Microglia-orchestrated neuroinflammation and synaptic remodeling: roles of pro-inflammatory cytokines and receptors in neurodegeneration

Fate Mapping Analysis Reveals That Adult Microglia Derive from Primitive Macrophages

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The TREM2-APOE Pathway Drives the Transcriptional Phenotype of Dysfunctional Microglia in Neurodegenerative Diseases

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Microglia states and nomenclature: A field at its crossroads

Paolicelli, R. C., Sierra, A., Stevens, B., Tremblay, M.-E., Aguzzi, A., Ajami, B., Amit, I., Audinat, E., Bechmann, I., Bennett, M., et al. (2022) · Neuron · doi:10.1016/j.neuron.2022.10.020 · Cited by 1,973 · see citing works

NLRP3 inflammasome activation drives tau pathology

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Immune modulation of learning, memory, neural plasticity and neurogenesis

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Interleukin-6, a Major Cytokine in the Central Nervous System

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Unexpected role of interferon-γ in regulating neuronal connectivity and social behaviour

Filiano, A. J., Xu, Y., Tustison, N. J., Marsh, R. L., Baker, W., Smirnov, I., Overall, C. C., Gadani, S. P., Turner, S. D., Weng, Z., et al. (2016) · Nature · doi:10.1038/nature18626 · Cited by 697 · see citing works

The Microglial Innate Immune Receptor TREM2 Is Required for Synapse Elimination and Normal Brain Connectivity

Filipello, F., Morini, R., Corradini, I., Zerbi, V., Canzi, A., Michalski, B., Erreni, M., Markicevic, M., Starvaggi-Cucuzza, C., Otero, K., et al. (2018) · Immunity · doi:10.1016/j.immuni.2018.04.016 · Cited by 695 · see citing works

Injured sensory neuron–derived CSF1 induces microglial proliferation and DAP12-dependent pain

Guan, Z., Kuhn, J., Wang, X., Colquitt, B. M., Solórzano, C., Vaman, S., Guan, A. K., Evans-Reinsch, Z., Braz, J. M., Devor, M. G., et al. (2015) · Nature Neuroscience · doi:10.1038/nn.4189 · Cited by 554 · see citing works

Pharmacological targeting of CSF1R inhibits microglial proliferation and prevents the progression of Alzheimer’s-like pathology

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Repopulating Microglia Promote Brain Repair in an IL-6-Dependent Manner

Willis, E. F., MacDonald, K. P. A., Nguyen, Q. H., Garrido, A. L., Gillespie, E. R., Harley, S. B. R., Bartlett, P. F., Schroder, W. A., Yates, A. G., Anthony, D. C., et al. (2020) · Cell · doi:10.1016/j.cell.2020.02.013 · Cited by 520 · see citing works

Activation of microglia and astrocytes: a roadway to neuroinflammation and Alzheimer’s disease

Kaur, D., Sharma, V., & Deshmukh, R. R. (2019) · Inflammopharmacology · doi:10.1007/s10787-019-00580-x · Cited by 493 · see citing works

The role of interleukin-6 signaling in nervous tissue

Rothaug, M., Becker-Pauly, C., & Rose-John, S. (2016) · Biochimica et Biophysica Acta (BBA) - Molecular Cell Research · doi:10.1016/j.bbamcr.2016.03.018 · Cited by 491 · see citing works

TREM2, microglia, and neurodegenerative diseases

Yeh, F. L., Hansen, D. V., & Sheng, M. (2017) · Trends in Molecular Medicine · doi:10.1016/j.molmed.2017.03.008 · Cited by 440 · cited 2× · see citing works

Proteomic Analysis of Unbounded Cellular Compartments: Synaptic Clefts

Loh, K. H., Stawski, P. S., Draycott, A. S., Udeshi, N. D., Lehrman, E. K., Wilton, D. K., Svinkina, T., Deerinck, T. J., Ellisman, M. H., Stevens, B., et al. (2016) · Cell · doi:10.1016/j.cell.2016.07.041 · Cited by 399 · see citing works

TREM2 activation on microglia promotes myelin debris clearance and remyelination in a model of multiple sclerosis

Cignarella, F., Filipello, F., Bollman, B., Cantoni, C., Locca, A., Mikesell, R., Manis, M., Ibrahim, A., Deng, L., Benitez, B. A., et al. (2020) · Acta Neuropathologica · doi:10.1007/s00401-020-02193-z · Cited by 392 · see citing works

Gene expression and functional deficits underlie TREM2-knockout microglia responses in human models of Alzheimer’s disease

McQuade, A., Kang, Y. J., Hasselmann, J., Jairaman, A., Sotelo, A., Coburn, M., Shabestari, S. K., Chadarevian, J. P., Fote, G., Tu, C. H., et al. (2020) · Nature Communications · doi:10.1038/s41467-020-19227-5 · Cited by 361 · see citing works

Emerging Roles for CSF-1 Receptor and its Ligands in the Nervous System

Chiţu, V., Gökhan, Ş., Nandi, S., Mehler, M. F., & Stanley, E. R. (2016) · Trends in Neurosciences · doi:10.1016/j.tins.2016.03.005 · Cited by 354 · see citing works

TREM2 activation attenuates neuroinflammation and neuronal apoptosis via PI3K/Akt pathway after intracerebral hemorrhage in mice

Chen, S., Peng, J.-H., Sherchan, P., Ma, Y.-J., Xiang, S., Yan, F., Zhao, H., Jiang, Y., Wang, N., Zhang, J. H., et al. (2020) · Journal of Neuroinflammation · doi:10.1186/s12974-020-01853-x · Cited by 352 · see citing works

Complement C1q-dependent excitatory and inhibitory synapse elimination by astrocytes and microglia in Alzheimer’s disease mouse models

Dejanovic, B., Wu, T., Tsai, M.-C., Graykowski, D., Gandham, V. D., Rose, C. M., Bakalarski, C. E., Ngu, H., Wang, Y., Pandey, S., et al. (2022) · Nature Aging · doi:10.1038/s43587-022-00281-1 · Cited by 341 · see citing works

Selective removal of astrocytic APOE4 strongly protects against tau-mediated neurodegeneration and decreases synaptic phagocytosis by microglia

Wang, C., Xiong, M., Gratuze, M., Bao, X., Shi, Y., Andhey, P. S., Manis, M., Schroeder, C., Yin, Z., Madore, C., et al. (2021) · Neuron · doi:10.1016/j.neuron.2021.03.024 · Cited by 334 · see citing works

Sensory lesioning induces microglial synapse elimination via ADAM10 and fractalkine signaling

Gunner, G., Cheadle, L., Johnson, K. M., Ayata, P., Badimon, A., Mondo, E., Nagy, M. A., Liu, L., Bemiller, S. M., Kim, K.-W., et al. (2019) · Nature Neuroscience · doi:10.1038/s41593-019-0419-y · Cited by 311 · see citing works

Stress-Induced Neuronal Colony Stimulating Factor 1 Provokes Microglia-Mediated Neuronal Remodeling and Depressive-like Behavior

Wohleb, E. S., Terwilliger, R., Duman, C. H., & Duman, R. S. (2018) · Biological Psychiatry · doi:10.1016/j.biopsych.2017.05.026 · Cited by 288 · see citing works

The role of microglia in processing and spreading of bioactive tau seeds in Alzheimer’s disease

Hopp, S. C., Lin, Y., Oakley, D., Roe, A. D., DeVos, S. L., Hanlon, D., & Hyman, B. T. (2018) · Journal of Neuroinflammation · doi:10.1186/s12974-018-1309-z · Cited by 286 · see citing works

Behavioral, inflammatory and neurochemical disturbances in LPS and UCMS-induced mouse models of depression

Zhao, X., Cao, F., Liu, Q., Li, X., Xu, G., Liu, G., Zhang, Y., Yang, X., Yi, S., Xu, F., et al. (2017) · Behavioural Brain Research · doi:10.1016/j.bbr.2017.05.064 · Cited by 278 · see citing works

T cells promote microglia-mediated synaptic elimination and cognitive dysfunction during recovery from neuropathogenic flaviviruses

Garber, C., Soung, A., Vollmer, L. L., Kanmogne, M., Last, A., Brown, J., & Klein, R. S. (2019) · Nature Neuroscience · doi:10.1038/s41593-019-0427-y · Cited by 272 · see citing works

Impact of TREM2R47H variant on tau pathology–induced gliosis and neurodegeneration

Gratuze, M., Leyns, C. E. G., Sauerbeck, A. D., St-Pierre, M.-K., Xiong, M., Kim, N., Serrano, J. R., Tremblay, M.-È., Kummer, T. T., Colonna, M., et al. (2020) · Journal of Clinical Investigation · doi:10.1172/jci138179 · Cited by 252 · see citing works

Fractalkine receptor deficiency impairs microglial and neuronal responsiveness to chronic stress

Milior, G., Lecours, C., Samson, L., Bisht, K., Poggini, S., Pagani, F., Deflorio, C., Lauro, C., Alboni, S., Limatola, C., et al. (2015) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2015.07.024 · Cited by 247 · see citing works

Microglial TNF-α Suppresses Cocaine-Induced Plasticity and Behavioral Sensitization

Lewitus, G. M., Konefal, S., Greenhalgh, A. D., Pribiag, H., Augereau, K., & Stellwagen, D. (2016) · Neuron · doi:10.1016/j.neuron.2016.03.030 · Cited by 244 · see citing works

Pathogenesis of synaptic degeneration in Alzheimer's disease and Lewy body disease

Overk, C. R., & Masliah, E. (2014) · Biochemical Pharmacology · doi:10.1016/j.bcp.2014.01.015 · Cited by 242 · see citing works

Lentivirus-mediated interleukin-1β (IL-1β) knock-down in the hippocampus alleviates lipopolysaccharide (LPS)-induced memory deficits and anxiety- and depression-like behaviors in mice

Li, M., Li, C., Yu, H., Cai, X., Shen, X., Sun, X., Wang, J., Zhang, Y., & Wang, C. (2017) · Journal of Neuroinflammation · doi:10.1186/s12974-017-0964-9 · Cited by 236 · see citing works

Microglial repopulation resolves inflammation and promotes brain recovery after injury: RICE et al.

Rice, R. A., Pham, J., Lee, R. J., Najafi, A. R., West, B. L., & Green, K. N. (2017) · Glia · doi:10.1002/glia.23135 · Cited by 228 · cited 1× · see citing works

Microglia Are Indispensable for Synaptic Plasticity in the Spinal Dorsal Horn and Chronic Pain

Zhou, L.-J., Peng, J., Xu, Y.-N., Zeng, W.-J., Zhang, J., Wei, X., Mai, C.-L., Lin, Z.-J., Liu, Y., Murugan, M., et al. (2019) · Cell Reports · doi:10.1016/j.celrep.2019.05.087 · Cited by 228 · see citing works

Tumor Necrosis Factor and Interleukin-1β Modulate Synaptic Plasticity during Neuroinflammation

Rizzo, F. R., Musella, A., Vito, F. D., Fresegna, D., Bullitta, S., Vanni, V., Guadalupi, L., Bassi, M. S., Buttari, F., Mandolesi, G., et al. (2018) · Neural Plasticity · doi:10.1155/2018/8430123 · Cited by 213 · see citing works

Caspase-1 inhibitor exerts brain-protective effects against sepsis-associated encephalopathy and cognitive impairments in a mouse model of sepsis

Xu, X.-E., Liu, L., Wang, Y.-C., Wang, C.-T., Zheng, Q., Liu, Q.-X., Li, Z.-F., Bai, X.-J., & Liu, X.-H. (2019) · Brain, Behavior, and Immunity · doi:10.1016/j.bbi.2019.05.038 · Cited by 211 · see citing works

Zika virus replicates in adult human brain tissue and impairs synapses and memory in mice

Figueiredo, C. P., Barros‐Aragão, F. G. Q., Neris, R. L. S., Frost, P. S., Soares, C., Souza, I. N. D. O., Zeidler, J. D., Zamberlan, D. C., de Sousa, V. L., de Souza, A. S., et al. (2019) · Nature Communications · doi:10.1038/s41467-019-11866-7 · Cited by 211 · see citing works

Loss of microglial SIRPα promotes synaptic pruning in preclinical models of neurodegeneration

Ding, X., Wang, J., Huang, M., Chen, Z., Liu, J., Zhang, Q., Zhang, C., Xiang, Y., Zen, K., & Li, L. (2021) · Nature Communications · doi:10.1038/s41467-021-22301-1 · Cited by 180 · see citing works

Early-life high-fat diet-induced obesity programs hippocampal development and cognitive functions via regulation of gut commensal Akkermansia muciniphila

Yang, Y., Zhong, Z., Wang, B., Xia, X., Yao, W., Huang, L., Wang, Y., & Ding, W. (2019) · Neuropsychopharmacology · doi:10.1038/s41386-019-0437-1 · Cited by 179 · see citing works

TREM2 modifies microglial phenotype and provides neuroprotection in P301S tau transgenic mice

Jiang, T., Zhang, Y.-D., Chen, Q., Gao, Q., Zhu, X.-C., Zhou, J.-S., Shi, J.-Q., Lu, H., Tan, L., & Yu, J.-T. (2016) · Neuropharmacology · doi:10.1016/j.neuropharm.2016.01.028 · Cited by 176 · see citing works

TREM2 receptor protects against complement-mediated synaptic loss by binding to complement C1q during neurodegeneration

Zhong, L., Sheng, X., Wang, W., Li, Y., Zhuo, R., Wang, K., Zhang, L., Hu, D.-D., Hong, Y., Chen, L., et al. (2023) · Immunity · doi:10.1016/j.immuni.2023.06.016 · Cited by 168 · see citing works

Reactive microglia and IL1β/IL-1R1-signaling mediate neuroprotection in excitotoxin-damaged mouse retina

Todd, L. J., Palazzo, I., Suarez, L., Liu, X., Volkov, L. I., Hoang, T. V., Campbell, W. A., Blackshaw, S., Quan, N., & Fischer, A. J. (2019) · Journal of Neuroinflammation · doi:10.1186/s12974-019-1505-5 · Cited by 164 · see citing works

BDNF promotes activation of astrocytes and microglia contributing to neuroinflammation and mechanical allodynia in cyclophosphamide-induced cystitis

Ding, H., Chen, J., Su, M., Lin, Z., Zhan, H., Yang, F., Li, W., Xie, J., Huang, Y. L., Liu, X., et al. (2020) · Journal of Neuroinflammation · doi:10.1186/s12974-020-1704-0 · Cited by 162 · see citing works

TREM2/DAP12 Signal Elicits Proinflammatory Response in Microglia and Exacerbates Neuropathic Pain

Kobayashi, M., Konishi, H., Sayo, A., Takai, T., & Kiyama, H. (2016) · Journal of Neuroscience · doi:10.1523/jneurosci.1238-16.2016 · Cited by 160 · see citing works

Microglia mediate neurocognitive deficits by eliminating C1q-tagged synapses in sepsis-associated encephalopathy

Chung, H.-Y., Wickel, J., Hahn, N., Mein, N., Schwarzbrunn, M., Koch, P., Ceanga, M., Haselmann, H., Baade-Büttner, C., von Stackelberg, N., et al. (2023) · Science Advances · doi:10.1126/sciadv.abq7806 · Cited by 156 · see citing works

TREM2 modulates microglia phenotypes in the neuroinflammation of Parkinson's disease

Zhang, Y., Feng, S., Nie, K., Li, Y., Gao, Y., Gan, R., Wang, L., Li, B., Sun, X., Wang, L., et al. (2018) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2018.03.226 · Cited by 152 · see citing works

Interplay between inflammation and neural plasticity: Both immune activation and suppression impair LTP and BDNF expression

Golia, M. T., Poggini, S., Alboni, S., Garofalo, S., Albanese, N. C., Viglione, A., Ajmone‐Cat, M. A., St-Pierre, A., Brunello, N., Limatola, C., et al. (2019) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2019.07.003 · Cited by 152 · see citing works

Priming of microglia with IFN-γ slows neuronal gamma oscillations in situ

Ta, T., Dikmen, H. O., Schilling, S., Chausse, B., Lewen, A., Hollnagel, J., & Kann, O. (2019) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1813562116 · Cited by 151 · see citing works

Interferon γ: a master cytokine in microglia-mediated neural network dysfunction and neurodegeneration

Kann, O., Almouhanna, F., & Chausse, B. (2022) · Trends in Neurosciences · doi:10.1016/j.tins.2022.10.007 · Cited by 150 · see citing works

Lipopolysaccharide-induced neuroinflammation induces presynaptic disruption through a direct action on brain tissue involving microglia-derived interleukin 1 beta

Sheppard, O., Coleman, M. P., & Durrant, C. S. (2019) · Journal of Neuroinflammation · doi:10.1186/s12974-019-1490-8 · Cited by 149 · see citing works

Prenatal interleukin 6 elevation increases glutamatergic synapse density and disrupts hippocampal connectivity in offspring

Mirabella, F., Desiato, G., Mancinelli, S., Fossati, G., Rasile, M., Morini, R., Markicevic, M., Grimm, C., Amegandjin, C. A., Termanini, A., et al. (2021) · Immunity · doi:10.1016/j.immuni.2021.10.006 · Cited by 148 · see citing works

Role of proBDNF and BDNF in dendritic spine plasticity and depressive-like behaviors induced by an animal model of depression

Qiao, H., An, S.-C., Xu, C. S., & Ma, X. (2017) · Brain Research · doi:10.1016/j.brainres.2017.02.020 · Cited by 137 · see citing works

Interferon-γ signaling synergizes with LRRK2 in neurons and microglia derived from human induced pluripotent stem cells

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CX3CR1+ monocytes modulate learning and learning-dependent dendritic spine remodeling via TNF-α

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Role of the CD200-CD200R Axis During Homeostasis and Neuroinflammation

Manich, G., Recasens, M., Valente, T., Almolda, B., González, B., & Castellano, B. (2018) · Neuroscience · doi:10.1016/j.neuroscience.2018.10.030 · Cited by 126 · see citing works

Absence of IFNγ promotes hippocampal plasticity and enhances cognitive performance

Monteiro, S., Ferreira, F. M., Pinto, V., Roque, S., Morais, M., Calçada, D. D. S., Mota, C., Correia‐Neves, M., & Cerqueira, J. (2016) · Translational Psychiatry · doi:10.1038/tp.2015.194 · Cited by 125 · see citing works

Retrograde BDNF to TrkB signaling promotes synapse elimination in the developing cerebellum

Choo, M., Miyazaki, T., Yamazaki, M., Kawamura, M., Nakazawa, T., Zhang, J., Tanimura, A., Uesaka, N., Watanabe, M., Sakimura, K., et al. (2017) · Nature Communications · doi:10.1038/s41467-017-00260-w · Cited by 123 · see citing works

Early-Life Social Isolation-Induced Depressive-Like Behavior in Rats Results in Microglial Activation and Neuronal Histone Methylation that Are Mitigated by Minocycline

Wang, H.-T., Huang, F., Hu, Z., Zhang, W., Qiao, X., Huang, Y., Dai, R., Li, F., & Li, C.-Q. (2017) · Neurotoxicity Research · doi:10.1007/s12640-016-9696-3 · Cited by 121 · see citing works

Microglia‐synapse engulfment via PtdSer‐TREM2 ameliorates neuronal hyperactivity in Alzheimer's disease models

Rueda‐Carrasco, J., Sokolova, D., Lee, S., Childs, T., Jurčáková, N., Crowley, G., Schepper, S. D., Ge, J. Z., Lachica, J., Toomey, C. E., et al. (2023) · The EMBO Journal · doi:10.15252/embj.2022113246 · Cited by 120 · see citing works

TNFα and IL-1β but not IL-18 Suppresses Hippocampal Long-Term Potentiation Directly at the Synapse

Prieto, G. A., Tong, L., Smith, E. D., & Cotman, C. W. (2018) · Neurochemical Research · doi:10.1007/s11064-018-2517-8 · Cited by 118 · see citing works

Deprivation-Induced Homeostatic Spine Scaling In Vivo Is Localized to Dendritic Branches that Have Undergone Recent Spine Loss

Barnes, S. J., Franzoni, E., Jacobsen, R. I., Erdélyi, F., Szabó, G., Claudia Clopath, A., Keller, G. B., & Keck, T. (2017) · Neuron · doi:10.1016/j.neuron.2017.09.052 · Cited by 118 · see citing works

TREM2 overexpression rescues cognitive deficits in APP/PS1 transgenic mice by reducing neuroinflammation via the JAK/STAT/SOCS signaling pathway

Ruganzu, J. B., Zheng, Q., Wu, X., He, Y., Peng, X., Jin, H., Zhou, J., Ma, R., Ji, S., Ma, Y., et al. (2020) · Experimental Neurology · doi:10.1016/j.expneurol.2020.113506 · Cited by 116 · see citing works

miR-142-3p Is a Key Regulator of IL-1β-Dependent Synaptopathy in Neuroinflammation

Mandolesi, G., Vito, F. D., Musella, A., Gentile, A., Bullitta, S., Fresegna, D., Sepman, H., Sanza, C. D., Haji, N., Mori, F., et al. (2016) · Journal of Neuroscience · doi:10.1523/jneurosci.0851-16.2016 · Cited by 116 · see citing works

TNF-α-sensitive brain pericytes activate microglia by releasing IL-6 through cooperation between IκB-NFκB and JAK-STAT3 pathways

Matsumoto, J., Dohgu, S., Takata, F., Machida, T., Hatip, F. F. B., Hatip‐Al‐Khatib, I., Yamauchi, A., & Kataoka, Y. (2018) · Brain Research · doi:10.1016/j.brainres.2018.04.023 · Cited by 113 · see citing works

Visceral adipose NLRP3 impairs cognition in obesity via IL-1R1 on CX3CR1+ cells

Guo, D.-H., Yamamoto, M., Hernandez, C. M., Khodadadi, H., Baban, B., & Stranahan, A. M. (2020) · Journal of Clinical Investigation · doi:10.1172/jci126078 · Cited by 112 · see citing works

TREM2 Deficiency Aggravates NLRP3 Inflammasome Activation and Pyroptosis in MPTP-Induced Parkinson’s Disease Mice and LPS-Induced BV2 Cells

Huang, P., Zhang, Z., Zhang, P., Feng, J., Xie, J., Zheng, Y., Liang, X., Zhu, B., Chen, Z., Feng, S., et al. (2024) · Molecular Neurobiology · doi:10.1007/s12035-023-03713-0 · Cited by 111 · see citing works

Microglia-derived IL-1β contributes to axon development disorders and synaptic deficit through p38-MAPK signal pathway in septic neonatal rats

Han, Q., Lin, Q., Huang, P., Chen, M., Hu, X., Fu, H. Q., He, S., Shen, F., Zeng, H., & Deng, Y. (2017) · Journal of Neuroinflammation · doi:10.1186/s12974-017-0805-x · Cited by 110 · see citing works

The Role of BDNF in Age-Dependent Changes of Excitatory and Inhibitory Synaptic Markers in the Human Prefrontal Cortex

Oh, H., Lewis, D. A., & Sibille, E. L. (2016) · Neuropsychopharmacology · doi:10.1038/npp.2016.126 · Cited by 109 · see citing works

Neuroprotective Effect of TREM-2 in Aging and Alzheimer’s Disease Model

Raha, A. A., Henderson, J. W., Stott, S., Vuono, R., Foscarin, S., Friedland, R. P., Zaman, S. H., & Raha‐Chowdhury, R. (2016) · Journal of Alzheimer s Disease · doi:10.3233/jad-160663 · Cited by 109 · see citing works

Absence of microglial CX3CR1 impairs the synaptic integration of adult-born hippocampal granule neurons

Bolós, M., Perea, J. R., Terreros‐Roncal, J., Pallas‐Bazarra, N., Jurado‐Arjona, J., Ávila, J., & Llorens-Martı́n, M. (2017) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2017.10.002 · Cited by 109 · see citing works

Peri-Synaptic Glia Recycles Brain-Derived Neurotrophic Factor for LTP Stabilization and Memory Retention

Vignoli, B., Battistini, G., Melani, R., Blum, R., Santi, S., Berardi, N., & Canossa, M. (2016) · Neuron · doi:10.1016/j.neuron.2016.09.031 · Cited by 108 · see citing works

The role of microglia and their CX3CR1 signaling in adult neurogenesis in the olfactory bulb

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Microglia control glutamatergic synapses in the adult mouse hippocampus

Basilico, B., Ferrucci, L., Ratano, P., Golia, M. T., Grimaldi, A., Rosito, M., Ferretti, V., Reverte, I., Sanchini, C., Marrone, M. C., et al. (2021) · Glia · doi:10.1002/glia.24101 · Cited by 103 · see citing works

Analysis of the Role of CX3CL1 (Fractalkine) and Its Receptor CX3CR1 in Traumatic Brain and Spinal Cord Injury: Insight into Recent Advances in Actions of Neurochemokine Agents

Poniatowski, Ł. A., Wojdasiewicz, P., Krawczyk, M., Szukiewicz, D., Gasik, R., Kubaszewski, Ł., & Kurkowska‐Jastrzębska, I. (2016) · Molecular Neurobiology · doi:10.1007/s12035-016-9787-4 · Cited by 102 · see citing works

Macrophage-Colony Stimulating Factor Derived from Injured Primary Afferent Induces Proliferation of Spinal Microglia and Neuropathic Pain in Rats

Okubo, M., Yamanaka, H., Kobayashi, K., Dai, Y., Kanda, H., Yagi, H., & Noguchi, K. (2016) · PLoS ONE · doi:10.1371/journal.pone.0153375 · Cited by 101 · see citing works

TREM2 is required for microglial instruction of astrocytic synaptic engulfment in neurodevelopment

Jay, T. R., von Saucken, V. E., Muñoz, B., Codocedo, J. F., Atwood, B. K., Lamb, B. T., & Landreth, G. E. (2019) · Glia · doi:10.1002/glia.23664 · Cited by 97 · see citing works

Glucocorticoid receptor antagonism prevents microglia-mediated neuronal remodeling and behavioral despair following chronic unpredictable stress

Horchar, M. J., & Wohleb, E. S. (2019) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2019.06.030 · Cited by 96 · see citing works

<scp>TREM2</scp>‐induced activation of microglia contributes to synaptic integrity in cognitively intact aged individuals with Alzheimer's neuropathology

Fracassi, A., Marcatti, M., Tumurbaatar, B., Woltjer, R., Moreno, S., & Taglialatela, G. (2023) · Brain Pathology · doi:10.1111/bpa.13108 · Cited by 92 · see citing works

Interleukin-1β mediates alterations in mitochondrial fusion/fission proteins and memory impairment induced by amyloid-β oligomers

Batista, A. F., Rody, T., Forny-Germano, L., Cerdeiro, S., Bellio, M., Ferreira, S. T., Munoz, D. P., & De Felice, F. G. (2021) · Journal of Neuroinflammation · doi:10.1186/s12974-021-02099-x · Cited by 91 · see citing works

Recent Advances of Colony-Stimulating Factor-1 Receptor (CSF-1R) Kinase and Its Inhibitors

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Fractalkine/CX3CR1 is involved in the cross-talk between neuron and glia in neurological diseases.

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Brain-derived neurotrophic factor (BDNF) has direct anti-inflammatory effects on microglia

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BDNF-induced LTP is associated with rapid Arc/Arg3.1-dependent enhancement in adult hippocampal neurogenesis

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Interleukin‐1beta released by microglia initiates the enhanced glutamatergic activity in the spinal dorsal horn during paclitaxel‐associated acute pain syndrome

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Microglial Trem2 induces synaptic impairment at early stage and prevents amyloidosis at late stage in APP/PS1 mice

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The microglial fractalkine receptor is not required for activity-dependent plasticity in the mouse visual system

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Inhibiting tumor necrosis factor-α before amyloidosis prevents synaptic deficits in an Alzheimer's disease model

Cavanagh, C., Tse, Y. C., Nguyen, H.-B., Krantic, S., Breitner, J. C. S., Quirion, R., & Wong, T. P. (2016) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2016.07.009 · Cited by 79 · see citing works

Neuroinflammatory inhibition of synaptic long‐term potentiation requires immunometabolic reprogramming of microglia

York, E. M., Zhang, J., Choi, H. B., & MacVicar, B. A. (2020) · Glia · doi:10.1002/glia.23913 · Cited by 78 · see citing works

The CD200/CD200R signaling pathway contributes to spontaneous functional recovery by enhancing synaptic plasticity after stroke

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Intraperitoneal injection of IFN-γ restores microglial autophagy, promotes amyloid-β clearance and improves cognition in APP/PS1 mice

He, Z., Yang, Y., Xing, Z., Zuo, Z., Wang, R., Gu, H., Qi, F., & Yao, Z. (2020) · Cell Death and Disease · doi:10.1038/s41419-020-2644-4 · Cited by 77 · see citing works

Neuronal autophagy aggravates microglial inflammatory injury by downregulating CX3CL1/fractalkine after ischemic stroke

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Brain interference: Revisiting the role of IFNγ in the central nervous system

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IL-1β expression is increased and regulates GABA transmission following chronic ethanol in mouse central amygdala

Patel, R. R., Khom, S., Steinman, M. Q., Varodayan, F. P., Kiosses, W. B., Hedges, D. M., Vlkolinský, R., Nadav, T., Polis, I. Y., Bajo, M., et al. (2018) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2018.10.009 · Cited by 70 · see citing works

Loss of TREM2 Confers Resilience to Synaptic and Cognitive Impairment in Aged Mice

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Early posttraumatic CSF1R inhibition via PLX3397 leads to time- and sex-dependent effects on inflammation and neuronal maintenance after traumatic brain injury in mice

Wang, Y., Wernersbach, I., Strehle, J., Li, S., Appel, D., Klein, M., Ritter, K., Hummel, R., Tegeder, I., & Schäfer, M. K. E. (2022) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2022.07.164 · Cited by 69 · see citing works

Microglia TREM2R47H Alzheimer-linked variant enhances excitatory transmission and reduces LTP via increased TNF-α levels

Ren, S., Yao, W., Tambini, M. D., Yin, T., Norris, K. A., & D'Adamio, L. (2020) · eLife · doi:10.7554/elife.57513 · Cited by 68 · see citing works

Mitochondrial ROS cause motor deficits induced by synaptic inactivity: Implications for synapse pruning

Sidlauskaite, E., Gibson, J. W., Megson, I. L., Whitfield, P. D., Tovmasyan, A. G., Batinic̈‐Haberle, I., Murphy, M. P., Moult, P. R., & Cobley, J. N. (2018) · Redox Biology · doi:10.1016/j.redox.2018.03.012 · Cited by 68 · see citing works

Calycosin Preserves BDNF/TrkB Signaling and Reduces Post-Stroke Neurological Injury after Cerebral Ischemia by Reducing Accumulation of Hypertrophic and TNF-α-Containing Microglia in Rats

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TREM2 alters the phagocytic, apoptotic and inflammatory response to Aβ42 in HMC3 cells

Akhter, R., Shao, Y., Formica, S., Khrestian, M., & Bekris, L. M. (2021) · Molecular Immunology · doi:10.1016/j.molimm.2020.12.035 · Cited by 68 · see citing works

Microglia and BDNF at the crossroads of stressor related disorders: Towards a unique trophic phenotype

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Curcumin Protects Against Chronic Stress-induced Dysregulation of Neuroplasticity and Depression-like Behaviors via Suppressing IL-1β Pathway in Rats

Fan, C., Song, Q., Wang, P., Li, Y., Yang, M., Liu, B., & Yu, S. Y. (2018) · Neuroscience · doi:10.1016/j.neuroscience.2018.09.028 · Cited by 65 · see citing works

Increased IL-6 expression in astrocytes is associated with emotionality, alterations in central amygdala GABAergic transmission, and excitability during alcohol withdrawal

Roberts, A. J., Khom, S., Bajo, M., Vlkolinský, R., Polis, I. Y., Cates‐Gatto, C., Roberto, M., & Gruol, D. L. (2019) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2019.08.185 · Cited by 65 · see citing works

Microglia Mediate HIV-1 gp120-Induced Synaptic Degeneration in Spinal Pain Neural Circuits

Ru, W., Liu, X., Bae, C., Shi, Y., Walikonis, R. S., Chung, J. M., & Tang, S. (2019) · Journal of Neuroscience · doi:10.1523/jneurosci.2851-18.2019 · Cited by 65 · see citing works

Dysfunction of Microglial STAT3 Alleviates Depressive Behavior via Neuron–Microglia Interactions

Kwon, S.-H., Han, J.-K., Choi, M., Kwon, Y.-J., Kim, S. J., Yi, E. H., Shin, J.-C., Cho, I.-H., Kim, B.-H., Jeong Kim, S., et al. (2017) · Neuropsychopharmacology · doi:10.1038/npp.2017.93 · Cited by 64 · see citing works

Cross-talk between GABAergic postsynapse and microglia regulate synapse loss after brain ischemia

Cramer, T. L. M., Gill, R., Thirouin, Z. S., Vaas, M., Sampath, S., Martineau, F. S., Noya, S. B., Panzanelli, P., Sudharshan, T. J. J., Colameo, D., et al. (2022) · Science Advances · doi:10.1126/sciadv.abj0112 · Cited by 63 · see citing works

Effects of CX3CR1 and Fractalkine Chemokines in Amyloid Beta Clearance and p-Tau Accumulation in Alzheimer,s Disease (AD) Rodent Models: Is Fractalkine a Systemic Biomarker for AD?

Merino, J. J., Muñetón‐Gómez, V. C., Álvarez, M., & Toledano‐Díaz, A. (2016) · Current Alzheimer Research · doi:10.2174/1567205013666151116125714 · Cited by 62 · see citing works

Tumor necrosis factor (TNF) modulates synaptic plasticity in a concentration-dependent manner through intracellular calcium stores

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Neuroinflammation induces synaptic scaling through IL-1β-mediated activation of the transcriptional repressor REST/NRSF

Buffolo, F., Petrosino, V., Albini, M., Moschetta, M., Carlini, F., Floss, T., Kerlero de Rosbo, N., Cesca, F., Rocchi, A., Uccelli, A., et al. (2021) · Cell Death &amp; Disease · doi:10.1038/s41419-021-03465-6 · Cited by 60 · see citing works

The ROS-mediated activation of IL-6/STAT3 signaling pathway is involved in the 27-hydroxycholesterol-induced cellular senescence in nerve cells

Liu, J., Liu, Y., Chen, J., Hu, C., Teng, M., Jiao, K., Shen, Z., Zhu, D., Jia, Y., Li, Z., et al. (2017) · Toxicology in Vitro · doi:10.1016/j.tiv.2017.07.013 · Cited by 59 · see citing works

Fluoride activates microglia, secretes inflammatory factors and influences synaptic neuron plasticity in the hippocampus of rats

Yang, L., Jin, P., Wang, X., Zhou, Q. W., Lin, X., & Xi, S. (2018) · NeuroToxicology · doi:10.1016/j.neuro.2018.09.006 · Cited by 59 · see citing works

Astroglial major histocompatibility complex class I following immune activation leads to behavioral and neuropathological changes

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Involvement of Akt/CREB signaling pathways in the protective effect of EPA against interleukin-1β-induced cytotoxicity and BDNF down-regulation in cultured rat hippocampal neurons

Dong, Y., Pu, K., Duan, W., Chen, H., Chen, L., & Wang, Y. (2018) · BMC Neuroscience · doi:10.1186/s12868-018-0455-7 · Cited by 58 · see citing works

Inflammaging and Brain: Curcumin and Its Beneficial Potential as Regulator of Microglia Activation

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BDNF rescues BAF53b-dependent synaptic plasticity and cocaine-associated memory in the nucleus accumbens

White, A. O., Kramár, E. A., López, A. J., Kwapis, J. L., Doan, J., Saldana, D., Davatolhagh, M. F., Alaghband, Y., Blurton-Jones, M. M., Matheos, D. P., et al. (2016) · Nature Communications · doi:10.1038/ncomms11725 · Cited by 56 · see citing works

Synapse-specific effects of IL-1β on long-term potentiation in the mouse hippocampus

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Cocaine-mediated activation of microglia and microglial MeCP2 and BDNF production

Cotto, B., Li, H., Tuma, R. F., Ward, S. J., & Langford, D. (2018) · Neurobiology of Disease · doi:10.1016/j.nbd.2018.05.017 · Cited by 56 · see citing works

Interleukin-6 Disrupts Synaptic Plasticity and Impairs Tissue Damage Compensation in Multiple Sclerosis

Bassi, M. S., Iezzi, E., Mori, F., Simonelli, I., Gilio, L., Buttari, F., Sica, F., Paolis, N. D., Mandolesi, G., Musella, A., et al. (2019) · Neurorehabilitation and neural repair · doi:10.1177/1545968319868713 · Cited by 56 · see citing works

CD200R1 agonist attenuates glial activation, inflammatory reactions, and hypersensitivity immediately after its intrathecal application in a rat neuropathic pain model

Hernangómez, M., Klusáková, I., Joukal, M., Hradilová‐Svíženská, I., Guaza, C., & Dubový, P. (2016) · Journal of Neuroinflammation · doi:10.1186/s12974-016-0508-8 · Cited by 54 · see citing works

Inhibition of IL-1β Signaling Normalizes NMDA-Dependent Neurotransmission and Reduces Seizure Susceptibility in a Mouse Model of Creutzfeldt–Jakob Disease

Bertani, I., Iori, V., Trusel, M., Maroso, M., Foray, C., Mantovani, S., Tonini, R., Vezzani, A., & Chiesa, R. (2017) · Journal of Neuroscience · doi:10.1523/jneurosci.1301-17.2017 · Cited by 54 · see citing works

Downregulation of TREM2 expression exacerbates neuroinflammatory responses through TLR4-mediated MAPK signaling pathway in a transgenic mouse model of Alzheimer’s disease

Ruganzu, J. B., Peng, X., He, Y., Wu, X., Zheng, Q., Ding, B., Lin, C., Guo, H., Yang, Z., Zhang, X. L., et al. (2021) · Molecular Immunology · doi:10.1016/j.molimm.2021.12.018 · Cited by 54 · see citing works

The microbiota restrains neurodegenerative microglia in a model of amyotrophic lateral sclerosis

Cox, L. M., Calcagno, N., Gauthier, C., Madore, C., Butovsky, O., & Weiner, H. L. (2022) · Microbiome · doi:10.1186/s40168-022-01232-z · Cited by 53 · see citing works

Synapse Pruning: Mitochondrial ROS with Their Hands on the Shears

Cobley, J. N. (2018) · BioEssays · doi:10.1002/bies.201800031 · Cited by 53 · see citing works

Rbfox1 up-regulation impairs BDNF-dependent hippocampal LTP by dysregulating TrkB isoform expression levels

Tomassoni‐Ardori, F., Fulgenzi, G., Becker, J., Barrick, C. A., Palko, M. E., Kuhn, S. A., Kopardé, V. N., Cam, M. C., Yanpallewar, S. U., Oberdoerffer, S., et al. (2019) · eLife · doi:10.7554/elife.49673 · Cited by 53 · see citing works

Alzheimer's disease‐associated R47H TREM2 increases, but wild‐type TREM2 decreases, microglial phagocytosis of synaptosomes and neuronal loss

Popescu, A. S., Butler, C. A., Allendorf, D. H., Piers, T. M., Mallach, A., Roewe, J., Reinhardt, P., Cinti, A., Redaelli, L., Boudesco, C., et al. (2022) · Glia · doi:10.1002/glia.24318 · Cited by 53 · see citing works

Increased expression of colony‐stimulating factor‐1 in mouse spinal cord with experimental autoimmune encephalomyelitis correlates with microglial activation and neuronal loss

Gushchina, S. V., Pryce, G., Yip, P. K., Wu, D., Pallier, P. N., Giovannoni, G., Baker, D., & Bo, X. (2018) · Glia · doi:10.1002/glia.23464 · Cited by 52 · see citing works

iPSC ‐derived microglia carrying the TREM2 R47H /+ mutation are proinflammatory and promote synapse loss

Penney, J., Ralvenius, W. T., Loon, A. R., Cerit, O., Dileep, V., Milo, B., Pao, P., Woolf, H., & Tsai, L. (2023) · Glia · doi:10.1002/glia.24485 · Cited by 51 · see citing works

Lack of IL-1R8 in neurons causes hyperactivation of IL-1 receptor pathway and induces MECP2-dependent synaptic defects

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A Trem2R47H mouse model without cryptic splicing drives age- and disease-dependent tissue damage and synaptic loss in response to plaques

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Disease progression-dependent expression of CD200R1 and CX3CR1 in mouse models of Parkinson's disease

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IL-1β impairs retrograde flow of BDNF signaling by attenuating endosome trafficking

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Enhanced fear and altered neuronal activation in forebrain limbic regions of CX3CR1-deficient mice

Schubert, I., Ahlbrand, R. A., Winter, A. S., Vollmer, L. L., Lewkowich, I. P., & Sah, R. (2017) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2017.09.013 · Cited by 49 · see citing works

TNF-α–mediated reduction in inhibitory neurotransmission precedes sporadic Alzheimer’s disease pathology in young Trem2 rats

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Regulation of IL-6 secretion by astrocytes via TLR4 in the fragile X mouse model.

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BDNF‐induced endocannabinoid release modulates neocortical glutamatergic neurotransmission

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Upregulation of TREM2 Ameliorates Neuroinflammatory Responses and Improves Cognitive Deficits Triggered by Surgical Trauma in Appswe/PS1dE9 Mice

Jiang, Y., Li, Z., Ma, H., Cao, X., Liu, F., Tian, A., Sun, X.-J., Li, X., & Wang, J. (2018) · Cellular Physiology and Biochemistry · doi:10.1159/000489155 · Cited by 47 · see citing works

BDNF increases synaptic NMDA receptor abundance by enhancing the local translation of Pyk2 in cultured hippocampal neurons

Afonso, P. M., Luca, P. D., Carvalho, R. D. S., Cortes, L., Pinheiro, P. S., Oliveiros, B., Almeida, R. D., Mele, M., & Duarte, C. B. (2019) · Science Signaling · doi:10.1126/scisignal.aav3577 · Cited by 47 · see citing works

Neuroprotective and anti-inflammatory effects of isoliquiritigenin in kainic acid-induced epileptic rats via the TLR4/MYD88 signaling pathway

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Downregulation of synapse-associated protein expression and loss of homeostatic microglial control in cerebrospinal fluid of infectious patients with delirium and patients with Alzheimer’s disease

van Ton, A. M. P., Verbeek, M. M., Alkema, W. B. L., Pickkers, P., & Abdo, W. F. (2020) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2020.06.027 · Cited by 45 · see citing works

Neuroinflammation in the normal-appearing white matter (NAWM) of the multiple sclerosis brain causes abnormalities at the nodes of Ranvier

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Diazepam limits microglia-mediated neuronal remodeling in the prefrontal cortex and associated behavioral consequences following chronic unpredictable stress

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Analysis of the Impact of CD200 on Phagocytosis

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Microglial NLRP3 Inflammasome Induces Excitatory Synaptic Loss Through IL-1β-Enriched Microvesicle Release: Implications for Sepsis-Associated Encephalopathy

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Neuronal brain‐derived neurotrophic factor manipulates microglial dynamics

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IL-6 trans-signaling in the brain influences the behavioral and physio-pathological phenotype of the Tg2576 and 3xTgAD mouse models of Alzheimer’s disease

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Inflammation-induced GluA1 trafficking and membrane insertion of Ca2+ permeable AMPA receptors in dorsal horn neurons is dependent on spinal tumor necrosis factor, PI3 kinase and protein kinase A

Wigerblad, G., Huie, J. R., Yin, H. Z., Leinders, M., Pritchard, R. A., Koehrn, F. J., Xiao, W. H., Bennett, G. J., Huganir, R. L., Ferguson, A. R., et al. (2017) · Experimental Neurology · doi:10.1016/j.expneurol.2017.04.004 · Cited by 40 · see citing works

Tumor Necrosis Factor-α-Mediated Metaplastic Inhibition of LTP Is Constitutively Engaged in an Alzheimer's Disease Model

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Profiling TREM2 expression in amyotrophic lateral sclerosis

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Alzheimer risk-increasing TREM2 variant causes aberrant cortical synapse density and promotes network hyperexcitability in mouse models

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Chronic exposure of alcohol triggers microglia-mediated synaptic elimination inducing cognitive impairment

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IL-1β suppresses cLTP-induced surface expression of GluA1 and actin polymerization via ceramide-mediated Src activation

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Differential role of interleukin‐1β in neuroinflammation‐induced impairment of spatial and nonspatial memory in hyperammonemic rats

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CD200Fc reduces TLR4-mediated inflammatory responses in LPS-induced rat primary microglial cells via inhibition of the NF-κB pathway

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Low-dose PLX5622 treatment prevents neuroinflammatory and neurocognitive sequelae after sepsis

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Oral Application of Magnesium-L-Threonate Attenuates Vincristine-induced Allodynia and Hyperalgesia by Normalization of Tumor Necrosis Factor-&agr;/Nuclear Factor-&kgr;B Signaling

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The CD200R1 microglial inhibitory receptor as a therapeutic target in the MPTP model of Parkinson’s disease

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CD200 Inhibits Inflammatory Response by Promoting KATP Channel Opening in Microglia Cells in Parkinson’s Disease

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BDNF Controls Bidirectional Endocannabinoid Plasticity at Corticostriatal Synapses

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Neuronal impairment following chronic Toxoplasma gondii infection is aggravated by intestinal nematode challenge in an IFN-γ-dependent manner

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Therapeutic effects of ellagic acid on memory, hippocampus electrophysiology deficits, and elevated TNF-α level in brain due to experimental traumatic brain injury.

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Delivery of exogenous proteins by mesenchymal stem cells attenuates early memory deficits in a murine model of Alzheimer's disease

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Interleukin-1β Modulates Synaptic Transmission and Synaptic Plasticity During the Acute Phase of Sepsis in the Senescence-Accelerated Mouse Hippocampus

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CX3CL1/CX3CR1 signal mediates M1-type microglia and accelerates high-altitude-induced forgetting

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Interferon-Gamma and Interleukin-1Beta Enhance the Secretion of Brain-Derived Neurotrophic Factor and Promotes the Survival of Cortical Neurons in Brain Injury

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Endocannabinoid-Dependent Long-Term Potentiation of Synaptic Transmission at Rat Barrel Cortex

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Interferon-γ facilitates the synaptic transmission between primary afferent C-fibres and lamina I neurons in the rat spinal dorsal horn via microglia activation

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Nhe5 deficiency enhances learning and memory via upregulating Bdnf/TrkB signaling in mice

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Inhibition of LTP-Induced Translation by IL-1β Reduces the Level of Newly Synthesized Proteins in Hippocampal Dendrites

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Microglia Mediate Synaptic Material Clearance at the Early Stage of Rats With Retinitis Pigmentosa

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The effect of IL-1β on synaptophysin expression and electrophysiology of hippocampal neurons through the PI3K/Akt/mTOR signaling pathway in a rat model of mesial temporal lobe epilepsy

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Triggering Receptor Expressed on Myeloid Cells 2 Overexpression Inhibits Proinflammatory Cytokines in Lipopolysaccharide-Stimulated Microglia

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Inhibition of NF-κB signaling in IKKβF/F;LysM Cre mice causes motor deficits but does not alter pathogenesis of Spinocerebellar ataxia type 1

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TNF‐α/TNFR2 Regulatory Axis Stimulates EphB2‐Mediated Neuroregeneration Via Activation of NF‐κB

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Combination of tea polyphenols and proanthocyanidins prevents menopause-related memory decline in rats via increased hippocampal synaptic plasticity by inhibiting p38 MAPK and TNF-α pathway

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Tumor Necrosis Factor Alpha (TNF-α) Disrupts Kir4.1 Channel Expression Resulting in Müller Cell Dysfunction in the Retina

Hassan, I., Luo, Q., Majumdar, S., Dominguez, J. M., Busik, J. V., & Bhatwadekar, A. D. (2017) · Investigative Ophthalmology & Visual Science · doi:10.1167/iovs.16-20712 · Cited by 25 · see citing works

Shen-Qi-Jie-Yu-Fang exerts effects on a rat model of postpartum depression by regulating inflammatory cytokines and CD4+CD25+ regulatory T cells

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β-amyloid inhibits hippocampal LTP through TNFR/IKK/NF-κB pathway

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TREM2 regulates microglial phagocytosis of synapses in innate immune tolerance

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NLRP3-GSDMD-dependent IL-1β Secretion from Microglia Mediates Learning and Memory Impairment in a Chronic Intermittent Hypoxia-induced Mouse Model

Li, C., Zhao, Z., Jin, J., Zhao, C., Zhao, B., & Liu, Y. (2023) · Neuroscience · doi:10.1016/j.neuroscience.2023.12.006 · Cited by 24 · see citing works

Neonatal proinflammatory stress induces accumulation of corticosterone and interleukin-6 in the hippocampus of juvenile rats: Potential mechanism of synaptic plasticity impairments

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Implication of microglia activation and CSF1/CSF1R pathway in lumbar disc degeneration-related back pain

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Distinct Protein Expression Networks are Activated in Microglia Cells after Stimulation with IFN-γ and IL-4

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Interaction of Tau, IL-6 and mitochondria on synapse and cognition following sevoflurane anesthesia in young mice

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Repurposing of pexidartinib for microglia depletion and renewal

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BDNF contributes to the neonatal incision-induced facilitation of spinal long-term potentiation and the exacerbation of incisional pain in adult rats

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Aging and an Immune Challenge Interact to Produce Prolonged, but Not Permanent, Reductions in Hippocampal L-LTP and mBDNF in a Rodent Model with Features of Delirium

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CD200R/Foxp3-mediated signalling regulates microglial activation

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An enriched environment restores hepatitis B vaccination-mediated impairments in synaptic function through IFN-γ/Arginase1 signaling

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TREM2 improves microglia function and synaptic development in autism spectrum disorders by regulating P38 MAPK signaling pathway

Tian, Y., Xiao, X., Liu, W., Cheng, S., Qian, N., Wang, L., Liu, Y., Ai, R., & Zhu, X. (2024) · Molecular Brain · doi:10.1186/s13041-024-01081-x · Cited by 21 · see citing works

Rethinking early Alzheimer’s disease: An impaired internal model updating disorder?

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Discovery of a Neuroprotective Diosgenin Derivative as a Novel Antidepressant Candidate Targeting LPS-TLR4 Signaling

Yoo, Y., Baek, S. Y., Lee, H., Lee, J., Lee, H., Lee, H., Ma, H., Kim, Y., Choi, H., Lee, J. T., et al. (2026) · Journal of Medicinal Chemistry · doi:10.1021/acs.jmedchem.5c02981 · Cited by 6 · see citing works

The impact of CSF1R inhibitor-mediated microglial depletion in rodent models of Alzheimer’s and Parkinson’s disease: a systematic review and meta-analysis

Ferreira, A. F. F., Santos-Silva, A. C., Muratori, B. G., & Britto, L. R. G. (2026) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2026.1733682 · Cited by 5 · see citing works

Neuroimaging-Guided Insights into the Molecular and Network Mechanisms of Chronic Pain and Neuromodulation

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Astrocyte-mediated hippocampal damage in the pathogenesis of dysexecutive syndrome following COVID-19: A narrative review

Messina, A., Bella, F., Maccarone, G., Avincola, G., & Signorelli, M. S. (2026) · Journal of Psychiatric Research · doi:10.1016/j.jpsychires.2026.01.007 · Cited by 3 · see citing works

Advances in cellular and structural engineering of brain organoids for disease modeling: A Comprehensive Review

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Dual immune armies in glaucoma: microglia and monocyte-derived macrophages

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The Microbiota–Gut–Brain Axis in Insomnia: Mechanisms and Intervention Strategies

Yang, M., Chen, Q., Meng, Z., Gu, X., & Bai, C. (2026) · Life · doi:10.3390/life16040583 · Cited by 3 · see citing works

Lipid metabolic regulation of neuroinflammation in Alzheimer’s disease

Li, T., Guo, K., Ma, Y., Zhao, J., Cao, Y., Zhang, R., Li, X., Wei, J., Ma, Y., Zhu, Z., et al. (2026) · Frontiers in Immunology · doi:10.3389/fimmu.2026.1815719 · Cited by 3 · see citing works

Dentate gyrus microglial dynamics contributes to high-fat diet-induced depression-like behaviors in mice

Zhu, T., Ye, M., Huang, C., Jiang, Y., Gu, Y., Cao, Z., Xu, F., Su, J., & Yang, R. (2026) · Neuropharmacology · doi:10.1016/j.neuropharm.2026.110893 · Cited by 2 · see citing works

Platelet-Derived Granules and Extracellular Vesicles in Neurodegenerative Diseases: Neurovascular Mechanisms and Clinical Implications

Lee, B. M., Yoo, J.-R., & Jung, Y. (2026) · Cells · doi:10.3390/cells15080692 · Cited by 2 · see citing works

Targeting Pain and Depression in Alzheimer’s Disease: Translational Insights and Emerging Treatments

Costăchescu, I., Stanciu, G. D., Gogu, M.-R., & Tamba, B.-I. (2026) · Pharmaceuticals · doi:10.3390/ph19040626 · Cited by 2 · see citing works

Astrocytes and Microglia Regulate Opioid Receptor-Driven Cancer Brain Metastasis and Neural Injury: Remodeling the Brain Microenvironment

Cui, D., Wang, X., & Shang, X. (2026) · Journal of Inflammation Research · doi:10.2147/jir.s606362 · Cited by 2 · see citing works

Single-cell analysis of Powassan virus-infected brains reveals age-dependent neuroinflammatory crosstalk and progressive Alzheimer’s-like APP/Aβ accumulation

de Souza, M. R. M., Lindner, M. R., Mladinich, M. C., Gorbunova, E. E., Kirillov, V., Byrne, A. G., Laird, A. Y., Finnerty, C. E., Ikeda, P., Vorkas, C. K., et al. (2026) · mBio · doi:10.1128/mbio.01294-26 · Cited by 2 · see citing works

Transplantation of human iPSC-derived microglia ameliorates neuropathology and circuit dysfunction in progranulin-deficient mice

Davtyan, H., Naguib, S. A., Voskobiynyk, Y., Chadarevian, J. P., Capocchi, J. K., Giacchino, J. L., Eskandari‐Sedighi, G., DeNittis, V. R., Ford, J. B., Agababian, A., et al. (2026) · Molecular Neurodegeneration · doi:10.1186/s13024-026-00978-6 · Cited by 2 · see citing works

From gut microbiota to synaptic plasticity: Mechanisms shaping cognitive function and brain disorders

Azimzadeh, M., & Azimzadeh, M. (2026) · Behavioural Brain Research · doi:10.1016/j.bbr.2026.116404 · Cited by 2 · see citing works

Environmental endocrine disruptors at the synapse: mechanisms linking chemical exposure to cognitive and behavioral dysfunction

Jocsak, G., Kiss, D. S., Alymbaeva, D., Diebald, A., Zsarnovszky, A., Heinzlmann, A., & Bartha, T. (2026) · Frontiers in Behavioral Neuroscience · doi:10.3389/fnbeh.2026.1821381 · Cited by 1 · see citing works

ADME Profiling of Quantum Dots and Immune Responses: Impact of Dynamic Inflammatory Mediator Changes on the Nervous System

Wang, Z., Yao, Y., Liu, N., Wei, T., Huang, X., Zou, L., Hu, Y., Fang, Q., Guan, S., Niu, Y., et al. (2025) · Small · doi:10.1002/smll.202510266 · Cited by 1 · see citing works

Paeoniflorin mitigates hyperoxia-induced cognitive deficits in neonatal mice by modulating p38/JNK signaling to reduce oxidative stress and neuroinflammation

Huang, C., Zhang, X., Yu, J., Xuan, C., Xu, C., Li, X., Cui, H., & Xu, D. (2026) · Neuropharmacology · doi:10.1016/j.neuropharm.2026.110992 · Cited by 1 · see citing works

Cellular insights into hydrocephalus: The diverse roles and intricate crosstalk of multiple cell types

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Low-Dose Naltrexone in Chronic Pain Management: Mechanisms, Evidence, and Clinical Implications

McKenzie, A., Bittar, T. G., Dombrower, R., Raman, D., Hussain, H., Theeraphapphong, N., McKenzie, S. M., & Abd-Elsayed, A. A. (2026) · Journal of Personalized Medicine · doi:10.3390/jpm16030151 · Cited by 1 · see citing works

HDAC3 blockade inhibits neuroinflammation and pyroptosis to prevent dopaminergic neuron death in Parkinson’s disease models

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Targeting neuroinflammatory networks with marine natural products: evidence, mechanisms, and translational challenges

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Neuroendocrine-immune perturbations in metabolic disease: pathophysiological mechanisms underlying cognitive impairment

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The neuroimmune network in Alzheimer’s and Parkinson’s diseases: from mechanistic insights to biomarker-guided immunotherapies and clinical translation

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Histone Deacetylase Inhibitors Improve Memory Function and Decrease Neuropathology in APP/PS1 MicePreprint

McClarty, B. M., Monteiro, R., & Dong, H. (2026) · Research Square · doi:10.21203/rs.3.rs-10816126/v1 · Cited by 1 · see citing works

Wasf1 deletion attenuates tau hyperphosphorylation, microglial state transition, and cognitive deficits in P301S tau micePreprint

Berdasco, C., Cho, W.-H., Lee, J., Annu, A., Ledo, J. H., Jeong, Y. Y., Kim, Y.-S., An, S. S., Tanaka, Y., Ahn, J.-H., et al. (2026) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.64898/2026.01.14.699391

Infectious vs. Sterile Neuroinflammation: Differential Consequences on Neuronal CircuitryPreprint

Talero-López, D. (2026) · Qeios · doi:10.32388/1h63qt

PDCD4: A Double-Edged Sword in Neurological Diseases

Li, C., Zheng, K., Qiu, M. S., & Yang, J. (2026) · Molecular Neurobiology · doi:10.1007/s12035-026-05768-1

Bridging Regenerative and Restorative Stem Cell Therapies in Parkinson’s Disease

Onuigbo, C. C., Martínez-Lemus, J. D., Tharp, E., & Schiess, M. C. (2026) · Cells · doi:10.3390/cells15070578

Molecular and Mechanistic Divergence of Seizures in Pediatric Acute Lymphoblastic Leukemia: CNS Infiltration Versus Chemotherapy-Induced Neurotoxicity

Joo, J. D., Yang, W. S., & Koh, H. J. (2026) · International Journal of Molecular Sciences · doi:10.3390/ijms27073307

Regulation of IRGM1-Mediated Pyroptosis and Neuroinflammation by Transcription Factor NR3C1 Alleviates Early Brain Injury after Subarachnoid Hemorrhage

Xin, Y., Gong, M., & Fu, X. (2026) · Shock · doi:10.1097/shk.0000000000002846

Prenatal Maternal Inflammation Is Associated with Altered Offspring Mesolimbic White Matter Circuitry Observed in Late MidlifePreprint

Mopuru, R., Elliott, B. L., Hoffman, L. J., Tani, N., Kring, A. M., Breen, E. C., Cohn, B. A., Cirillo, P. M., Krigbaum, N. Y., D’Esposito, M., et al. (2026) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.64898/2026.04.06.716489

Phytochemical profiling and biological evaluation of hazelnut shell extract reveals neuroprotective potential in human microglial cells

Çağlar, Ö. (2026) · Molecular Biology Reports · doi:10.1007/s11033-026-11811-0

Small-molecule FTO inhibitor MO-I-500 protects C8-B4 microglial cells from erastin-induced ferroptosis

Greco, D., Das, D., Novotný, J., Olsen, M. J., & Telenský, P. (2026) · Scientific Reports · doi:10.1038/s41598-026-47881-0

Advancing Alzheimer’s Disease Research Using Brain Organoids and Organ-on-Chip Technologies

Singh, S. (2026) · American journal of student research. · doi:10.70251/hyjr2348.42413419

Ziziphus jujuba Mill. Suspension Ameliorates Scopolamine‐Induced Cognitive Impairment via PTGS2‐Centered Neuroinflammatory Signaling

Liu, Q., Wang, Y., Wang, B. Q., Wang, J., Zhang, M., Liu, Y., & Min, X. (2026) · Mediators of Inflammation · doi:10.1155/mi/8871660

Integrative transcriptomics and network pharmacology analysis of vincamine-mediated molecular networks in alzheimer’s disease

Bhamare, J. S., & Kaur, G. (2026) · Network Modeling Analysis in Health Informatics and Bioinformatics · doi:10.1007/s13721-026-00793-5

Neuroimmune Dysregulation and the Role of IL-10 in Depression: A Systematic Review

Cortes-Altamirano, J. L., Alfaro-Rodríguez, A., González-Maciel, A., Pérez-Guillé, B., Soriano‐Rosales, R. E., Jaime, H. B., Ávila-Luna, A., Bueno-Nava, A., Sánchez-Aparicio, P., & Dotor-Llerena, A. L. (2026) · Brain Sciences · doi:10.3390/brainsci16060548

Protective effects of gastrodin against bisphenol A-induced dopaminergic dysregulation and cognitive impairment in rats

Saifi, M. A., Javed, M., Jindal, G., Agarwal, N. B., & Raisuddin, S. (2026) · Naunyn-Schmiedeberg s Archives of Pharmacology · doi:10.1007/s00210-026-05445-z

Antiepileptic and antiepileptogenic effects of Lagenaria siceraria aqueous extract (Curcubitaceae) in PTZ-induced kindling in rats

Gnoupa, K.-G. K., Ngoupaye, G. T., Foutsop, A. F., Kom, B. T. D., Ngoufack, S. B. K., Noubouwo, J. C., & Diane, R. B. (2026) · IBRO Neuroscience Reports · doi:10.1016/j.ibneur.2026.05.008

High-Fat Diet Rapidly Induces Spatial Memory Deficits, Hippocampal Oxidative Stress, and CA1 Astrogliosis in Rats.

Khene, M. A., Belabbassi, O., Chabane, K., Kechkoul, L., Ousmaal, M. E. F., & Benaziza, D. (2026) · International Journal of Computational and Experimental Science and Engineering · doi:10.22399/ijcesen.5294

MST1/Drp1 axis mediates microglia pro-inflammatory activation following cerebral ischemia-reperfusion injury

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Neuroimaging evidence of mitochondrial dysfunction and inflammation in psychiatric disorders: a review

Li, J., Ma, X., Liu, J., Xu, W., Zhang, X., Liang, F., & Dou, Y. (2026) · Psychoradiology · doi:10.1093/psyrad/kkag023

Post-Translational Circadian Regulation of Inflammation: Mechanistic Control of Immune Signaling Networks

Gu, D., & Yuan, G. (2026) · Immuno · doi:10.3390/immuno6030042

NSAID use is associated with lower dementia and Alzheimer’s disease prevalence and slower cognitive decline: A retrospective longitudinal analysis of the NACC cohortPreprint

Hoehne, C. L., Salinas, V. H., Shirani, A., Stüve, O., & Stopschinski, B. E. (2026) · medRxiv · doi:10.64898/2026.06.27.26355593

Neuroinflammation-driven neurodegeneration: emerging biomarkers, mitochondrial therapeutics, and translational neuroprotective strategies

Hammad, M. Y., Fardoos, S., & Shakoor, K. (2026) · Exploration of Neuroprotective Therapy · doi:10.37349/ent.2026.1004162

Endogenous Neurotoxicity: A Pathophysiological Consequence of Homeostatic Dysfunction

Yanglem, S., Loushambam, B., Singh, S. M., & Vijayaraghavalu, S. (2026) · Neuroglia · doi:10.3390/neuroglia7030029

Colostrum Extracellular Vesicle Isolation, Characterization, and Function

Akter, S., Fayez, N., Kumar, M., Sil, S., & Gendelman, H. E. (2026) · Biomedicines · doi:10.3390/biomedicines14071549

Microglial synaptic pruning in early Alzheimer’s disease: emerging roles of the IL-1β-NLRP3 axis

Kaushik, A. S., & Singh, N. (2026) · Inflammopharmacology · doi:10.1007/s10787-026-02335-x

The drug discovery landscape of Alzheimer’s disease

Chinnathambi, S., & Prakash, L. E. (2026) · Advances in protein chemistry and structural biology · doi:10.1016/bs.apcsb.2026.07.005

Chemokine levels in the murine brain from early postnatal development to aging

Dantas, D. P., Campos, R. M. P., Galvani, R. G. A., Bonomo, A., & Pimentel‐Coelho, P. M. (2026) · Brain Behavior & Immunity - Health · doi:10.1016/j.bbih.2026.101308

Infectious vs. Sterile Neuroinflammation: Differential Consequences on Neuronal CircuitryPreprint

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Silent action of dopamine receptor antagonist in synaptic remodelling: Molecular basis of tardive dyskinesia due to chronic antipsychotic exposure

Chakraborty, W., Anand, A., & Roy, K. K. (2026) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2026.111846

Pharmacological targeting of neuroimmune–synaptic interactions in Alzheimer's disease: Integrating NETosis, microglia, and synaptic vulnerability

Chen, J., & Chen, L.-H. (2026) · Current Opinion in Pharmacology · doi:10.1016/j.coph.2026.102650

The Pathophysiological Mechanisms of Glia in Animal Models of Chronic Orofacial Pain: A Systematic Review

Brito, A., Carneiro, B. D., & Pozza, D. H. (2026) · Pathophysiology · doi:10.3390/pathophysiology33030054

Immunosenescence in systemic lupus erythematosus: Mechanisms, clinical consequences, and therapeutic implications

Hillal, J. P. D., Weber, T. A., Staub, H. L., & Bauer, M. E. (2026) · Autoimmunity Reviews · doi:10.1016/j.autrev.2026.104144

Blocking the microglia-endothelial axis via SPP1-ITGAV disruption attenuates neuroinflammation in multiple sclerosis

Xiao, X., Shen, S., Cui, T., Tan, H., Hu, S., Deng, X., Huang, Y., Cui, C., Yu, B., Qiu, W., et al. (2026) · Journal of Translational Medicine · doi:10.1186/s12967-026-08735-5

Bungarus multicinctus venom induces pyroptosis via the NLRP3/Caspase-1/GSDMD pathway in BV2 cells

Luo, M., Wang, Z.-R., Tan, X.-L., Yang, X., & Ning, Z. (2026) · Cell Biology and Toxicology · doi:10.1007/s10565-026-10240-w

Long-term risk of dementia following encephalitis: a large-scale retrospective cohort study of electronic health records

Aditi, Blackwell, T. A., Fang, X., Sharma, S., Mendoza, M., LANDAY, A. L., Golovko, G., & Samir, P. (2026) · Journal of Neurology · doi:10.1007/s00415-026-14017-3

Targeting the Complement–Microglia Axis for Neuroprotection in Pediatric Epilepsy

Karayanni, M., Mitsoudis, N., Vanakliotou, M., Bakirtzis, C., Kesidou, E., Polyzoidou, E., & Liana, E. (2026) · Biomedicines · doi:10.3390/biomedicines14081788

Neural glial network instability in epilepsy

Naffaa, M. M. (2026) · Exploration of neuroscience · doi:10.37349/en.2026.1006144

Bioactive dietary polyphenols modulate hippocampal inflammasome activation and sex- specific affective behavioral deficits following peripheral Foxp3 + regulatory T cell depletionPreprint

Yang, E., Lin, H., Alvarez, J., Russo, S. J., Toro-Chacon, C., & Pasinetti, G. M. (2026) · Research Square · doi:10.21203/rs.3.rs-10425197/v1

Neuroimmune regulation of visceral pain: roles of microglia, purinergic signaling, and neuroinflammation

Wang, Y., Li, P., Dong, Y., Zhang, X., & Shang, K. (2026) · Frontiers in Immunology · doi:10.3389/fimmu.2026.1934162

Single-cell transcriptomics reveals distinct microglial state remodeling associated with the (R)-nicotine/diosmetin combination and galantamine in LPS-challenged BV2 cells

Liu, Y., Yu, H., Zhang, J., Li, X., Ma, Y., Guang, C., Mu, W., Chen, H., & Hou, H. (2026) · Frontiers in Immunology · doi:10.3389/fimmu.2026.1901868

Common metabolic, environmental, and molecular mechanisms underlying neurodevelopmental and neurodegenerative disorders

Vallés, A. S., & Barrantes, F. J. (2026) · Frontiers in Neurology · doi:10.3389/fneur.2026.1860052

Strain-Specific Cognitive and Neurobiological Vulnerabilities to Social Isolation in Late Middle-Aged Wistar, Wistar-Kyoto, and Spontaneously Hypertensive Rats

Mamedova, D. I., Nedogreeva, O. A., Aniol, V. A., Kvichansky, A. A., Tret’yakova, L. V., Riga, V. D., Лазарева, Н. А., Gulyaeva, N. V., & Stepanichev, M. Y. (2026) · Neurochemical Research · doi:10.1007/s11064-026-04889-2

Lactobacillus rhamnosus and Saccharomyces boulardii Attenuate LPS-Induced Cognitive and Affective Dysfunction Associated with Hippocampal Neuroinflammatory and Neurochemical Alterations

Aslanlar, D. A., Atalık, K. E. N., Öz, M., Yıldız, İ., & Yılmaz, M. T. (2026) · Neurochemical Research · doi:10.1007/s11064-026-04883-8

Biological complexity of epileptogenesis and the emerging role of natural molecules in neuroprotection: A review

Алексеевич, П. М., Skovorodko, P., Dorchenko, E., Milorava, G., Ivanova, E., Aigubova, Z., & Sarkisova, M. (2026) · Scripta Medica · doi:10.5937/scriptamed57-67911

Ursolic acid attenuates LPS-induced cognitive dysfunction through the modulation of oxidative stress, neuroinflammation, and hippocampal synaptic plasticity

Choi, G.-Y., Lee, S., Je, A. R., Choi, H., Moon, E., Cho, E., Kwon, S., Lee, K., & Kweon, H. (2026) · Phytomedicine · doi:10.1016/j.phymed.2026.158788

Chemotherapy-Induced Remodeling of the Gut Microbiota–Inflammation Axis: Implications for the Course of Bipolar Disorder

Li, S., Wang, S., Ren, Y., & Yan, J. (2026) · Journal of Multidisciplinary Healthcare · doi:10.2147/jmdh.s637471

Rational engineering of ginseng polysaccharide-based composite nanoparticles for orchestrating microglial homeostasis and suppressing complement-mediated synaptic injury in Alzheimer's disease

Yu, Y., Chen, M.-H., Ding, S., Zhang, G., Kong, L., Liu, Y., Zang, J., Zheng, Y., Zhang, Y.-N., Li, X., et al. (2026) · Chemical Engineering Journal · doi:10.1016/j.cej.2026.182033

Intestinal Klebsiella pneumoniae enhances neuroinflammation and seizure susceptibility in a pentylenetetrazole-induced acute seizure model

Li, J., Wang, Y., Cai, W., Chen, S., Zhang, L., & Wang, T. (2026) · Frontiers in Neuroscience · doi:10.3389/fnins.2026.1850015

Radiation-induced temporal lobe injury disrupts neuro-immune crosstalk: A key driver of immune dysfunction in locally advanced nasopharyngeal carcinoma

Gao, J., Xie, R., Rao, C., Jiao, J., Zhang, W., Hu, Y., Yang, B., Zhao, H., Yuan, P., Xie, T., et al. (2026) · Journal of International Medical Research · doi:10.1177/03000605261483860

Hippocampal Volume Mediates the Association Between Serum Ferritin and Cognition in Non‐Dialysis End‐Stage Renal Disease Patients

Si, J., Zhu, M., & Mingzhe, D. (2026) · Brain and Behavior · doi:10.1002/brb3.71777

Cystatin F as a neuroimmune effector in CNS inflammation and neurodegeneration

Murray, K., Fernandez, K., & Lane, T. E. (2026) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2026.1959727

Neuroplasticity under constraint: From sensory ecology to neuroinflammation

Diniz, D. G., Bento-Torres, N. V. O., Bento‐Torres, J., Jardim, N. Y. V., Sosthenes, M. C. K., Krejčová, L. V., dos Santos, Z. A., de Sousa, A. A., da Costa, E. R., Pereira, P. D. C., et al. (2026) · Brain Behavior and Immunity Integrative · doi:10.1016/j.bbii.2026.100199

Toward a Phase‐Based Biological Stratification of Autism Spectrum Disorder: A Neuroinflammatory Developmental Framework

Gabr, R. I. (2026) · Developmental Neurobiology · doi:10.1002/dneu.70063

Shenghui Decoction ameliorates cognitive impairment and neuroinflammation in APP/PS1 mice via modulation of the HMGB1/TLR4/NLRP3 pathway

Liu, X., Song, X., Zhang, J., Ma, S., Wang, X., Guo, Y., Gao, B., Wang, X., & Duan, J. (2026) · Journal of Ethnopharmacology · doi:10.1016/j.jep.2026.122426

Glia-Informed Design of Smart Biomimetic Biomaterials for Brain Repair and Neural Tissue Engineering

Naffaa, M. M. (2026) · European Cells and Materials · doi:10.22203/ecm.v059a02

Targeting glial modulation: molecular mechanisms of Polygonatum in neurological disorders

Liu, Z., Luo, Y., Zheng, C., Long, X., Zhao, Y., Pan, Z., Xu, B., & Sun, J. (2026) · Frontiers in Pharmacology · doi:10.3389/fphar.2026.1969384

Mesenchymal stromal cell-derived extracellular vesicles attenuate inflammation-associated cognitive impairment and hippocampal microglial-synaptic remodeling

Ayyubova, G., Gasimov, E. K., Rzayev, F., Mehraliyeva, G., Sadigi, I., Guliyeva, N., Ismayilova, S. H., & Ayyubova, N. (2026) · Scientific Reports · doi:10.1038/s41598-026-73800-4

NF-ΚB-ASSOCIATED INFLAMMATION AND COGNITIVE IMPAIRMENT IN SCHIZOPHRENIA: A REVIEW

Mahardika, A., Tanra, A. J., & Limo, E. (2026) · Acta Innovations · doi:10.62441/actainnovations.v63i.794

The nose–brain axis as a neuroimmune conduit: how allergic rhinitis rewires the central nervous system

Han, Z., Cheng, F., Wang, Y., Zhang, H., Wang, L., & Zhao, C. (2026) · Frontiers in Immunology · doi:10.3389/fimmu.2026.1920083

A statistical framework for integrative imaging genomics with biclustering and ensemble penalized regression in Alzheimer’s disease

Chen, H., Yong, H., Hou, L., Liu, L., & Ma, C. (2026) · NeuroImage · doi:10.1016/j.neuroimage.2026.122267

Screening the anti-neuroinflammatory active fraction of Wenmian San and exploring the underlying mechanism by UPLC–Triple-TOF-MS/MS-based network pharmacology, DEGs, WGCNA, and molecular docking

Liu, F., Xu, T.-S., Zhao, J.-Z., Xu, P., Jiang, P.-P., Xu, Q., Liu, L., & Dai, Q. (2026) · Natural Product Research · doi:10.1080/14786419.2026.2738221

Nipsnap 1 deficiency shifts neuronal and synaptic signaling toward inflammatory pathway and impairs cognitive functions in the aging brain

Sharoar, M. G., Zaman, Z., Singh, N., Fathi, E., Graham, S. F., Zhu, X., & Homayouni, R. (2026) · npj Aging · doi:10.1038/s41514-026-00529-9

Glial-derived extracellular vesicles as therapeutic drug carriers for targeted drug delivery in neurodegenerative diseases

Lekshmi, S. S. A., Palathingal, M., Manikkath, J., Sarath Chandran, C., & Nampoothiri, M. (2026) · Journal of Drug Delivery Science and Technology · doi:10.1016/j.jddst.2026.109009

Cognitive Impairment in Asthma: Emerging Evidence, Clinical Consequences, and Future Directions

Mengash, A. S., & Siraj, R. A. (2026) · Journal of Clinical Medicine · doi:10.3390/jcm15197761

Glial lipid reprogramming in brain aging: Lipid identity, organelle stress, and redox vulnerability

Rana, M., Ko, W., Nepali, K., Ko, C.-Y., Yen, T., Jan, J., Taliyan, R., Li, C.-H., & Yang, C. (2026) · Redox Biology · doi:10.1016/j.redox.2026.104453

Food Allergy Induces Anxiety-like Behavior and Neuroimmune Dysregulation in the Prefrontal Cortex of Mice

Liu, Y., Guo, C., & Yu, X. (2026) · International Journal of Molecular Sciences · doi:10.3390/ijms27219431

Relaxin-2 protects synaptic integrity via hippocampal NLRP3-mTOR-autophagy pathways in an age-dependent Alzheimer-like model

Wang, D., Zhigang, Z., & Ding, Y. (2026) · Acta Pharmaceutica · doi:10.2478/acph-2026-0023

Role of macrophages in immunometabolism and neurodegeneration

Mishra, P., Khan, A., Doshi, Z., Tungare, K., & Nand, S. (2026) · Elsevier eBooks · doi:10.1016/b978-0-443-44253-7.00018-7

Protective Effects of Daflon Against Haloperidol-Induced Neurobehavioral Alterations, Oxidative Stress, Neuroinflammation, and Cerebellar Histomorphological Changes in MicePreprint

Samaila, S., Christopher, C. H., Williams, I. K., Michael, J. C., Adedayo, L. D., & Danborno, A. M. (2026) · Research Square · doi:10.21203/rs.3.rs-11224606/v1

Astrocyte- and Microglia-Derived Factors in Neuroinflammation: Impact on Neuronal and Synaptic Structure and Function

Soldavini, G. C., Gomez, M. B., Cuello, J. M., Codagnone, M. G., & Reinés, A. G. (2026) · Biocell · doi:10.32604/biocell.2026.082340

Microglia: Dynamic Mediators of Synapse Development and Plasticity

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Role of Pro-Inflammatory Cytokines Released from Microglia in Neurodegenerative Diseases

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Microglia mediated neuroinflammation in neurodegenerative diseases: A review on the cell signaling pathways involved in microglial activation

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