Dysfunction of Microglial STAT3 Alleviates Depressive Behavior via Neuron–Microglia Interactions
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SOCS2 is involved in STAT3 pathway activation and can mediate microglial polarization regulation.
“We identified miR-9-5p binding sites in the 3'-UTR of SOCS2 mRNA (Fig. 5a), which was involved in STAT3 pathway activation and able to mediate microglial polarization regulation [35–37].”
From Neuron secrete exosomes containing miR-9-5p to promote polarization of M1 microglia in depression (2022) · cites this paper as [35]
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Synaptic Dysfunction in Depression: Potential Therapeutic Targets
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“As neuronal mechanisms of depression, the increased synaptic transmission could be a potent mechanism from a therapeutic point of view (Duman and Aghajanian, 2012a).”
BackgroundCytokines and major depression
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Microglia and neuroinflammation: a pathological perspective
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Layer V cortical neurons require microglial support for survival during postnatal development
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“Recent studies showed that neuroinflammation caused by stress-induced activation of microglia leads to depressive-like behaviors (Brites and Fernandes, 2015; Steiner et al, 2011; Streit et al, 2004).”
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Sorted by citations
Neuron secrete exosomes containing miR-9-5p to promote polarization of M1 microglia in depression
Xian, X., Cai, L.-L., Li, Y., Wang, R.-C., Xu, Y.-H., Chen, Y.-J., Xie, Y.-H., Zhu, X.-L., & Li, Y.-F. (2022) · Journal of Nanobiotechnology · doi:10.1186/s12951-022-01332-w · Cited by 169 · see citing works
Yang, G., Xu, X., Gao, W., Wang, X., Zhao, Y., & Xu, Y. (2025) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2025.1700692 · Cited by 85 · see citing works
miR-124 ameliorates depressive-like behavior by targeting STAT3 to regulate microglial activation
Lou, D., Wang, J., & Wang, X. (2019) · Molecular and Cellular Probes · doi:10.1016/j.mcp.2019.101470 · Cited by 58 · see citing works
- Authors
- Kwon, S.-H., Han, J.-K., Choi, M., Kwon, Y.-J., Kim, S. J., Yi, E. H., Shin, J.-C., Cho, I.-H., Kim, B.-H., Jeong Kim, S., & Ye, S.-K.
- Venue
- Neuropsychopharmacology
- Published
- 2017-05-08
- Volume
- 42
- Issue
- 10
- Pages
- 2072-2086
- ISSN
- 0893-133X
- 1740-634X
- PMC
- PMC5561349
- Cited by
- 64
- References
- 11
- Language
- en
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