Cited by 27Eating Disorders and BehaviorsAdvanced Neuroimaging Techniques and ApplicationsNeural and Behavioral Psychology Studies

Human habit neural circuitry may be perturbed in eating disorders

Wang, Allan R., Kuijper, Fiene Marie, Barbosa, Daniel A. N., Hagan, Kelsey E., Lee, Eric, Tong, Elizabeth, Choi, Eun Young, McNab, Jennifer A. +2 more·2023·Science Translational Medicine

Abstract

Circuit-based mechanisms mediating the development and execution of habitual behaviors involve complex cortical-striatal interactions that have been investigated in animal models and more recently in humans. However, how human brain circuits implicated in habit formation may be perturbed in psychiatric disorders remains unclear. First, we identified the locations of the sensorimotor putamen and associative caudate in the human brain using probabilistic tractography from Human Connectome Project data. We found that multivariate connectivity of the sensorimotor putamen was altered in humans with binge eating disorder and bulimia nervosa and that the degree of alteration correlated with severity of disordered eating behavior. Furthermore, the extent of this circuit aberration correlated with mean diffusivity in the sensorimotor putamen and decreased basal dopamine D 2/3 receptor binding potential in the striatum, consistent with previously reported microstructural changes and dopamine signaling mediating habit learning in animal models. Our findings suggest a neural circuit that links habit learning and binge eating behavior in humans, which could, in part, explain the treatment-resistant behavior common to eating disorders and other psychiatric conditions.

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Crossref · 10.1126/scitranslmed.abo4919

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93 of 93 references verified0 citation errors · 0 not checkable

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  • Symptom-related, cue-induced hyperactivity in OFC and increased functional connectivity between OFC and striatum have been reported in patients with compulsive disorders.

    “Symptom-related, cue-induced hyperactivity in the OFC and increased functional connectivity between the OFC and striatum have been reported in patients with compulsive disorders69–72.”

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Authors
Wang, A. R., Kuijper, F. M., Barbosa, D. A. N., Hagan, K. E., Lee, E., Tong, E., Choi, E. Y., McNab, J. A., Bohon, C., & Halpern, C. H.
Affiliations
  • Stanford Medicine (US)
  • Université Paris Cité (FR)
  • Pennsylvania Hospital (US)
Corresponding author
  • Bohon, Cara
  • Halpern, Casey H.
Venue
Science Translational Medicine
Published
2023-03-29
Volume
15
Issue
689
Pages
eabo4919-eabo4919
ISSN
  • 1946-6234 (ISSN-L)
  • 1946-6242
OpenAlex
W4361302969
Cited by
27
References
93
Citations by year
2026: 10 · 2025: 9 · 2024: 6 · 2023: 2
FWCI
7.87
Type
journal article
Language
en
Open access
closed
Locations
  • Science Translational Medicine (publishedVersion)
  • PubMed (publishedVersion)
Funders
National Institute of Mental Health (K23MH106794)
Topics
  • Social Sciences › Psychology › Clinical Psychology › Eating Disorders and Behaviors
  • Health Sciences › Medicine › Radiology, Nuclear Medicine and Imaging › Advanced Neuroimaging Techniques and Applications
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Neural and Behavioral Psychology Studies
Keywords
eating disorders, binge eating disorder, bulimia nervosa, habit learning, probabilistic tractography, mean diffusivity, disordered eating
MeSH terms
Animals, Feeding and Eating Disorders, Brain, Dopamine, Habits, Humans, Bulimia Nervosa

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