Imaging of anticancer drug action in single cells

Deep learning

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Fiji: an open-source platform for biological-image analysis

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Angiogenesis in cancer and other diseases

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Cancer nanomedicine: progress, challenges and opportunities

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CellProfiler: image analysis software for identifying and quantifying cell phenotypes

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Visualization and analysis of gene expression in tissue sections by spatial transcriptomics

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Mechanism-driven biomarkers to guide immune checkpoint blockade in cancer therapy

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EMT, cancer stem cells and drug resistance: an emerging axis of evil in the war on cancer

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Clinical development success rates for investigational drugs

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CSF-1R inhibition alters macrophage polarization and blocks glioma progression

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Accumulation of sub-100 nm polymeric micelles in poorly permeable tumours depends on size

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Enzymatic targeting of the stroma ablates physical barriers to treatment of pancreatic ductal adenocarcinoma

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Stromal Elements Act to Restrain, Rather Than Support, Pancreatic Ductal Adenocarcinoma

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Defining CD8+ T cells that provide the proliferative burst after PD-1 therapy

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Highly multiplexed imaging of tumor tissues with subcellular resolution by mass cytometry

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Lattice light-sheet microscopy: Imaging molecules to embryos at high spatiotemporal resolution

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Vascular permeability in a human tumor xenograft: molecular size dependence and cutoff size.

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viSNE enables visualization of high dimensional single-cell data and reveals phenotypic heterogeneity of leukemia

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Nanometer resolution imaging and tracking of fluorescent molecules with minimal photon fluxes

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Hyaluronan impairs vascular function and drug delivery in a mouse model of pancreatic cancer

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Multiplexed ion beam imaging of human breast tumors

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Angiotensin inhibition enhances drug delivery and potentiates chemotherapy by decompressing tumour blood vessels

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Cancer cells induce metastasis-supporting neutrophil extracellular DNA traps

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The role of myeloid cells in cancer therapies

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In vivo magnetic resonance imaging of transgene expression

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Clinical translation of an ultrasmall inorganic optical-PET imaging nanoparticle probe

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Protein-retention expansion microscopy of cells and tissues labeled using standard fluorescent proteins and antibodies

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In vivo imaging reveals a tumor-associated macrophage-mediated resistance pathway in anti-PD-1 therapy

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Collagen-based cell migration models in vitro and in vivo

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Phase II and phase III failures: 2013–2015

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High affinity restricts the localization and tumor penetration of single-chain fv antibody molecules.

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Real-Time Imaging Reveals Local, Transient Vascular Permeability, and Tumor Cell Intravasation Stimulated by TIE2hi Macrophage–Derived VEGFA

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ScaleS: an optical clearing palette for biological imaging

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Intravital Imaging Reveals How BRAF Inhibition Generates Drug-Tolerant Microenvironments with High Integrin β1/FAK Signaling

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A Cellular Trojan Horse for Delivery of Therapeutic Nanoparticles into Tumors

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Highly multiplexed imaging of single cells using a high-throughput cyclic immunofluorescence method

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MorphoGraphX: A platform for quantifying morphogenesis in 4D

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Near-infrared fluorescent proteins for multicolor in vivo imaging

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Whole-Body Imaging with Single-Cell Resolution by Tissue Decolorization

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Imaging Tumor-Stroma Interactions during Chemotherapy Reveals Contributions of the Microenvironment to Resistance

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Bevacizumab-Induced Transient Remodeling of the Vasculature in Neuroblastoma Xenografts Results in Improved Delivery and Efficacy of Systemically Administered Chemotherapy

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Visualization of immediate immune responses to pioneer metastatic cells in the lung

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Tumour‐associated macrophages act as a slow‐release reservoir of nano‐therapeutic Pt(IV) pro‐drug

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T–B-cell entanglement and ICOSL-driven feed-forward regulation of germinal centre reaction

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Histo-Cytometry: A Method for Highly Multiplex Quantitative Tissue Imaging Analysis Applied to Dendritic Cell Subset Microanatomy in Lymph Nodes

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Improved tools for the Brainbow toolbox

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Vascular bursts enhance permeability of tumour blood vessels and improve nanoparticle delivery

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High content screening: seeing is believing

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Dynamic signaling by T follicular helper cells during germinal center B cell selection

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Plasticity between Epithelial and Mesenchymal States Unlinks EMT from Metastasis-Enhancing Stem Cell Capacity

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The proliferation rate paradox in antimitotic chemotherapy

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In vivo Real-time Tracking of Single Quantum Dots Conjugated with Monoclonal Anti-HER2 Antibody in Tumors of Mice

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An Enhanced Monomeric Blue Fluorescent Protein with the High Chemical Stability of the Chromophore

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Predicting therapeutic nanomedicine efficacy using a companion magnetic resonance imaging nanoparticle

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Tridimensional Visualization and Analysis of Early Human Development

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TGF-β blockade improves the distribution and efficacy of therapeutics in breast carcinoma by normalizing the tumor stroma

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Direct evidence for cancer-cell-autonomous extracellular protein catabolism in pancreatic tumors

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Marginating Dendritic Cells of the Tumor Microenvironment Cross-Present Tumor Antigens and Stably Engage Tumor-Specific T Cells

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Amino-Biphosphonate–Mediated MMP-9 Inhibition Breaks the Tumor-Bone Marrow Axis Responsible for Myeloid-Derived Suppressor Cell Expansion and Macrophage Infiltration in Tumor Stroma

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Reporter gene imaging of targeted T cell immunotherapy in recurrent glioma

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Live dynamic imaging of caveolae pumping targeted antibody rapidly and specifically across endothelium in the lung

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Prevention of vascular inflammation by nanoparticle targeting of adherent neutrophils

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A mouse-human phase 1 co-clinical trial of a protease-activated fluorescent probe for imaging cancer

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Direct wavefront sensing for high-resolution in vivo imaging in scattering tissue

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Simultaneous two-photon calcium imaging at different depths with spatiotemporal multiplexing

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Nano-palladium is a cellular catalyst for in vivo chemistry

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Neutrophil-Mediated Delivery of Therapeutic Nanoparticles across Blood Vessel Barrier for Treatment of Inflammation and Infection

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BigDataViewer: visualization and processing for large image data sets

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Adaptive light-sheet microscopy for long-term, high-resolution imaging in living organisms

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Catumaxomab: Clinical development and future directions

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Technologies for imaging neural activity in large volumes

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Transient tissue priming via ROCK inhibition uncouples pancreatic cancer progression, sensitivity to chemotherapy, and metastasis

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Whole-body tissue stabilization and selective extractions via tissue-hydrogel hybrids for high-resolution intact circuit mapping and phenotyping

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Quantitative PET of EGFR expression in xenograft-bearing mice using 64Cu-labeled cetuximab, a chimeric anti-EGFR monoclonal antibody

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Selective uptake of single-walled carbon nanotubes by circulating monocytes for enhanced tumour delivery

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BigNeuron: Large-Scale 3D Neuron Reconstruction from Optical Microscopy Images

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Molecular imaging using fluorescent lectins permits rapid endoscopic identification of dysplasia in Barrett's esophagus

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Segmentation and quantification of subcellular structures in fluorescence microscopy images using Squassh

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Systemic antithrombotic effects of ADAMTS13

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Radiation therapy primes tumors for nanotherapeutic delivery via macrophage-mediated vascular bursts

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Hybrid PET-optical imaging using targeted probes

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Bisphosphonates in the Adjuvant Setting of Breast Cancer Therapy—Effect on Survival: A Systematic Review and Meta-Analysis

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Single Reporter for Targeted Multimodal in Vivo Imaging

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In Vivo Imaging of T Cell PrimingA presentation from the 11th Joint Meeting of the Signal Transduction Society (STS), Signal Transduction: Receptors, Mediators and Genes, Weimar, Germany, 1 to 3 November 2007.

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Dynamically varying interactions between heregulin and ErbB proteins detected by single-molecule analysis in living cells

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Efficient Acid‐Catalyzed 18F/19F Fluoride Exchange of BODIPY Dyes

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Thromboxane A2 acts as tonic immunoregulator by preferential disruption of low-avidity CD4+ T cell–dendritic cell interactions

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In vivo visualization of albumin degradation in the proximal tubule

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In vivo imaging and histochemistry are combined in the cryosection labelling and intravital microscopy technique

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Long-term High-Resolution Intravital Microscopy in the Lung with a Vacuum Stabilized Imaging Window

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In vivo real-time imaging of chemotherapy response on the liver metastatic tumor microenvironment using multiphoton microscopy

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Intravital Imaging of Tumor Apoptosis with FRET Probes During Tumor Therapy

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Heat‐Induced Radiolabeling of Nanoparticles for Monocyte Tracking by PET

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Multichannel Imaging to Quantify Four Classes of Pharmacokinetic Distribution in Tumors

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Intravital imaging of donor allogeneic effector and regulatory T cells with host dendritic cells during GVHD

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Receptor–Ligand Interactions: Binding Affinities Studied by Single‐Molecule and Super‐Resolution Microscopy on Intact Cells

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Putative CD133 + melanoma cancer stem cells induce initial angiogenesis in vivo

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CD24 + tumor-initiating cells from oral squamous cell carcinoma induce initial angiogenesis in vivo

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Interference with C a2+ release activated C a2+ ( CRAC ) channel function delays T ‐cell arrest in vivo

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The HIV-1 envelope protein gp120 is captured and displayed for B cell recognition by SIGN-R1+ lymph node macrophages

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Effects of chronic kidney disease on liver transport: quantitative intravital microscopy of fluorescein transport in the rat liver

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Intravital imaging reveals conversion between distinct tumor vascular morphologies and localized vascular response to Sunitinib

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A non-invasive imaging for the in vivo tracking of high-speed vesicle transport in mouse neutrophils

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Tumor Targeting and Pharmacokinetics of a Near-Infrared Fluorescent-Labeled δ-Opioid Receptor Antagonist Agent, Dmt-Tic-Cy5

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Endrov: an integrated platform for image analysis

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Molecular imaging in oncology drug development

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Functional characterization of hepatic transporters using intravital microscopy

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Visualizing and quantifying difference in cytoplasmic and nuclear metabolism in the hepatobiliary system in vivo

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Imaging fibrosis in pancreatic cancer using second harmonic generation

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Steady state anisotropy two-photon microscopy resolves multiple, spectrally similar fluorophores, enabling in vivo multilabel imaging

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PET in Neurological and Psychiatric Disorders: Technologic Advances and Clinical Applications

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Approaches to Improve EPR-Based Drug Delivery for Cancer Therapy and Diagnosis

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Improving nanotherapy delivery and action through image-guided systems pharmacology

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Pharmacological and toxicological aspects of drug metabolism

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Pharmacological and toxicological aspects of drug metabolism

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Drug Interactions ? Causes & Implications

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Delay Between Drug Action, Drug Effect and Final Drug Exposure

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Drug Resistance and Drug Synergism

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