CoChat
Sign Up
Cited by 24Neurotransmitter Receptor Influence on BehaviorEating Disorders and BehaviorsRegulation of Appetite and Obesity

Trace Amine Associated Receptor 1 (TAAR1) Modulation of Food Reward

Open access
Moore, Catherine F., Sabino, Valentina, Cottone, Pietro·2018·Frontiers in Pharmacology
DOI 10.3389/fphar.2018.00129PMC PMC5835105
Open this paper in CoChat — free accountOpen PDF

Abstract

Eating disorders and some forms of obesity are characterized by addictive-like, compulsive eating behavior which contains numerous similarities with compulsive drug use. Food intake is in part mediated by reward and reinforcement processes that can become dysregulated in these disorders. Additionally, impairments in inhibitory control regulation of reward-related responding can cause or further exacerbate binge and compulsive eating. Dysfunctions in two neurotransmitter systems in the mesocorticolimbic pathway, dopamine and glutamate, are thought to contribute to maladaptive eating behaviors. The trace amine associated receptor 1 (TAAR1) system is a promising therapeutic target for compulsive eating behavior due to the role of TAAR1 in synaptic transmission and in the modulation of dopaminergic and glutamatergic signaling. In support of this notion, the TAAR1 agonist RO5256390 was found to decrease the reinforcing effects of palatable food-cues and to reduce binge-like and compulsive-like eating of palatable food. Additionally, prolonged, intermittent access to palatable food was shown to downregulate TAAR1 in the prefrontal cortex, suggesting a potential role for TAAR1 signaling in inhibitory control processes. Research into the role of TAAR1 in addiction, including TAAR1's ability to modulate psychostimulant reward and reinforcement, bolsters support for TAAR1 agonism as a pharmacological treatment for compulsive eating and other addictive behaviors. This review summarizes the evidence for TAAR1 agonism as a promising therapeutic for compulsive eating behavior as well as the hypothesized mechanism responsible for these effects.

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

A few free checks a day · papers already verified open instantly · results are public

Integrity signals

Registry

Crossref · 10.3389/fphar.2018.00129

Cites

8 of 8 references verified0 citation errors · 0 not checkable

Statistics

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

A few free checks a day · papers already verified open instantly · results are public

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

  • LDX is a specific agonist of TAAR1, a protein involved in DA pathway modulation.

    “LDX is also a specific agonist of TAAR1 [169], a protein involved in DA pathway modulation [170].”

    From Molecular Characterisation of the Mechanism of Action of Stimulant Drugs Lisdexamfetamine and Methylphenidate on ADHD Neurobiology: A Review (2022) · cites this paper as [169]

    The Discussion and Conclusions section (page unavailable) says that amphetamine, the active metabolite of LDX, activates TAAR1 and suggests that LDX and TAAR1 agonism may work through similar mechanisms. It does not establish that LDX itself is a specific TAAR1 agonist. The separate dopamine-pathway clause is attached to citation [170], not this source. (LLM, conf=0.86)

    Experimental — accuracy not yet measured

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

Cites

Flagged first, then by citations

Research works printed but not linked: 73

  1. American Psychiatric Association (2013). Diagnostic and Statistical Manual of Mental Disorders. Washington, DC: American Psychiatric Association 10.1176/appi.books.9780890425596 · DOI · Paper page
  2. Avena N. M. Rada P. Hoebel B. G. (2008). Evidence for sugar addiction: behavioral and neurochemical effects of intermittent, excessive sugar intake. Neurosci. Biobehav. Rev. 32 20– 39. 10.1016/j.neubiorev.2007.04.019 17617461 PMC2235907 · DOI · Paper page
  3. Balodis I. M. Molina N. D. Kober H. Worhunsky P. D. White M. A. Rajita S. (2013). Divergent neural substrates of inhibitory control in binge eating disorder relative to other manifestations of obesity. Obesity 21 367– 377. 10.1002/oby.20068 23404820 PMC3610836 · DOI
  4. Banca P. Harrison N. A. Voon V. (2016). Compulsivity across the pathological misuse of drug and non-drug rewards. Front. Behav. Neurosci. 10: 154. 10.3389/fnbeh.2016.00154 27536223 PMC4971057 · DOI
  5. Barker J. M. Taylor J. R. Chandler L. J. (2014). A unifying model of the role of the infralimbic cortex in extinction and habits. Learn. Mem. 21 441– 448. 10.1101/lm.035501.114 25128534 PMC4138355 · DOI
  6. Belin D. Mar A. C. Dalley J. W. Robbins T. W. Everitt B. J. (2008). High impulsivity predicts the switch to compulsive cocaine-taking. Science 320 1352– 1355. 10.1126/science.1158136 18535246 PMC2478705 · DOI · Paper page
  7. Berger D. F. Sagvolden T. (1998). Sex differences in operant discrimination behaviour in an animal model of attention-deficit hyperactivity disorder. Behav. Brain Res. 94 73– 82. 10.1016/S0166-4328(97)00171-X 9708841 · DOI
  8. Blasio A. Iemolo A. Sabino V. Petrosino S. Steardo L. Rice K. C. (2013). Rimonabant precipitates anxiety in rats withdrawn from palatable food: role of the central amygdala. Neuropsychopharmacology 38 2498– 2507. 10.1038/npp.2013.153 23793355 PMC3799070 · DOI
  9. Borowsky B. Adham N. Jones K. A. Raddatz R. Artymyshyn R. Ogozalek K. L. (2001). Trace amines: identification of a family of mammalian G protein-coupled receptors. Proc. Natl. Acad. Sci. U.S.A. 98 8966– 8971. 10.1073/pnas.151105198 11459929 PMC55357 · DOI
  10. Bradaia A. Trube G. Stalder H. Norcross R. D. Ozmen L. Wettstein J. G. (2009). The selective antagonist EPPTB reveals TAAR1-mediated regulatory mechanisms in dopaminergic neurons of the mesolimbic system. Proc. Natl. Acad. Sci. U.S.A. 106 20081– 20086. 10.1073/pnas.0906522106 19892733 PMC2785295 · DOI
  11. Corwin R. L. Avena N. M. Boggiano M. M. (2011). Feeding and reward: perspectives from three rat models of binge eating. Physiol. Behav. 104 87– 97. 10.1016/j.physbeh.2011.04.041 21549136 PMC3132131 · DOI
  12. Cottone P. Sabino V. Steardo L. Zorrilla E. P. (2008). Opioid-dependent anticipatory negative contrast and binge-like eating in rats with limited access to highly preferred food. Neuropsychopharmacology 33 524– 535. 10.1038/sj.npp.1301430 17443124 · DOI
  13. Cottone P. Wang X. Park J. W. Valenza M. Blasio A. Kwak J. (2012). Antagonism of sigma-1 receptors blocks compulsive-like eating. Neuropsychopharmacology 37 2593– 2604. 10.1038/npp.2012.89 22713906 PMC3473342 · DOI
  14. Cowdrey F. A. Park R. J. Harmer C. J. McCabe C. (2011). Increased neural processing of rewarding and aversive food stimuli in recovered anorexia nervosa. Biol. Psychiatry 70 736– 743. 10.1016/j.biopsych.2011.05.028 21714958 · DOI · Paper page
  15. Dalley J. W. Everitt B. J. Robbins T. W. (2011). Impulsivity, compulsivity, and top-down cognitive control. Neuron 69 680– 694. 10.1016/j.neuron.2011.01.020 21338879 · DOI · Paper page
  16. Davis C. (2013a). From passive overeating to “food addiction”: a spectrum of compulsion and severity. ISRN Obes. 2013: 435027. 10.1155/2013/435027 24555143 PMC3901973 · DOI
  17. Davis C. (2013b). A narrative review of binge eating and addictive behaviors: shared associations with seasonality and personality factors. Front. Psychiatry 4: 183. 10.3389/fpsyt.2013.00183 24409156 PMC3873524 · DOI
  18. Davis C. Carter J. C. (2009). Compulsive overeating as an addiction disorder. A review of theory and evidence. Appetite 53 1– 8. 10.1016/j.appet.2009.05.018 19500625 · DOI
  19. de Zwaan M. (2001). Binge eating disorder and obesity. Int. J. Obes. Relat. Metab. Disord. 25(Suppl. 1) S51– S55. 10.1038/sj.ijo.0801699 11466589 · DOI · Paper page
  20. Dingemans A. E. van Furth E. F. (2012). Binge Eating Disorder psychopathology in normal weight and obese individuals. Int. J. Eat. Disord. 45 135– 138. 10.1002/eat.20905 22170025 · DOI
  21. Dore R. Valenza M. Wang X. Rice K. C. Sabino V. Cottone P. (2014). The inverse agonist of CB1 receptor SR141716 blocks compulsive eating of palatable food. Addict. Biol. 19 849– 861. 10.1111/adb.12056 23587012 PMC3720761 · DOI
  22. Espinoza S. Lignani G. Caffino L. Maggi S. Sukhanov I. Leo D. (2015). TAAR1 modulates cortical glutamate NMDA receptor function. Neuropsychopharmacology 40 2217– 2227. 10.1038/npp.2015.65 25749299 PMC4613611 · DOI
  23. Everitt B. J. Robbins T. W. (2000). Second-order schedules of drug reinforcement in rats and monkeys: measurement of reinforcing efficacy and drug-seeking behaviour. Psychopharmacology 153 17– 30. 10.1007/s002130000566 11255926 · DOI
  24. Everitt B. J. Robbins T. W. (2005). Neural systems of reinforcement for drug addiction: from actions to habits to compulsion. Nat. Neurosci. 8 1481– 1489. 10.1038/nn1579 16251991 · DOI · Paper page
  25. Ferguson K. J. Spitzer R. L. (1995). Binge eating disorder in a community-based sample of successful and unsuccessful dieters. Int. J. Eat. Disord. 18 167– 172. 7581419
  26. Ferragud A. Howell A. D. Moore C. F. Ta T. L. Hoener M. C. Sabino V. (2017). The trace amine-associated receptor 1 agonist RO5256390 blocks compulsive, binge-like eating in rats. Neuropsychopharmacology 42 1458– 1470. 10.1038/npp.2016.233 27711047 PMC5436108 · DOI
  27. Flament M. F. Bissada H. Spettigue W. (2012). Evidence-based pharmacotherapy of eating disorders. Int. J. Neuropsychopharmacol. 15 189– 207. 10.1017/S1461145711000381 21414249 · DOI
  28. Gearhardt A. N. Corbin W. R. Brownell K. D. (2009). Preliminary validation of the Yale Food Addiction Scale. Appetite 52 430– 436. 10.1016/j.appet.2008.12.003 19121351 · DOI · Paper page
  29. Giuliano C. Cottone P. (2015). The role of the opioid system in binge eating disorder. CNS Spectr. 20 537– 545. 10.1017/S1092852915000668 26499083 PMC4831059 · DOI · Paper page
  30. Giuliano C. Robbins T. W. Nathan P. J. Bullmore E. T. Everitt B. J. (2012). Inhibition of opioid transmission at the μ-opioid receptor prevents both food seeking and binge-like eating. Neuropsychopharmacology 37 2643– 2652. 10.1038/npp.2012.128 22805601 PMC3473330 · DOI
  31. Goodman D. W. (2010). Lisdexamfetamine dimesylate (vyvanse), a prodrug stimulant for attention-deficit/hyperactivity disorder. P T 35 273– 287. 20514273 PMC2873712
  32. Harkness J. H. Shi X. Janowsky A. Phillips T. J. (2015). Trace amine-associated receptor 1 regulation of methamphetamine intake and related traits. Neuropsychopharmacology 40 2175– 2184. 10.1038/npp.2015.61 25740289 PMC4613607 · DOI
  33. Hendrikse J. J. Cachia R. L. Kothe E. J. McPhie S. Skouteris H. Hayden M. J. (2015). Attentional biases for food cues in overweight and individuals with obesity: a systematic review of the literature. Obes. Rev. 16 424– 432. 10.1111/obr.12265 25752592 · DOI
  34. Hone-Blanchet A. Fecteau S. (2014). Overlap of food addiction and substance use disorders definitions: analysis of animal and human studies. Neuropharmacology 85 81– 90. 10.1016/j.neuropharm.2014.05.019 24863044 · DOI
  35. Hudson J. I. McElroy S. L. Ferreira-Cornwell M. C. Radewonuk J. Gasior M. (2017). Efficacy of lisdexamfetamine in adults with moderate to severe binge-eating disorder: a randomized clinical trial. JAMA Psychiatry 74 903– 910. 10.1001/jamapsychiatry.2017.1889 28700805 PMC5710231 · DOI · Paper page
  36. Iemolo A. Blasio A. St Cyr S. A. Jiang F. Rice K. C. Sabino V. (2013). CRF-CRF1 receptor system in the central and basolateral nuclei of the amygdala differentially mediates excessive eating of palatable food. Neuropsychopharmacology 38 2456– 2466. 10.1038/npp.2013.147 23748225 PMC3799065 · DOI
  37. Jentsch J. D. Taylor J. R. (1999). Impulsivity resulting from frontostriatal dysfunction in drug abuse: implications for the control of behavior by reward-related stimuli. Psychopharmacology 146 373– 390. 10.1007/PL00005483 10550488 · DOI · Paper page
  38. Lehnert T. Sonntag D. Konnopka A. Riedel-Heller S. Konig H. H. (2013). Economic costs of overweight and obesity. Best Pract. Res. Clin. Endocrinol. Metab. 27 105– 115. 10.1016/j.beem.2013.01.002 23731873 · DOI
  39. Liu J. F. Siemian J. N. Seaman R. Jr. Zhang Y. Li J. X. (2017). Role of TAAR1 within the subregions of the mesocorticolimbic dopaminergic system in cocaine-seeking behavior. J. Neurosci. 37 882– 892. 10.1523/JNEUROSCI.2006-16.2016 28123023 PMC5296782 · DOI
  40. Liu J. F. Thorn D. A. Zhang Y. Li J. X. (2016). Effects of trace amine-associated receptor 1 agonists on the expression, reconsolidation, and extinction of cocaine reward memory. Int. J. Neuropsychopharmacol. 19: pyw009. 10.1093/ijnp/pyw009 26822713 PMC4966273 · DOI
  41. Meule A. Lutz A. Vogele C. Kubler A. (2012). Women with elevated food addiction symptoms show accelerated reactions, but no impaired inhibitory control, in response to pictures of high-calorie food-cues. Eat. Behav. 13 423– 428. 10.1016/j.eatbeh.2012.08.001 23121803 · DOI
  42. Miller G. M. Verrico C. D. Jassen A. Konar M. Yang H. Panas H. (2005). Primate trace amine receptor 1 modulation by the dopamine transporter. J. Pharmacol. Exp. Ther. 313 983– 994. 10.1124/jpet.105.084459 15764732 · DOI
  43. Moore C. F. Panciera J. I. Sabino V. Cottone P. (2017a). Neuropharmacology of compulsive eating. Philos. Trans. R. Soc. Lond. B Biol. Sci. 373: 20170024. 10.1098/rstb.2017.0024 29352024 PMC5790823 · DOI
  44. Moore C. F. Sabino V. Koob G. F. Cottone P. (2017b). Neuroscience of compulsive eating behavior. Front. Neurosci. 11: 469 10.3389/fnins.2017.00469 PMC5573809 28883784 · DOI
  45. Moorman D. E. James M. H. McGlinchey E. M. Aston-Jones G. (2015). Differential roles of medial prefrontal subregions in the regulation of drug seeking. Brain Res. 1628(Pt A) 130– 146. 10.1016/j.brainres.2014.12.024 25529632 PMC4472631 · DOI
  46. Morris M. J. Beilharz J. E. Maniam J. Reichelt A. C. Westbrook R. F. (2015). Why is obesity such a problem in the 21st century? The intersection of palatable food, cues and reward pathways, stress, and cognition. Neurosci. Biobehav. Rev. 58 36– 45. 10.1016/j.neubiorev.2014.12.002 25496905 · DOI
  47. Myers K. P. (2017). Sensory-specific satiety is intact in rats made obese on a high-fat high-sugar choice diet. Appetite 112 196– 200. 10.1016/j.appet.2017.01.013 28089926 · DOI
  48. Ng L. Davis C. (2013). Cravings and food consumption in Binge Eating Disorder. Eat. Behav. 14 472– 475. 10.1016/j.eatbeh.2013.08.011 24183139 · DOI
  49. Nieh E. H. Matthews G. A. Allsop S. A. Presbrey K. N. Leppla C. A. Wichmann R. (2015). Decoding neural circuits that control compulsive sucrose seeking. Cell 160 528– 541. 10.1016/j.cell.2015.01.003 25635460 PMC4312417 · DOI · Paper page
  50. Pei Y. Asif-Malik A. Hoener M. Canales J. J. (2017). A partial trace amine-associated receptor 1 agonist exhibits properties consistent with a methamphetamine substitution treatment. Addict. Biol. 22 1246– 1256. 10.1111/adb.12410 27193165 · DOI
  51. Pei Y. Lee J. Leo D. Gainetdinov R. R. Hoener M. C. Canales J. J. (2014). Activation of the trace amine-associated receptor 1 prevents relapse to cocaine seeking. Neuropsychopharmacology 39 2299– 2308. 10.1038/npp.2014.88 24722355 PMC4138750 · DOI
  52. Pei Y. Mortas P. Hoener M. C. Canales J. J. (2015). Selective activation of the trace amine-associated receptor 1 decreases cocaine’s reinforcing efficacy and prevents cocaine-induced changes in brain reward thresholds. Prog. Neuropsychopharmacol. Biol. Psychiatry 63 70– 75. 10.1016/j.pnpbp.2015.05.014 26048337 · DOI
  53. Raab S. Wang H. Uhles S. Cole N. Alvarez-Sanchez R. Kunnecke B. (2016). Incretin-like effects of small molecule trace amine-associated receptor 1 agonists. Mol. Metab. 5 47– 56. 10.1016/j.molmet.2015.09.015 26844206 PMC4703809 · DOI
  54. Rada P. Avena N. M. Hoebel B. G. (2005). Daily bingeing on sugar repeatedly releases dopamine in the accumbens shell. Neuroscience 134 737– 744. 10.1016/j.neuroscience.2005.04.043 15987666 · DOI
  55. Revel F. G. Moreau J. L. Gainetdinov R. R. Bradaia A. Sotnikova T. D. Mory R. (2011). TAAR1 activation modulates monoaminergic neurotransmission, preventing hyperdopaminergic and hypoglutamatergic activity. Proc. Natl. Acad. Sci. U.S.A. 108 8485– 8490. 10.1073/pnas.1103029108 21525407 PMC3101002 · DOI
  56. Revel F. G. Moreau J. L. Gainetdinov R. R. Ferragud A. Velazquez-Sanchez C. Sotnikova T. D. (2012). Trace amine-associated receptor 1 partial agonism reveals novel paradigm for neuropsychiatric therapeutics. Biol. Psychiatry 72 934– 942. 10.1016/j.biopsych.2012.05.014 22705041 · DOI
  57. Revel F. G. Moreau J. L. Pouzet B. Mory R. Bradaia A. Buchy D. (2013). A new perspective for schizophrenia: TAAR1 agonists reveal antipsychotic- and antidepressant-like activity, improve cognition and control body weight. Mol. Psychiatry 18 543– 556. 10.1038/mp.2012.57 22641180 · DOI
  58. Robbins T. W. Curran H. V. de Wit H. (2012). Special issue on impulsivity and compulsivity. Psychopharmacology 219 251– 252. 10.1007/s00213-011-2584-x 22124671 · DOI
  59. Robinson M. J. Burghardt P. R. Patterson C. M. Nobile C. W. Akil H. Watson S. J. (2015). Individual differences in cue-induced motivation and striatal systems in rats susceptible to diet-induced obesity. Neuropsychopharmacology 40 2113– 2123. 10.1038/npp.2015.71 25761571 PMC4613617 · DOI
  60. Rossetti C. Spena G. Halfon O. Boutrel B. (2014). Evidence for a compulsive-like behavior in rats exposed to alternate access to highly preferred palatable food. Addict. Biol. 19 975– 985. 10.1111/adb.12065 23654201 · DOI
  61. Schmitz F. Naumann E. Trentowska M. Svaldi J. (2014). Attentional bias for food cues in binge eating disorder. Appetite 80 70– 80. 10.1016/j.appet.2014.04.023 24816319 · DOI
  62. Shank L. M. Tanofsky-Kraff M. Nelson E. E. Shomaker L. B. Ranzenhofer L. M. Hannallah L. M. (2015). Attentional bias to food cues in youth with loss of control eating. Appetite 87 68– 75. 10.1016/j.appet.2014.11.027 25435490 PMC4333006 · DOI
  63. Smith K. L. Rao R. R. Velazquez-Sanchez C. Valenza M. Giuliano C. Everitt B. J. (2015). The uncompetitive N-methyl-D-aspartate antagonist memantine reduces binge-like eating, food-seeking behavior, and compulsive eating: role of the nucleus accumbens shell. Neuropsychopharmacology 40 1163– 1171. 10.1038/npp.2014.299 25381776 PMC4367459 · DOI
  64. Thorn D. A. Jing L. Qiu Y. Gancarz-Kausch A. M. Galuska C. M. Dietz D. M. (2014). Effects of the trace amine-associated receptor 1 agonist RO5263397 on abuse-related effects of cocaine in rats. Neuropsychopharmacology 39 2309– 2316. 10.1038/npp.2014.91 24743376 PMC4138753 · DOI
  65. Tomasi D. Volkow N. D. (2013). Striatocortical pathway dysfunction in addiction and obesity: differences and similarities. Crit. Rev. Biochem. Mol. Biol. 48 1– 19. 10.3109/10409238.2012.735642 23173916 PMC3557663 · DOI
  66. van Huijstee A. N. Mansvelder H. D. (2014). Glutamatergic synaptic plasticity in the mesocorticolimbic system in addiction. Front. Cell. Neurosci. 8: 466 10.3389/fncel.2014.00466 PMC4299443 25653591 · DOI
  67. Velazquez-Sanchez C. Ferragud A. Moore C. F. Everitt B. J. Sabino V. Cottone P. (2014). High trait impulsivity predicts food addiction-like behavior in the rat. Neuropsychopharmacology 39 2463– 2472. 10.1038/npp.2014.98 24776685 PMC4138758 · DOI
  68. Velazquez-Sanchez C. Santos J. W. Smith K. L. Ferragud A. Sabino V. Cottone P. (2015). Seeking behavior, place conditioning, and resistance to conditioned suppression of feeding in rats intermittently exposed to palatable food. Behav. Neurosci. 129 219– 224. 10.1037/bne0000042 25798634 PMC4456453 · DOI
  69. Vickers S. P. Goddard S. Brammer R. J. Hutson P. H. Heal D. J. (2017). Investigation of impulsivity in binge-eating rats in a delay-discounting task and its prevention by the d-amphetamine prodrug, lisdexamfetamine. J. Psychopharmacol. 31 784– 797. 10.1177/0269881117691672 28372478 · DOI
  70. Volkow N. D. Wise R. A. (2005). How can drug addiction help us understand obesity? Nat. Neurosci. 8 555– 560. 10.1038/nn1452 15856062 · DOI · Paper page
  71. Whiteford H. A. Degenhardt L. Rehm J. Baxter A. J. Ferrari A. J. Erskine H. E. (2013). Global burden of disease attributable to mental and substance use disorders: findings from the Global Burden of Disease Study 2010. Lancet 382 1575– 1586. 10.1016/S0140-6736(13)61611-6 23993280 · DOI · Paper page
  72. World Health Organization (2000). Obesity: Preventing and Managing the Global Epidemic. Report of a WHO consultation. WHO Technical Report Series 894 Geneva: World Health Organization. 11234459
  73. Xie Z. Westmoreland S. V. Bahn M. E. Chen G. L. Yang H. Vallender E. J. (2007). Rhesus monkey trace amine-associated receptor 1 signaling: enhancement by monoamine transporters and attenuation by the D2 autoreceptor in vitro. J. Pharmacol. Exp. Ther. 321 116– 127. 10.1124/jpet.106.116863 17234900 · DOI

Cited by

Sorted by citations

Authors
Moore, C. F., Sabino, V., & Cottone, P.
Affiliations
Boston University (US)
Corresponding author
Cottone, Pietro
ORCID
Venue
Frontiers in Pharmacology
Publisher
Frontiers Media SA
Published
2018-02-27
Volume
9
Pages
129-129
ISSN
1663-9812 (ISSN-L)
DOI
10.3389/fphar.2018.00129
PMC
PMC5835105
OpenAlex
W2793967543
Cited by
24
References
8
Citations by year
2026: 1 · 2025: 3 · 2024: 1 · 2023: 6 · 2022: 4 · 2021: 2 · 2020: 3 · 2019: 3 · 2018: 1
FWCI
0.29
Type
journal article
Language
en
Open access
Licence
Locations
  • Frontiers in Pharmacology (publishedVersion, cc-by)
  • Europe PMC (PubMed Central) (publishedVersion, cc-by)
  • PubMed Central (publishedVersion, cc-by)
  • PubMed (publishedVersion)
  • DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
Funders
  • National Institutes of Health (DA030425, DA044664, MH091945, MH093650, AA024439, AA025038)
  • Burroughs Wellcome Fund (1011479)
Topics
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
  • Social Sciences › Psychology › Clinical Psychology › Eating Disorders and Behaviors
  • Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Regulation of Appetite and Obesity
Keywords
TAAR1, TAAR1 agonists, food reward, compulsive eating, binge eating, eating disorders, obesity, inhibitory control, mesocorticolimbic pathway, dopamine, glutamate, prefrontal cortex, addiction

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review