- Oskar-Bordeaux (Universite de Bordeaux) (submittedVersion)
- Funders
- Agence Nationale de la Recherche (ANR-13-NEUR-0004, ANR-11-JSV1-0006)
- Institut National de la Recherche Agronomique
- Topics
- Life Sciences › Neuroscience › Biological Psychiatry › Tryptophan and brain disorders
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Adipokines, Inflammation, and Metabolic Diseases
- Life Sciences › Neuroscience › Behavioral Neuroscience › Stress Responses and Cortisol
- Keywords
- depression, adiposity, obesity, overweight, low-grade inflammation, neuroinflammation, brain function, therapeutic target, depression prevention
- MeSH terms
- Depressive Disorder, Humans, Inflammation, Overweight
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